1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2107-2111

  Bovens, Stefanie ^a   Kaptur, Martina ^a   Elfringhoff, Alwine Schulze ^a   Lehr, Matthias ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Bioisosters; Cytosolic phospholipase A2 inhibitors; Indole; Metabolic stability; Solubility

Indexed keywords

1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 CARBOXYLIC ACID; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 6 CARBOXYLIC ACID; BENZIMIDAZOLE DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; CYTOSOLIC PHOSPHOLIPASE A2; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LIVER MICROSOME; NONHUMAN; RAT;

BENZIMIDAZOLES; CYTOSOL; GROUP IV PHOSPHOLIPASES A2; HUMANS; INDAZOLES; INDOLES; PROPIONIC ACIDS; STEREOISOMERISM; TRIAZOLES;

RATTUS;

EID: 63149125026     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.019     Document Type: Article

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