Three-dimensional structure of AmpC β-lactamase from Escherichia coli bound to a transition-state analogue: Possible implications for the oxyanion hypothesis and for inhibitor design

Biochemistry

Volumn 37, Issue 46, 1998, Pages 16082-16092

  Usher, Ken C ^a,d   Blaszczak, Larry C ^c   Weston, G Scott ^b   Shoichet, Brian K ^b   Remington, S James ^a  

^a UNIVERSITY OF OREGON   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; BORONIC ACID DERIVATIVE; HYDROGEN; OXYGEN; SERINE PROTEINASE;

ARTICLE; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANIONS; BACTERIAL PROTEINS; BETA-LACTAMASES; BORONIC ACIDS; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENTEROBACTER CLOACAE; ENZYME INHIBITORS; ESCHERICHIA COLI; MODELS, MOLECULAR;

EID: 0032542009     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981210f     Document Type: Article

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