Leptin receptors are developmentally regulated in rat pituitary and hypothalamus

Molecular and Cellular Endocrinology

Volumn 210, Issue 1-2, 2003, Pages 1-8

  Morash, Barbara A ^a,b   Imran, Ali ^b   Wilkinson, Diane ^a,b   Ur, Ehud ^a,b   Wilkinson, Michael ^a,b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Development; Hypothalamus; Leptin; Long and short leptin receptors; Pituitary

Indexed keywords

BRAIN PROTEIN; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PROTEIN SUBUNIT;

AGE DISTRIBUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HYPOPHYSIS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEWBORN; NONHUMAN; ONTOGENY; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE;

EID: 0242579365     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2003.09.003     Document Type: Article

References (65)

1. Ahima R.S., Flier J.S. Leptin. Annu. Rev. Physiol. 62:2000;413-437.
2. Ahima R.S., Bjorbaek C., Osei S., Flier J.S. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology. 140:1999;2755-2762.
3. Ashworth C.J., Hoggard N., Thomas L., Mercer J.G., Wallace J.M., Lea R.G. Placental leptin. Rev. Reprod. 5:2000;18-24.
4. Bado A., Levasseur S., Attoub S., Kermorgant S., Laigneau J.P., Bortoluzzi M.N., Moizo L., Lehy T., Guerre-Millo M., Le Marchand-Brustel Y., Lewin M.J. The stomach is a source of leptin. Nature. 394:1998;790-793.
5. Bennett B.D., Solar G.P., Yuan J.Q., Mathias J., Thomas G.R., Matthews W. A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol. 6:1996;1170-1180.
6. Beretta E., Dube M.G., Kalra P.S., Kalra S.P. Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr. Res. 52:2002;189-198.
7. Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272:1997;32686-32695.
8. Burguera B., Couce M.E., Long J., Lamsam J., Laakso K., Jensen M.D., Parisi J.E., Lloyd R.V. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology. 71:2000;187-195.
9. Carro E., Pinilla L., Seoane L.M., Considine R.V., Aguilar E., Casanueva F.F., Dieguez C. Influence of endogenous leptin tone on the estrous cycle and luteinizing hormone pulsatility in female rats. Neuroendocrinology. 66:1997;375-377.
10. Casanueva F.F., Dieguez C. Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol. 20:1999;317-363.
11. Chen S.C., Cunningham J.J., Smeyne R.J. Expression of OB receptor splice variants during prenatal development of the mouse. J. Receptor Signal Transduction Res. 20:2000;87-103.
12. Clement K., Vaisse C., Lahlou N., Cabrol S., Pelloux V., Cassuto D., Gourmelen M., Dina C., Chambaz J., Lacorte J.M., Basdevant A., Bougneres P., Lebouc Y., Froguel P., Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:1998;398-401.
13. Devaskar S.U., Anthony R., Hay W. Jr. Ontogeny and insulin regulation of fetal ovine white adipose tissue leptin expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282:2002;R431-R438.
14. Dicou E., Attoub S., Gressens P. Neuroprotective effects of leptin in vivo and in vitro. Neuroreport. 12:2001;3947-3951.
15. Dieterich K.D., Lehnert H. Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma. Exp. Clin. Endocrinol. Diabetes. 106:1998;522-525.
16. Ehrhardt R.A., Bell A.W., Boisclair Y.R. Spatial and developmental regulation of leptin in fetal sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282:2002;R1628-R1635.
17. Elmquist J.K., Maratos-Flier E., Saper C.B., Flier J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nat. Neurosci. 1:1998;445-450.
18. Emilsson V., O'Dowd J., Nolan A.L., Cawthorne M.A. Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic islets and clonal beta-cells. Endocrinology. 142:2001;4414-4419.
19. Håkansson M.L., Brown H., Ghilardi N., Skoda R.C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18:1998;559-572.
20. Himms-Hagen J. Physiological roles of the leptin endocrine system: differences between mice and humans. Crit. Rev. Clin. Lab. Sci. 36:1999;575-655.
21. Hoggard N., Haggarty P., Thomas L., Lea R.G. Leptin expression in placental and fetal tissues: does leptin have a functional role? Biochem. Soc. Trans. 29:2001;57-63.
22. Iqbal J., Pompolo S., Murakami T., Grouzmann E., Sakurai T., Meister B., Clarke I.J. Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus. Brain Res. 920:2001;55-64.
23. Isono M., Inoue R., Kamida T., Kobayashi H., Matsuyama J. Significance of leptin expression in invasive potential of pituitary adenomas. Clin. Neurol. Neurosurg. 105:2003;111-116.
24. Jin L., Burguera B.G., Couce M.E., Scheithauer B.W., Lamsan J., Eberhardt N.L., Kulig E., Lloyd R.V. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J. Clin. Endocrinol. Metab. 84:1999;2903-2911.
25. Jin L., Zhang S., Burguera B.G., Couce M.E., Osamura R.Y., Kulig E., Lloyd R.V. Leptin and leptin receptor expression in rat and mouse pituitary cells. Endocrinology. 141:2000;333-339.
26. Jin L., Tsumanuma I., Ruebel K.H., Bayliss J.M., Lloyd R.V. Analysis of homogeneous populations of anterior pituitary folliculostellate cells by laser capture microdissection and reverse transcription-polymerase chain reaction. Endocrinology. 142:2001;1703-1709.
27. Johnson R.M., Johnson T.M., Londraville R.L. Evidence for leptin expression in fishes. J. Exp. Zool. 286:2000;718-724.
28. Knerr I., Schuster S., Nomikos P., Buchfelder M., Dotsch J., Schoof E., Fahlbusch R., Rascher W. Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. Neuropathol. Appl. Neurobiol. 27:2001;215-222.
29. Korbonits M., Chitnis M.M., Gueorguiev M., Jordan S., Norman D., Kaltsas G., Burrin J.M., Grossman A.B. Leptin in pituitary adenomas - a novel paracrine regulatory system. Pituitary. 4:2001;49-55.
30. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., Friedman J.M. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635.
31. Lin J., Richard Barb C., Kraeling R.R., Rampacek G.B. Developmental changes in the long form leptin receptor and related neuropeptide gene expression in the pig brain. Biol. Reprod. 64:2001;1614-1618.
32. Lin J., Barb C.R., Kraeling R.R., Rampacek G.B. Growth hormone releasing factor decreases long form leptin receptor expression in porcine anterior pituitary cells. Domest Anim. Endocrinol. 24:2003;95-101.
33. Lloyd R.V., Jin L., Tsumanuma I., Vidal S., Kovacs K., Horvath E., Scheithauer B.W., Couce M.E., Burguera B. Leptin and leptin receptor in anterior pituitary function. Pituitary. 4:2001;33-47.
34. Matsuda J., Yokota I., Tsuruo Y., Murakami T., Ishimura K., Shima K., Kuroda Y. Development changes in long-form leptin receptor expression and localization in rat brain. Endocrinology. 140:1999;5233-5238.
35. Mistry A.M., Swick A., Romsos D.R. Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice. Am. J. Physiol. 277:1999;R742-R747.
36. Morash B., Li A., Murphy P., Wilkinson M., Ur E. Leptin gene expression in the brain and pituitary gland. Endocrinology. 140:1999;5995-5997.
37. Morash B., Johnstone J., Leopold C., Li A., Murphy P., Ur E., Wilkinson M. The regulation of leptin gene expression in the C6 glioblastoma cell line. Mol. Cell. Endocrinol. 165:2000;97-105.
38. Morash B., Wilkinson D., Murphy P., Ur E., Wilkinson M. Developmental regulation of leptin gene expression in rat brain and pituitary. Mol. Cell. Endocrinol. 185:2001;151-159.
39. Mounzih K., Qiu J., Ewart-Toland A., Chehab F.F. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology. 139:1998;5259-5262.
40. Murakami T., Yamashita T., Iida M., Kuwajima M., Shima K. A short form of leptin receptor performs signal transduction. Biochem. Biophys. Res. Commun. 231:1997;26-29.
41. Popovic V., Damjanovic S., Dieguez C., Casanueva F.F. Leptin and the pituitary. Pituitary. 4:2001;7-14.
42. Proulx K., Richard D., Walker C.D. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology. 143:2002;4683-4692.
43. Quinton N.D., Smith R.F., Clayton P.E., Gill M.S., Shalet S., Justice S.K., Simon S.A., Walters S., Postel-Vinay M.C., Blakemore A.I., Ross R.J. Leptin binding activity changes with age: the link between leptin and puberty. J. Clin. Endocrinol. Metab. 84:1999;2336-2341.
44. Reseland J.E., Syversen U., Bakke I., Qvigstad G., Eide L.G., Hjertner O., Gordeladze J.O., Drevon C.A. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J. Bone Min. Res. 16:2001;1426-1433.
45. Sakuma E., Herbert D.C., Soji T. Leptin and ciliary neurotrophic factor enhance the formation of gap junctions between folliculo-stellate cells in castrated male rats. Arch. Histol. Cytol. 65:2002;269-278.
46. Shanley L.J., Irving A.J., Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J. Neurosci. 21:2001;RC186.
47. Shimon I., Yan X., Magoffin D.A., Friedman T.C., Melmed S. Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J. Clin. Endocrinol. Metab. 83:1998;4059-4064.
48. Smith J.T., Waddell B.J. Developmental changes in plasma leptin and hypothalamic leptin receptor expression in the rat: peripubertal changes and the emergence of sex differences. J. Endocrinol. 176:2003;313-319.
49. Smith-Kirwin S.M., O'Connor D.M., De Johnston J., Lancey E.D., Hassink S.G., Funanage V.L. Leptin expression in human mammary epithelial cells and breast milk. J. Clin. Endocrinol. Metab. 83:1998;1810-1813.
50. Smith G.D., Jackson L.M., Foster D.L. Leptin regulation of reproductive function and fertility. Theriogenology. 57:2002;73-86.
51. Sone M., Nagata H., Takekoshi S., Osamura R.Y. Expression and localization of leptin receptor in the normal rat pituitary gland. Cell Tissue Res. 305:2001;351-356.
52. Steppan C.M., Swick A.G. A role for leptin in brain development. Biochem. Biophy. Res. Comm. 256:1999;600-602.
53. Steppan C.M., Lazar M.A. Resistin and obesity-associated insulin resistance. Trends Endocrinol. Metab. 13:2002;18-23.
54. Tannenbaum G.S., Gurd W., Lapointe M. Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone. Endocrinology. 139:1998;3871-3875.
55. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272:1997;6093-6096.
56. Tena-Sempere M., Pinilla L., Zhang F.P., Gonzalez L.C., Huhtaniemi I., Casanueva F.F., Dieguez C., Aguilar E. Developmental and hormonal regulation of leptin receptor (Ob-R) messenger ribonucleic acid expression in rat testis. Biol. Reprod. 64:2001;634-643.
57. Trayhurn P., Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc. 60:2001;329-339.
58. Unger R.H. Lipotoxic diseases. Annu. Rev. Med. 53:2002;319-336.
59. Uotani S., Bjorbaek C., Tornoe J., Flier J.S. Functional properties of leptin receptor isoforms internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes. 48:1999;279-286.
60. Vidal S., Cohen S.M., Horvath E., Kovacs K., Scheithauer B.W., Burguera B.G., Lloyd R.V. Subcellular localization of leptin in non-tumorous and adenomatous human pituitaries: an immuno-ultrastructural study. J. Histochem. Cytochem. 48:2000;1147-1152.
61. Wang J., Liu R., Hawkins M., Barzilai N., Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 393:1998;684-688.
62. Watanobe H., Schioth H.B. Postnatal profile of plasma leptin concentrations in male and female rats: relation with the maturation of the pituitary-gonadal axis. Regul. Pept. 105:2002;23-28.
63. Wilkinson M., Morash B., Ur E. The brain is a source of leptin. Front Horm Res. 26:2000;106-125.
64. Yamashita S. Histochemistry and cytochemistry of nuclear receptors. Prog. Histochem. Cytochem. 36:2001;91-176.
65. Yu W.H., Kimura M., Walczewska A., Karanth S., McCann S.M. Role of leptin in hypothalamic-pituitary function. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1023-1028.