Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2

Cancer Research

Volumn 61, Issue 18, 2001, Pages 6693-6697

  Gomez Manzano, C ^a   Mitlianga, P ^a   Fueyo, J ^a   Lee, H Y ^a   Hu, M ^a   Spurgers, K B ^a   Glass, T L ^a   Koul, D ^a   Liu, T J ^a   McDonnell, T J ^a   Yung, W K A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN BCL X; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2; TRANSCRIPTION FACTOR E2F4; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE STRUCTURE; GENETIC ANALYSIS; GLIOMA; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TRANSACTIVATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

BINDING SITES; CELL CYCLE; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; E2F2 TRANSCRIPTION FACTOR; E2F4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; GENES, BCL-2; GLIOMA; HUMANS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0035884509     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Gene therapy for gliomas: Molecular targets, adenoviral vectors, and oncolytic adenovirus
2. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
3. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development
4. p53 and E2F-1 cooperate to mediate apoptosis
5. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo
6. E2F-1 functions in mice to promote apoptosis and suppress proliferation
7. Tumor induction and tissue atrophy in mice lacking E2F-1
8. The t(14;18) chromosome translations involved in B-cell neoplasms result from mistakes in VDJ joining
9. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
10. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
11. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
12. E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation
13. Bcl-2-induced changes in E2F regulatory complexes reveal the potential for integrated cell cycle and cell death functions
14. Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F
15. Distinct roles for E2F proteins in cell growth control and apoptosis
16. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis
17. A negative regulatory element in the bcl-2 5′-untranslated region inhibits expression from an upstream promoter
18. Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53
19. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma
20. Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells
21. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
22. Bcl-2 family members and the mitochondria in apoptosis
23. Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor
24. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
25. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation
26. Bcl-2 retards cell cycle entry through p27Kip1, pRB relative p130, and altered E2F regulation
27. Regulation of apoptosis by ElA and Myc oncoproteins
28. Regulation of the p53 tumor suppressor protein
29. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
30. Genetic determinants of p53-induced apoptosis and growth arrest
31. Human gliomas with wild-type p53 express bcl-2
32. Increased levels of p21WAF1/Cip1 in human brain tumors