The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 5, 2010, Pages 1983-1988

  Auerbach, Tamar ^a   Mermershtain, Inbal ^a   Davidovich, Chen ^a   Bashan, Anat ^a   Belousoff, Matthew ^a   Wekselman, Itai ^a   Zimmerman, Ella ^a   Xiong, Liqun ^b   Klepacki, Dorota ^b   Arakawa, Kenji ^c   Kinashi, Haruyasu ^c   Mankin, Alexander S ^b   Yonath, Ada ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Lankamycin; Resistance; Ribosomes; rRNA; Synergism

Indexed keywords

DALFOPRISTIN; ERYTHROMYCIN; LANKACIDIN C; LANKACIDIN M; LANKAMYCIN; PEPTIDYLTRANSFERASE; QUINUPRISTIN; STREPTOGRAMIN DERIVATIVE; UNCLASSIFIED DRUG; VIRGINIAMYCIN M; VIRGINIAMYCIN S;

ARTICLE; BACTERIAL GROWTH; BINDING SITE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; STREPTOMYCES; STREPTOMYCES ROCHEI; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEINOCOCCUS; DRUG DISCOVERY; DRUG SYNERGISM; ERYTHROMYCIN; MACROLIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RIBOSOME SUBUNITS, LARGE, BACTERIAL; RIBOSOMES;

BACTERIA (MICROORGANISMS); STREPTOMYCES ROCHEI;

EID: 76649088360     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914100107     Document Type: Article

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