Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 23, 2002, Pages 14658-14663

  Liu, Mingfu ^a   Douthwaite, Stephen ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CARBOMYCIN; CLARITHROMYCIN; CLINDAMYCIN; ERYTHROMYCIN; GENE PRODUCT; GUANINE; LACTONE; LINCOMYCIN; MACROLIDE; METHYLTRANSFERASE; MYCINAMICIN; RNA 23S; SPIRAMYCIN; TYLOSIN;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG STRUCTURE; GENE EXPRESSION; GENE INACTIVATION; GLYCOSYLATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA METHYLATION; RNA STRUCTURE; STREPTOMYCES FRADIAE;

ADENINE; BINDING SITES; DNA PRIMERS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENES, BACTERIAL; GUANINE; METHYLATION; RNA, RIBOSOMAL, 23S; STREPTOMYCES; TYLOSIN;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOMYCES; STREPTOMYCES FRADIAE;

EID: 0037069328     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.232580599     Document Type: Article

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