An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA

Nature

Volumn 438, Issue 7067, 2005, Pages 520-524

  Martin Schmeing, T ^a   Huang, Kevin S ^a   Strobel, Scott A ^a   Steitz, Thomas A ^a,b  

^a YALE UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; ESTERS; HYDROLYSIS; SUBSTRATES;

NUCLEOPHILIC ATTACK; PEPTIDE BOND FORMATION;

RNA;

AMINOACYL TRANSFER RNA; CARBONYL DERIVATIVE; NUCLEOTIDE; PEPTIDE TRANSFER RIBONUCLEIC ACID; PEPTIDYLTRANSFERASE; RIBOSOME RNA; TRANSFER RNA; UNCLASSIFIED DRUG; WATER;

BIOLOGY;

ARTICLE; CATALYSIS; CHEMICAL BOND; COMPLEX FORMATION; CONFORMATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; HALOARCULA MARISMORTUI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RIBOSOME SUBUNIT;

ESCHERICHIA COLI; HALOARCULA MARISMORTUI;

EID: 28544452248     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04152     Document Type: Article

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