Structure and function of Syk protein-tyrosine kinase

Journal of Biochemistry

Volumn 130, Issue 2, 2001, Pages 177-186

  Sada, K ^a   Takano, T ^a   Yanagi, S ^a   Yamamura, H ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Genetic analysis; ITAM; PTK; Syk; ZAP 70

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AUTOPHOSPHORYLATION; CALCIUM MOBILIZATION; CELL FUNCTION; CELL MATURATION; ENZYME STRUCTURE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; NONHUMAN; PATHOGENESIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVIEW; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 0034874786     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a002970     Document Type: Review

References (136)

1. Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis
2. Characterization of partially purified cytosolic protein-tyrosine kinase from porcine spleen
3. Purification and characterization of cytosolic protein-tyrosine kinase from porcine spleen
4. Purification and characterization of protein-tyrosine kinase from bovine thymus
5. Purification and characterization of cytosolic protein-tyrosine kinase from bovine platelets
6. Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis
7. ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain
8. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
9. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide
10. syk with the γ and β subunits of the high-affinity receptor for immuno-globulin E
11. Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling
12. Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk
13. Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130
14. A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling
15. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
16. Cbl-mediated negative regulation of the Syk tyrosine kinase
17. Inhibition of signaling through the B cell antigen receptor by the prooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain
18. Point mutation of a tyrosine in the linker region of Syk results in a gain of function
19. The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase
20. Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product
21. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
22. LAT is essential for FcεRI-mediated mast cell activation
23. SLP-76 deficiency impaires signaling via the high-affinity IgE receptor in mast cells
24. BLNK: Connecting Syk and Btk to calcium signals
25. 319 is required for T-cell antigen receptor-dependent phospholipase C-γ1 and Ras activation
26. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
27. Phsophorylation of Syk activation loop tyrosines is essential for Syk function
28. Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity
29. T cell activation by clustered tyrosine kinases
30. Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling
31. Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70
32. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function
33. T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70
34. Compartmentalized IgE receptor-mediated signal transduction in living cells
35. Visualization of Syk-antigen receptor interactions using green fluorescent protein: Differential roles for Syk and Lyn in the regulation of receptor capping and internalization
36. Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812)
37. syk
38. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
39. Syk tyrosine kinase required for mouse viability and B-cell development
40. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling
41. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
42. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
43. Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase
44. Tyrosine kinase SYK: Essential functions for immunereceptor signaling
45. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
46. Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation
47. Syk tyrosine kinase is required for the positive selection of immune B cells into the recirculating B cell pool
48. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Igα/Igβ immunoreceptor tyrosine activation motif binding and autophosphorylation
49. CD45 modulates phosphorylation of both autophosphorylation and negati ve regulatory tyrosines of Lyn in B cells
50. 2+ mobilization through distinct pathways
51. BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius
52. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells
53. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
54. SH3P7 is a cytoskeleton adaptor protein and is coupled to signal transduction from lymphocyte antigen receptor
55. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
56. syk in high affinity IgE receptor signaling
57. Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor
58. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE
59. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering
60. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor
61. SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcεRI signaling
62. Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells
63. Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor in mast cells
64. Syk deficiency in nonreleaser basophils
65. SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells
66. 2-terminal kinase 1
67. Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells
68. Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcγRI signaling
69. Regulation of protein kinase CβI by two protein-tyrosine kinases, Btk and Syk
70. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages
71. The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils
72. Syk protein tyrosine kinase regulates Fc receptor γ-chain-mediated transport to lysosomes
73. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: Possible link with the c-myc induction pathway
74. Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193
75. syk and erythropoietin receptor
76. Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) singaling: Activation of Syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
77. syk in collagen-induced signal transduction in platelets
78. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation and mouse platelets by collagen
79. Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI
80. A novel association of Fc receptor γ-chian with glycoprotein VI and their co-expression as a collagen receptor in human platelets
81. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor Glycoprotein VI-Fc receptor γ chain complex on human platelets
82. Collagen mediates changes in intracellular calcium in primary megakaryocytes through syk-dependent and -independent pathways
83. 2+ mobilization in platelets
84. syk to the cytoskeleton in thrombin-stimulated platelets
85. syk expressed in hematopoietic cells
86. Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak
87. Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets
88. 3
89. 3 is different and cooperative with each other in a megakaryoblastic leukemia cell line
90. Genetic and pharmacological analysis of involvement of Src-family, Syk and Btk tyrosine kinases in platelet shape change
91. 3 signaling in platelets
92. CrkL is an adaptor for Wiskott-Aldrich syndrome protein and Syk
93. syk
94. Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src, and Syk as assessed by phage display
95. Adaptor function for Syk kinases-interacting protein 3BP2 in IL-2 gene activation
96. 2 pathway by FcεRI is not shared by a G protein-coupled receptor
97. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
98. Vav1 regulates phospholipase Cγ activation and calcium responses in mast cells
99. 2-terminal kinase 1, and p38 mitogen-activated protein kinase
100. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT
101. Cross-linking of the B cell receptor induces activation of phospholipase D through Syk, Btk and phospholipase C-γ2
102. Requirement of Syk-phospholipase C-γ2 pathway for phorbol ester-induced phospholipase D activation in DT40 cells
103. CD45 is essential for FcεRI signaling by ZAP70, but not Syk, in Syk-negative mast cells
104. Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
105. Positive regulation of c-Jun N-terminal kinase and TNF-α production but not histamine release by SHP-1 in RBL-2H3 mast cells
106. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates α-tubulin on tyrosine
107. syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides
108. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
109. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
110. The product of the protooncogene c-cbl: A negative regulator of the Syk tyrosine kinase
111. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
112. The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction
113. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
114. Inhibition of mast cell FcεRI-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol
115. Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol
116. Distinct mechanisms of STAT phosphorylation via the interferon-α/β receptor
117. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcε receptor I-mediated activation of Syk
118. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase
119. lyn regulates calcium mobilization in chicken B cell oxidant stress signaling
120. Distinctive functions of Syk N-terminal and C-terminal SH2 domains in the signaling cascade elicited by oxidative stress in B cells
121. Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress
122. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress
123. G(s)alpha repression of adipogenesis via Syk
124. Protein-tyrosine kinase Syk expressed in human nasal fibroblasts and its effect on RANTES production
125. Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: Involvement of Syk in signaling events of hepatocytes
126. Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells
127. + thymic selection in humans lacking Zap-70 kinase
128. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
129. Temperature-sensitive ZAP70 mutants degrading through a proteosome-independent pathway
130. Distinct T cell development consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70
131. Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)
132. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells
133. syk and comparison with those by insulin receptor kinase
134. BLNK: A central linker protein in B cell activation
135. Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling
136. Syk is upstream of phosphoinositide 3-kinase in B cell receptor signaling