-
1
-
-
0041488913
-
Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway
-
Alonso M, Tamasdan C, Miller DC, Newcomb EW. 2003. Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. Mol Cancer Ther 2:139-150.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 139-150
-
-
Alonso, M.1
Tamasdan, C.2
Miller, D.C.3
Newcomb, E.W.4
-
2
-
-
0037164865
-
Mitochondrial release of apopotosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
-
Arnoult D, Parone P, Martinou JC, Antonsson B, Estaquier J, Ameisen JC. 2002. Mitochondrial release of apopotosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 159:923-929.
-
(2002)
J Cell Biol
, vol.159
, pp. 923-929
-
-
Arnoult, D.1
Parone, P.2
Martinou, J.C.3
Antonsson, B.4
Estaquier, J.5
Ameisen, J.C.6
-
3
-
-
0035266318
-
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells
-
Asselin E, Mills GB, Tsang BK. 2001. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res 61:1862-1868.
-
(2001)
Cancer Res
, vol.61
, pp. 1862-1868
-
-
Asselin, E.1
Mills, G.B.2
Tsang, B.K.3
-
4
-
-
0027954495
-
Heat-shock proteins as molecular chaperones
-
Becker J, Craig EA. 1994. Heat-shock proteins as molecular chaperones. Eur J Biochem 219:11-23.
-
(1994)
Eur J Biochem
, vol.219
, pp. 11-23
-
-
Becker, J.1
Craig, E.A.2
-
5
-
-
0030812207
-
Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
-
Bible KC, Kaufman SH. 1997. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration. Cancer Res 57:3375-3380.
-
(1997)
Cancer Res
, vol.57
, pp. 3375-3380
-
-
Bible, K.C.1
Kaufman, S.H.2
-
6
-
-
0029737509
-
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90
-
Blagosklonny MV, Toretsky J, Bohen S, Neckers L. 1996. Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. Proc Natl Acad Sci USA 93:8379-8383.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8379-8383
-
-
Blagosklonny, M.V.1
Toretsky, J.2
Bohen, S.3
Neckers, L.4
-
7
-
-
0034771555
-
The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy
-
Blagosklonny MV, Fojo T, Bhalla KN, Kim JS, Trepel JB, Figg WD, Rivera Y, Neckers LM. 2001. The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy. Leukemia 15:1537-1543.
-
(2001)
Leukemia
, vol.15
, pp. 1537-1543
-
-
Blagosklonny, M.V.1
Fojo, T.2
Bhalla, K.N.3
Kim, J.S.4
Trepel, J.B.5
Figg, W.D.6
Rivera, Y.7
Neckers, L.M.8
-
8
-
-
0019444479
-
The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins
-
Brugge JS, Erikson E, Erikson RL. 1981. The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins. Cell 25:363-372.
-
(1981)
Cell
, vol.25
, pp. 363-372
-
-
Brugge, J.S.1
Erikson, E.2
Erikson, R.L.3
-
9
-
-
0038615946
-
Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo
-
Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS. 2003. Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63:2742-2746.
-
(2003)
Cancer Res
, vol.63
, pp. 2742-2746
-
-
Choe, G.1
Horvath, S.2
Cloughesy, T.F.3
Crosby, K.4
Seligson, D.5
Palotie, A.6
Inge, L.7
Smith, B.L.8
Sawyers, C.L.9
Mischel, P.S.10
-
10
-
-
0028823398
-
Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity
-
Coumailleau P, Poellinger L, Gustafsson JA, Whitelaw ML. 1995. Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. J Biol Chem 270:25291-25300.
-
(1995)
J Biol Chem
, vol.270
, pp. 25291-25300
-
-
Coumailleau, P.1
Poellinger, L.2
Gustafsson, J.A.3
Whitelaw, M.L.4
-
11
-
-
0026749295
-
Unusual expression and localization of heat-shock proteins in human tumor cells
-
Ferrarini M, Heltai S, Zocchi MR, Rugarli C. 1992. Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer 51:613-619.
-
(1992)
Int J Cancer
, vol.51
, pp. 613-619
-
-
Ferrarini, M.1
Heltai, S.2
Zocchi, M.R.3
Rugarli, C.4
-
12
-
-
0035884509
-
Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2
-
Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WKA. 2001. Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res 61:6693-6697.
-
(2001)
Cancer Res
, vol.61
, pp. 6693-6697
-
-
Gomez-Manzano, C.1
Mitlianga, P.2
Fueyo, J.3
Lee, H.Y.4
Hu, M.5
Spurgers, K.B.6
Glass, T.L.7
Koul, D.8
Liu, T.J.9
McDonnell, T.J.10
Yung, W.K.A.11
-
13
-
-
0029789568
-
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
-
Gradin K, McGuire J, Wenger RH, Kvietikova I, fhitelaw ML, Toftgard R, Tora L, Gassmann M, Poellinger L. 1996. Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor. Mol Cell Biol 16:5221-5231.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5221-5231
-
-
Gradin, K.1
McGuire, J.2
Wenger, R.H.3
Kvietikova, I.4
Fhitelaw, M.L.5
Toftgard, R.6
Tora, L.7
Gassmann, M.8
Poellinger, L.9
-
14
-
-
0030863995
-
The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
-
Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO. 1997. The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. J Biol Chem 272:23843-23850.
-
(1997)
J Biol Chem
, vol.272
, pp. 23843-23850
-
-
Grenert, J.P.1
Sullivan, W.P.2
Fadden, P.3
Haystead, T.A.4
Clark, J.5
Mimnaugh, E.6
Krutzsch, H.7
Ochel, H.J.8
Schulte, T.W.9
Sausville, E.10
Neckers, L.M.11
Toft, D.O.12
-
15
-
-
0035872442
-
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis
-
Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. 2001. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res 61:4003-4009.
-
(2001)
Cancer Res
, vol.61
, pp. 4003-4009
-
-
Hostein, I.1
Robertson, D.2
DiStefano, F.3
Workman, P.4
Clarke, P.A.5
-
16
-
-
0037012040
-
Mitochondrial dysfunction is an essential step for killing of non-small lung carcinomas resistant to conventional treatment
-
Joseph B, Marchetti P, Formstecher P, Kroemer G, Lewensohn R, Zhivotovsky B. 2002. Mitochondrial dysfunction is an essential step for killing of non-small lung carcinomas resistant to conventional treatment. Oncogene 21:65-77.
-
(2002)
Oncogene
, vol.21
, pp. 65-77
-
-
Joseph, B.1
Marchetti, P.2
Formstecher, P.3
Kroemer, G.4
Lewensohn, R.5
Zhivotovsky, B.6
-
17
-
-
0037454761
-
Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas
-
Kim S, Kang J, Hu W, Evers BM, Chung DH. 2003. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. Int J Cancer 103:352-359.
-
(2003)
Int J Cancer
, vol.103
, pp. 352-359
-
-
Kim, S.1
Kang, J.2
Hu, W.3
Evers, B.M.4
Chung, D.H.5
-
18
-
-
0034885197
-
2-Methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells
-
Kumar AP, Garcia GE, Slaga TJ. 2001. 2-methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells. Mol Carcinog 31:111-124.
-
(2001)
Mol Carcinog
, vol.31
, pp. 111-124
-
-
Kumar, A.P.1
Garcia, G.E.2
Slaga, T.J.3
-
19
-
-
0037342895
-
Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines
-
Ling YH, Liebes L, Jiang JD, Holland JF, Elliott PJ, Adams J, Muggia FM, Perez-Soler R. 2003. Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res 9:1145-1154.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1145-1154
-
-
Ling, Y.H.1
Liebes, L.2
Jiang, J.D.3
Holland, J.F.4
Elliott, P.J.5
Adams, J.6
Muggia, F.M.7
Perez-Soler, R.8
-
20
-
-
0034987702
-
Malignant glioma: Genetics and biology of a grave matter
-
Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. 2001. Malignant glioma: Genetics and biology of a grave matter. Genes Dev 15:1311-1333.
-
(2001)
Genes Dev
, vol.15
, pp. 1311-1333
-
-
Maher, E.A.1
Furnari, F.B.2
Bachoo, R.M.3
Rowitch, D.H.4
Louis, D.N.5
Cavenee, W.K.6
DePinho, R.A.7
-
21
-
-
0032429749
-
Checking on the cell cycle
-
Mercer WE. 1998. Checking on the cell cycle. J Cell Biochem Suppl 30-31:50-54.
-
(1998)
J Cell Biochem Suppl
, vol.30-31
, pp. 50-54
-
-
Mercer, W.E.1
-
22
-
-
0029812759
-
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
-
Mimnaugh EG, Chavany C, Neckers L. 1996. Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin. J Biol Chem 271:22796-22801.
-
(1996)
J Biol Chem
, vol.271
, pp. 22796-22801
-
-
Mimnaugh, E.G.1
Chavany, C.2
Neckers, L.3
-
23
-
-
0036023440
-
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly (ADP-ribose) polymerase cleavage
-
Nabha SM, Mohammad RM, Dandashi MH, Coupaye-Gerard B, Aboukameel A, Pettit GR, Al-Katib AM. 2002. Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly (ADP-ribose) polymerase cleavage. Clin Cancer Res 8:2735-2741.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2735-2741
-
-
Nabha, S.M.1
Mohammad, R.M.2
Dandashi, M.H.3
Coupaye-Gerard, B.4
Aboukameel, A.5
Pettit, G.R.6
Al-Katib, A.M.7
-
24
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
Neckers L. 2002. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8:55-61.
-
(2002)
Trends Mol Med
, vol.8
, pp. 55-61
-
-
Neckers, L.1
-
25
-
-
0032753492
-
Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin
-
Nguyen DM, Chen A, Mixon A, Schrump DS. 1999. Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin. J Thorac Cardiovasc Surg 118:908-915.
-
(1999)
J Thorac Cardiovasc Surg
, vol.118
, pp. 908-915
-
-
Nguyen, D.M.1
Chen, A.2
Mixon, A.3
Schrump, D.S.4
-
26
-
-
0035266132
-
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts
-
Nimmanapalli R, O'Bryan E, Bhalla K. 2001. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Cancer Res 61:1799-1804.
-
(2001)
Cancer Res
, vol.61
, pp. 1799-1804
-
-
Nimmanapalli, R.1
O'Bryan, E.2
Bhalla, K.3
-
27
-
-
0038637205
-
The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines
-
Park JW, Yeh MW, Wong MG, Lobo M, Hyun WC, Dun QY, Clark OH. 2003. The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines. J Clin Endocrinol Metab 88:3346-3353.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3346-3353
-
-
Park, J.W.1
Yeh, M.W.2
Wong, M.G.3
Lobo, M.4
Hyun, W.C.5
Dun, Q.Y.6
Clark, O.H.7
-
28
-
-
0037318902
-
Mitochondria, AIF and caspases - Rivaling for cell death execution
-
Penninger J, Kroemer G. 2000. Mitochondria, AIF and caspases - Rivaling for cell death execution. Nat Cell Biol 5:97-99.
-
(2000)
Nat Cell Biol
, vol.5
, pp. 97-99
-
-
Penninger, J.1
Kroemer, G.2
-
29
-
-
0034657818
-
Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation
-
Ruth AC, Roninson IB. 2000. Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res 60:2576-2578.
-
(2000)
Cancer Res
, vol.60
, pp. 2576-2578
-
-
Ruth, A.C.1
Roninson, I.B.2
-
30
-
-
0022342203
-
Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein
-
Sanchez ER, Toft DO, Schlesinger MJ, Pratt WB. 1985. Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. J Biol Chem 260:12398-12401.
-
(1985)
J Biol Chem
, vol.260
, pp. 12398-12401
-
-
Sanchez, E.R.1
Toft, D.O.2
Schlesinger, M.J.3
Pratt, W.B.4
-
31
-
-
0034718540
-
Modulation of Akt kinase activity by binding to Hsp90
-
Sato S, Fujita N, Tsuruo T. 2000. Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 97:10832-10837.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10832-10837
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
32
-
-
0034730944
-
The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme
-
Schlegel J, Piontek G, Budde B, Neff F, Kraus A. 2000. The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme. Cancer Lett 158:103-108.
-
(2000)
Cancer Lett
, vol.158
, pp. 103-108
-
-
Schlegel, J.1
Piontek, G.2
Budde, B.3
Neff, F.4
Kraus, A.5
-
33
-
-
0027979892
-
Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry
-
Schmid I, Uittenbogaart CH, Giorgi JV. 1994. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry 15:12-20.
-
(1994)
Cytometry
, vol.15
, pp. 12-20
-
-
Schmid, I.1
Uittenbogaart, C.H.2
Giorgi, J.V.3
-
34
-
-
0029122080
-
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives
-
Schnur RC, Corman ML, Gallaschun RJ, Cooper BA, Dee MF, Doty JL, Muzzi ML, Moyer JD, DiOrio CI, Barbacci EG, et al. 1995. Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J Med Chem 38:3806-3812.
-
(1995)
J Med Chem
, vol.38
, pp. 3806-3812
-
-
Schnur, R.C.1
Corman, M.L.2
Gallaschun, R.J.3
Cooper, B.A.4
Dee, M.F.5
Doty, J.L.6
Muzzi, M.L.7
Moyer, J.D.8
DiOrio, C.I.9
Barbacci, E.G.10
-
35
-
-
0031590456
-
Geldanamycin-induced destabilization of Raf-1 involves the proteasome
-
Schulte TW, An WG, Neckers LM. 1997. Geldanamycin-induced destabilization of Raf-1 involves the proteasome. Biochem Biophys Res Commun 239:655-659.
-
(1997)
Biochem Biophys Res Commun
, vol.239
, pp. 655-659
-
-
Schulte, T.W.1
An, W.G.2
Neckers, L.M.3
-
36
-
-
0026722373
-
Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84)
-
Shaknovich R, Shue G, Kohtz DS. 1992. Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84). Mol Cell Biol 12:5059-5068.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5059-5068
-
-
Shaknovich, R.1
Shue, G.2
Kohtz, D.S.3
-
37
-
-
0037018847
-
A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
-
Shtivelman E, Sussman J, Stokoe D. 2002. A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr Biol 12:919-924.
-
(2002)
Curr Biol
, vol.12
, pp. 919-924
-
-
Shtivelman, E.1
Sussman, J.2
Stokoe, D.3
-
39
-
-
0027433644
-
Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system
-
Stancato LF, Chow YH, Hutchison KA, Perdew GH, Jove R, Pratt WB. 1993. Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. J Biol Chem 268:21711-21716.
-
(1993)
J Biol Chem
, vol.268
, pp. 21711-21716
-
-
Stancato, L.F.1
Chow, Y.H.2
Hutchison, K.A.3
Perdew, G.H.4
Jove, R.5
Pratt, W.B.6
-
40
-
-
0031005361
-
Crystal structure of an Hsp90-geldanamycin complex; Targeting of a protein chaperone by an antitumor agent
-
Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP. 1997. Crystal structure of an Hsp90-geldanamycin complex; Targeting of a protein chaperone by an antitumor agent. Cell 89:239-250.
-
(1997)
Cell
, vol.89
, pp. 239-250
-
-
Stebbins, C.E.1
Russo, A.A.2
Schneider, C.3
Rosen, N.4
Hartl, F.U.5
Pavletich, N.P.6
-
42
-
-
0034175616
-
Analysis promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
-
Takahashi Y, Rayman JB, Dynlacht BD. 2000. Analysis promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression. Genes Dev 14:804-816.
-
(2000)
Genes Dev
, vol.14
, pp. 804-816
-
-
Takahashi, Y.1
Rayman, J.B.2
Dynlacht, B.D.3
-
43
-
-
0031767393
-
Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses
-
Weller M, Rieger J, Grimmel C, Van Meir EG, De Tribolet N, Krajewski S, Reed JC, von Deimling A, Dichgans J. 1998. Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses. Int J Cancer 79:640-644.
-
(1998)
Int J Cancer
, vol.79
, pp. 640-644
-
-
Weller, M.1
Rieger, J.2
Grimmel, C.3
Van Meir, E.G.4
De Tribolet, N.5
Krajewski, S.6
Reed, J.C.7
Von Deimling, A.8
Dichgans, J.9
-
44
-
-
0026735864
-
Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition
-
Whitesell L, Shifrin SD, Schwab G, Neckers LM. 1992. Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition. Cancer Res 52:1721-1728.
-
(1992)
Cancer Res
, vol.52
, pp. 1721-1728
-
-
Whitesell, L.1
Shifrin, S.D.2
Schwab, G.3
Neckers, L.M.4
-
45
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role or stress proteins in oncogenic transformation
-
Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. 1994. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role or stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 91:8324-8328.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
46
-
-
0030878952
-
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
-
Whitesell L, Sutphin P, An WG, Schulte T, Blagosklonny MV, Neckers L. 1997. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14:2809-2816.
-
(1997)
Oncogene
, vol.14
, pp. 2809-2816
-
-
Whitesell, L.1
Sutphin, P.2
An, W.G.3
Schulte, T.4
Blagosklonny, M.V.5
Neckers, L.6
-
47
-
-
0035793546
-
Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
-
Xu W, Mimnaugh E, Rosser MF, Nicchitta C, Marcu M, Yarden Y, Neckers L. 2001. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 276:3702-3708.
-
(2001)
J Biol Chem
, vol.276
, pp. 3702-3708
-
-
Xu, W.1
Mimnaugh, E.2
Rosser, M.F.3
Nicchitta, C.4
Marcu, M.5
Yarden, Y.6
Neckers, L.7
-
48
-
-
0035110959
-
Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: A novel target mechanism concept for pharmacokinetic modulating chemotherapy
-
Yoshikawa R, Kusunoki M, Yanagi H, Noda M, Furuyama JI, Yamamura T, Hashimoto-Tamaoki T. 2001. Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: A novel target mechanism concept for pharmacokinetic modulating chemotherapy. Cancer Res 61:1029-1037.
-
(2001)
Cancer Res
, vol.61
, pp. 1029-1037
-
-
Yoshikawa, R.1
Kusunoki, M.2
Yanagi, H.3
Noda, M.4
Furuyama, J.I.5
Yamamura, T.6
Hashimoto-Tamaoki, T.7
-
49
-
-
0037067317
-
Mediation of polyADP-ribose polymerase-1-dependent cell death by apoptosis-inducing factor
-
Yu S-W, Wang J, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirer GG, Dawson TM, Dawson VL. 2002. Mediation of poly(ADP-ribose polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297:259-263.
-
(2002)
Science
, vol.297
, pp. 259-263
-
-
Yu, S.-W.1
Wang, J.2
Poitras, M.F.3
Coombs, C.4
Bowers, W.J.5
Federoff, H.J.6
Poirer, G.G.7
Dawson, T.M.8
Dawson, V.L.9
-
50
-
-
0037784052
-
Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion
-
Zagzag D, Nomura M, Friedlander DR, Blanco CY, Gagner JP, Nomura N, Newcomb EW. 2003. Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. J Cell Physiol 196:394-402.
-
(2003)
J Cell Physiol
, vol.196
, pp. 394-402
-
-
Zagzag, D.1
Nomura, M.2
Friedlander, D.R.3
Blanco, C.Y.4
Gagner, J.P.5
Nomura, N.6
Newcomb, E.W.7
-
51
-
-
0034735569
-
Akt regulates cell survival and apoptosis at a postmitochondrial level
-
Zhou H, Li XM, Meinkoth J, Pittman RN. 2000. Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol 151:483-494.
-
(2000)
J Cell Biol
, vol.151
, pp. 483-494
-
-
Zhou, H.1
Li, X.M.2
Meinkoth, J.3
Pittman, R.N.4
|