Oxidative stress in the trabecular meshwork of POAG;Oxidativer stress im trabekelwerk beim POWG

Klinische Monatsblatter fur Augenheilkunde

Volumn 227, Issue 2, 2010, Pages 99-107

  Welge Lüßen, Ulrich ^a   Birke, K ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Glaucoma; Oxidative stress; Trabecular meshwork

Indexed keywords

ANTIOXIDANT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBONATE DEHYDRATASE INHIBITOR; METALLOPROTEINASE; OXYGEN RADICAL; PROSTAGLANDIN DERIVATIVE;

AGE DISTRIBUTION; CELL AGING; CELL DEATH; CYTOSKELETON; DISEASE COURSE; EXTRACELLULAR MATRIX; EYE BLOOD FLOW; HEREDITY; HUMAN; IN VITRO STUDY; INTRAOCULAR PRESSURE; MORPHOLOGY; OPEN ANGLE GLAUCOMA; OPTIC NERVE; OPTIC NERVE DISEASE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN DEGRADATION; REVIEW; TRABECULAR MESHWORK;

ANTIOXIDANTS; APOPTOSIS; CELL AGING; CYTOSKELETON; EXTRACELLULAR MATRIX; GLAUCOMA, OPEN-ANGLE; HUMANS; INFLAMMATION MEDIATORS; MICROSCOPY, ELECTRON; OPTIC NEUROPATHY, ISCHEMIC; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RISK FACTORS; TRABECULAR MESHWORK;

EID: 77149154991     PISSN: 00232165     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1245171     Document Type: Review

References (102)

1. Berisha F, Schmetterer K, Vass C et al. Effect of trabeculectomy on ocular blood flow. Br J Ophthalmol 2005; 89: 185-188
2. Grieshaber MC, Flammer J. Blood flow in glaucoma. Curr Opin Ophthalmol 2005; 16: 79-83
3. Harju M, Vesti E. Blood flow of the optic nerve head and peripapillary retina in exfoliation syndrome with unilateral glaucoma or ocular hypertension. Graefes Arch Clin Exp Ophthalmol 2001; 239: 271-277
4. Liton PB, Challa P, Stinnett S et al. Cellular senescence in the glaucomatous outflow pathway. Exp Gerontol 2005; 40: 745-748
5. Lutjen-Drecoll E. Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease. Exp Eye Res 2005; 81: 1-4
6. Sacca SC, Bolognesi C, Battistella A et al. Gene-environment interactions in ocular diseases. Mutat Res 2009; 667: 98-117
7. Klein BE, Klein R, Linton KL. Intraocular pressure in an American community. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 1992; 33: 2224-2228
8. Leske MC, Connell AM, Wu SY et al. Distribution of intraocular pressure. The Barbados Eye Study. Arch Ophthalmol 1997; 115: 1051-1057
9. Tielsch JM, Sommer A, Katz J et al. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA 1991; 266: 369-374
10. Weih LM, Mukesh BN, McCarty CA et al. Association of demographic, familial, medical, and ocular factors with intraocular pressure. Arch Ophthalmol 2001; 119: 875-880
11. Wu SY, Leske MC. Associations with intraocular pressure in the Barbados Eye Study. Arch Ophthalmol 1997; 115: 1572-1576
12. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298-300
13. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 2000; 35: 927-945
14. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621
15. Toussaint O, Remacle J, Dierick JF et al. From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing. Int J Biochem Cell Biol 2002; 34: 1415-1429
16. Chen J, Goligorsky MS. Premature senescence of endothelial cells: Methusaleh's dilemma. Am J Physiol Heart Circ Physiol 2006; 290: H1729-1739
17. Dumont P, Burton M, Chen QM et al. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med 2000; 28: 361-373
18. Terman A, Brunk UT. Oxidative stress, accumulation of biological "garbage", and aging. Antioxid Redox Signal 2006; 8: 197-204
19. Ding G, Franki N, Kapasi AA et al. Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats. Exp Mol Pathol 2001; 70: 43-53
20. Martin JA, Buckwalter JA. The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J Bone Joint Surg Am 2003; 85-A (Suppl 2): 106-110
21. Wiemann SU, Satyanarayana A, Tsahuridu M et al. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 2002; 16: 935-942
22. Feher J, Kovacs I, Artico M et al. Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging 2006; 27: 983-993
23. Roth F, Bindewald A, Holz FG. Keypathophysiologic pathways in age-related macular disease. Graefes Arch Clin Exp Ophthalmol 2004; 242: 710-716
24. Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol 2004; 122: 598-614
25. Tezel G, Luo C, Yang X. Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci 2007; 48: 1201-1211
26. Wolfs RC, Klaver CC, Ramrattan RS et al. Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Arch Ophthalmol 1998; 116: 1640-1645
27. Fingert JH, Heon E, Liebmann JM et al. Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum Mol Genet 1999; 8: 899-905
28. Adam MF, Belmouden A, Binisti P et al. Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma. Hum Mol Genet 1997; 6: 2091-2097
29. O'Brien ET, Ren X, Wang Y. Localization of myocilin to the golgi apparatus in Schlemm's canal cells. Invest Ophthalmol Vis Sci 2000; 41: 3842-3849
30. Ueda J,Wentz-Hunter KK, Cheng EL et al. Ultrastructural localization of myocilin in human trabecular meshwork cells and tissues. J Histochem Cytochem 2000; 48: 1321-1330
31. Fingert JH, Stone EM, Sheffield VC et al. Myocilin glaucoma. Surv Ophthalmol 2002; 47: 547-561
32. Liu Y, Vollrath D. Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma. Hum Mol Genet 2004; 13: 1193-1204
33. He Y, Leung KW, Zhuo YH et al. Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells. Mol Vis 2009; 15: 815-825
34. Izzotti A, Sacca SC, Cartiglia C et al. Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am J Med 2003; 114: 638-646
35. Oz O, Aras Ates N, Tamer L et al. Glutathione S-transferaseM1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Eur J Ophthalmol 2006; 16: 105-110
36. Sekine Y, Hommura S, Harada S. Frequency of glutathione-S- transferase 1 gene deletion and its possible correlation with cataract formation. Exp Eye Res 1995; 60: 159-163
37. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005; 45: 51-88
38. Galambos P, Vafiadis J, Vilchez SE et al. Compromised autoregulatory control of ocular hemodynamics in glaucoma patients after postural change. Ophthalmology 2006; 113: 1832-1836
39. Haggendal E, Nilsson NJ, Norback B. Aspects of the autoregulation of cerebral blood flow. Int Anesthesiol Clin 1969; 7: 353-367
40. Harris A, Ciulla TA, Chung HS et al. Regulation of retinal and optic nerve blood flow. Arch Ophthalmol 1998; 116: 1491-1495
41. Ehrlich R, Kheradiya NS,Winston DM et al. Age-related ocular vascular changes. Graefes Arch Clin Exp Ophthalmol 2009; 247: 583-591
42. Moore D, Harris A, Wudunn D et al. Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma? Clin Ophthalmol 2008; 2: 849-861
43. Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res 2006; 612: 105-114
44. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol 2002; 282: C227-C241
45. Proell V, Carmona-Cuenca I, Murillo MM et al. TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. Comp Hepatol 2007; 6: 1
46. Abu-Amero KK, Morales J, Bosley TM. Mitochondrial abnormalities in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 2006; 47: 2533-2541
47. Sacca SC, Pascotto A, Camicione P et al. Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. Arch Ophthalmol 2005; 123: 458-463
48. Ferreira SM, Lerner SF, Brunzini R et al. Oxidative stress markers in aqueous humor of glaucoma patients. Am J Ophthalmol 2004; 137: 62-69
49. He Y, Leung KW, Zhang YH et al. Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci 2008; 49: 1447-1458
50. Balansky RM, Izzotti A, D'Agostini F et al. Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice. Carcinogenesis 2003; 24: 1525-1532
51. Wei H, Ca Q, Rahn R et al. DNA structural integrity and base composition affect ultraviolet light-induced oxidative DNA damage. Biochemistry 1998; 37: 6485-6490
52. Nakabayashi M. Review of the ischemia hypothesis for ocular hypertension other than congenital glaucoma and closed-angle glaucoma. Ophthalmologica 2004; 218: 344-349
53. Globus MY, Busto R, Lin B et al. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 1995; 65: 1250-1256
54. Saugstad OD. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatr 1996; 85: 1-4
55. Matsuda S, Gomi F, Katayama T et al. Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress. Jpn J Ophthalmol 2006; 50: 229-234
56. Zhang X, Li J, Sejas DP et al. Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells. Blood 2005; 106: 75-85
57. Azhar G, Liu L, Zhang X et al. Influence of age on hypoxia/reoxygenation-induced DNA fragmentation and bcl-2, bcl-xl, bax and fas in the rat heart and brain. Mech Ageing Dev 1999; 112: 5-25
58. Ben-Yosef Y, Lahat N, Shapiro S et al. Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation. Circ Res 2002; 90: 784-791
59. Torii H, Kubota H, Ishihara H et al. Cilostazol inhibits the redistribution of the actin cytoskeleton and junctional proteins on the blood-brain barrier under hypoxia/reoxygenation. Pharmacol Res 2007; 55: 104-110
60. Alge CS, Priglinger SG, Neubauer AS et al. Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin. Invest Ophthalmol Vis Sci 2002; 43: 3575-3582
61. Cumurcu T, Bulut Y, Demir HD et al. Aqueous humor erythropoietin levels in patients with primary open-angle glaucoma. J Glaucoma 2007; 16: 645-648
62. Noecker R. Effects of common ophthalmic preservatives on ocular health. Adv Ther 2001; 18: 205-215
63. Debbasch C, Brignole F, Pisella PJ et al. Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells. Invest Ophthalmol Vis Sci 2001; 42: 642-652
64. Guenoun JM, Baudouin C, Rat P et al. In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci 2005; 46: 2444-2450
65. Temple MD, Perrone GG, Dawes IW. Complex cellular responses to reactive oxygen species. Trends Cell Biol 2005; 15: 319-326
66. Fuchshofer R, Yu AL, Teng HH et al. Hypoxia/reoxygenation induces CTGF and PAI-1 in cultured human retinal pigment epithelium cells. Exp Eye Res 2009; 88: 889-899
67. Madigan MC, Penfold PL, Provis JM et al. Intermediate filament expression in human retinal macroglia. Histopathologic changes associated with age-related macular degeneration. Retina 1994; 14: 65-74
68. Rauhut D, Rohen JW. Electron Microscopic study of the trabecular meshwork in alphachymotrypsin glaucoma. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1972; 184: 29-41
69. Babizhayev MA, Brodskaya MW. Fibronectin detection in drainage outflow system of human eyes in ageing and progression of open-angle glaucoma. Mech Ageing Dev 1989; 47: 145-157
70. Trabecular extracellular matrix regulation In: Acott TS (Hrsg). Baltimore: Wiliams & Wilkins, 1992: 125-157
71. Welge-Lussen U, Eichhorn M, Bloemendal H et al. Classification of human scleral spur cells in monolayer culture. Eur J Cell Biol 1998; 75: 78-84
72. Yu AL, Fuchshofer R, Kampik A et al. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues. Invest Ophthalmol Vis Sci 2008; 49: 4872-4880
73. Liton PB, Gonzalez P, Epstein DL. The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp Eye Res 2009; 88: 724-728
74. Alvarado J, Murphy C, Juster R. Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals. Ophthalmology 1984; 91: 564-579
75. Tan JC, Peters DM, Kaufman PL. Recent developments in understanding the pathophysiology of elevated intraocular pressure. Curr Opin Ophthalmol 2006; 17: 168-174
76. Gardel ML, Shin JH, MacKintosh FC et al. Scaling of F-actin network rheology to probe single filament elasticity and dynamics. Phys Rev Lett 2004; 93: 188102
77. Dalle-Donne I, Rossi R, Giustarini D et al. Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment. Free Radic Biol Med 2001; 31: 1075-1083
78. Zhu J, Zhou K, Hao JJ et al. Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits. J Cell Sci 2005; 118: 807-817
79. Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res 2009; 28: 348-368
80. Li G, Luna C, Liton PB et al. Sustained stress response after oxidative stress in trabecular meshwork cells. Mol Vis 2007; 13: 2282-2288
81. Liton PB, Luna C, Challa P et al. Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue. Mol Vis 2006; 12: 774-790
82. Wang N, Chintala SK, Fini ME et al. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med 2001; 7: 304-309
83. Caballero M, Liton PB, Epstein DL et al. Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. Biochem Biophys Res Commun 2003; 308: 346-352
84. Costarides AP, Riley MV, Green K. Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen peroxide. Ophthalmic Res 1991; 23: 284-294
85. Riley MV. Physiologic neutralization mechanisms and the response of the corneal endothelium to hydrogen peroxide. CLAO J 1990; 16: S16-21, discussion S21-S12
86. Sacca SC, Izzotti A, Rossi P et al. Glaucomatous outflow pathway and oxidative stress. Exp Eye Res 2007; 84: 389-399
87. Chow CK, Ibrahim W, Wei Z et al. Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radic Biol Med 1999; 27: 580-587
88. Giblin FJ, McCready JP, Kodama T et al. A direct correlation between the levels of ascorbic acid and H2O2 in aqueous humor. Exp Eye Res 1984; 38: 87-93
89. Ringvold A, Anderssen E, Kjonniksen I. Distribution of ascorbate in the anterior bovine eye. Invest Ophthalmol Vis Sci 2000; 41: 20-23
90. Kang JH, Pasquale LR, Willett W et al. Antioxidant intake and primary open-angle glaucoma: a prospective study. Am J Epidemiol 2003; 158: 337-346
91. Varma SD. Scientific basis for medical therapy of cataracts by antioxidants. Am J Clin Nutr 1991; 53: 335S-345S
92. Augustin W, Wiswedel I, Noack H et al. Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria. Mol Cell Biochem 1997; 174: 199-205
93. Hamard P, Blondin C, Debbasch C et al. In vitro effects of preserved and unpreserved antiglaucoma drugs on apoptotic marker expression by human trabecular cells. Graefes Arch Clin Exp Ophthalmol 2003; 241: 1037-1043
94. Kim EJ, Kwon KJ, Park JY et al. Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation. J Neurosci Res 2002; 70: 97-107
95. Towndrow KM, Jia Z, Lo HH et al. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol 2003; 16: 312-319
96. Towndrow KM, Mertens JJ, Jeong JK et al. Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells. Chem Res Toxicol 2000; 13: 111-117
97. Thieme H, Schimmat C, Munzer G et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci 2006; 47: 938-945
98. Miyamoto N, Izumi H, Miyamoto R et al. Nipradilol and timolol induce Foxo3a and peroxiredoxin 2 expression and protect trabecular meshwork cells from oxidative stress. Invest Ophthalmol Vis Sci 2009; 50: 2777-2784
99. Kinshuck D. Glauline (metipranolol) induced uveitis and increase in intraocular pressure. Br J Ophthalmol 1991; 75: 575
100. Zanon-Moreno V, Garcia-Medina JJ, Gallego-Pinazo R et al. Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma. Eur J Ophthalmol 2009; 19: 565-571
101. Coleman AL, Stone KL, Kodjebacheva G et al. Glaucoma risk and the consumption of fruits and vegetables among older women in the study of osteoporotic fractures. Am J Ophthalmol 2008; 145: 1081-1089
102. Luna C, Li G, Liton PB et al. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. Food Chem Toxicol 2009; 47: 198-204