Glutathione in human plasma: Decline in association with aging, age- related macular degeneration, and diabetes

Free Radical Biology and Medicine

Volumn 24, Issue 5, 1998, Pages 699-704

  Samiec, Paula S ^a   Drews Botsch, Carolyn ^a,b   Flagg, Elaine W ^b   Kurtz, Joanne C ^a   Sternberg Jr , Paul ^a   Reed, Robyn L ^a   Jones, Dean P ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Aging; Antioxidants; Blood plasma; Diabetes; Free radical; Glutathione; Glutathione disulfide; Human; Macular degeneration; Redox state

Indexed keywords

ANTIOXIDANT; DITHIOTHREITOL; FREE RADICAL; GLUTATHIONE; LIPID PEROXIDE;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; OXIDATION REDUCTION STATE; PLASMA; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANALYSIS OF VARIANCE; DIABETES MELLITUS; FEMALE; GLUTATHIONE; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED;

EID: 0032521155     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00286-4     Document Type: Article

References (39)

1. Reed D. J. Glutathione Toxicologic implications . Annu. Rev. Pharmacol. Toxicol. 30:1990;603-631.
2. Wefers, H.; Sies, H. Antioxidant effects of ascorbate and glutathione in microsomal lipid peroxidation are dependent on vitamin E. In: Poli, G.; Cheeseman, K. H.; Dianzani, M. U.; Slater, T. F., eds. Advances in biosciences, vol. 76: Free radicals in the pathogenesis of liver injury. New York: Pergamon Press; 1989:309-316.
3. Winkler B. S., Orselli S. M., Rex T. S. The redox couple between glutathione and ascorbic acid A chemical and physiological perspective . Free Radic. Biol. Med. 17:1994;333-349.
4. Henning S. M., Zhang J. Z., McKee R. W., Swenseid M. E., Jacob R. A. Glutathione blood levels and other oxidants defense indices in men fed diets low in vitamin C. J. Nutr. 121:1991;1969-1975.
5. Costagliola C., Menzione M. Effect of vitamin E on the oxidative state of glutathione in plasma. Clin. Physiol. Biochem. 8:1990;140-143.
6. Rikans L. E., Moore D. R. Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats. Biochim. Biophys. Acta. 966:1988;269-275.
7. Vandewoude M. F. J., Vandewoude M. G. Vitamin E status in normal population The influence of age . J. Am. Coll. Nutr. 6:1987;307-311.
8. Flagg E. W., Coates R. J., Jones D. P., Eley J. W., Gunter E. W., Jackson B., Greenberg R. S. Plasma total glutathione in humans and its association with demographic and health-related factors. Br. J. Nutr. 70:1993;797-808.
9. Kretzschmar M., Müller D. Aging, training and exercise. A review of effects on plasma glutathione and lipid peroxides. Sports Med. 10:1993;196-209.
10. Lang C. A., Naryshkin S., Schneider D. L., Mills B. J., Lindeman R. D. Low blood glutathione levels in healthy aging adults. J. Lab. Clin. Med. 120:1992;720-725.
11. Chawla R. K., Lewis F. W., Kutner M. H., Bate D. M., Roy R. G. B., Rudman D. Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroenterology. 87:1984;770-776.
12. Buhl R., Holroyd K. J., Mastrangeli A., Cantin A. M., Jaffe H. A., Wells F. B., Saltini C., Crystal R. G. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet. ii:1989;1294-1298.
13. Eck H.-P., Gmunder H., Hartman M., Petzoldt D., Daniel V., Droge W. Low concentration of acid-soluble thiol (cysteine) in the blood plasma of HIV-1 infected patients. Biol. Chem. Hoppe-Seyler. 370:1989;101-108.
14. Smith C. V., Jones D. P., Guenthner T. M., Lash L. H., Lauterburg B. H. Compartmentation of glutathione. Implications for the study of toxicity and disease. Toxicol. Appl. Pharmacol. 140:1996;1-12.
15. Roum J. H., Buhl R., McElvaney N. G., Borok Z., Crystal R. G. Systemic deficiency of glutathione in cystic fibrosis. J. Appl. Physiol. 75:1993;2419-2424.
16. Bai C., Jones D. P. GSH transport and GSH-dependent detoxication in small intestine of rats of exposed in vivo to hypoxia. Am. J. Physiol. 271:1996;G701-G706.
17. Young R. W. Pathophysiology of age-related macular degeneration. Surv. Ophthalmol. 31:1987;291-306.
18. Young R. W. Solar radiation and age-related macular degeneration. Surv. Ophthalmol. 32:1988;252-269.
19. Antioxidant status and neovascular age-related macular degeneration. Arch. Ophthalmol. 111:1993;104-109.
20. Bono A., Caimi G., Catania A., Sarno A., Pandolfo L. Red cell peroxide metabolism in diabetes mellitus. Horm. Metab. Res. 19:1987;264-266.
21. Murakami K., Kondo T., Ohtsuku Y., Fujiwara Y., Shimada M., Kawakami Y. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism. 38:1989;753-758.
22. Forrester T. E., Badaloo V., Bennett F. I., Jackson A. A. Excessive excretion of 5-oxoproline and decreased levels of blood glutathione in type II diabetes mellitus. Eur. J. Clin. Nutr. 44:1990;847-850.
23. Costagliola C., Iuliano G., Menzione M., Nesti A., Simonelli F., Rinaldi E. Systemic human diseases as oxidative risk factors in cataractogenesis. I. Diabetes. Ophthal. Res. 20:1988;308-316.
24. Kaji H., Kurasaki K., Ito K., Saito T., Saito K., Nijoke T., Kojima Y., Ohsaki Y., Ide H., Tsuji M. Increased lipoperoxide value and glutathione peroxide activity in blood plasma of type II (non-insulin dependent) diabetic women. Klin. Wochenschr. 63:1985;765-768.
25. Oser B. L. Hawk's physiological chemistry. 14th ed. 1965;1096 McGraw Hill, New York.
26. Lash L. H., Jones D. P. Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma. Arch. Biochem. Biophys. 240:1985;583-592.
27. Fariss M. W., Reed D. J. High-performance liquid chromatography of thiols and disulfides Dinitrophenol derivatives . Methods Enzymol. 143:1987;101-109.
28. Jones D. P., Kurtz J. C., Sternberg P. Thiol and disulfide forms of glutathione (GSH) cysteine (Cys), cysteinylglycine (CG) and homocysteine (HC) in human plasma. FASEB J. 11:1997;A150.
29. Jaeschke H., Wendel A. Diurnal fluctation and pharmacological alteration of mouse organ glutathione content. Biochem. Pharmacol. 34:1985;1029-1033.
30. Smaaland R., Svardal A. M., Lote K., Ueland P. M., Laerum O. D. Glutathione content in human bone marrow and circadian stage relation to DNA synthesis. J Natl. Cancer Inst. 83:1991;1092-1098.
31. Samiec, P. Regulation and utilization of extracellular GSH. Ph.D. Dissertation. Emory University, Atlanta, GA; 1995.
32. Rost J., Rapoport S. Reduction potential of glutathione. Nature. 201:1964;185.
33. Clark W. M. Oxidation-reduction potentials of organic systems. 1960;Williams & Wilkins, Baltimore.
34. Gilbert H. F. Molecular and cellular aspects of thiol-disulfide exchange. Adv. Enzymol. Related Areas Mol. Biol. 63:1990;69-172.
35. Abate C., Patel L., Rauscher F. J., Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science. 249:1990;1157-1161.
36. Hwang C., Sinskey A. J. The role of oxidation-reduction potential in monitoring growth of cultured mammalian cells. Spier R. E., Griffiths J. B., Meignier B. Production of biologicals from animal cells in culture. 1991;548-567 Halley Court, Oxford.
37. Malorni W., Rivabene R., Santini M. T., Donelli G. N-Acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells. FEBS Lett. 327:1993;75-78.
38. Young I. S., Torney J. J., Trimble E. R. The effect of ascorbate supplementation on oxidative stress in the streptozotocin diabetic rat. Free Radic. Biol. Med. 13:1992;41-46.
39. Ookhtens M., Mittur A. V. Developmental changes in plasma thiol-disulfide turnover in rats A multicompartmental approach . Am. J. Physiol. 267:1994;R415-R425.