Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation

Circulation Research

Volumn 90, Issue 7, 2002, Pages 784-791

  Ben Yosef, Yaara ^a   Lahat, Nitza ^a,b   Shapiro, Sarah ^a   Bitterman, Haim ^a,b   Miller, Ariel ^a,b  

^a CARMEL MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Endothelium; Hypoxia; Matrix metalloproteinases; Reoxygenation; Tissue inhibitors of matrix metalloproteinases

Indexed keywords

GELATINASE A; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME RELEASE; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; REOXYGENATION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM;

BLOTTING, NORTHERN; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MICROCIRCULATION; OXYGEN; RNA STABILITY; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2; UP-REGULATION;

EID: 0037134413     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000015588.70132.DC     Document Type: Article

References (38)

1. Endothelial cell hypoxic stress proteins
2. Endothelial cell response to hypoxic stress
3. Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types
4. Angiogenesis
5. Mechanisms of angiogenesis and arteriogenesis
6. Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
7. Matrix metalloproteinases, novel target for directed cancer therapy
8. Transcriptional control of matrix metalloproteinases and tissue inhibitors of metalloproteinases
9. Activation mechanisms of matrix metalloproteinases
10. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions
11. Mechanism of cell surface activation of 72-kDa type IV collagenase
12. Adaptive responses of the endothelium to stress
13. Permanent cell line expressing human factor VIII-related antigen established by hybridization
14. Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 glioblastoma cells
15. Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells
16. Endothelial cell responses to hypoxia: Initiation of a cascade of cellular interactions
17. Extracellular matrix metalloproteinase production in endothelial cells: Implications for angiogenesis
18. Collagenase-1, stromelysin-1 and 92 kDa gelatinase are associated with tumor necrosis factor-α induced morphological change of human endothelial cells in vitro
19. Hypoxia stimulates proximal tubular cell matrix production via TGF-β independent mechanism
20. Hypoxia arrests ovarian carcinoma cell cycle progression, but invasion is unaffected
21. Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2
22. 5 in cultured human endothelial cells
23. Membrane-type metalloproteinases in tumor invasion
24. Matrix metalloproteinases in cerebrovascular disease
25. Estimation of gelatinase content in rat brain: Effect of focal ischemia
26. Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart
27. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
28. Molecular insights into renal interstitial fibrosis
29. Human microvascular endothelial cells differ from macrovascular endothelial cells in their expression of matrix metalloproteinases
30. Macrovascular and microvascular endothelium during long-term hypoxia: Alterations in cell growth, monolayer permeability, and cell surface coagulant properties
31. Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation
32. Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cells
33. Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter
34. Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of pro-thrombin to thrombin results in progelatinase A activation and cell proliferation
35. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
36. The AP-1 site and MMP regulation: What is all the fuss about?
37. Activation of human umbilical vein endothelial cell progelatinase A by phorbol myristate acetate: A protein kinase C-dependent mechanism involving a membrane-type matrix metalloproteinase
38. Structure and characterization of the human tissue inhibitor of metalloproteinase-2 gene