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Volumn 55, Issue 2, 2007, Pages 104-110

Cilostazol inhibits the redistribution of the actin cytoskeleton and junctional proteins on the blood-brain barrier under hypoxia/reoxygenation

Author keywords

Actin cytoskeleton; Adherens junction proteins; Cilostazol; Hypoxia reoxygenation; Tight junction proteins

Indexed keywords

BETA CATENIN; CILOSTAZOL; F ACTIN; PROTEIN; PROTEIN ZO1; PROTEIN ZO2; UNCLASSIFIED DRUG;

EID: 33846565008     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2006.10.010     Document Type: Article
Times cited : (34)

References (46)
  • 2
    • 0036175952 scopus 로고    scopus 로고
    • Neuroprotective effect of cilostazol against focal cerebral ischemia via anti-apoptotic action in rats
    • Choi J.M., Shin H.K., Kim K.Y., Lee J.H., and Hong K.W. Neuroprotective effect of cilostazol against focal cerebral ischemia via anti-apoptotic action in rats. J Pharmacol Exp Ther 300 (2002) 787-793
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 787-793
    • Choi, J.M.1    Shin, H.K.2    Kim, K.Y.3    Lee, J.H.4    Hong, K.W.5
  • 3
    • 0036156874 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced apoptosis by cilostazol in human umbilical vein endothelial cells
    • Kim K.Y., Shin H.K., Choi J.M., and Hong K.W. Inhibition of lipopolysaccharide-induced apoptosis by cilostazol in human umbilical vein endothelial cells. J Pharmacol Exp Ther 300 (2002) 709-715
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 709-715
    • Kim, K.Y.1    Shin, H.K.2    Choi, J.M.3    Hong, K.W.4
  • 4
    • 33747183132 scopus 로고    scopus 로고
    • Protection from apoptotic cell death by cilostazol, phosphodiesterase type III inhibitor, via cAMP-dependent protein kinase activation
    • Kim M.J., Lee J.H., Park S.Y., Hong K.W., Kim C.D., Kim K.Y., et al. Protection from apoptotic cell death by cilostazol, phosphodiesterase type III inhibitor, via cAMP-dependent protein kinase activation. Pharmacol Res 54 (2006) 261-267
    • (2006) Pharmacol Res , vol.54 , pp. 261-267
    • Kim, M.J.1    Lee, J.H.2    Park, S.Y.3    Hong, K.W.4    Kim, C.D.5    Kim, K.Y.6
  • 5
    • 9844267305 scopus 로고    scopus 로고
    • Cilostazol, a cAMP phosphodiesterase inhibitor, attenuates the production of monocyte chemoattractant protein-1 in response to tumor necrosis factor-α in vascular endothelial cells
    • Nishino Y., Kashiwagi A., Takahara N., Hidaka H., and Kikkawa R. Cilostazol, a cAMP phosphodiesterase inhibitor, attenuates the production of monocyte chemoattractant protein-1 in response to tumor necrosis factor-α in vascular endothelial cells. Horm Metab Res 29 (1997) 491-495
    • (1997) Horm Metab Res , vol.29 , pp. 491-495
    • Nishino, Y.1    Kashiwagi, A.2    Takahara, N.3    Hidaka, H.4    Kikkawa, R.5
  • 6
    • 0029964604 scopus 로고    scopus 로고
    • Effect of cilostazol on the production of platelet-derived growth factor in cultured human vascular endothelial cells
    • Mizutani M., Okuda Y., and Yamashita K. Effect of cilostazol on the production of platelet-derived growth factor in cultured human vascular endothelial cells. Biochem Mol Med 57 (1996) 156-158
    • (1996) Biochem Mol Med , vol.57 , pp. 156-158
    • Mizutani, M.1    Okuda, Y.2    Yamashita, K.3
  • 7
    • 0034904647 scopus 로고    scopus 로고
    • Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-κB binding to its recognition sequence
    • Otsuki M., Saito H., Xu X., Sumitani S., Kouhara H., Kurabayashi M., et al. Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-κB binding to its recognition sequence. Atherosclerosis 158 (2001) 121-128
    • (2001) Atherosclerosis , vol.158 , pp. 121-128
    • Otsuki, M.1    Saito, H.2    Xu, X.3    Sumitani, S.4    Kouhara, H.5    Kurabayashi, M.6
  • 8
    • 33846579599 scopus 로고    scopus 로고
    • Hashimoto A, Miyakoda G, Hirose Y, Mori T. Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A-and phosphatidylinositol 3-kinase/Akt-dependent mechanism. Atherosalerosis, in press.
  • 11
    • 0036084919 scopus 로고    scopus 로고
    • Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation
    • Karen S.M., and Davis T.P. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol 282 (2002) H1485-H1494
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Karen, S.M.1    Davis, T.P.2
  • 12
    • 0036845862 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinaseactivation during reoxgenation is required to restore ischaemia-inducced endothelial barrier failure
    • Wachtel M., Frei K., Ehler E., Bauer C., Gassmann M., and Gloor S.M. Extracellular signal-regulated protein kinaseactivation during reoxgenation is required to restore ischaemia-inducced endothelial barrier failure. Biochem J 367 (2002) 873-879
    • (2002) Biochem J , vol.367 , pp. 873-879
    • Wachtel, M.1    Frei, K.2    Ehler, E.3    Bauer, C.4    Gassmann, M.5    Gloor, S.M.6
  • 13
    • 0344009459 scopus 로고    scopus 로고
    • Effects of hypoxia-reoxgenation on rat blood-brain barrier permeability and tight junctional protein expression
    • Witt K.A., Mark K.S., Hom S., and Davis T.P. Effects of hypoxia-reoxgenation on rat blood-brain barrier permeability and tight junctional protein expression. Am J Physiol Heart Circ Physiol 285 (2003) H2820-H2831
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Witt, K.A.1    Mark, K.S.2    Hom, S.3    Davis, T.P.4
  • 14
    • 15544387084 scopus 로고    scopus 로고
    • Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells
    • Wojciak-Stothard B., Tsang L.Y., and Haworth G. Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 288 (2005) L749-L760
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Wojciak-Stothard, B.1    Tsang, L.Y.2    Haworth, G.3
  • 15
    • 33750870793 scopus 로고    scopus 로고
    • Microvascular permeability and number of tight junctions are modulated by cAMP
    • Adamson R.H., Liu B., Nilson Fry G., Rubin L.L., and Curry F.E. Microvascular permeability and number of tight junctions are modulated by cAMP. Am J Physiol 274 (1998) H1885-H1894
    • (1998) Am J Physiol , vol.274
    • Adamson, R.H.1    Liu, B.2    Nilson Fry, G.3    Rubin, L.L.4    Curry, F.E.5
  • 16
    • 0034833680 scopus 로고    scopus 로고
    • Cyclic AMP and acidic fibroblast growth factor have opposing effects on tight and adherens junctions in microvascular endothelial cells in vitro
    • Dye J.F., Leach L., Clark P., and Firth A. Cyclic AMP and acidic fibroblast growth factor have opposing effects on tight and adherens junctions in microvascular endothelial cells in vitro. Microvasc Res 62 (2001) 94-113
    • (2001) Microvasc Res , vol.62 , pp. 94-113
    • Dye, J.F.1    Leach, L.2    Clark, P.3    Firth, A.4
  • 17
    • 0344585455 scopus 로고    scopus 로고
    • Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells
    • Fan Y., Wu D.Z., Gong Y.Q., Zhou J.Y., and Hu Z.B. Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol 481 (2003) 33-40
    • (2003) Eur J Pharmacol , vol.481 , pp. 33-40
    • Fan, Y.1    Wu, D.Z.2    Gong, Y.Q.3    Zhou, J.Y.4    Hu, Z.B.5
  • 18
    • 0033387723 scopus 로고    scopus 로고
    • Hypoxia/aglycemia increases endothelial permeability: role of second messengers and cytoskeleton
    • Park J.H., Okayama N., Gute D., Krsmanovic A., Battarbee H., and Alexander J.S. Hypoxia/aglycemia increases endothelial permeability: role of second messengers and cytoskeleton. Am J Physiol 277 (1999) C1066-C1074
    • (1999) Am J Physiol , vol.277
    • Park, J.H.1    Okayama, N.2    Gute, D.3    Krsmanovic, A.4    Battarbee, H.5    Alexander, J.S.6
  • 19
    • 0030748912 scopus 로고    scopus 로고
    • F-actin cytoskeleton and sucrose permeability of immortalized rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors
    • Rist R.J., Romero I.A., Chan M.W., Couraud P.O., Roux F., and Abbott N.J. F-actin cytoskeleton and sucrose permeability of immortalized rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors. Brain Res 768 (1997) 10-18
    • (1997) Brain Res , vol.768 , pp. 10-18
    • Rist, R.J.1    Romero, I.A.2    Chan, M.W.3    Couraud, P.O.4    Roux, F.5    Abbott, N.J.6
  • 21
    • 0028246186 scopus 로고
    • Modulation of tight junction structure in blood-brain barrier endothelial cells. Effect of tissue culture, second messengers and coculture astrocytes
    • Wolburg H., Neuhaus J., Kniesel U., Krauß, Schmid E.M., Öcalan M., et al. Modulation of tight junction structure in blood-brain barrier endothelial cells. Effect of tissue culture, second messengers and coculture astrocytes. J Cell Sci 107 (1994) 1347-1357
    • (1994) J Cell Sci , vol.107 , pp. 1347-1357
    • Wolburg, H.1    Neuhaus, J.2    Kniesel, U.3    Krauß4    Schmid, E.M.5    Öcalan, M.6
  • 22
    • 0042344708 scopus 로고    scopus 로고
    • Protein kinase signaling in the modulation of microvascular permeability
    • Yuan S.Y. Protein kinase signaling in the modulation of microvascular permeability. Vasc Res 39 (2003) 213-223
    • (2003) Vasc Res , vol.39 , pp. 213-223
    • Yuan, S.Y.1
  • 23
    • 0344443260 scopus 로고    scopus 로고
    • Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats-an MRI study
    • Lee J.H., Lee Y.K., Ishikawa M., Koga K., Fukunaga M., Miyakoda G., et al. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats-an MRI study. Brain Res 994 (2003) 91-98
    • (2003) Brain Res , vol.994 , pp. 91-98
    • Lee, J.H.1    Lee, Y.K.2    Ishikawa, M.3    Koga, K.4    Fukunaga, M.5    Miyakoda, G.6
  • 24
    • 20444446335 scopus 로고    scopus 로고
    • Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization
    • Weber C.C., Cai H., Ehrbar M., Kubota H., Martiny-Baron G., Weber W., et al. Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization. J Biol Chem 280 (2005) 22445-22453
    • (2005) J Biol Chem , vol.280 , pp. 22445-22453
    • Weber, C.C.1    Cai, H.2    Ehrbar, M.3    Kubota, H.4    Martiny-Baron, G.5    Weber, W.6
  • 25
    • 17444406065 scopus 로고    scopus 로고
    • Permeability studies on in vitro blood-brain barrier models: physiology, pathology and pharmacology
    • Deli M.A., Ábrahám C.S., Kataoka Y., and Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology and pharmacology. Cell Mol Neurobiol 25 (2005) 59-127
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 59-127
    • Deli, M.A.1    Ábrahám, C.S.2    Kataoka, Y.3    Niwa, M.4
  • 26
    • 0024594707 scopus 로고
    • Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties
    • Stelzner T.J., Weil J.V., and O'Brien R.F. Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J Cell Physiol 139 (1989) 157-166
    • (1989) J Cell Physiol , vol.139 , pp. 157-166
    • Stelzner, T.J.1    Weil, J.V.2    O'Brien, R.F.3
  • 27
    • 0028822474 scopus 로고
    • Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer
    • Plateel M., Dehouck M.P., Torpier G., Cecchelli R., and Teissier E. Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer. J Neurochem 65 (1995) 2138-2145
    • (1995) J Neurochem , vol.65 , pp. 2138-2145
    • Plateel, M.1    Dehouck, M.P.2    Torpier, G.3    Cecchelli, R.4    Teissier, E.5
  • 28
    • 0027195164 scopus 로고
    • Role of phosphodiesterases in the regulation of endothelial permeability in vitro
    • Suttorp N., Weber U., Welsch T., and Schudt C. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J Clin Invest 91 (1993) 1421-1428
    • (1993) J Clin Invest , vol.91 , pp. 1421-1428
    • Suttorp, N.1    Weber, U.2    Welsch, T.3    Schudt, C.4
  • 29
    • 0027363848 scopus 로고
    • Opposing roles of cyclic AMP in the vascular control of edema formation
    • Warren J.B., Wilson A.J., Loi R.K., and Coughlan M.L. Opposing roles of cyclic AMP in the vascular control of edema formation. FASEB J 7 (1993) 1394-1400
    • (1993) FASEB J , vol.7 , pp. 1394-1400
    • Warren, J.B.1    Wilson, A.J.2    Loi, R.K.3    Coughlan, M.L.4
  • 30
    • 0042062395 scopus 로고    scopus 로고
    • VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors
    • Favot L., Keravis T., Holl V., Le Bec A., and Lugnier C. VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors. Thromb Haemost 90 (2003) 334-343
    • (2003) Thromb Haemost , vol.90 , pp. 334-343
    • Favot, L.1    Keravis, T.2    Holl, V.3    Le Bec, A.4    Lugnier, C.5
  • 31
    • 0034990531 scopus 로고    scopus 로고
    • Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement
    • Liu F., Verin A.D., Borbiev T., and Garcia J.G. Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement. Am J Physiol Lung Cell Mol Physiol 280 (2001) L1309-L1317
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280
    • Liu, F.1    Verin, A.D.2    Borbiev, T.3    Garcia, J.G.4
  • 32
    • 0032861251 scopus 로고    scopus 로고
    • Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction
    • Lum H., Jaffe H.A., Schulz I.T., Masood A., RayChaudhury A., and Green R.D. Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction. Am J Physiol 277 (1999) C580-C588
    • (1999) Am J Physiol , vol.277
    • Lum, H.1    Jaffe, H.A.2    Schulz, I.T.3    Masood, A.4    RayChaudhury, A.5    Green, R.D.6
  • 33
    • 0038172667 scopus 로고    scopus 로고
    • PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction
    • Qiao J., Huang F., and Lum H. PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 284 (2003) L972-L980
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Qiao, J.1    Huang, F.2    Lum, H.3
  • 34
    • 0033192720 scopus 로고    scopus 로고
    • Cereport™ (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers
    • Jasmina B.M., Stins M., Jovanovic S., Kim K.S., Bartus R.T., and Zlokovic B.V. Cereport™ (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res 16 (1999) 1360-1365
    • (1999) Pharm Res , vol.16 , pp. 1360-1365
    • Jasmina, B.M.1    Stins, M.2    Jovanovic, S.3    Kim, K.S.4    Bartus, R.T.5    Zlokovic, B.V.6
  • 36
    • 2942718916 scopus 로고    scopus 로고
    • Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly
    • Birukova A.A., Liu F., Garcia J.G., and Verin A.D. Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol 287 (2004) L86-L93
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Birukova, A.A.1    Liu, F.2    Garcia, J.G.3    Verin, A.D.4
  • 37
    • 14944377651 scopus 로고    scopus 로고
    • Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
    • Cullere X., Shaw S.K., Andersson L., Hirahashi J., Luscinskas F.W., and Mayadas T.N. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 105 (2005) 1950-1955
    • (2005) Blood , vol.105 , pp. 1950-1955
    • Cullere, X.1    Shaw, S.K.2    Andersson, L.3    Hirahashi, J.4    Luscinskas, F.W.5    Mayadas, T.N.6
  • 38
    • 11144305139 scopus 로고    scopus 로고
    • Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
    • Fukuhara S., Sakurai A., Sano H., Yamagishi A., Somekawa S., Takakura N., et al. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 25 (2005) 136-146
    • (2005) Mol Cell Biol , vol.25 , pp. 136-146
    • Fukuhara, S.1    Sakurai, A.2    Sano, H.3    Yamagishi, A.4    Somekawa, S.5    Takakura, N.6
  • 39
    • 24144444059 scopus 로고    scopus 로고
    • Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    • Kooistra M.R., Corada M., Dejana E., and Bos J.L. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 579 (2005) 4966-4972
    • (2005) FEBS Lett , vol.579 , pp. 4966-4972
    • Kooistra, M.R.1    Corada, M.2    Dejana, E.3    Bos, J.L.4
  • 40
    • 0347756750 scopus 로고    scopus 로고
    • Transference of recombinant VE-cadherin cytoplasmic domain alters endothelial junctional integrity and porcine microvascular permeability
    • Guo M., Wu M.H., Granger H.J., and Yuan S.Y. Transference of recombinant VE-cadherin cytoplasmic domain alters endothelial junctional integrity and porcine microvascular permeability. J Physiol 554 (2003) 78-88
    • (2003) J Physiol , vol.554 , pp. 78-88
    • Guo, M.1    Wu, M.H.2    Granger, H.J.3    Yuan, S.Y.4
  • 41
    • 17644422166 scopus 로고    scopus 로고
    • Effect of oxidative stress on the junctional proteins of cultured cerebral endothelial cells
    • Krizbai I.A., Bauer H., Bresgen N., Eckl P.M., Farkas A., Szatmári E., et al. Effect of oxidative stress on the junctional proteins of cultured cerebral endothelial cells. Cell Mol Neurobiol 25 (2005) 129-139
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 129-139
    • Krizbai, I.A.1    Bauer, H.2    Bresgen, N.3    Eckl, P.M.4    Farkas, A.5    Szatmári, E.6
  • 42
    • 4444307751 scopus 로고    scopus 로고
    • Statins inhibit reoxgenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3β and transcription factor β-catenin
    • Bergmann M.W., Rechner C., Freund C., Baurand A., Jamali A.E., and Dietz R. Statins inhibit reoxgenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3β and transcription factor β-catenin. J Mol Cell Cardiol 37 (2004) 681-690
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 681-690
    • Bergmann, M.W.1    Rechner, C.2    Freund, C.3    Baurand, A.4    Jamali, A.E.5    Dietz, R.6
  • 43
    • 0141768242 scopus 로고    scopus 로고
    • The condition inactivation of β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    • Cattelino A., Liebner S., Gallini R., Zanetti A., Balconi G., Corsi A., et al. The condition inactivation of β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 162 (2003) 1111-1122
    • (2003) J Cell Biol , vol.162 , pp. 1111-1122
    • Cattelino, A.1    Liebner, S.2    Gallini, R.3    Zanetti, A.4    Balconi, G.5    Corsi, A.6
  • 45
    • 26444486391 scopus 로고    scopus 로고
    • Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination
    • Hino S., Tanji C., Nakayama K.I., and Kikuchi A. Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination. Mol Cell Biol 25 (2005) 9063-9072
    • (2005) Mol Cell Biol , vol.25 , pp. 9063-9072
    • Hino, S.1    Tanji, C.2    Nakayama, K.I.3    Kikuchi, A.4
  • 46
    • 0142026252 scopus 로고    scopus 로고
    • Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and-independent pathways
    • Ishizaki T., Chiba H., Kojima T., Fujibe M., Soma T., Miyajima H., et al. Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and-independent pathways. Exp Cell Res 290 (2003) 275-288
    • (2003) Exp Cell Res , vol.290 , pp. 275-288
    • Ishizaki, T.1    Chiba, H.2    Kojima, T.3    Fujibe, M.4    Soma, T.5    Miyajima, H.6


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