Nanomolar inhibitors of AmpC β-lactamase

Journal of the American Chemical Society

Volumn 125, Issue 3, 2003, Pages 685-695

  Morandi, Federica ^a   Caselli, Emilia ^b   Morandi, Stefania ^b   Focia, Pamela J ^c   Blázquez, Jesús ^d   Shoichet, Brian K ^a   Prati, Fabio ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c NORTHWESTERN UNIVERSITY   (United States)

^d HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYME INHIBITION; ORGANIC ACIDS; X RAY CRYSTALLOGRAPHY;

PENICILLIN;

ENZYMES;

BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BORONIC ACID DERIVATIVE; CARBOXYLIC ACID; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CHYMOTRYPSIN INHIBITOR; GLYCYLBORONIC ACID; PENICILLIN DERIVATIVE; PHENYL GROUP; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPARATIVE STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; INHIBITION KINETICS; PHASE TRANSITION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BORON COMPOUNDS; BORONIC ACIDS; CEFTAZIDIME; CRYSTALLOGRAPHY, X-RAY; DRUG SYNERGISM; ENZYME INHIBITORS; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 0037460187     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0288338     Document Type: Article

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