1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 945-952

  Forster, Laura ^a   Ludwig, Joachim ^a   Kaptur, Martina ^a   Bovens, Stefanie ^a   Elfringhoff, Alwine Schulze ^a   Holtfrerich, Angela ^a   Lehr, Matthias ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

1 Indol 1 yl propan 2 one; Cytosolic phospholipase A2 ; Fatty acid amide hydrolase; Inhibitors; Monoacylglycerol lipase

Indexed keywords

1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]IMIDAZOLE 4 CARBOXYLIC ACID; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]IMIDAZOLE 5 CARBOXYLIC ACID; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 CARBOXYLIC ACID; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]PYRAZOLE 3 CARBOXYLIC ACID; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]PYRAZOLE 4 CARBOXYLIC ACID; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]PYRAZOLE 5 CARBOXYLIC ACID; 1 BENZIMIDAZOL 1 YL 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 1 BENZOTRIAZOL 1 YL 3 (4 OCTYLPHENOXY)PROPAN 2 OL; 1 BENZOTRIAZOL 1 YL 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 1 BROMO 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 1 IMIDAZOL 1 YL 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 1 INDOL 1 YL PROPAN 2 ONE; 1 OXIRANYLMETHYLBENZOTRIAZOLE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CYTOSOLIC PHOSPHOLIPASE A2; ETHYL 1 [2 HYDROXY 3 (4 OCTYLPHENOXY)PROPYL]PYRAZOLE 4 CARBOXYLATE; ETHYL 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]PYRAZOLE 4 CARBOXYLATE; FATTY ACID AMIDASE INHIBITOR; HETEROCYCLIC COMPOUND; METHYL 1 [2 HYDROXY 3 (4 OCTYLPHENOXY)PROPYL]IMIDAZOLE 4 CARBOXYLATE; METHYL 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]PYRAZOLE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY;

AMIDOHYDROLASES; ANIMALS; ENZYME INHIBITORS; GROUP IV PHOSPHOLIPASES A2; HETEROCYCLIC COMPOUNDS; HUMANS; INDOLES; MOLECULAR CONFORMATION; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76449106208     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.028     Document Type: Article

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