Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 543-556

  Duez, Stéphanie ^a   Coudray, Laëtitia ^a   Mouray, Elisabeth ^b   Grellier, Philippe ^b   Dubois, Joëlle ^a  

^a INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Farnesyltransferase inhibitors; FPP analogues; Imidazole; Malaria; Trypanosoma

Indexed keywords

2 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYL)MALONIC ACID; 2 (5,9,13 TRIMETHYLTETRADECA 2,4,8,12 TETRAENOYLAMINO)MALONIC ACID; 3 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLIDENE)MALONIC ACID; 3 OXO 3 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY)PROPANOIC ACID; 4 OXO 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY)BUTANOIC ACID; 5,9,13 TRIMETHYL N (PHENYLSULFONYL)TETRADECA 4,8,12 TRIENAMIDE; 5,9,13 TRIMETHYLTETRADECA 2,4,8,12 TETRAENAMIDE; 5,9,13 TRIMETHYLTETRADECA 4,8,12 TRIENAMIDE; 5,9,13 TRIMETHYLTETRADECA 4,8,12 TRIENOYLSULFAMIC ACID; 8,12,16 TRIMETHYL 4 OXOHEPTADECA 7,11,15 TRIENOIC ACID; 9,13,17 TRIMETHYL 5 OXO OCTADECA 8,12,16 TRIENOIC ACID; DIETHYL 2 (3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN2 YL)MALONATE; DIETHYL 2 (5,9,13 TRIMETHYLTETRADECA 2,4,8,12 TETRAENOYLAMINO)MALONATE; DIETHYL 2 (5,9,13 TRIMETHYLTETRADECA 4,8,12 TRIENOYL)PENTANEDIOATE; DIETHYL 2 (5,9,13 TRIMETHYLTETRADECA 4,8,12 TRIENOYL)SUCCINATE; DIETHYL 2 (5,9,13 TRIMETHYLTETRADECA 4,8,12 TRIENOYLAMINO)MALONATE; DIETHYL 2 [3 (5 FORMYL 1 METHYL 1H IMIDAZOL 2 YL)ALLYL]MALONATE; DIETHYL 2 [3 (5 FORMYL 1 METHYL 1H IMIDAZOL 2 YL)PROPYL)MALONATE; DIETHYL 2 [3 [5 ((TERT BUTYLDIMETHYLSILYLOXY)METHYL) 1 METHYL 1H IMIDAZOL 2 YL)MALONATE; DIETHYL 2 [3 [5 ((TERT BUTYLDIMETHYLSILYLOXY)METHYL) 1 METHYL 1H IMIDAZOL 2 YL]PROPYL]MALONATE; DIMETHYL 2 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYL)MALONATE; DIMETHYL 3 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLIDENE)MALONATE; DOCETAXEL; ETHYL 7,11,15 TRIMETHYL 3 OXOHEXADECA 6,10,14 TRIENOATE; FARNESYL DIPHOSPHATE; IMIDAZOLE; MALONIC ACID; N HYDROXY 5,9,13 TRIMETHYLTETRADECA 4,8,12 TRIENAMIDE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; KINETICS;

BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FARNESYLTRANSTRANSFERASE; HUMANS; KINETICS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYISOPRENYL PHOSPHATES; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA;

EID: 76449101336     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.017     Document Type: Article

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