메뉴 건너뛰기




Volumn 53, Issue 9, 2009, Pages 1088-1095

Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome;Diminuição da produção de leptina pelo tecido adiposo na obesidade associada à síndrome metabólica severa

Author keywords

Adipokines; Leptin; Leptinemia; Metabolic syndrome; Obesity

Indexed keywords


EID: 77149153389     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/s0004-27302009000900005     Document Type: Article
Times cited : (35)

References (52)
  • 1
    • 0034471041 scopus 로고    scopus 로고
    • Report of a WHO consultation. World Health Organ Tech Rep Ser
    • Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000; 894: i-xii,1-253.
    • (2000) Obesity: Preventing and Managing the Global Epidemic , vol.894
  • 2
    • 26944475323 scopus 로고    scopus 로고
    • IBGE [Internet], Comunicação Social [cited 2009 Mar 10]; Available from
    • IBGE [Internet]. Pesquisa de Orçamentos Familiares - 2002-2003. Comunicação Social [cited 2009 Mar 10]; Available from: http://www.ibge.gov.br/home/presidencia/noticias/noticia_impres-sao.php? id_noticia=278.
    • Pesquisa De Orçamentos Familiares - 2002-2003
  • 3
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415-28.
    • (2005) Lancet , vol.365 , Issue.9468 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 5
    • 55849141253 scopus 로고    scopus 로고
    • Central control of body weight and appetite
    • Woods SC, D'Alessio DA. Central control of body weight and appetite. J Clin Endocrinol Metab. 2008;93(11 Suppl 1):S37-50.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.11 SUPPL. 1
    • Woods, S.C.1    D'alessio, D.A.2
  • 7
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110(8):1093-103.
    • (2002) J Clin Invest , vol.110 , Issue.8 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3    Keogh, J.M.4    Lawrence, E.5    Agwu, C.6
  • 8
    • 6344221594 scopus 로고    scopus 로고
    • Congenital leptin deficiency due to homozygosity for the Delta133G mutation: Report of another case and evaluation of response to four years of leptin therapy
    • Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O'Rahilly S, et al. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab. 2004;89(10):4821-6.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.10 , pp. 4821-4826
    • Gibson, W.T.1    Farooqi, I.S.2    Moreau, M.3    Depaoli, A.M.4    Lawrence, E.5    O'Rahilly, S.6
  • 9
    • 12144289998 scopus 로고    scopus 로고
    • Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptindeficient adults
    • Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, et al. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptindeficient adults. Proc Natl Acad Sci U S A. 2004;101(13):4531-6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.13 , pp. 4531-4536
    • Licinio, J.1    Caglayan, S.2    Ozata, M.3    Yildiz, B.O.4    de Miranda, P.B.5    O'Kirwan, F.6
  • 10
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387(6636):903-8.
    • (1997) Nature , vol.387 , Issue.6636 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3    Soos, M.A.4    Rau, H.5    Wareham, N.J.6
  • 11
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptinmediated defects
    • Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptinmediated defects. J Clin Endocrinol Metab. 1999;84(10):3686-95.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.10 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 15
    • 0033005654 scopus 로고    scopus 로고
    • Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice
    • Muoio DM, Dohm GL, Tapscott EB, Coleman RA. Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. Am J Physiol. 1999;276(5 Pt 1):E913-21.
    • (1999) Am J Physiol , vol.276 , Issue.5 PART 1
    • Muoio, D.M.1    Dohm, G.L.2    Tapscott, E.B.3    Coleman, R.A.4
  • 16
    • 33748970803 scopus 로고    scopus 로고
    • Leptin and atherosclerosis
    • Beltowski J. Leptin and atherosclerosis. Atherosclerosis. 2006;189(1):47-60.
    • (2006) Atherosclerosis , vol.189 , Issue.1 , pp. 47-60
    • Beltowski, J.1
  • 17
    • 49549116886 scopus 로고    scopus 로고
    • Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin
    • Eriksson M, Johnson O, Boman K, Hallmans G, Hellsten G, Nilsson TK, et al. Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. Thromb Res. 2008;122(5):701-8.
    • (2008) Thromb Res , vol.122 , Issue.5 , pp. 701-708
    • Eriksson, M.1    Johnson, O.2    Boman, K.3    Hallmans, G.4    Hellsten, G.5    Nilsson, T.K.6
  • 18
    • 63649161041 scopus 로고    scopus 로고
    • Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects
    • Paz-Filho GJ, Andrews D, Esposito K, Erol HK, Delibasi T, Wong ML, et al. Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects. Horm Metab Res. 2009;41(2):164-7.
    • (2009) Horm Metab Res , vol.41 , Issue.2 , pp. 164-167
    • Paz-Filho, G.J.1    Andrews, D.2    Esposito, K.3    Erol, H.K.4    Delibasi, T.5    Wong, M.L.6
  • 19
    • 0035209720 scopus 로고    scopus 로고
    • Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals
    • van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord. 2001;25(12):1759-66.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , Issue.12 , pp. 1759-1766
    • van Dielen, F.M.1    van't Veer, C.2    Schols, A.M.3    Soeters, P.B.4    Buurman, W.A.5    Greve, J.W.6
  • 20
    • 34247874560 scopus 로고    scopus 로고
    • Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: A prospective cohort study
    • Brennan AM, Li TY, Kelesidis I, Gavrila A, Hu FB, Mantzoros CS. Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study. Diabetologia. 2007;50(6):1178-85.
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1178-1185
    • Brennan, A.M.1    Li, T.Y.2    Kelesidis, I.3    Gavrila, A.4    Hu, F.B.5    Mantzoros, C.S.6
  • 21
    • 34547944365 scopus 로고    scopus 로고
    • Leptin and coronary heart disease risk: Prospective case control study of British women
    • Lawlor DA, Smith GD, Kelly A, Sattar N, Ebrahim S. Leptin and coronary heart disease risk: prospective case control study of British women. Obesity (Silver Spring). 2007;15(7):1694-701.
    • (2007) Obesity (silver Spring) , vol.15 , Issue.7 , pp. 1694-1701
    • Lawlor, D.A.1    Smith, G.D.2    Kelly, A.3    Sattar, N.4    Ebrahim, S.5
  • 22
    • 10744232583 scopus 로고    scopus 로고
    • Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: Impact on cardiovascular mortality
    • Piemonti L, Calori G, Mercalli A, Lattuada G, Monti P, Garancini MP, et al. Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality. Diabetes Care. 2003;26(10):2883-9.
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2883-2889
    • Piemonti, L.1    Calori, G.2    Mercalli, A.3    Lattuada, G.4    Monti, P.5    Garancini, M.P.6
  • 24
    • 0035909997 scopus 로고    scopus 로고
    • Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    • Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104(25):3052-6.
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3052-3056
    • Wallace, A.M.1    McMahon, A.D.2    Packard, C.J.3    Kelly, A.4    Shepherd, J.5    Gaw, A.6
  • 25
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome - a new world-wide definition. A Consensus Statement from the International Diabetes Federation
    • Alberti KG, Zimmet P, Shaw J. Metabolic syndrome - a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006;23(5):469-80.
    • (2006) Diabet Med , vol.23 , Issue.5 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 27
    • 0032815249 scopus 로고    scopus 로고
    • Plasma leptin levels strongly correlate with plasma renin activity in patients with essential hypertension
    • Uckaya G, Ozata M, Sonmez A, Kinalp C, Eyileten T, Bingol N, et al. Plasma leptin levels strongly correlate with plasma renin activity in patients with essential hypertension. Horm Metab Res. 1999;31(7):435-8.
    • (1999) Horm Metab Res , vol.31 , Issue.7 , pp. 435-438
    • Uckaya, G.1    Ozata, M.2    Sonmez, A.3    Kinalp, C.4    Eyileten, T.5    Bingol, N.6
  • 28
    • 0344026285 scopus 로고    scopus 로고
    • Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans
    • McNeely MJ, Boyko EJ, Weigle DS, Shofer JB, Chessler SD, Leonnetti DL, et al. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care. 1999;22(1):65-70.
    • (1999) Diabetes Care , vol.22 , Issue.1 , pp. 65-70
    • McNeely, M.J.1    Boyko, E.J.2    Weigle, D.S.3    Shofer, J.B.4    Chessler, S.D.5    Leonnetti, D.L.6
  • 29
    • 0037260480 scopus 로고    scopus 로고
    • Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children
    • Valle M, Gascon F, Martos R, Bermudo F, Ceballos P, Suanes A. Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children. Int J Obes Relat Metab Disord. 2003;27(1):13-8.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.1 , pp. 13-18
    • Valle, M.1    Gascon, F.2    Martos, R.3    Bermudo, F.4    Ceballos, P.5    Suanes, A.6
  • 30
    • 0031889402 scopus 로고    scopus 로고
    • Leptin concentrations in serum from a randomly recruited sample of 50- to 80-year-old men and women: Positive association with plasma insulin-like growth factors (IGFs) and IGF-binding protein-3 in lean, but not in obese, individuals
    • Seck T, Englaro P, Blum WF, Scheidt-Nave C, Rascher W, Ziegler R, et al. Leptin concentrations in serum from a randomly recruited sample of 50- to 80-year-old men and women: positive association with plasma insulin-like growth factors (IGFs) and IGF-binding protein-3 in lean, but not in obese, individuals. Eur J Endocrinol. 1998;138(1):70-5.
    • (1998) Eur J Endocrinol , vol.138 , Issue.1 , pp. 70-75
    • Seck, T.1    Englaro, P.2    Blum, W.F.3    Scheidt-Nave, C.4    Rascher, W.5    Ziegler, R.6
  • 31
    • 0033188367 scopus 로고    scopus 로고
    • Chen M. [Association of serum leptin concentrations with blood pressure]
    • Wang G, Tang J, Chen M. [Association of serum leptin concentrations with blood pressure]. Zhonghua Yi Xue Za Zhi. 1999;79(9):664-7.
    • (1999) Zhonghua Yi Xue Za Zhi , vol.79 , Issue.9 , pp. 664-667
    • Wang, G.1    Tang, J.2
  • 32
    • 0036120013 scopus 로고    scopus 로고
    • Reduced leptin concentrations in subjects with type 2 diabetes mellitus in Sudan
    • Abdelgadir M, Elbagir M, Eltom M, Berne C, Ahren B. Reduced leptin concentrations in subjects with type 2 diabetes mellitus in Sudan. Metabolism. 2002;51(3):304-6.
    • (2002) Metabolism , vol.51 , Issue.3 , pp. 304-306
    • Abdelgadir, M.1    Elbagir, M.2    Eltom, M.3    Berne, C.4    Ahren, B.5
  • 33
    • 0034087734 scopus 로고    scopus 로고
    • Serum leptin levels in patients with hyperlipidemias
    • Haluzik M, Fiedler J, Nedvidkova J, Ceska R. Serum leptin levels in patients with hyperlipidemias. Nutrition. 2000;16(6):429-33.
    • (2000) Nutrition , vol.16 , Issue.6 , pp. 429-433
    • Haluzik, M.1    Fiedler, J.2    Nedvidkova, J.3    Ceska, R.4
  • 34
    • 0032853754 scopus 로고    scopus 로고
    • Serum leptin concentration in moderate and severe obesity: Relationship with clinical, anthropometric and metabolic factors
    • Liuzzi A, Savia G, Tagliaferri M, Lucantoni R, Berselli ME, Petroni ML, et al. Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int J Obes Relat Metab Disord. 1999;23(10):1066-73.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , Issue.10 , pp. 1066-1073
    • Liuzzi, A.1    Savia, G.2    Tagliaferri, M.3    Lucantoni, R.4    Berselli, M.E.5    Petroni, M.L.6
  • 35
    • 0034964328 scopus 로고    scopus 로고
    • Leptin and HDL-cholesterol in non-diabetic normotensive subjects
    • Marinari GM, Scopinaro N, Adami GF. Leptin and HDL-cholesterol in non-diabetic normotensive subjects. Obes Surg. 2001;11(3):252-3.
    • (2001) Obes Surg , vol.11 , Issue.3 , pp. 252-253
    • Marinari, G.M.1    Scopinaro, N.2    Adami, G.F.3
  • 36
    • 22744443610 scopus 로고    scopus 로고
    • Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: Study from Mumbai, Western India
    • Marita AR, Sarkar JA, Rane S. Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: study from Mumbai, Western India. Mol Cell Biochem. 2005;275(1-2):143-51.
    • (2005) Mol Cell Biochem , vol.275 , Issue.1-2 , pp. 143-151
    • Marita, A.R.1    Sarkar, J.A.2    Rane, S.3
  • 39
    • 0035122578 scopus 로고    scopus 로고
    • Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population
    • Hu FB, Chen C, Wang B, Stampfer MJ, Xu X. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes Relat Metab Disord. 2001;25(1):121-5.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , Issue.1 , pp. 121-125
    • Hu, F.B.1    Chen, C.2    Wang, B.3    Stampfer, M.J.4    Xu, X.5
  • 42
    • 0029819643 scopus 로고    scopus 로고
    • Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss
    • Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab. 1996;81(12):4406-13.
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.12 , pp. 4406-4413
    • Havel, P.J.1    Kasim-Karakas, S.2    Mueller, W.3    Johnson, P.R.4    Gingerich, R.L.5    Stern, J.S.6
  • 43
    • 10344260142 scopus 로고    scopus 로고
    • Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates
    • Ostlund RE Jr, Yang JW, Klein S, Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab. 1996;81(11):3909-13.
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.11 , pp. 3909-3913
    • Ostlund Jr, R.E.1    Yang, J.W.2    Klein, S.3    Gingerich, R.4
  • 46
    • 33644967119 scopus 로고    scopus 로고
    • The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity
    • Dyck DJ, Heigenhauser GJ, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf). 2006;186(1):5-16.
    • (2006) Acta Physiol (oxf) , vol.186 , Issue.1 , pp. 5-16
    • Dyck, D.J.1    Heigenhauser, G.J.2    Bruce, C.R.3
  • 48
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest. 2000;106(2):171-6.
    • (2000) J Clin Invest , vol.106 , Issue.2 , pp. 171-176
    • Shulman, G.I.1
  • 49
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology. 2003;144(12):5159-65.
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5159-5165
    • Unger, R.H.1
  • 50
    • 0242696221 scopus 로고    scopus 로고
    • Lipid overload and overflow: Metabolic trauma and the metabolic syndrome
    • Unger RH. Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol Metab. 2003;14(9):398-403.
    • (2003) Trends Endocrinol Metab , vol.14 , Issue.9 , pp. 398-403
    • Unger, R.H.1
  • 51
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996;348(9021):159-61.
    • (1996) Lancet , vol.348 , Issue.9021 , pp. 159-161
    • Caro, J.F.1    Kolaczynski, J.W.2    Nyce, M.R.3    Ohannesian, J.P.4    Opentanova, I.5    Goldman, W.H.6
  • 52
    • 33845588762 scopus 로고    scopus 로고
    • Emerging therapeutic strategies for obesity
    • Foster-Schubert KE, Cummings DE. Emerging therapeutic strategies for obesity. Endocr Rev. 2006;27(7):779-93.
    • (2006) Endocr Rev , vol.27 , Issue.7 , pp. 779-793
    • Foster-Schubert, K.E.1    Cummings, D.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.