Energetic, structural, and antimicrobial analyses of β-lactam side chain recognition by β-lactamases

Chemistry and Biology

Volumn 8, Issue 1, 2001, Pages 17-31

  Caselli, Emilia ^a,b   Powers, Rachel A ^a   Blasczcak, Larry C ^c   Wu, Chyun Yeh Earnest ^c   Prati, Fabio ^b   Shoichet, Brian K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Antibiotic resistance; Drug design; Interaction energy; Structure based inhibitor design; Transition state analog

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAM; BETA LACTAMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ELECTRICITY; ENTEROBACTER CLOACAE; HUMAN; IN VITRO STUDY; KINETICS; METABOLISM; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BETA-LACTAMS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENTEROBACTER CLOACAE; HUMANS; KINETICS; MODELS, MOLECULAR; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 0035113737     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00052-1     Document Type: Article

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