Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei

Molecular and Biochemical Parasitology

Volumn 82, Issue 1, 1996, Pages 67-80

  Field, Helen ^a   Blench, Ian ^a   Croft, Simon ^b   Field, Mark C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

G proteins; Mevalonate; Prenylation; Trypanosoma; Ultrastructure

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENALINE; MEVALONIC ACID;

ARTICLE; CELL METABOLISM; CONTROLLED STUDY; EUKARYOTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; TRYPANOSOMA BRUCEI; ULTRASTRUCTURE;

EUKARYOTA; KINETOPLASTIDA; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0030581643     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(96)02723-5     Document Type: Article

References (30)

1. [1] Grunler, J., Ericsson, J. and Dallner, G. (1994) Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochem. Biophys. Acta 1212, 259-277.
2. [2] Gutteridge, W.E. and Coombes, G.H. (1977) Lipid Metabolism. In: Biochemistry of Parasitic Protozoa, The MacMillan Press Ltd., London, UK. pp. 108-120.
3. [3] Mann, J. (1987) Metabolites derived from mevalonate: isoprenoids. Chapter 3 in: Secondary Metabolism, Edition II, Clarendon Press, Oxford, UK. pp. 95-171.
4. [4] Farnsworth, C.C., Casey, P.J., Howald, W.N., Glomset, J.A. and Gelb, M.H. (1990) Structural characterization of prenyl groups attached to proteins, Methods 1, 231-240.
5. [5] Goldstein, J.L. and Brown, M.S. (1990) Regulation of the mevalonate pathway. Nature 343, 425-430.
6. [6] Hampton, R.Y. and Rine, J. (1994) Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. J. Cell Biol. 125, 299-312.
7. [7] Lum, P.K. and Wright, R. (1995) Degradation of HMG-CoA reductase-induced membranes in the fission yeast, Schizosaccharomyces pombe. J. Cell Biol. 131, 81-94.
8. [8] Giannakouros, T. and Magee, A.I. (1993) Protein prenylation and associated modifications. In: Lipid Modifications of Proteins (Schlessinger, M., ed), CRC Press, Boca Raton, FL, USA, pp. 135-162.
9. [9] Nuoffer, C. and Balch, W.E. (1994) GTPases: multifunctional molecular switches regulating vesicle traffic. Annu. Rev. Biochem. 63, 949-990.
10. [10] Gibbs, J.B., Oliff, A. and Kohl, N.L. (1994) Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell 77, 175-178.
11. [11] Low, P., Dallner, G., Mayor, S., Cohen, S., Chait, B.T. and Menon, A.K. (1991) The mevalonate pathway in the bloodstream form of Trypanosoma brucei. J. Biol. Chem. 266, 19250-19257.
12. [12] Parodi, A.J. and Quesada-Allue, L.A., (1982) Protein glycosylation in Trypanosoma cruzi. I. Characterization of dolichol-bound monosaccharides and oligosaccharides synthesized 'in vivo'. J. Biol. Chem. 257, 7637-7640.
13. [13] Quesada-Allue, L.A. and Parodi, A.J. (1983) Novel mannose carrier in the trypanosomatid Crithidia fasciculala behaving as a short alpha-saturated polyprenyl phosphate. Biochem. J. 212, 123-128.
14. [14] Field, M.C., Field, H. and Boothroyd, J.C. (1995) A homologue of the nuclear GTPase Ran/TC4 from Trypanosoma brucei, Mol. Biochem. Parasitol. 69, 131-134.
15. [15] Field, M.C. and Boothroyd, J.C. (1995) Trypanosoma brucei; molecular cloning of homologues of small GTP-binding proteins involved in vesicle trafficking. Exp. Parasitol. 81, 313-320.
16. [16] Coulter, L.J. and Hide, G. (1995) Trypanosoma brucei: characterisation of a life cycle stage-specific G-protein. Exp. Parasitol. 80, 308-318.
17. [17] El-Sayed, N.M.A., Alarcon, C.M., Beck, J.C., Sheffield, V.C. and Donelson, J.E. (1995) cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite. Mol. Biochem. Parasitol. 73, 75-90.
18. [18] Luján, H.D., Mowatt, M., Chen, G.-Z. and Nash, T. (1995) Isoprenylation of proteins in the protozoa Giardia lamblia. Mol. Biochem. Parasitol. 72, 121-127.
19. [19] Coppens, I., Bastin, P., Levade, T. and Courtoy, P.J. (1995) Activity, pharmacological inhibition and biological regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei. Mol. Biochem. Parasitol. 69, 29-40.
20. [20] Chen, G-Z. and Bennet, J.L. (1993) Characterization of mevalonate-labelled lipids isolated from parasite proteins in Schistosoma mansoni. Mol. Biochem. Parasitol. 59, 287-292.
21. [21] Brun, R. and Schonenberger, M. (1979) Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in semi-defined medium. Acta Tropica 36, 286-292.
22. [22] Hirumi, H. and Hirumi, K., (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol. 75, 985-989.
23. [23] Gelb, M.H., Farnsworth, C.C. and Glomset, J.A. (1992) Structural analysis of prenylated proteins. In: Lipid Modifications of Proteins - A Practical Approach (Hooper, N. and Turner, A.J., eds), IRL Press, Oxford, UK, pp. 231-259.
24. [24] Gellen, M.J., Papiez, J., Girgis, K. and Gibson, D.M., (1991) In situ measurement of HMG-CoA reductase activity in digitonin-permiabilised hepatocytes. Biochem. Biophys. Res. Comm. 180, 525-530.
25. [25] Schulz, S., Bhling, F. and Ansorge, S. (1994) Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene and related monoterpenes. Eur. J. Immunol. 24, 301-307.
26. [26] Casey, P.J., Solski, P.A., Der, C.J. and Buss, J.E. (1989) p21 ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA 86, 8323-8327.
27. [27] Chin, D.J., Luskey, K.L., Anderson, R.G., Faust, J.R., Goldstein, J.L. and Brown, M.S. (1982) Appearance of crystalloid endoplasmic reticulum in compactin resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl coenzyme A reductase. Proc. Natl. Acad. Sci. USA 79, 1185-1189.
28. [28] Pittler, S.J., Fliesler, S.J., Fisher, P.L., Keller, R.K. and Rapp, L.M. (1995) In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. J. Cell Biol. 130, 431-439.
29. [29] Coppens, I. and Courtoy P.J. (1995) Exogenous and endogenous sources of sterols in the culture-adapted procyclic trypomastigotes of Trypanosoma brucei. Mol. Biochem. Parasitol. 73, 179-188.
30. [30] Dagley, S. and Nicholson, D.E. (1970) An introduction to metabolic pathways. Blackwell Scientific, Oxford, UK.