-
1
-
-
0034874786
-
Structure and function of Syk protein-tyrosine kinase
-
Sada K, Takano T, Yanagi S, Yamamura H. Structure and function of Syk protein-tyrosine kinase. J Biochem 2001;130: 177-186.
-
(2001)
J Biochem
, vol.130
, pp. 177-186
-
-
Sada, K.1
Takano, T.2
Yanagi, S.3
Yamamura, H.4
-
2
-
-
0025946132
-
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis
-
Taniguchi T, Kobayashi T, Kondo J, Takahashi K, Nakamura H, Suzuki J, Nagai K, Yamada T, Nakamura S, Yamamura H. Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem 1991;266: 15790-15796.
-
(1991)
J Biol Chem
, vol.266
, pp. 15790-15796
-
-
Taniguchi, T.1
Kobayashi, T.2
Kondo, J.3
Takahashi, K.4
Nakamura, H.5
Suzuki, J.6
Nagai, K.7
Yamada, T.8
Nakamura, S.9
Yamamura, H.10
-
3
-
-
0026042989
-
Identification of the phosphorylation sites of H2B histone by a catalytic fragment of p72syk from porcine spleen
-
Sakai K, Tanaka Y, Asahi M, Shimomura R, Taniguchi T, Hashimoto E, Yamamura H. Identification of the phosphorylation sites of H2B histone by a catalytic fragment of p72syk from porcine spleen. FEBS Lett 1991;294:104-108.
-
(1991)
FEBS Lett
, vol.294
, pp. 104-108
-
-
Sakai, K.1
Tanaka, Y.2
Asahi, M.3
Shimomura, R.4
Taniguchi, T.5
Hashimoto, E.6
Yamamura, H.7
-
4
-
-
0034693754
-
Signaling network of the Btk family kinases
-
Qiu Y, Kung HJ. Signaling network of the Btk family kinases. Oncogene 2000;19:5651-5661.
-
(2000)
Oncogene
, vol.19
, pp. 5651-5661
-
-
Qiu, Y.1
Kung, H.J.2
-
5
-
-
0033919659
-
Pre-B and pre-T-cell receptors: Conservation of strategies in regulating early lymphocyte development
-
Muljo SA, Schlissel MS. Pre-B and pre-T-cell receptors: Conservation of strategies in regulating early lymphocyte development. Immunol Rev 2000;175:80-93.
-
(2000)
Immunol Rev
, vol.175
, pp. 80-93
-
-
Muljo, S.A.1
Schlissel, M.S.2
-
6
-
-
0032555744
-
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide
-
Futterer K, Wong J, Grucza RA, Chan AC, Waksman G. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J Mol Biol 1998;281:523-537.
-
(1998)
J Mol Biol
, vol.281
, pp. 523-537
-
-
Futterer, K.1
Wong, J.2
Grucza, R.A.3
Chan, A.C.4
Waksman, G.5
-
7
-
-
84988043558
-
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
-
Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, Zoller MJ and Karas JL. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 1995;377:32-38.
-
(1995)
Nature
, vol.377
, pp. 32-38
-
-
Hatada, M.H.1
Lu, X.2
Laird, E.R.3
Green, J.4
Morgenstern, J.P.5
Lou, M.6
Marr, C.S.7
Phillips, T.B.8
Ram, M.K.9
Theriault, K.10
Zoller, M.J.11
Karas, J.L.12
-
8
-
-
61849166005
-
The structure, regulation, and function of ZAP-70
-
Au-Yeung BB, Deindl S, Hsu LY, Palacios EH, Levin SE, Kuriyan J, Weiss A. The structure, regulation, and function of ZAP-70. Immunol Rev 2009;228:41-57.
-
(2009)
Immunol Rev
, vol.228
, pp. 41-57
-
-
Au-Yeung, B.B.1
Deindl, S.2
Hsu, L.Y.3
Palacios, E.H.4
Levin, S.E.5
Kuriyan, J.6
Weiss, A.7
-
9
-
-
0034096191
-
Functional dissection of BCR signaling pathways
-
Kurosaki T. Functional dissection of BCR signaling pathways. Curr Opin Immunol 2000;12:276-281.
-
(2000)
Curr Opin Immunol
, vol.12
, pp. 276-281
-
-
Kurosaki, T.1
-
10
-
-
0028355565
-
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
-
Kurosaki T, Takata M, Yamanashi Y, Inazu T, Taniguchi T, Yamamoto T, Yamamura H. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med 1994;179:1725-1729.
-
(1994)
J Exp Med
, vol.179
, pp. 1725-1729
-
-
Kurosaki, T.1
Takata, M.2
Yamanashi, Y.3
Inazu, T.4
Taniguchi, T.5
Yamamoto, T.6
Yamamura, H.7
-
11
-
-
0025323932
-
Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor
-
Gold MR, Law DA, DeFranco AL. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Nature 1990;345:810-813.
-
(1990)
Nature
, vol.345
, pp. 810-813
-
-
Gold, M.R.1
Law, D.A.2
Defranco, A.L.3
-
12
-
-
0037199989
-
Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase
-
Hong JJ, Yankee TM, Harrison ML, Geahlen RL. Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. J Biol Chem 2002;277:31703-31714.
-
(2002)
J Biol Chem
, vol.277
, pp. 31703-31714
-
-
Hong, J.J.1
Yankee, T.M.2
Harrison, M.L.3
Geahlen, R.L.4
-
13
-
-
0029082078
-
Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM)
-
Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol 1995;155:3281-3285.
-
(1995)
J Immunol
, vol.155
, pp. 3281-3285
-
-
Cambier, J.C.1
-
14
-
-
66149112125
-
Early events of B cell activation by antigen
-
Depoil D, Weber M, Treanor B, Fleire SJ, Carrasco YR, Harwood NE, Batista FD. Early events of B cell activation by antigen. Sci Signal 2009;2:pt1.
-
(2009)
Sci Signal
, vol.2
-
-
Depoil, D.1
Weber, M.2
Treanor, B.3
Fleire, S.J.4
Carrasco, Y.R.5
Harwood, N.E.6
Batista, F.D.7
-
15
-
-
0242708772
-
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
-
Jun JE, Goodnow CC. Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling. Nat Immunol 2003;4:1057-1064.
-
(2003)
Nat Immunol
, vol.4
, pp. 1057-1064
-
-
Jun, J.E.1
Goodnow, C.C.2
-
16
-
-
0030966218
-
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
-
Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 1997;6: 419-428.
-
(1997)
Immunity
, vol.6
, pp. 419-428
-
-
Healy, J.I.1
Dolmetsch, R.E.2
Timmerman, L.A.3
Cyster, J.G.4
Thomas, M.L.5
Crabtree, G.R.6
Lewis, R.S.7
Goodnow, C.C.8
-
17
-
-
7944231534
-
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
-
Palacios EH,Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 2004;23:7990-8000.
-
(2004)
Oncogene
, vol.23
, pp. 7990-8000
-
-
Palacios, E.H.1
Weiss, A.2
-
18
-
-
0033178653
-
T cell receptor-mediated signs and signals governing T cell development
-
van Oers NS. T cell receptor-mediated signs and signals governing T cell development. Semin Immunol 1999;11: 227-237.
-
(1999)
Semin Immunol
, vol.11
, pp. 227-237
-
-
Van Oers, N.S.1
-
20
-
-
0242624487
-
Systematic identification of regulatory proteins critical for T-cell activation
-
Chu P, Pardo J, Zhao H, Li CC, Pali E, Shen MM, Qu K, Yu SX, Huang BC, Yu P, Masuda ES, Molineaux SM, Kolbinger F, Aversa G, de Vries J, Payan DG, Liao XC. Systematic identification of regulatory proteins critical for T-cell activation. J Biol 2003;2:21.
-
(2003)
J Biol
, vol.2
, pp. 21
-
-
Chu, P.1
Pardo, J.2
Zhao, H.3
Li, C.C.4
Pali, E.5
Shen, M.M.6
Qu, K.7
Yu, S.X.8
Huang, B.C.9
Yu, P.10
Masuda, E.S.11
Molineaux, S.M.12
Kolbinger, F.13
Aversa, G.14
De Vries, J.15
Payan, D.G.16
Liao, X.C.17
-
21
-
-
0037446543
-
The FcR gamma subunit and Syk kinase replace the CD3 zetachain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells
-
Krishnan S,Warke VG, NambiarMP, Tsokos GC, Farber DL. The FcR gamma subunit and Syk kinase replace the CD3 zetachain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J Immunol 2003;170: 4189-4195.
-
(2003)
J Immunol
, vol.170
, pp. 4189-4195
-
-
Krishnan Swarke, V.G.1
Nambiar, M.P.2
Tsokos, G.C.3
Farber, D.L.4
-
22
-
-
0035124549
-
T cell receptor signalling
-
Lin J, Weiss A. T cell receptor signalling. J Cell Sci 2001;114: 243-244.
-
(2001)
J Cell Sci
, vol.114
, pp. 243-244
-
-
Lin, J.1
Weiss, A.2
-
23
-
-
0032211059
-
Differential requirements for ZAP-70 in TCR signaling and T cell development
-
Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A. Differential requirements for ZAP-70 in TCR signaling and T cell development. J Immunol 1998;161:4688-4694.
-
(1998)
J Immunol
, vol.161
, pp. 4688-4694
-
-
Kadlecek, T.A.1
Van Oers, N.S.2
Lefrancois, L.3
Olson, S.4
Finlay, D.5
Chu, D.H.6
Connolly, K.7
Killeen, N.8
Weiss, A.9
-
24
-
-
0028269436
-
Defective T cell receptor signaling and CD8 + thymic selection in humans lacking zap-70 kinase
-
Arpaia E, Shahar M, Dadi H, Cohen A, Roifman CM. Defective T cell receptor signaling and CD8 + thymic selection in humans lacking zap-70 kinase. Cell 1994;76: 947-958.
-
(1994)
Cell
, vol.76
, pp. 947-958
-
-
Arpaia, E.1
Shahar, M.2
Dadi, H.3
Cohen, A.4
Roifman, C.M.5
-
25
-
-
0028340167
-
ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
-
Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 1994;264:1599-1601. (Pubitemid 24227717)
-
(1994)
Science
, vol.264
, Issue.5165
, pp. 1599-1601
-
-
Chan, A.C.1
Kadlecek, T.A.2
Elder, M.E.3
Filipovich, A.H.4
Kuo, W.-L.5
Iwashima, M.6
Parslow, T.G.7
Weiss, A.8
-
26
-
-
0032498231
-
LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998;92: 83-92.
-
(1998)
Cell
, vol.92
, pp. 83-92
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
Trible, R.P.4
Samelson, L.E.5
-
27
-
-
0028889302
-
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
-
Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 1995;378:298-302.
-
(1995)
Nature
, vol.378
, pp. 298-302
-
-
Turner, M.1
Mee, P.J.2
Costello, P.S.3
Williams, O.4
Price, A.A.5
Duddy, L.P.6
Furlong, M.T.7
Geahlen, R.L.8
Tybulewicz, V.L.9
-
28
-
-
0028783322
-
Syk tyrosine kinase required for mouse viability and B-cell development
-
Cheng AM, Rowley B, PaoW, Hayday A, Bolen JB, Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 1995;378:303-306.
-
(1995)
Nature
, vol.378
, pp. 303-306
-
-
Cheng, A.M.1
Rowley, B.2
Paow Hayday, A.3
Bolen, J.B.4
Pawson, T.5
-
29
-
-
0030802798
-
Protein tyrosine kinases in thymocyte development
-
Cheng AM, Chan AC. Protein tyrosine kinases in thymocyte development. Curr Opin Immunol 1997;9:528-533.
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 528-533
-
-
Cheng, A.M.1
Chan, A.C.2
-
30
-
-
33847406959
-
Involvement of Src and Syk tyrosine kinases in HIV-1 transfer from dendritic cells to CD4+T lymphocytes
-
Gilbert C, Barat C, Cantin R, Tremblay MJ. Involvement of Src and Syk tyrosine kinases in HIV-1 transfer from dendritic cells to CD4+T lymphocytes. J Immunol 2007;178: 2862-2871.
-
(2007)
J Immunol
, vol.178
, pp. 2862-2871
-
-
Gilbert, C.1
Barat, C.2
Cantin, R.3
Tremblay, M.J.4
-
31
-
-
0034665654
-
Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation
-
Martelli MP, Lin H, Zhang W, Samelson LE, Bierer BE. Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. Blood 2000;96: 2181-2190.
-
(2000)
Blood
, vol.96
, pp. 2181-2190
-
-
Martelli, M.P.1
Lin, H.2
Zhang, W.3
Samelson, L.E.4
Bierer, B.E.5
-
32
-
-
0026073372
-
Demonstration of the origin of human mast cells from CD34+bone marrow progenitor cells
-
Kirshenbaum AS, Kessler SW, Goff JP, Metcalfe DD. Demonstration of the origin of human mast cells from CD34+bone marrow progenitor cells. J Immunol 1991;146: 1410-1415.
-
(1991)
J Immunol
, vol.146
, pp. 1410-1415
-
-
Kirshenbaum, A.S.1
Kessler, S.W.2
Goff, J.P.3
Metcalfe, D.D.4
-
33
-
-
47949107183
-
The development of allergic inflammation
-
Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008;454:445-454.
-
(2008)
Nature
, vol.454
, pp. 445-454
-
-
Galli, S.J.1
Tsai, M.2
Piliponsky, A.M.3
-
34
-
-
61849130484
-
The tyrosine kinase network regulating mast cell activation
-
Gilfillan AM, Rivera J. The tyrosine kinase network regulating mast cell activation. Immunol Rev 2009;228:149-169.
-
(2009)
Immunol Rev
, vol.228
, pp. 149-169
-
-
Gilfillan, A.M.1
Rivera, J.2
-
35
-
-
0033976068
-
Point mutation of a tyrosine in the linker region of Syk results in a gain of function
-
Sada K, Zhang J, Siraganian RP. Point mutation of a tyrosine in the linker region of Syk results in a gain of function. J Immunol 2000;164:338-344.
-
(2000)
J Immunol
, vol.164
, pp. 338-344
-
-
Sada, K.1
Zhang, J.2
Siraganian, R.P.3
-
36
-
-
0033522219
-
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
-
Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature 1999;398:84-90.
-
(1999)
Nature
, vol.398
, pp. 84-90
-
-
Meng, W.1
Sawasdikosol, S.2
Burakoff, S.J.3
Eck, M.J.4
-
37
-
-
0030499383
-
Functional and physical interactions of Syk family kinaseswith theVav proto-oncogene product
-
Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A. Functional and physical interactions of Syk family kinaseswith theVav proto-oncogene product. Immunity 1996;5: 591-604.
-
(1996)
Immunity
, vol.5
, pp. 591-604
-
-
Deckert, M.1
Tartare-Deckert, S.2
Couture, C.3
Mustelin, T.4
Altman, A.5
-
38
-
-
0033198133
-
CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells
-
Zhang J, Siraganian RP. CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells. J Immunol 1999;163:2508-2516.
-
(1999)
J Immunol
, vol.163
, pp. 2508-2516
-
-
Zhang, J.1
Siraganian, R.P.2
-
40
-
-
0026577464
-
Protein-tyrosine phosphorylation: An essential component of Fc epsilon RI signaling
-
Benhamou M, Siraganian RP. Protein-tyrosine phosphorylation: An essential component of Fc epsilon RI signaling. Immunol Today 1992;13:195-197.
-
(1992)
Immunol Today
, vol.13
, pp. 195-197
-
-
Benhamou, M.1
Siraganian, R.P.2
-
41
-
-
33947240223
-
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
-
ZouW, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 2007; 176:877-888.
-
(2007)
J Cell Biol
, vol.176
, pp. 877-888
-
-
Zouw Kitaura, H.1
Reeve, J.2
Long, F.3
Tybulewicz, V.L.4
Shattil, S.J.5
Ginsberg, M.H.6
Ross, F.P.7
Teitelbaum, S.L.8
-
42
-
-
0345448261
-
High dose M-CSF partially rescues the Dap122/2 osteoclast phenotype
-
Faccio R, Zou W, Colaianni G, Teitelbaum SL, Ross FP. High dose M-CSF partially rescues the Dap122/2 osteoclast phenotype. J Cell Biochem 2003;90:871-883.
-
(2003)
J Cell Biochem
, vol.90
, pp. 871-883
-
-
Faccio, R.1
Zou, W.2
Colaianni, G.3
Teitelbaum, S.L.4
Ross, F.P.5
-
43
-
-
11144354330
-
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
-
Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004;428:758-763.
-
(2004)
Nature
, vol.428
, pp. 758-763
-
-
Koga, T.1
Inui, M.2
Inoue, K.3
Kim, S.4
Suematsu, A.5
Kobayashi, E.6
Iwata, T.7
Ohnishi, H.8
Matozaki, T.9
Kodama, T.10
Taniguchi, T.11
Takayanagi, H.12
Takai, T.13
-
44
-
-
0034788345
-
Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals
-
Desaulniers P, Fernandes M, Gilbert C, Bourgoin SG, Naccache PH. Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals. J Leukoc Biol 2001;70:659-668.
-
(2001)
J Leukoc Biol
, vol.70
, pp. 659-668
-
-
Desaulniers, P.1
Fernandes, M.2
Gilbert, C.3
Bourgoin, S.G.4
Naccache, P.H.5
-
45
-
-
0030829551
-
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages
-
CrowleyMT, Costello PS, Fitzer-Attas CJ, Turner M,Meng F, Lowell C, Tybulewicz VL, DeFranco AL. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J ExpMed 1997;186:1027-1039.
-
(1997)
J Exp Med
, vol.186
, pp. 1027-1039
-
-
Crowley, M.T.1
Costello, P.S.2
Fitzer-Attas, C.J.3
Turner, M.4
Meng, F.5
Lowell, C.6
Tybulewicz, V.L.7
Defranco, A.L.8
-
46
-
-
0031911975
-
Crystal-induced neutrophil activation VI. Involvement of FcgammaRIIIB (CD16) and CD11b in response to inflammatory microcrystals
-
Barabe F, Gilbert C, Liao N, Bourgoin SG, Naccache PH. Crystal-induced neutrophil activation VI. Involvement of FcgammaRIIIB (CD16) and CD11b in response to inflammatory microcrystals. FASEB J 1998;12:209-220.
-
(1998)
FASEB J
, vol.12
, pp. 209-220
-
-
Barabe, F.1
Gilbert, C.2
Liao, N.3
Bourgoin, S.G.4
Naccache, P.H.5
-
47
-
-
3442885624
-
Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils
-
Ryckman C, Gilbert C, de Medicis R, Lussier A, Vandal K, Tessier PA. Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils. J Leukoc Biol 2004;76:433-440.
-
(2004)
J Leukoc Biol
, vol.76
, pp. 433-440
-
-
Ryckman, C.1
Gilbert, C.2
De Medicis, R.3
Lussier, A.4
Vandal, K.5
Tessier, P.A.6
-
48
-
-
0031807018
-
The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils
-
Kiefer F, Brumell J, Al-AlawiN, Latour S, Cheng A, Veillette A, Grinstein S, Pawson T. The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils. Mol Cell Biol 1998;18:4209-4220.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4209-4220
-
-
Kiefer, F.1
Brumell, J.2
Al-Alawin Latour, S.3
Cheng, A.4
Veillette, A.5
Grinstein, S.6
Pawson, T.7
-
49
-
-
55349123588
-
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells
-
Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 2008;29:807-818.
-
(2008)
Immunity
, vol.29
, pp. 807-818
-
-
Ng, G.1
Sharma, K.2
Ward, S.M.3
Desrosiers, M.D.4
Stephens, L.A.5
Schoel, W.M.6
Li, T.7
Lowell, C.A.8
Ling, C.C.9
Amrein, M.W.10
Shi, Y.11
-
50
-
-
60449117455
-
Kinase inhibitors for the treatment of inflammatory and autoimmune disorders
-
Bhagwat SS. Kinase inhibitors for the treatment of inflammatory and autoimmune disorders. Purinergic Signal 2009;5: 107-115.
-
(2009)
Purinergic Signal
, vol.5
, pp. 107-115
-
-
Bhagwat, S.S.1
-
51
-
-
43049113886
-
Syk inhibitors as treatment for allergic rhinitis
-
Masuda ES, Schmitz J. Syk inhibitors as treatment for allergic rhinitis. Pulm Pharmacol Ther 2008;21:461-467.
-
(2008)
Pulm Pharmacol Ther
, vol.21
, pp. 461-467
-
-
Masuda, E.S.1
Schmitz, J.2
-
52
-
-
12444324540
-
Potent small molecule inhibitors of spleen tyrosine kinase (Syk)
-
Lai JY, Cox PJ, Patel R, Sadiq S, Aldous DJ, Thurairatnam S, Smith K, Wheeler D, Jagpal S, Parveen S, Fenton G, Harrison TK, McCarthy C, Bamborough P. Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg Med Chem Lett 2003;13:3111-3114.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 3111-3114
-
-
Lai, J.Y.1
Cox, P.J.2
Patel, R.3
Sadiq, S.4
Aldous, D.J.5
Thurairatnam, S.6
Smith, K.7
Wheeler, D.8
Jagpal, S.9
Parveen, S.10
Fenton, G.11
Harrison, T.K.12
McCarthy, C.13
Bamborough, P.14
-
53
-
-
0041932075
-
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigeninduced airway inflammation in rodents
-
Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, IshimoriM, Nagai H, Li YF, Yura T, Bacon KB. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5- ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigeninduced airway inflammation in rodents. J Pharmacol Exp Ther 2003;306:1174-1181.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 1174-1181
-
-
Yamamoto, N.1
Takeshita, K.2
Shichijo, M.3
Kokubo, T.4
Sato, M.5
Nakashima, K.6
Ishimorim Nagai, H.7
Li, Y.F.8
Yura, T.9
Bacon, K.B.10
-
54
-
-
38349159571
-
Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets
-
Bhavaraju K, Kim S, Daniel JL, Kunapuli SP. Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5- sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol 2008;580:285-290.
-
(2008)
Eur J Pharmacol
, vol.580
, pp. 285-290
-
-
Bhavaraju, K.1
Kim, S.2
Daniel, J.L.3
Kunapuli, S.P.4
-
55
-
-
33751197936
-
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
-
Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A, Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther 2006;319:998-1008.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 998-1008
-
-
Braselmann, S.1
Taylor, V.2
Zhao, H.3
Wang, S.4
Sylvain, C.5
Baluom, M.6
Qu, K.7
Herlaar, E.8
Lau, A.9
Young, C.10
Wong, B.R.11
Lovell, S.12
Sun, T.13
Park, G.14
Argade, A.15
Jurcevic, S.16
Pine, P.17
Singh, R.18
Grossbard, E.B.19
Payan, D.G.20
Masuda, E.S.21
more..
-
56
-
-
33645867986
-
A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes
-
Cha HS, Boyle DL, Inoue T, Schoot R, Tak PP, Pine P, Firestein GS. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther 2006;317:571-578.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 571-578
-
-
Cha, H.S.1
Boyle, D.L.2
Inoue, T.3
Schoot, R.4
Tak, P.P.5
Pine, P.6
Firestein, G.S.7
-
57
-
-
34547849752
-
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
-
Pine PR, Chang B, Schoettler N, Banquerigo ML, Wang S, Lau A, Zhao F, Grossbard EB, Payan DG, Brahn E. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol 2007;124:244-257.
-
(2007)
Clin Immunol
, vol.124
, pp. 244-257
-
-
Pine, P.R.1
Chang, B.2
Schoettler, N.3
Banquerigo, M.L.4
Wang, S.5
Lau, A.6
Zhao, F.7
Grossbard, E.B.8
Payan, D.G.9
Brahn, E.10
-
58
-
-
33748058807
-
Identification of the Syk kinase inhibitor R112 by a human mast cell screen
-
Rossi AB, Herlaar E, Braselmann S, Huynh S, Taylor V, Frances R, Issakani SD, Argade A, Singh R, Payan DG, Masuda ES. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol 2006;118: 749-755.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 749-755
-
-
Rossi, A.B.1
Herlaar, E.2
Braselmann, S.3
Huynh, S.4
Taylor, V.5
Frances, R.6
Issakani, S.D.7
Argade, A.8
Singh, R.9
Payan, D.G.10
Masuda, E.S.11
-
59
-
-
0037446255
-
Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors
-
Yamamoto N, Hasegawa H, Seki H, Ziegelbauer K, Yasuda T. Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors. Anal Biochem 2003;315: 256-261.
-
(2003)
Anal Biochem
, vol.315
, pp. 256-261
-
-
Yamamoto, N.1
Hasegawa, H.2
Seki, H.3
Ziegelbauer, K.4
Yasuda, T.5
-
60
-
-
0020436689
-
The revised criteria for the classification of systemic lupus erythematosus
-
Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ. The revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277.
-
(1982)
Arthritis Rheum
, vol.25
, pp. 1271-1277
-
-
Tan, E.M.1
Cohen, A.S.2
Fries, J.F.3
Masi, A.T.4
McShane, D.J.5
Rothfield, N.F.6
Schaller, J.G.7
Talal, N.8
Winchester, R.J.9
-
61
-
-
0033065837
-
Immune cell signaling defects in lupus: Activation, anergy and death
-
Tsokos GC, Liossis SN. Immune cell signaling defects in lupus: Activation, anergy and death. Immunol Today 1999;20: 119-124.
-
(1999)
Immunol Today
, vol.20
, pp. 119-124
-
-
Tsokos, G.C.1
Liossis, S.N.2
-
62
-
-
0031789146
-
Differential oncogene and TNF-alpha mRNA expression in bone marrow cells from systemic lupus erythematosus patients
-
Alvarado-de la Barrera C, Alcocer-Varela J, Richaud-Patin Y, Alarcon-Segovia D, Llorente L. Differential oncogene and TNF-alpha mRNA expression in bone marrow cells from systemic lupus erythematosus patients. Scand J Immunol 1998;48:551-556.
-
(1998)
Scand J Immunol
, vol.48
, pp. 551-556
-
-
Alvarado-De La Barrera, C.1
Alcocer-Varela, J.2
Richaud-Patin, Y.3
Alarcon-Segovia, D.4
Llorente, L.5
-
63
-
-
8444223507
-
Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus
-
Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I. Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus. Arthritis Rheum 2004;50:3580-3590.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 3580-3590
-
-
Anolik, J.H.1
Barnard, J.2
Cappione, A.3
Pugh-Bernard, A.E.4
Felgar, R.E.5
Looney, R.J.6
Sanz, I.7
-
64
-
-
0030784484
-
CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes
-
Inaoki M, Sato S, Weintraub BC, Goodnow CC, Tedder TF. CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J Exp Med 1997;186:1923-1931.
-
(1997)
J Exp Med
, vol.186
, pp. 1923-1931
-
-
Inaoki, M.1
Sato, S.2
Weintraub, B.C.3
Goodnow, C.C.4
Tedder, T.F.5
-
65
-
-
0034544489
-
Quantitative genetic variation in CD19 expression correlates with autoimmunity
-
Sato S, Hasegawa M, Fujimoto M, Tedder TF, Takehara K. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 2000;165:6635-6643.
-
(2000)
J Immunol
, vol.165
, pp. 6635-6643
-
-
Sato, S.1
Hasegawa, M.2
Fujimoto, M.3
Tedder, T.F.4
Takehara, K.5
-
66
-
-
0033697728
-
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
-
Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 2000;13:47-57.
-
(2000)
Immunity
, vol.13
, pp. 47-57
-
-
Fujimoto, M.1
Fujimoto, Y.2
Poe, J.C.3
Jansen, P.J.4
Lowell, C.A.5
Defranco, A.L.6
Tedder, T.F.7
-
68
-
-
0027399703
-
Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain
-
Irving BA, Chan AC,Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med 1993;177:1093-1103.
-
(1993)
J Exp Med
, vol.177
, pp. 1093-1103
-
-
Irving, B.A.1
Chan, A.C.2
Weiss, A.3
-
69
-
-
0032521293
-
Elf-1 regulates basal expression from the T cell antigen receptor zeta-chain gene promoter
-
Rellahan BL, Jensen JP, Howcroft TK, Singer DS, Bonvini E, Weissman AM. Elf-1 regulates basal expression from the T cell antigen receptor zeta-chain gene promoter. J Immunol 1998; 160:2794-2801.
-
(1998)
J Immunol
, vol.160
, pp. 2794-2801
-
-
Rellahan, B.L.1
Jensen, J.P.2
Howcroft, T.K.3
Singer, D.S.4
Bonvini, E.5
Weissman, A.M.6
-
70
-
-
0037111374
-
Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus
-
Juang YT, Tenbrock K, Nambiar MP, Gourley MF, Tsokos GC. Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus. J Immunol 2002;169:6048-6055.
-
(2002)
J Immunol
, vol.169
, pp. 6048-6055
-
-
Juang, Y.T.1
Tenbrock, K.2
Nambiar, M.P.3
Gourley, M.F.4
Tsokos, G.C.5
-
71
-
-
0034744286
-
Fc epsilon receptor type i gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus
-
Enyedy EJ, NambiarMP, Liossis SN, Dennis G, Kammer GM, Tsokos GC. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum 2001;44: 1114-1121.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 1114-1121
-
-
Enyedy, E.J.1
Nambiar, M.P.2
Liossis, S.N.3
Dennis, G.4
Kammer, G.M.5
Tsokos, G.C.6
-
72
-
-
0038062836
-
Rewiring the T-cell: Signaling defects and novel prospects for the treatment of SLE
-
Tsokos GC, Nambiar MP, Tenbrock K, Juang YT. Rewiring the T-cell: Signaling defects and novel prospects for the treatment of SLE. Trends Immunol 2003;24:259-263.
-
(2003)
Trends Immunol
, vol.24
, pp. 259-263
-
-
Tsokos, G.C.1
Nambiar, M.P.2
Tenbrock, K.3
Juang, Y.T.4
-
73
-
-
2942586874
-
Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus
-
Krishnan S, Nambiar MP, Warke VG, Fisher CU, Mitchell J, DelaneyN,TsokosGC. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 2004;172:7821-7831.
-
(2004)
J Immunol
, vol.172
, pp. 7821-7831
-
-
Krishnan, S.1
Nambiar, M.P.2
Warke, V.G.3
Fisher, C.U.4
Mitchell, J.5
Delaney, N.6
Tsokos, G.C.7
-
74
-
-
56149099718
-
Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation
-
Deng GM, Tsokos GC. Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation. J Immunol 2008;181:4019-4026.
-
(2008)
J Immunol
, vol.181
, pp. 4019-4026
-
-
Deng, G.M.1
Tsokos, G.C.2
-
75
-
-
43949092440
-
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
-
Bahjat FR, Pine PR, Reitsma A, Cassafer G, Baluom M, Grillo S, Chang B, Zhao FF, Payan DG, Grossbard EB, Daikh DI. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum 2008;58:1433-1434.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1433-1434
-
-
Bahjat, F.R.1
Pine, P.R.2
Reitsma, A.3
Cassafer, G.4
Baluom, M.5
Grillo, S.6
Chang, B.7
Zhao, F.F.8
Payan, D.G.9
Grossbard, E.B.10
Daikh, D.I.11
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