2-Methoxyestradiol blocks cell-cycle progression at G2/M phase and inhibits growth of human prostate cancer cells

Molecular Carcinogenesis

Volumn 31, Issue 3, 2001, Pages 111-124

  Kumar, Addanki P ^a,b   Garcia, Gretchen E ^a   Slaga, Thomas J ^a  

^a UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Apoptosis; Estrogenic metabolite; Wee1 kinase

Indexed keywords

2 METHOXYESTRADIOL; ANDROGEN; BIOTIN; CASPASE 3; CELL CYCLE PROTEIN; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; ESTRADIOL; ESTROGEN RECEPTOR; FLUORESCEIN ISOTHIOCYANATE; PHOSPHOTRANSFERASE; PROTEIN P21; REGULATOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL GROWTH; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; ENZYME ASSAY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALE; METABOLITE; NICK END LABELING; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CDC2 PROTEIN KINASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; GENES, P53; HUMANS; IN SITU NICK-END LABELING; MALE; MITOSIS; MUTATION; NUCLEAR PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTORS, ESTROGEN; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034885197     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.1046     Document Type: Article

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