메뉴 건너뛰기




Volumn 20, Issue 2, 2010, Pages 481-489

Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy

Author keywords

Glioblastoma; Leptin; Leptin receptor; Malignant progression; Novel biomarker

Indexed keywords

KI 67 ANTIGEN; LEPTIN; LEPTIN RECEPTOR; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; STAT3 PROTEIN;

EID: 75949101329     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2009.00323.x     Document Type: Article
Times cited : (56)

References (80)
  • 1
    • 17744375347 scopus 로고    scopus 로고
    • Regulation of neuronal and glial proteins by leptin: Implications for brain development
    • Ahima RS, Bjorbaek C, Osei S, Flier JS (1999) Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140 : 2755 2762.
    • (1999) Endocrinology , vol.140 , pp. 2755-2762
    • Ahima, R.S.1    Bjorbaek, C.2    Osei, S.3    Flier, J.S.4
  • 2
    • 0033747214 scopus 로고    scopus 로고
    • Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways
    • Attoub S, Noe V, Pirola L, Bruyneel E, Chastre E, Mareel M et al (2000) Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J 14 : 2329 2338.
    • (2000) FASEB J , vol.14 , pp. 2329-2338
    • Attoub, S.1    Noe, V.2    Pirola, L.3    Bruyneel, E.4    Chastre, E.5    Mareel, M.6
  • 4
    • 0032416683 scopus 로고    scopus 로고
    • Mutations of TP53, amplification of EGFR, MDM2 and CDK4, and deletions of CDKN2A in malignant astrocytomas
    • Biernat W, Debiec-Rychter M, Liberski PP (1998) Mutations of TP53, amplification of EGFR, MDM2 and CDK4, and deletions of CDKN2A in malignant astrocytomas. Pol J Pathol 49 : 267 271.
    • (1998) Pol J Pathol , vol.49 , pp. 267-271
    • Biernat, W.1    Debiec-Rychter, M.2    Liberski, P.P.3
  • 5
    • 2442676505 scopus 로고    scopus 로고
    • Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas
    • Biernat W, Huang H, Yokoo H, Kleihues P, Ohgaki H (2004) Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol 14 : 131 136.
    • (2004) Brain Pathol , vol.14 , pp. 131-136
    • Biernat, W.1    Huang, H.2    Yokoo, H.3    Kleihues, P.4    Ohgaki, H.5
  • 7
    • 0032538875 scopus 로고    scopus 로고
    • Leptin, the product of Ob gene, promotes angiogenesis
    • Bouloumie A, Drexler HC, Lafontan M, Busse R (1998) Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83 : 1059 1066.
    • (1998) Circ Res , vol.83 , pp. 1059-1066
    • Bouloumie, A.1    Drexler, H.C.2    Lafontan, M.3    Busse, R.4
  • 9
    • 24944523270 scopus 로고    scopus 로고
    • RNAi-mediated silencing of leptin gene expression increases cell death in C6 glioblastoma cells
    • Brown R, Morash B, Ur E, Wilkinson M (2005) RNAi-mediated silencing of leptin gene expression increases cell death in C6 glioblastoma cells. Brain Res Mol Brain Res 139 : 357 360.
    • (2005) Brain Res Mol Brain Res , vol.139 , pp. 357-360
    • Brown, R.1    Morash, B.2    Ur, E.3    Wilkinson, M.4
  • 11
    • 0032977544 scopus 로고    scopus 로고
    • Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas
    • discussion 2 3
    • Buschges R, Weber RG, Actor B, Lichter P, Collins VP, Reifenberger G (1999) Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas. Brain Pathol 9 : 435 442 discussion 2 3.
    • (1999) Brain Pathol , vol.9 , pp. 435-442
    • Buschges, R.1    Weber, R.G.2    Actor, B.3    Lichter, P.4    Collins, V.P.5    Reifenberger, G.6
  • 12
    • 0035933126 scopus 로고    scopus 로고
    • Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
    • Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y (2001) Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc Natl Acad Sci USA 98 : 6390 6395.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6390-6395
    • Cao, R.1    Brakenhielm, E.2    Wahlestedt, C.3    Thyberg, J.4    Cao, Y.5
  • 15
    • 2442475308 scopus 로고    scopus 로고
    • Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells
    • Catalano S, Mauro L, Marsico S, Giordano C, Rizza P, Rago V et al (2004) Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J Biol Chem 279 : 19908 19915.
    • (2004) J Biol Chem , vol.279 , pp. 19908-19915
    • Catalano, S.1    Mauro, L.2    Marsico, S.3    Giordano, C.4    Rizza, P.5    Rago, V.6
  • 16
    • 58149388704 scopus 로고    scopus 로고
    • Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation
    • Catalano S, Giordano C, Rizza P, Gu G, Barone I, Bonofiglio D et al (2009) Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. J Cell Physiol 218 : 490 500.
    • (2009) J Cell Physiol , vol.218 , pp. 490-500
    • Catalano, S.1    Giordano, C.2    Rizza, P.3    Gu, G.4    Barone, I.5    Bonofiglio, D.6
  • 18
    • 0031868650 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma
    • Chan AS, Leung SY, Wong MP, Yuen ST, Cheung N, Fan YW, Chung LP (1998) Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. Am J Surg Pathol 22 : 816 826.
    • (1998) Am J Surg Pathol , vol.22 , pp. 816-826
    • Chan, A.S.1    Leung, S.Y.2    Wong, M.P.3    Yuen, S.T.4    Cheung, N.5    Fan, Y.W.6    Chung, L.P.7
  • 19
    • 12244271468 scopus 로고    scopus 로고
    • Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells
    • Choi JH, Park SH, Leung PC, Choi KC (2005) Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells. J Clin Endocrinol Metab 90 : 207 210.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 207-210
    • Choi, J.H.1    Park, S.H.2    Leung, P.C.3    Choi, K.C.4
  • 20
    • 0035404677 scopus 로고    scopus 로고
    • Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups
    • Davis FG, Kupelian V, Freels S, McCarthy B, Surawicz T (2001) Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro Oncol 3 : 152 158.
    • (2001) Neuro Oncol , vol.3 , pp. 152-158
    • Davis, F.G.1    Kupelian, V.2    Freels, S.3    McCarthy, B.4    Surawicz, T.5
  • 22
    • 0033651790 scopus 로고    scopus 로고
    • Anatomic basis of leptin action in the hypothalamus
    • Elmquist JK (2000) Anatomic basis of leptin action in the hypothalamus. Front Horm Res 26 : 21 41.
    • (2000) Front Horm Res , vol.26 , pp. 21-41
    • Elmquist, J.K.1
  • 23
  • 24
    • 57149133679 scopus 로고    scopus 로고
    • Leptin/HER2 crosstalk in breast cancer: In vitro study and preliminary in vivo analysis
    • Fiorio E, Mercanti A, Terrasi M, Micciolo R, Remo A, Auriemma A et al (2008) Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. BMC Cancer 8 : 305.
    • (2008) BMC Cancer , vol.8 , pp. 305
    • Fiorio, E.1    Mercanti, A.2    Terrasi, M.3    Micciolo, R.4    Remo, A.5    Auriemma, A.6
  • 25
    • 8544260325 scopus 로고    scopus 로고
    • Leptin induces cell migration and the expression of growth factors in human prostate cancer cells
    • Frankenberry KA, Somasundar P, McFadden DW, Vona-Davis LC (2004) Leptin induces cell migration and the expression of growth factors in human prostate cancer cells. Am J Surg 188 : 560 565.
    • (2004) Am J Surg , vol.188 , pp. 560-565
    • Frankenberry, K.A.1    Somasundar, P.2    McFadden, D.W.3    Vona-Davis, L.C.4
  • 26
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick L, Wang XY, Eley G, James CD (2000) Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 60 : 1383 1387.
    • (2000) Cancer Res , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3    James, C.D.4
  • 29
    • 5144229540 scopus 로고    scopus 로고
    • Leptin interferes with the effects of the antiestrogen ICI 182 780 in MCF-7 breast cancer cells
    • Garofalo C, Sisci D, Surmacz E (2004) Leptin interferes with the effects of the antiestrogen ICI 182 780 in MCF-7 breast cancer cells. Clin Cancer Res 10 : 6466 6475.
    • (2004) Clin Cancer Res , vol.10 , pp. 6466-6475
    • Garofalo, C.1    Sisci, D.2    Surmacz, E.3
  • 30
    • 33645066625 scopus 로고    scopus 로고
    • Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: Possible role of obesity-related stimuli
    • Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J et al (2006) Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 12 : 1447 1453.
    • (2006) Clin Cancer Res , vol.12 , pp. 1447-1453
    • Garofalo, C.1    Koda, M.2    Cascio, S.3    Sulkowska, M.4    Kanczuga-Koda, L.5    Golaszewska, J.6
  • 31
    • 0042706427 scopus 로고    scopus 로고
    • A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells
    • Gonzalez RR, Leavis PC (2003) A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells. Endocrine 21 : 185 195.
    • (2003) Endocrine , vol.21 , pp. 185-195
    • Gonzalez, R.R.1    Leavis, P.C.2
  • 32
    • 33748751983 scopus 로고    scopus 로고
    • Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)
    • Gonzalez RR, Cherfils S, Escobar M, Yoo JH, Carino C, Styer AK et al (2006) Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 281 : 26320 26328.
    • (2006) J Biol Chem , vol.281 , pp. 26320-26328
    • Gonzalez, R.R.1    Cherfils, S.2    Escobar, M.3    Yoo, J.H.4    Carino, C.5    Styer, A.K.6
  • 34
    • 0037146224 scopus 로고    scopus 로고
    • Leptin - A growth factor in normal and malignant breast cells and for normal mammary gland development
    • Hu X, Juneja SC, Maihle NJ, Cleary MP (2002) Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 94 : 1704 1711.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1704-1711
    • Hu, X.1    Juneja, S.C.2    Maihle, N.J.3    Cleary, M.P.4
  • 35
    • 3042817487 scopus 로고    scopus 로고
    • Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    • Ishikawa M, Kitayama J, Nagawa H (2004) Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 10 : 4325 4331.
    • (2004) Clin Cancer Res , vol.10 , pp. 4325-4331
    • Ishikawa, M.1    Kitayama, J.2    Nagawa, H.3
  • 36
    • 33745767945 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas
    • Jensen RL, Ragel BT, Whang K, Gillespie D (2006) Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. J Neurooncol 78 : 233 247.
    • (2006) J Neurooncol , vol.78 , pp. 233-247
    • Jensen, R.L.1    Ragel, B.T.2    Whang, K.3    Gillespie, D.4
  • 37
    • 0042966942 scopus 로고    scopus 로고
    • A novel approach to glioma gene therapy: Down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes
    • Ke LD, Fueyo J, Chen X, Steck PA, Shi YX, Im SA, Yung WK (1998) A novel approach to glioma gene therapy: down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes. Int J Oncol 12 : 1391 1396.
    • (1998) Int J Oncol , vol.12 , pp. 1391-1396
    • Ke, L.D.1    Fueyo, J.2    Chen, X.3    Steck, P.A.4    Shi, Y.X.5    Im, S.A.6    Yung, W.K.7
  • 38
    • 0041349558 scopus 로고    scopus 로고
    • The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines
    • Ke LD, Shi YX, Im SA, Chen X, Yung WK (2000) The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines. Clin Cancer Res 6 : 2562 2572.
    • (2000) Clin Cancer Res , vol.6 , pp. 2562-2572
    • Ke, L.D.1    Shi, Y.X.2    Im, S.A.3    Chen, X.4    Yung, W.K.5
  • 39
    • 0037086156 scopus 로고    scopus 로고
    • VEGF(121), VEGF(165) overexpression enhances tumorigenicity in U251 MG but not in NG-1 glioma cells
    • Ke LD, Shi YX, Yung WK (2002) VEGF(121), VEGF(165) overexpression enhances tumorigenicity in U251 MG but not in NG-1 glioma cells. Cancer Res 62 : 1854 1861.
    • (2002) Cancer Res , vol.62 , pp. 1854-1861
    • Ke, L.D.1    Shi, Y.X.2    Yung, W.K.3
  • 40
    • 0034911848 scopus 로고    scopus 로고
    • Gene expression of adrenomedullin, leptin, their receptors and neuropeptide y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans
    • Knerr I, Schuster S, Nomikos P, Buchfelder M, Dotsch J, Schoof E et al (2001) Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. Neuropathol Appl Neurobiol 27 : 215 222.
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 215-222
    • Knerr, I.1    Schuster, S.2    Nomikos, P.3    Buchfelder, M.4    Dotsch, J.5    Schoof, E.6
  • 41
    • 35748951939 scopus 로고    scopus 로고
    • Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1alpha in human colorectal cancer
    • Koda M, Sulkowska M, Kanczuga-Koda L, Cascio S, Colucci G, Russo A et al (2007) Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1alpha in human colorectal cancer. Ann Oncol 18 (Suppl. 6 vi116 vi119.
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL 6
    • Koda, M.1    Sulkowska, M.2    Kanczuga-Koda, L.3    Cascio, S.4    Colucci, G.5    Russo, A.6
  • 46
    • 34248147408 scopus 로고    scopus 로고
    • Evidences that leptin up-regulates E-cadherin expression in breast cancer: Effects on tumor growth and progression
    • Mauro L, Catalano S, Bossi G, Pellegrino M, Barone I, Morales S et al (2007) Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression. Cancer Res 67 : 3412 3421.
    • (2007) Cancer Res , vol.67 , pp. 3412-3421
    • Mauro, L.1    Catalano, S.2    Bossi, G.3    Pellegrino, M.4    Barone, I.5    Morales, S.6
  • 47
    • 47249142005 scopus 로고    scopus 로고
    • Leptin and mTOR: Partners in metabolism and inflammation
    • Maya-Monteiro CM, Bozza PT (2008) Leptin and mTOR: partners in metabolism and inflammation. Cell Cycle 7 : 1713 1717.
    • (2008) Cell Cycle , vol.7 , pp. 1713-1717
    • Maya-Monteiro, C.M.1    Bozza, P.T.2
  • 48
    • 0033304752 scopus 로고    scopus 로고
    • Leptin gene expression in the brain and pituitary gland
    • Morash B, Li A, Murphy PR, Wilkinson M, Ur E (1999) Leptin gene expression in the brain and pituitary gland. Endocrinology 140 : 5995 5998.
    • (1999) Endocrinology , vol.140 , pp. 5995-5998
    • Morash, B.1    Li, A.2    Murphy, P.R.3    Wilkinson, M.4    Ur, E.5
  • 49
    • 0035924089 scopus 로고    scopus 로고
    • Developmental regulation of leptin gene expression in rat brain and pituitary
    • DOI 10.1016/S0303-7207(01)00626-8, PII S0303720701006268
    • Morash B, Wilkinson D, Murphy P, Ur E, Wilkinson M (2001) Developmental regulation of leptin gene expression in rat brain and pituitary. Mol Cell Endocrinol 185 : 151 159. (Pubitemid 33103964)
    • (2001) Molecular and Cellular Endocrinology , vol.185 , Issue.1-2 , pp. 151-159
    • Morash, B.1    Wilkinson, D.2    Murphy, P.3    Ur, E.4    Wilkinson, M.5
  • 50
    • 0242579365 scopus 로고    scopus 로고
    • Leptin receptors are developmentally regulated in rat pituitary and hypothalamus
    • Morash BA, Imran A, Wilkinson D, Ur E, Wilkinson M (2003) Leptin receptors are developmentally regulated in rat pituitary and hypothalamus. Mol Cell Endocrinol 210 : 1 8.
    • (2003) Mol Cell Endocrinol , vol.210 , pp. 1-8
    • Morash, B.A.1    Imran, A.2    Wilkinson, D.3    Ur, E.4    Wilkinson, M.5
  • 51
    • 6344279925 scopus 로고    scopus 로고
    • Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters
    • Morelli C, Garofalo C, Sisci D, del Rincon S, Cascio S, Tu X et al (2004) Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters. Oncogene 23 : 7517 7526.
    • (2004) Oncogene , vol.23 , pp. 7517-7526
    • Morelli, C.1    Garofalo, C.2    Sisci, D.3    Del Rincon, S.4    Cascio, S.5    Tu, X.6
  • 52
    • 64249132485 scopus 로고    scopus 로고
    • Leptin signaling in brain: A link between nutrition and cognition?
    • Morrison CD (2009) Leptin signaling in brain: a link between nutrition and cognition? Biochim Biophys Acta 1792 : 401 408.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 401-408
    • Morrison, C.D.1
  • 53
    • 0037112423 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas
    • Narita Y, Nagane M, Mishima K, Huang HJ, Furnari FB, Cavenee WK (2002) Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Cancer Res 62 : 6764 6769.
    • (2002) Cancer Res , vol.62 , pp. 6764-6769
    • Narita, Y.1    Nagane, M.2    Mishima, K.3    Huang, H.J.4    Furnari, F.B.5    Cavenee, W.K.6
  • 55
    • 58149471244 scopus 로고    scopus 로고
    • Epidemiology of brain tumors
    • Ohgaki H (2009) Epidemiology of brain tumors. Methods Mol Biol 472 : 323 342.
    • (2009) Methods Mol Biol , vol.472 , pp. 323-342
    • Ohgaki, H.1
  • 56
    • 0037152340 scopus 로고    scopus 로고
    • Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: Reciprocal involvement of PKC-alpha and PPAR expression
    • Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M et al (2002) Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta 1592 : 107 116.
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 107-116
    • Okumura, M.1    Yamamoto, M.2    Sakuma, H.3    Kojima, T.4    Maruyama, T.5    Jamali, M.6
  • 57
    • 0035973147 scopus 로고    scopus 로고
    • Potential role of leptin in angiogenesis: Leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro
    • Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE et al (2001) Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33 : 95 102.
    • (2001) Exp Mol Med , vol.33 , pp. 95-102
    • Park, H.Y.1    Kwon, H.M.2    Lim, H.J.3    Hong, B.K.4    Lee, J.Y.5    Park, B.E.6
  • 58
    • 34250158420 scopus 로고    scopus 로고
    • Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis
    • discussion 7
    • Ragel BT, Couldwell WT, Gillespie DL, Jensen RL (2007) Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis. Neurosurg Rev 30 : 181 187 discussion 7.
    • (2007) Neurosurg Rev , vol.30 , pp. 181-187
    • Ragel, B.T.1    Couldwell, W.T.2    Gillespie, D.L.3    Jensen, R.L.4
  • 59
    • 34447266935 scopus 로고    scopus 로고
    • Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status
    • Ray A, Nkhata KJ, Cleary MP (2007) Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol 30 : 1499 1509.
    • (2007) Int J Oncol , vol.30 , pp. 1499-1509
    • Ray, A.1    Nkhata, K.J.2    Cleary, M.P.3
  • 60
    • 0029800810 scopus 로고    scopus 로고
    • Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets
    • Reifenberger G, Ichimura K, Reifenberger J, Elkahloun AG, Meltzer PS, Collins VP (1996) Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. Cancer Res 56 : 5141 5145.
    • (1996) Cancer Res , vol.56 , pp. 5141-5145
    • Reifenberger, G.1    Ichimura, K.2    Reifenberger, J.3    Elkahloun, A.G.4    Meltzer, P.S.5    Collins, V.P.6
  • 61
    • 50449097298 scopus 로고    scopus 로고
    • Surgical management of newly diagnosed glioblastoma in adults: Role of cytoreductive surgery
    • Ryken TC, Frankel B, Julien T, Olson JJ (2008) Surgical management of newly diagnosed glioblastoma in adults: role of cytoreductive surgery. J Neurooncol 89 : 271 286.
    • (2008) J Neurooncol , vol.89 , pp. 271-286
    • Ryken, T.C.1    Frankel, B.2    Julien, T.3    Olson, J.J.4
  • 63
    • 33749016521 scopus 로고    scopus 로고
    • AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma
    • Sathornsumetee S, Hjelmeland AB, Keir ST, McLendon RE, Batt D, Ramsey T et al (2006) AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma. Cancer Res 66 : 8722 8730.
    • (2006) Cancer Res , vol.66 , pp. 8722-8730
    • Sathornsumetee, S.1    Hjelmeland, A.B.2    Keir, S.T.3    McLendon, R.E.4    Batt, D.5    Ramsey, T.6
  • 65
    • 57149100169 scopus 로고    scopus 로고
    • Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor
    • Saxena NK, Taliaferro-Smith L, Knight BB, Merlin D, Anania FA, O'Regan RM, Sharma D (2008) Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. Cancer Res 68 : 9712 9722.
    • (2008) Cancer Res , vol.68 , pp. 9712-9722
    • Saxena, N.K.1    Taliaferro-Smith, L.2    Knight, B.B.3    Merlin, D.4    Anania, F.A.5    O'Regan, R.M.6    Sharma, D.7
  • 66
    • 33947537241 scopus 로고    scopus 로고
    • Mechanisms of disease: Adipokines and breast cancer - Endocrine and paracrine mechanisms that connect adiposity and breast cancer
    • Schaffler A, Scholmerich J, Buechler C (2007) Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab 3 : 345 354.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 345-354
    • Schaffler, A.1    Scholmerich, J.2    Buechler, C.3
  • 67
    • 33745108419 scopus 로고    scopus 로고
    • Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways
    • Sharma D, Saxena NK, Vertino PM, Anania FA (2006) Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr Relat Cancer 13 : 629 640.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 629-640
    • Sharma, D.1    Saxena, N.K.2    Vertino, P.M.3    Anania, F.A.4
  • 70
    • 48949091209 scopus 로고    scopus 로고
    • Leptin augments proliferation of breast cancer cells via transactivation of HER2
    • Soma D, Kitayama J, Yamashita H, Miyato H, Ishikawa M, Nagawa H (2008) Leptin augments proliferation of breast cancer cells via transactivation of HER2. J Surg Res 149 : 9 14.
    • (2008) J Surg Res , vol.149 , pp. 9-14
    • Soma, D.1    Kitayama, J.2    Yamashita, H.3    Miyato, H.4    Ishikawa, M.5    Nagawa, H.6
  • 74
    • 34248157798 scopus 로고    scopus 로고
    • Obesity hormone leptin: A new target in breast cancer?
    • Surmacz E (2007) Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res 9 : 301.
    • (2007) Breast Cancer Res , vol.9 , pp. 301
    • Surmacz, E.1
  • 75
    • 33947320145 scopus 로고    scopus 로고
    • Insulin-like growth factor type i biology and targeting in malignant gliomas
    • Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD (2007) Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience 145 : 795 811.
    • (2007) Neuroscience , vol.145 , pp. 795-811
    • Trojan, J.1    Cloix, J.F.2    Ardourel, M.Y.3    Chatel, M.4    Anthony, D.D.5
  • 76
    • 34547741589 scopus 로고    scopus 로고
    • Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    • Vona-Davis L, Rose DP (2007) Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 14 : 189 206.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 189-206
    • Vona-Davis, L.1    Rose, D.P.2
  • 78
    • 54049144617 scopus 로고    scopus 로고
    • Comparison of STAT3 with HIF-1alpha, Ob and ObR expressions in human endometrioid adenocarcinomas
    • Wincewicz A, Koda M, Sulkowska M, Kanczuga-Koda L, Sulkowski S (2008) Comparison of STAT3 with HIF-1alpha, Ob and ObR expressions in human endometrioid adenocarcinomas. Tissue Cell 40 : 405 410.
    • (2008) Tissue Cell , vol.40 , pp. 405-410
    • Wincewicz, A.1    Koda, M.2    Sulkowska, M.3    Kanczuga-Koda, L.4    Sulkowski, S.5
  • 79
  • 80
    • 34547675747 scopus 로고    scopus 로고
    • Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer
    • Zhao X, Huang K, Zhu Z, Chen S, Hu R (2007) Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer. J Gastroenterol Hepatol 22 : 1317 1321.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1317-1321
    • Zhao, X.1    Huang, K.2    Zhu, Z.3    Chen, S.4    Hu, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.