Peripheral metabolic actions of leptin

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 16, Issue 4, 2002, Pages 653-666

  Muoio, Deborah M ^a   Dohm, G Lynis ^b  

^a DUKE UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Adipose tissue; Energy balance; Glucose metabolism; Insulin signalling; Leptin; Lipid metabolism; Liver; Obesity; Pancreas; Skeletal muscle; Triacylglycerol; Type 2 diabetes; Oxidation

Indexed keywords

BRAIN RECEPTOR; CHOLESTEROL; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; LIPID; MEMBRANE LIPID; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADRENERGIC ACTIVITY; BRAIN; CHOLESTEROL METABOLISM; DISEASE MODEL; ENERGY; ENERGY BALANCE; ENERGY METABOLISM; EVIDENCE BASED MEDICINE; FATTY ACID OXIDATION; FEEDING BEHAVIOR; FOOD INTAKE; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HOMEOSTASIS; HORMONE ACTION; HORMONE DEFICIENCY; HUMAN; INSULIN RELEASE; LIPID METABOLISM; LIPID STORAGE; LIVER; METABOLIC DISORDER; MORBID OBESITY; MORBIDITY; NEUROENDOCRINE SYSTEM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SKELETAL MUSCLE; TRANSCRIPTION REGULATION;

EID: 0036918878     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.2002.0223     Document Type: Review

References (83)

1. Zhang Y, Proenca R, Maffei M et al. Positional cloning of the mouse obese gene and its human homologue. Science 1994; 372: 425-432.
2. Pelleymounter MA, Cullen MJ, Baker MB et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
3. Wang J, Liu R, Hawkins M et al. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 1998; 393: 684-688.
4. Bado A, Levasseur S, Attoub S et al. The stomach is a source of leptin. Nature 1998; 394: 790-793.
5. Masuzaki H, Ogawa Y, Sagawa N et al. Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nature Medicine 1997; 3: 1029-1033.
6. Maffei M, Halaas JL, Ravussin E et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects. Nature Medicine 1995; 1: 1155-1161.
7. Tartaglia LA, Dembski M, Weng X et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271.
8. Lee G, Proenca R, Montez JM et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
9. Crouse JA, Elliott GE, Burgess TL et al. Altered cell surface expression and signaling of leptin receptors containing the fatty mutation. Journal of Biological Chemistry 1998; 273: 18365-18373.
10. Kolaczynski JW, Ohannesian JP, Considine RV et al. Response of leptin to short-term and prolonged overfeeding in humans. Journal of Clinical Endocrinology and Metabolism 1996; 81: 4162-4165.
11. Halaas JL, Gajiwala KS, Maffei M et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-546.
12. Friedman JM. Leptin, leptin receptors, and the control of body weight. Nutrition Reviews 1998; 56: s38-s46.
13. Levin N, Nelson C, Gurney A et al. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proceedings of the National Academy of Sciences of the USA 1996; 93: 1726-1730.
14. Berti L, Kellerer M, Capp E et al. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a P13-kinase mediated effect. Diabetologia 1997; 40: 606-609.
15. Cohen B, Novick D & Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-1188.
16. Commins SP, Watson PM, Padgett MA et al. Induction of uncoupling protein expression in brown and white adipose tissue by leptin. Endocrinology 1999; 140: 292-300.
17. Emilsson V, Liu Y, Cawthorne MA et al. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997; 46: 313-316.
18. Harris RBS. Acute and chronic effects of leptin on glucose utilization in lean mice. Biochemical and Biophysical Research Communications 1998; 245: 502-509.
19. Kellerer M, Koch M, Metzinger E et al. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2(JAK-2) and insulin receptor substrate-2(IRS-2) dependent pathways. Diabetologia 1997; 40: 1358-1362.
20. Kroder G, Kellerer M & Haring HU. Effect of leptin on insulin signaling in rat I fibroblasts overexpressing HIR. Experimental and Clinical Endocrinology and Diabetes 1996; 104: 66-72.
21. Kulkarni RN, Wang Z, Wang R et al. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. Journal of Clinical Investigation 1997; 100: 2729-2736.
22. Muller G, Ertl J, Gerl M et al. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. Journal of Biological Chemistry 1997; 272: 10 585-10 593.
23. Shimabukuro M, Koyama K, Chen G et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proceedings of the National Academy of Sciences of the USA 1997; 94: 4637-4641.
24. Muoio DM, Dohm GL, Fiedorek FT Jr et al. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 1997; 46: 1360-1363.
25. Minokoshi Y, Kim YB, Peroni OD et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002; 415: 339-343.
26. Harris RB. Leptin - Much more than a satiety signal. Annual Review of Nutrition 2000; 20: 45-75.
27. Ghilardi N, Ziegler S, Wiestner A et al. Defective STAT signaling by the leptin receptor in diabetic mice. Proceedings of the National Academy of Sciences of the USA 1996; 93: 6231-6235.
28. Tartaglia LA. The leptin receptor. Journal of Biological Chemistry 1997; 272: 6093-6096.
29. Hirano T, Matsuda T & Nakajima K. Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells 1994; 12: 262-277.
30. Bjorbaek C, Uotani S, Da Silva B et al. Divergent signaling capacities of the long and short isoforms of the leptin receptor. Journal of Biological Chemistry 1997; 272: 32 686-32 695.
31. Murakami T, Yamashita T, Iida M et al. A short form of the leptin receptor performs signal transduction. Biochemical and Biophysical Research Communications 1997; 231: 26-29.
32. Fukuda H, Iritani N, Sugimoto T et al. Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats. European Journal of Biochemistry 1999; 260: 505-511.
33. Muoio DM, Dohm GL, Tapscott EB et al. Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. American Journal of Physiology 1999; 276: E913-E921.
34. Steinberg GR & Dyck DJ. Development of leptin resistance in rat soleus muscle in response to high-fat diets. American Journal of Physiology 2000; 279: E1374-E1382.
35. McGarry JD, Mills SE, Long CS et al. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Biochemical Journal 1983; 214: 21-28.
36. Sullivan JE, Brocklehurst KJ, Marley AE et al. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Letters 1994; 353: 33-36.
37. Muoio DM, Seefeld K, Witters LA et al. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochemical Journal 1999; 338: 783-791.
38. Dulloo AG, Stock MJ, Solinas G et al. Leptin directly stimulates thermogenesis in skeletal muscle. FEBS Letters 2002; 515: 109-113.
39. Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE et al. Direct effects of leptin on brown and white adipose tissue. Journal of Clinical Investigation 1997; 100: 2858-2864.
40. Wang MY, Lee Y & Unger RH. Novel form of lipolysis induced by leptin. Journal of Biological Chemistry 1999; 274: 17 541-17 544.
41. Fruhbeck G, Aguado M, Gomez-Ambrosi J et al. Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice. Biochemical and Biophysical Research Communications 1998; 250: 99-102.
42. Wang ZW, Zhou YT, Lee Y et al. Hyperleptinemia depletes fat from denervated fat tissue. Biochemical and Biophysical Research Communications 1999; 260: 653-657.
43. Fruhbeck G & Gomez-Ambrosi J. Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide. Cellular Signalling 2001; 13: 827-833.
44. Fruhbeck G, Gomez-Ambrosi J & Salvador J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB Journal 2001; 15: 333-340.
45. Zhou YT, Shimabukuro M, Koyama K et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proceedings of the National Academy of Sciences of the USA 1997; 94: 6386-6390.
46. Boss O, Muzzin P & Giacobino JP. The uncoupling proteins, a review. European Journal of Endocrinology 1998; 139: 1-9.
47. Zhou YT, Wang ZW, Higa M et al. Reversing adipocyte differentiation: Implications for treatment of obesity. Proceedings of the National Academy of Sciences of the USA 1999; 96: 2391-2395.
48. Lee Y, Wang MY, Kakuma T et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. Journal of Biological Chemistry 2001; 276: 5629-5635.
49. Jezek P, Engstova H, Zackova M et al. Fatty acid cycling mechanism and mitochondrial uncoupling proteins. Biochemical and Biophysical Research Communications 1998; 1365: 319-327.
50. Liang CP & Tall AR. Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. Journal of Biological Chemistry 2001; 276: 49 066-49 076.
51. Zhou YT, Shimabukuro M, Wang MY et al. Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proceedings of the National Academy of Sciences of the USA 1998; 95: 8898-8903.
52. Ceddia RB, William WNJ, Lima FB et al. Leptin inhibits insulin-stimulated incorporation of glucose into lipids and stimulates glucose decarboxylation in isolated rat adipocytes. Journal of Endocrinology 1998; 158: R7-R9.
53. Silver DL, Wang N & Tall AR. Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake. Journal of Clinical Investigation 2000; 105: 151-159.
54. Silver DL, Jiang XC & Tall AR. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. Journal of Biological Chemistry 1999; 274: 4140-4146.
55. VanPatten S, Ranginani N, Shefer S et al. Impaired biliary lipid secretion in obese Zucker rats: Leptin promotes hepatic cholesterol clearance. American Journal of Physiology 2001; 281: G393-G404.
56. Unger RH & Orci L. Diseases of liporegulation: New perspective on obesity and related disorders. FASEB Journal 2001; 15: 312-321.
57. Shimabukuro M, Zhou YT, Levi M et al. Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes. Proceedings of the National Academy of Sciences of the USA 1998; 95: 2498-2502.
58. Schmitz-Peiffer C. Signalling aspects of insulin resistance in skeletal muscle: Mechanisms induced by lipid oversupply. Cellular Signalling 2000; 12: 583-594.
59. Shulman GI. Cellular mechanisms of insulin resistance. Journal of Clinical Investigation 2000; 106: 171-176.
60. Shimabukuro M, Wang MY, Zhou YT et al. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proceedings of the National Academy of Sciences of the USA 1998; 95: 9558-9561.
61. Koyama K, Chen G, Lee Y et al. Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity. American Journal of Physiology 1997; 273: E708-E713.
62. Wang MY, Koyama K, Shimabukuro M et al. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proceedings of the National Academy of Sciences of the USA 1998; 95: 714-718.
63. Ebihara K, Ogawa Y, Masuzaki H et al. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes 2001; 50: 1440-1448.
64. Shimomura I, Hammer RE, Ikemoto S et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999; 401: 73-76.
65. Oral EA, Simha V, Ruiz E et al. Leptin-replacement therapy for lipodystrophy. New England Journal of Medicine 2002; 346: 570-578.
66. Yaspelkis BB III, Davis JR, Saberi M et al. Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats. American Journal of Physiology 2001; 280: E130-E142.
67. Rossetti L, Massillon D, Barzilai N et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. Journal of Biological Chemistry 1997; 272: 27 758-27 763.
68. Kamohara S, Burcelin R, Halaas JL et al. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 374-377.
69. Wang JL, Chinookoswong N, Scully S et al. Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 1999; 140: 2117-2124.
70. Nemecz M, Preininger K, Englisch R et al. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 1999; 29: 166-172.
71. Ceddia RB, Willima WN Jr & Curi R. Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: Evidence for an effect of leptin on glucose uptake and decarboxylation. International Journal of Obesity and Related Metabolic Disorders 1999; 23: 75-82.
72. Yaspelkis BB III, Ansari L, Ramey EL et al. Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport. Metabolism 1999; 48: 671-676.
73. Ceddia RB, William WN Jr & Curi R. Leptin increases glucose transport and utilization in skeletal muscle in vitro. General Pharmacology 1998; 31: 799-801.
74. Liu Y, Emilsson V & Cawthorne MA. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Letters 1997; 411: 351-355.
75. Zierath JR, Frevert EU, Ryder JW et al. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes 1998; 47: 1-4.
76. Sweeney G, Keen J, Somwar R et al. High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in 16 rat skeletal muscle cells. Endocrinology 2001; 142: 4806-4812.
77. Bates SH, Gardiner JV, Jones RB et al. Acute stimulation of glucose uptake by leptin in 16 muscle cells. Hormone Metabolism Research 2002; 34: 111-115.
78. Cases JA, Gabriely I, Ma XH et al. Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 2001; 50: 348-352.
79. Lupi R, Marchetti P, Maffei M et al. Effects of acute or prolonged exposure to human leptin on isolated human islet function. Biochemical and Biophysical Research Communications 1999; 256: 637-641.
80. Zhao AZ, Bornfeldt KE & Beavo JA. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. Journal of Clinical Investigation 1998; 102: 869-873.
81. Chen NG, Swick AG & Romsos DR. Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice. Journal of Clinical Investigation 1997; 100: 1174-1179.
82. + channels in pancreatic beta-cells. Diabetes 1997; 46: 1087-1093.
83. Kim YB, Uotani S, Pierroz DD et al. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin. Endocrinology 2000; 141: 2328-2339.