Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 8, 2007, Pages 1317-1321

  Zhao, Xiaolong ^a,c   Huang, Kaihong ^b   Zhu, Zhaohua ^b   Chen, Shuhong ^b   Hu, Renming ^a  

^a FUDAN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c NONE   (China)

Author keywords

Gastric cancer; Immunohistochemistry; Leptin; Survive analysis; Vascular endothelial growth factor

Indexed keywords

ANTINEOPLASTIC AGENT; LEPTIN; VASCULOTROPIN;

ARTICLE; BORRMANN CLASSIFICATION; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL FEATURE; CORRELATION ANALYSIS; DISEASE CLASSIFICATION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; STOMACH CARCINOMA; SURVIVAL RATE; TUMOR VOLUME;

EID: 34547675747     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.04941.x     Document Type: Article

References (27)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the obese gene and its human homologue. Nature 1994 372 : 425 32.
2. Tartaglia L, Dembski M, Weng X et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995 83 : 1263 71.
3. Senaris R, Garcia-Caballero T, Casabiell X et al. Synthesis of leptin in human placenta. Endocrinology 1997 138 : 4501 4.
4. Smith-Kirwin SM, O'Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage VL. Leptin expression in human mammary epithelial cells and breast milk. J. Clin. Endocrinol. Metab. 1998 83 : 1810 13.
5. Mix H, Widjaja A, Jandl O et al. Expression of leptin and leptin receptor isoforms in the human stomach. Gut 2000 47 : 481 6.
6. Saxena NK, Titus MA, Ding X et al. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB J. 2004 18 : 1612 14.
7. Hardwick JC, Van Den Brink GR, Offerhaus GJ, Van Deventer SJ, Peppelenbosch MP. Leptin is a growth factor for colonic epithelial cells. Gastroenterology 2001 121 : 79 90.
8. Schneider R, Bornstein SR, Chrousos GP, Boxberger S, Ehninger G, Breidert M. Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor. Horm. Metab. Res. 2001 33 : 1 6.
9. Konopleva M, Mikhail A, Estrov Z et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999 93 : 1668 76.
10. Sierra-Honigmann MR, Nath AK, Murakami C et al. Biological action of leptin as an angiogenic factor. Science 1998 281 : 1683 95.
11. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 2003 348 : 1625 38.
12. Stattin P, Soderberg S, Hallmans G et al. Leptin is associated with increased prostate cancer risk: a nested case-referent study. J. Clin. Endocrinol. Metab. 2001 86 : 1341 5.
13. Stattin P, Lukanova A, Biessy C et al. Obesity and colon cancer: does leptin provide a link? Int. J. Cancer 2004 109 : 149 52.
14. Stephenson GD, Rose DP. Breast cancer and obesity: an update. Nutr. Cancer 2003 45 : 1 16.
15. Boyd DB. Insulin and cancer. Integr. Cancer Ther. 2003 2 : 315 29.
16. Surmacz E. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene 2003 22 : 6589 97.
17. Mantzoros CS, Moschos SJ. Leptin: in search of role(s) in human physiology and pathophysiology. Clin. Endocrinol. 1998 49 : 551 67.
18. Konturek PC, Brzozowski T, Sulekova Z et al. Role of leptin in ulcer healing. Eur. J. Pharmacol. 2001 414 : 87 97.
19. Azuma T, Suto H, Ito Y et al. Gastric leptin and Helicobacter pylori infection. Gut 2001 49 : 324 9.
20. Nio Y, Tsubono M, Kawabata K et al. Comparison of survival curves of gastric cancer patients after surgery according to the UICC stages classification and the general rules for gastric cancer study by the Japanese Research Society for Gastric Cancer. Ann. Surg. 1993 218 : 47 53.
21. Gatalica Z, Lele SM, Rampy BA, Norris BA. The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma. Cancer 2000 88 : 1378 83.
22. Tanigawa N, Amaya H, Matsumura M, Shimomatsuya T. Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma. J. Clin. Oncol. 1997 15 : 826 32.
23. Park HY, Kwon HM, Lim HJ et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp. Mol. Med. 2001 33 : 95 102.
24. Yamagishi S, Inagaki Y, Amano S, Okamoto T, Takeuchi M. Up-regulation of vascular endothelial growth factor and down-regulation of pigment epithelium-derived factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes. Int. J. Tissue React. 2002 24 : 137 42.
25. Cinti S, Matteis RD, Pico C et al. Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int. J. Obes. Relat. Metab. Disord. 2000 24 : 789 93.
26. Sobhani I, Buyse M, Goiot H et al. Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 2002 122 : 259 63.
27. Wang YH, Tache Y, Sheibel AB, Go VL, Wei JY. Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am. J. Physiol. 1997 273 : R833 7.