Design, synthesis and early structure-activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 8, 2000, Pages 1991-2006

  Schlitzer, Martin ^a   Böhm, Markus ^a   Sattler, Isabel ^b   Dahse, Hans Martin ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYLTRANSFERASE; LONG CHAIN FATTY ACID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; CELL DIVISION; DRUG DESIGN; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0342733573     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00138-3     Document Type: Article

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