Prenylation of proteins in Trypanosoma brucei

Molecular and Biochemical Parasitology

Volumn 87, Issue 1, 1997, Pages 61-69

  Yokoyama, Kohei ^a   Lin, Ying ^a   Stuart, Kenneth D ^a,b   Gelb, Michael H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Farnesylation; Geranylgeranylation; Isoprenylation; Mevalonic acid; Prenylation; Protein farnesyltransferase; Protein geranylgeranyltransferase; Trypanosoma brucei; Trypanosomatidae

Indexed keywords

PROTOZOAL PROTEIN;

ARTICLE; ISOTOPE LABELING; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN PURIFICATION; TRYPANOSOMA BRUCEI;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CELLS, CULTURED; FARNESYLTRANSTRANSFERASE; GENE EXPRESSION REGULATION; PROTEIN ISOPRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTOZOAN PROTEINS; SUBSTRATE SPECIFICITY; TRANSFERASES; TRYPANOSOMA BRUCEI BRUCEI;

EUKARYOTA; MAMMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 0030739945     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00043-1     Document Type: Article

References (33)

1. F.L. Zhang, P.J. Casey, Protein prenylation: Molecular mechanisms and functional consequences, Ann. Rev. Biochem. 65 (1996) 241-269.
2. J.A. Glomset, M.H. Gelb, C.C. Farnsworth, Prenyl proteins in eukaryotic cells: a new type of membrane anchor, Trends Biochem. Sci. 15 (1990) 139-142.
3. Y. Kamiya, A. Sakurai, S. Tamura, N. Takahashi, Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides, Biochem. Biophys. Res. Commun. 83 (1978) 1077-1083.
4. C.C. Farnsworth, S.L. Wolda, M.H. Gelb, J.A. Glomset, Human Lamin B contains a farnesylated cysteine residue, J. Biol. Chem. 264 (1989) 20422-20429.
5. C.C. Farnsworth, M.H. Gelb, J.A. Glomset, Identification of geranylgeranyl-modified proteins in HeLa cells, Science 247 (1990) 320-322.
6. H.C. Rilling, F. Bruenger, W.W. Epstein, P.F. Grain, Prenylated proteins: the structure of the isoprenoid group, Science 247 (1990) 318-320.
7. C.C. Farnsworth, M. Kawata, Y. Yoshida, Y. Takai, M.H. Gelb, J.A. Glomset, C Terminus of the small GTP-Binding protein smg p25A contains two geranylger-anylated cysteine residues and a methyl ester, Proc. Natl. Acad. Sci. USA 88 (1991) 6196-6200.
8. S. Clarke, Protein isoprenylation and methylation at carboxy-Terminal cysteine residues, Annu. Rev. Biochem. 61 (1992) 355-386.
9. M. Sinensky, R.J. Lutz, The prenylation of proteins, Bioessays 14 (1992) 25-31.
10. H.K. Yamane, C.C. Farnsworth, H. Xie, W. Howald, B.K.- Fung, B.K.-K., Clarke, S., Gelb, M.H., J.A. Glomset, Brain G protein γ-subunits contain an all-trans-geranylgeranyl cysteine methyl ester a their carboxyl termini, Proc. Natl. Acad. Sci. USA 87 (1990) 5868-5872.
11. S.M. Mumby, P.J. Casey, A.G. Gilman, S. Gutowski, P.C. Sternweis, G protein γ-subunits contain a 20-carbon isoprenoid, Proc. Natl. Acad. Sci. USA 87 (1990) 5873-5877.
12. J.C. Otto, P.J. Casey, The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells, J. Biol. Chem. 271 (1996) 4569-4572.
13. K. Yokoyama, G.W. Goodwin, F. Ghomashchi, J. Glomset, M.H. Gelb, Protein prenyltransferases, Biochem. Soc. Trans. 20 (1992) 489-494.
14. P.J. Casey, M.C. Seabra, Protein prenyltransferases, J. Biol. Chem. 271 (1996) 5289-5292.
15. C.C. Farnsworth, M.C. Seabra, L.H. Ericsson, M.H. Gelb, J.A. Glomset, Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases, Rab1A, Rab3A, and Rab5A, Proc. Natl. Acad. Sci. USA 91 (1994) 11963-11967.
16. H.D. Lujan, M.R. Mowatt, G.-Z. Chen, T.E. Nash, Isoprenylation of proteins in the protozoan Giardia lamblia, Mol. Biochem. Parasitol. 72 (1995) 121-127.
17. G.-Z. Chen, J.L. Bennett, Characterization of mevalonate-labeled lipids isolated from parasite proteins in Schistosoma mansoni, Mol. Biochem. Parasitol. 59 (1993) 287-292.
18. P. McGeady, S. Kuroda, K. Shimizu, Y. Takai, M.H. Gelb, The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase, J. Biol. Chem. 270 (1995) 26347-26351.
19. K. Yokoyama, G.W. Goodwin, F. Ghomashchi, J.A. Glomset, M.H. Gelb, A protein geranylgeranyltransferase from bovine brain: Implications for protein prenylation specificity, Proc. Natl. Acad. Sci. USA 88 (1991) 5302-5306.
20. K. Yokoyama, K. Zimmerman, J. Scholten, M.H. Gelb, Differential prenylpyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation, J. Biol. Chem. 272 (1997) 3944-3952.
21. C. Gabelli, C. Bilato, S. Martini, G.E. Tennyson, L.A. Zech, A. Corsini, M. Albanese, H.B.J. Brewer, G. Crepaldi, G. Baggio, Homozygous familial hypobetalipoproteinemia. Increased LDL catabolism in hypobetalipoproteinemia due to a truncated apolipoprotein B species, apo B-87 Padova, Arterioscler. Thromb. Vasc. Biol. 16 (1996) 1189-1196.
22. K. Yokoyama, P. McGeady, M.H. Gelb, Mammalian protein geranylgeranyltransferae-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling, Biochemistry 34 (1995) 1344-1354.
23. M.H. Gelb, C.C. Farnsworth, J.A. Glomset, Structural Analysis of Prenylated Proteins, in Lipidation of Proteins: A Practical Approach (Turner, A.J., Ed.) IRL Press, Oxford, 1992.
24. D.C. Crick, C.J. Waechter, D.A. Andres, Utilization of geranylgeraniol for protein isoprenylation in C6 glial cells, Biochem. Biophys. Res. Commun. 205 (1994) 955-961.
25. D.C. Crick, D.A. Andres, C.J. Waechter, Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells, Biochem. Biophys. Res. Commun. 211 (1995) 590-599.
26. D.L. Pompliano, E. Rands, M.D. Schaber, S.D. Mosser, N.J. Anthony, J.B. Gibbs, Steady-state kinetic mechanism of Ras farnesyl: protein transferase, Biochemistry 31 (1992) 3800-3807.
27. M.C. Seabra, Y. Reiss, P.J. Casey, M.S. Brown, J.L. Goldstein, Protein farnesyltransferase and geranylgeranyltransferase share a common α-subunit, Cell 65 (1991) 429-434.
28. Y. Reiss, J.L. Goldstein, M.C. Seabra, P.J. Casey, M.S. Brown, Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides, Cell 62 (1990) 81-88.
29. G.J. James, J.L. Goldstein, M.S. Brown, Polylysine and CVIM sequence of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptide mimetic in vitro, J. Biol. Chem. 270 (1995) 6221-6226.
30. S.L. Moores, M.D. Schaber, S.D. Mosser, E. Rands, M.B. O'Hara, V.M. Garsky, M.S. Marshall, D.L. Pompliano, J.B. Gibbs, Sequence dependence of protein Isoprenylation, J. Biol. Chem. 266 (1991) 14603-14610.
31. A.A. Finegold, D.I. Johnson, C.C. Farnsworth, M.H. Gelb, S.R. Judd, J.A. Glomset, F. Tamanoi, Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product, Proc. Natl. Acad. Sci. USA 88 (1991) 4448-4452.
32. B.E. Caplin, L.A. Hettich, M.S. Marshall, Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase, Biochem. Biophys. Acta 1205 (1994) 39-48.
33. I. Danjoh, A. Fujiyama, Enzymic characterization of fission yeast farnesyl transferase recognition of the -CAAL motif at the C-terminus, Eur. J. Biochem. 236 (1996) 847-851.