Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 12, 2003, Pages 2617-2626

  Thutewohl, Michael ^a   Kissau, Lars ^a   Popkirova, Boriana ^b   Karaguni, Ionna Maria ^b   Nowak, Thorsten ^c   Bate, Michael ^c   Kuhlmann, Jürgen ^b   Müller, Oliver ^b   Waldmann, Herbert ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 NAPHTHYL)ALANINE ALLYL ESTER HYDROTOSYLATE; 3 [3 (1 PENTENYL)PHENYL]ACRYLIC ACID; 4 [4 (1 PENTENYL)PHENYL]ACRYLIC ACID; ANTINEOPLASTIC AGENT; FARNESYL DIPHOSPHATE; FARNESYL TRANS TRANSFERASE; N 3 (2 BENZYLOXYPHENYL)ACRYLOYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 3 PHENYLACRYLOYL DEXTRO N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 3 PHENYLPROPIONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE ALLYL ESTER; N 3 [2 (1 PENTENYL)PHENYL]ACRYLOYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 3 [2 (1 PENTENYL)PHENYL]ACRYLOYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE 2 METHYLTHIAZOL 5 YLMETHYL ESTER; N 3 [2 (1 PENTENYL)PHENYL]ACRYLOYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE 2,4 DIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YLMETHYL ESTER; N 3 [2 (PENTYL)PHENYL]PROPIONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 3 [3 (1 PENTENYL)PHENYL]ACRYLOYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 3 [4 (PENTYL)PHENYL]ACRYLOYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 3 [4 (PENTYL)PHENYL]PROPIONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 4 NITROBENZYLOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 4 NITROBENZYLOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANYLMETHIONINE; N 4 NITROBENZYLOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANYLMETHIONINE SULFOXIDE; N 4 NITROBENZYLOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANYLPIPERIDINE 4 CARBOXYLIC AMIDE; N 9 FLUORENYLMETHOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N 9 FLUOROENYLMETHOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSINE ALLYL ESTER; N 9 FLUOROENYLMETHOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N BENZYLOXYCARBONYL DEXTRO TYROSYL N,O DIMETHYLTYROSYL N METHYLPHENYLALANINE; N METHYLPHENYLALANINE ALLYL ESTER; N,O DIMETHYLTYROSINE ALLYL ESTER; PEPTICINNAMIN E; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG SPECIFICITY; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

EID: 0038334904     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00160-3     Document Type: Article

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