The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme

Cancer Letters

Volumn 158, Issue 1, 2000, Pages 103-108

  Schlegel, Jürgen ^a   Piontek, Guido ^a   Budde, Barbara ^b   Neff, Frauke ^b   Kraus, Alison ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b 35043   (Germany)

Author keywords

Akt; Glioblastoma multiforme; Mitogen activated protein Kinase; Phosphatidylinositol 3' kinase; Protein kinase B; Signal transduction pathways

Indexed keywords

CELL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FRAMESHIFT MUTATION; GENE DELETION; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; ENZYME ACTIVATION; GLIOBLASTOMA; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENICITY TESTS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034730944     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00515-2     Document Type: Article

References (23)

1. Furnari F.B., Huang H.J.S., Cavenee W.K. Genetics and malignant progression of human brain tumours, Genetics and Cancer: a Second Look, Vol. 25, Imperial Cancer Research Fund, London. 1995;233-275.
2. Deimling A.V., Ammon K.V., Schoenfeld D., Wiestler O.D., Seizinger B.R., Louis D.N. Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol. 3:1993;19-26.
3. Schlegel J., Merdes A., Stumm G., Albert F.K., Forsting M., Hynes N.E., Kiessling M. Amplification of the epidermal growth factor receptor gene correlates with different growth behaviour in human glioblastoma. Int. J. Cancer. 56:1994;72-77.
4. Liu W., James C.D., Frederick L., Alderete B.E., Jenkins R.B. PTEN/NMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res. 57:1997;5254-5257.
5. Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., Puc J., Miliaresis C., Rodgers L., McCombie R., Bigner S.H., Giovanella B.C., Ittmann M., Tycko B., Hibshooth H., Wigler M.H., Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 275:1997;1943-1947.
6. Steck P.A., Pershouse M.A., Jasser S.A., Yung W.K.A., Lin H., Ligon A.H., Langford L.A., Baumgard M.L., Hattier T., Davis T., Frye C., Hu R., Swedlund B., Teng D.H.F., Tavtigian S.V. Identification of a cancidate tumour suppressor gene MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15:1997;356-362.
7. Li D.M., Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57:1997;2124-2129.
8. Cantley L.C., Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA. 96:1999;4240-4245.
9. Maehama T., Dixon J.E. The tumor suppressor PTEN/MMAC1, dephosphorylates the lipid second messanger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273:1998;13375-13378.
10. Stambolic V., Suzuki A., de la Pompa J.L., Brothers G.M., Mirtsos C., Sasaki T., Ruland J., Penninger J.M., Siderovski D.P., Mak T.W. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 95:1998;29-39.
11. Bondeva T., Pirola L., Bulgarelli-Leva G., Rubio I., Wetzker R., Wymann M.P. Bifurcation of lipid and protein kinase signals of PI3K gamma to the protein kinases PKB and MAPK. Science. 282:1998;293-296.
12. Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.C., Van Meir E.G. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol. 9:1999;469-479.
13. Kraus A., Neff F., Behn M., Schuermann M., Muenkel K., Schlegel J. Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells. Int. J. Cancer. 80:1999;930-934.
14. Haas-Kogan D., Shalev N., Wong M., Mills G., Yount G., Stokoe D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol. 8:1998;1195-1198.
15. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91:1997;231-241.
16. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:1999;857-868.
17. Yount G.L., Levine K.S., Kuriyama H., Haas-Kogan D.A., Israel M.A. Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells. Cancer Res. 59:1999;1362-1365.
18. Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., Reed J.C. Regulation of cell death protease caspase-9 by phosphorylation. Science. 282:1998;1318-1321.
19. Cobb M.H., Goldsmith E.J. How MAP kinases are regulated. J. Biol. Chem. 270:1995;14843-14846.
20. Yujiri T., Sather S., Fanger G.R., Johnson G.L. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science. 282:1998;1911-1914.
21. Zimmermann S., Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science. 286:1999;1741-1744.
22. Wick W., Furnari F.B., Naumann U., Cavenee W.K., Weller M. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. 18:1999;3936-3943.
23. Sebolt-Leopold J.S., Dudley D.T., Herrera R., Van Becelaere K., Wiland A., Gowan R.C., Tecle H., Barrett S.D., Bridges A., Przybranowski S., Leopold W.R., Saltiel A.R. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo [see comments]. Nat. Med. 5:1999;810-816.