23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 14, 2005, Pages 5180-5185

  Pfister, Peter ^a   Corti, Natascia ^a   Hobbie, Sven ^a   Bruell, Christian ^a   Zarivach, Raz ^b   Yonath, Ada ^b   Böttger, Erik C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Antibiotics; Conformation; Ketolides; Ribosomes; Structure

Indexed keywords

AZITHROMYCIN; CETHROMYCIN; CLARITHROMYCIN; ERYTHROMYCIN; JOSAMYCIN; KETOLIDE; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B; RNA 23S; SPIRAMYCIN; TELITHROMYCIN; TYLOSIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; BASE PAIRING; CPG ISLAND; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RIBOSOME; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

BASE SEQUENCE; BINDING SITES; CLARITHROMYCIN; DRUG RESISTANCE, BACTERIAL; KETOLIDES; MACROLIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM SMEGMATIS; NUCLEIC ACID CONFORMATION; PHENOTYPE; POINT MUTATION; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; SPECIES SPECIFICITY; TYLOSIN;

EID: 17044425907     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501598102     Document Type: Article

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