Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 4179-4191

  Myllymäki, Mikko J ^a   Käsnänen, Heikki ^b,c   Kataja, Antti O ^a   Lahtela Kakkonen, Maija ^b   Saario, Susanna M ^b   Poso, Antti ^b   Koskinen, Ari M P ^a  

^a AALTO UNIVERSITY   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Carbamate; Enantiomeric pair; FAAH inhibitor; Fatty acid amide hydrolase

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 3 (4 BENZYL 4,5 DIHYDROOXAZOL 2 YL)PHENYLCYCLOHEXYLCARBAMATE; 3 (4,5 DIHYDROOXAZOL 2 YL)PHENYLCYCLOPENTYLCARBAMATE; 3 (5 METHYL 4,5 DIHYDROOXAZOL 2 YL)PHENYLCYCLOHEXYLCARBAMATE; 3 (BENZO[D]OXAZOL 2 YL)PHENYLPROPYLCARBAMATE; 3 (OXAZOLO[4,5 B]PYRIDIN 2 YL)PHENYLPROPYLCARBAMATE; ANANDAMIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CARBAMIC ACID DERIVATIVE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; METHYL 2 [3 (CYCLOHEXYLCARBAMOYLOXY)PHENYL] 4,5 DIHYDROOXAZOLE 4 CARBOXYLATE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CEREBELLUM; CHEMICAL STRUCTURE; CHIRALITY; DRUG POTENCY; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TRANQUILIZING ACTIVITY;

AMIDOHYDROLASES; ANIMALS; BRAIN; CARBAMATES; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONOACYLGLYCEROL LIPASES; OXAZOLES; PROTEIN BINDING; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67749105976     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.05.012     Document Type: Article

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