Thermodynamic Cycle Analysis and Inhibitor Design against Beta-Lactamase

Biochemistry

Volumn 42, Issue 49, 2003, Pages 14483-14491

  Roth, Tomer A ^a,c   Minasov, George ^a,d   Morandi, Stefania ^b   Prati, Fabio ^b   Shoichet, Brian K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CHEMICAL BONDS; ENZYME INHIBITION; ENZYMES; HYDROGEN BONDS; IONS; THERMODYNAMIC PROPERTIES;

MUTANTS;

BIOCHEMISTRY;

ALDEHYDE; AMIDE; ASPARAGINE; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CARBOXYLIC ACID; CEPHALOSPORIN DERIVATIVE; LEUCINE; MUTANT PROTEIN; PENICILLIN DERIVATIVE; PHENYL GROUP;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIPOLE; DRUG DESIGN; DRUG SYNTHESIS; ENERGY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; GENE DELETION; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TECHNIQUE; THERMODYNAMICS; WILD TYPE; X RAY CRYSTALLOGRAPHY;

ALANINE; ASPARAGINE; BACTERIAL PROTEINS; BETA-LACTAMASES; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; LEUCINE; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 0348110659     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035054a     Document Type: Article

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