Actin carbonylation: From a simple marker of protein oxidation to relevant signs of severe functional impairment

Free Radical Biology and Medicine

Volumn 31, Issue 9, 2001, Pages 1075-1083

  Dalle Donne, I ^a   Rossi, R ^b   Giustarini, D ^b   Gagliano, N ^a   Lusini, L ^b   Milzani, A ^a   Di Simplicio, P ^b   Colombo, R ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Actin carbonylation; Actin functional impairment; Dityrosine; Free radicals; Hypochlorous acid; Intermolecular cross linking

Indexed keywords

ACTIN; AMINO ACID; BIOLOGICAL MARKER; CARBONYL DERIVATIVE; CYSTEINE; F ACTIN; HYPOCHLOROUS ACID; METHIONINE; PROTEIN; REDUCING AGENT;

ACTIN FILAMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DENATURATION; FUNCTIONAL DISEASE; IN VIVO STUDY; NONHUMAN; OXIDATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CONTENT; PURIFICATION; RABBIT; REDUCTION; STOICHIOMETRY;

ACTINS; ANIMALS; BIOLOGICAL MARKERS; CARBONIC ACID; CROSS-LINKING REAGENTS; CYSTEINE; FLUOROMETRY; HYPOCHLOROUS ACID; METHIONINE; MICROFILAMENTS; MUSCLE, SKELETAL; OXIDATION-REDUCTION; RABBITS; TYROSINE;

EID: 0035500775     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00690-6     Document Type: Article

References (54)

1. Protein oxidation in aging, disease, and oxidative stress
2. Reactive oxygen-mediated protein oxidation in aging and disease
3. Reactive oxygen-mediated protein oxidation in aging and disease
4. Protein oxidation in the brain in Alzheimer's disease
5. Actin is oxidized during myocardial ischemia
6. Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor alpha in a human colonic cell line
7. Myeloperoxisdase - A key regulator of neutrophil oxidant production
8. Oxidation of proteins in rat heart and lungs by polymorphonuclear leukocyte oxidants
9. Mechanisms of hypochlorite injury of target cells
10. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes
11. Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis
12. Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation
13. Oxidative modifications of apoB-100 by exposure of low density lipoproteins to HOCl in vitro
14. Proteins released from stimulated neutrophils contain very high levels of oxidized methionine
15. Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages
16. Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins
17. Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: A sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation
18. Oxidative damage to fibronectin. I. The effects of the neutrophil myeloperoxidase system and HOCl
19. Hypochlorite-induced damage to proteins: Formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation
20. Hypochlorite-induced oxidation of proteins in plasma: Formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation
21. Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite
22. Hypochlorous acid interactions with thiols, nucleotides, DNA, and other biological substrates
23. Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid
24. Characterization of the oxidation products of the reaction between reduced glutathione and hypochlorous acid
25. Neutrophils convert tyrosyl residues in albumin to chlorotyrosine
26. Long-lived oxidants generated by human neutrophils: Characterization and bioactivity
27. Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages
28. Hypochlorous acid and chloramines increase endothelial permeability: Possible involvement of cellular zinc
29. S-NO-Actin: S-nitrosylation kinetics and effect on isolated vascular smooth muscle
30. The measurement of actin concentration in solution: A comparison of methods
31. The acid ionization constant of HOCl from 5 to 35 degrees
32. Carbonyl assays for determination of oxidatively modified proteins
33. Tissue sulfhydryl groups
34. Reassessment of Ellman's reagent
35. The oxidation produced by hydrogen peroxide on Ca-ATP-G-actin
36. Cleavage of structural proteins during assembly of the head of bacteriophage T4
37. Fluorometric assay of proteins in the nanogram range
38. The t-butyl hydroperoxide-induced oxidation of actin Cys-374 is coupled with structural changes in distant regions of the protein
39. Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure
40. Thiol oxidation of actin produces dimers that enhance the elasticity of the F-actin network
41. Fragmentation of actin filaments
42. Complete amino-acid sequence of actin of rabbit skeletal muscle
43. Generation of nitrogen-chlorine oxidants by human phagocytes
44. Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation
45. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome
46. On the dynamics of the microfilament system in HeLa cells
47. From signal to pseudopod. How cells control cytoplasmic actin assembly
48. Cytoskeleton-plasma membrane interactions
49. Hyperpermeability of intestinal epithelial monolayers is induced by NO: Effect of low extracellular pH
50. Diapedesis and the permeability of venous microvessels to protein macromolecules: The impact of leukotriene B4 (LTB4)
51. Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery
52. Relationship between polyamines, actin distribution, and gastric mucosal ulcer healing in rats
53. Role of actin cytoskeleton in prostaglandin-induced protection against ethanol in an intestinal epithelial cell line, IEC-6
54. OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability