메뉴 건너뛰기




Volumn 9, Issue 2, 2010, Pages 279-283

Targeting the checkpoint kinase Chk1 in cancer therapy

Author keywords

Cancer; Chk1; Fbx6; Replication checkpoint; Therapy resistance

Indexed keywords

APHIDICOLIN; CAMPTOTHECIN; CHECKPOINT KINASE 1; DNA TOPOISOMERASE INHIBITOR; F BOX PROTEIN; MESYLIC ACID METHYL ESTER;

EID: 74949120032     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.2.10445     Document Type: Review
Times cited : (68)

References (50)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage response: Taking shape
    • Shiloh Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci 2006; 31:402-10.
    • (2006) Trends Biochem Sci , vol.31 , pp. 402-410
    • Shiloh, Y.1
  • 3
    • 5044236667 scopus 로고    scopus 로고
    • A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication
    • Pacek M, Walter JC. A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J 2004; 23:3667-76.
    • (2004) EMBO J , vol.23 , pp. 3667-3676
    • Pacek, M.1    Walter, J.C.2
  • 4
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATRdependent checkpoint
    • Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATRdependent checkpoint. Genes Dev 2005; 19:1040-52.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 5
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006; 8:37-45.
    • (2006) Nat Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5    Lukas, J.6
  • 7
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300:1542-8.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 8
    • 33644683073 scopus 로고    scopus 로고
    • Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP
    • Kim SM, Kumagai A, Lee J, Dunphy WG. Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. J Biol Chem 2005; 280:38355-64.
    • (2005) J Biol Chem , vol.280 , pp. 38355-38364
    • Kim, S.M.1    Kumagai, A.2    Lee, J.3    Dunphy, W.G.4
  • 9
    • 0037080675 scopus 로고    scopus 로고
    • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
    • Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev 2002; 16:198-208.
    • (2002) Genes Dev , vol.16 , pp. 198-208
    • Zou, L.1    Cortez, D.2    Elledge, S.J.3
  • 10
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001; 21:4129-39.
    • (2001) Mol Cell Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 11
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    • Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14:1448-59.
    • (2000) Genes Dev , vol.14 , pp. 1448-1459
    • Liu, Q.1    Guntuku, S.2    Cui, X.S.3    Matsuoka, S.4    Cortez, D.5    Tamai, K.6
  • 12
    • 85190568998 scopus 로고    scopus 로고
    • Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6:839-49.
    • Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6:839-49.
  • 13
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai A, Lee J, Yoo HY, Dunphy WG. TopBP1 activates the ATR-ATRIP complex. Cell 2006; 124:943-55.
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 14
    • 33746408535 scopus 로고    scopus 로고
    • Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
    • Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, et al. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell 2006; 23:331-41.
    • (2006) Mol Cell , vol.23 , pp. 331-341
    • Wang, X.1    Zou, L.2    Lu, T.3    Bao, S.4    Hurov, K.E.5    Hittelman, W.N.6
  • 15
  • 18
    • 24044476837 scopus 로고    scopus 로고
    • Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
    • Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, et al. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell 2005; 19:607-18.
    • (2005) Mol Cell , vol.19 , pp. 607-618
    • Zhang, Y.W.1    Otterness, D.M.2    Chiang, G.G.3    Xie, W.4    Liu, Y.C.5    Mercurio, F.6
  • 19
    • 30944435598 scopus 로고    scopus 로고
    • Rapid PIKKdependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
    • Smits VA, Reaper PM, Jackson SP. Rapid PIKKdependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr Biol 2006; 16:150-9.
    • (2006) Curr Biol , vol.16 , pp. 150-159
    • Smits, V.A.1    Reaper, P.M.2    Jackson, S.P.3
  • 20
    • 38649118240 scopus 로고    scopus 로고
    • Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
    • Shimada M, Niida H, Zineldeen DH, Tagami H, Tanaka M, Saito H, et al. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 2008; 132:221-32.
    • (2008) Cell , vol.132 , pp. 221-232
    • Shimada, M.1    Niida, H.2    Zineldeen, D.H.3    Tagami, H.4    Tanaka, M.5    Saito, H.6
  • 21
    • 34147206546 scopus 로고    scopus 로고
    • Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
    • Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M. Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 2007; 27:2572-81.
    • (2007) Mol Cell Biol , vol.27 , pp. 2572-2581
    • Niida, H.1    Katsuno, Y.2    Banerjee, B.3    Hande, M.P.4    Nakanishi, M.5
  • 22
    • 58549089689 scopus 로고    scopus 로고
    • Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
    • Wilsker D, Petermann E, Helleday T, Bunz F. Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci USA 2008; 105:20752-7.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20752-20757
    • Wilsker, D.1    Petermann, E.2    Helleday, T.3    Bunz, F.4
  • 23
    • 67649253108 scopus 로고    scopus 로고
    • Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
    • Walker M, Black EJ, Oehler V, Gillespie DA, Scott MT. Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity. Oncogene 2009; 28:2314-23.
    • (2009) Oncogene , vol.28 , pp. 2314-2323
    • Walker, M.1    Black, E.J.2    Oehler, V.3    Gillespie, D.A.4    Scott, M.T.5
  • 24
    • 0035162304 scopus 로고    scopus 로고
    • Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes
    • Oe T, Nakajo N, Katsuragi Y, Okazaki K, Sagata N. Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes. Dev Biol 2001; 229:250-61.
    • (2001) Dev Biol , vol.229 , pp. 250-261
    • Oe, T.1    Nakajo, N.2    Katsuragi, Y.3    Okazaki, K.4    Sagata, N.5
  • 25
    • 1642546298 scopus 로고    scopus 로고
    • Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
    • Katsuragi Y, Sagata N. Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol Biol Cell 2004; 15:1680-9.
    • (2004) Mol Biol Cell , vol.15 , pp. 1680-1689
    • Katsuragi, Y.1    Sagata, N.2
  • 26
    • 0034677597 scopus 로고    scopus 로고
    • Chen P, Luo C, Deng Y, Ryan K, Register J, Margosiak S, et al. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell 2000; 100:681-92.
    • Chen P, Luo C, Deng Y, Ryan K, Register J, Margosiak S, et al. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell 2000; 100:681-92.
  • 28
    • 58149314558 scopus 로고    scopus 로고
    • Regulation of Chk1 by its C-terminal domain
    • Kosoy A, O'Connell MJ. Regulation of Chk1 by its C-terminal domain. Mol Biol Cell 2008; 19:4546-53.
    • (2008) Mol Biol Cell , vol.19 , pp. 4546-4553
    • Kosoy, A.1    O'Connell, M.J.2
  • 30
    • 56449089043 scopus 로고    scopus 로고
    • Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity
    • Feng JM, Zhu H, Zhang XW, Ding J, Miao ZH. Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity. Cancer Biol Ther 2008; 7:1726-31.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1726-1731
    • Feng, J.M.1    Zhu, H.2    Zhang, X.W.3    Ding, J.4    Miao, Z.H.5
  • 31
    • 34547946751 scopus 로고    scopus 로고
    • Chk1 Instability Is Coupled to Mitotic Cell Death of p53-deficient Cells in Response to Virus-induced DNA Damage Signaling
    • Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P. Chk1 Instability Is Coupled to Mitotic Cell Death of p53-deficient Cells in Response to Virus-induced DNA Damage Signaling. J Mol Biol 2007; 372:397-406.
    • (2007) J Mol Biol , vol.372 , pp. 397-406
    • Jurvansuu, J.1    Fragkos, M.2    Ingemarsdotter, C.3    Beard, P.4
  • 32
    • 65549090186 scopus 로고    scopus 로고
    • DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress
    • Leung-Pineda V, Huh J, Piwnica-Worms H. DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res 2009; 69:2630-7.
    • (2009) Cancer Res , vol.69 , pp. 2630-2637
    • Leung-Pineda, V.1    Huh, J.2    Piwnica-Worms, H.3
  • 33
    • 68949221708 scopus 로고    scopus 로고
    • The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
    • Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, et al. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell 2009; 35:442-53.
    • (2009) Mol Cell , vol.35 , pp. 442-453
    • Zhang, Y.W.1    Brognard, J.2    Coughlin, C.3    You, Z.4    Dolled-Filhart, M.5    Aslanian, A.6
  • 34
    • 18844405191 scopus 로고    scopus 로고
    • PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
    • Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 2005; 19:1162-74.
    • (2005) Genes Dev , vol.19 , pp. 1162-1174
    • Lu, X.1    Nannenga, B.2    Donehower, L.A.3
  • 35
    • 33749626550 scopus 로고    scopus 로고
    • Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
    • Leung-Pineda V, Ryan CE, Piwnica-Worms H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol 2006; 26:7529-38.
    • (2006) Mol Cell Biol , vol.26 , pp. 7529-7538
    • Leung-Pineda, V.1    Ryan, C.E.2    Piwnica-Worms, H.3
  • 36
    • 1842614272 scopus 로고    scopus 로고
    • Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
    • den Elzen NR, O'Connell MJ. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J 2004; 23:908-18.
    • (2004) EMBO J , vol.23 , pp. 908-918
    • den Elzen, N.R.1    O'Connell, M.J.2
  • 37
    • 0035393594 scopus 로고    scopus 로고
    • DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
    • Lukas C, Bartkova J, Latella L, Falck J, Mailand N, Schroeder T, et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res 2001; 61:4990-3.
    • (2001) Cancer Res , vol.61 , pp. 4990-4993
    • Lukas, C.1    Bartkova, J.2    Latella, L.3    Falck, J.4    Mailand, N.5    Schroeder, T.6
  • 38
    • 0035947651 scopus 로고    scopus 로고
    • The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway
    • Hu B, Zhou XY, Wang X, Zeng ZC, Iliakis G, Wang Y. The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. J Biol Chem 2001; 276:17693-8.
    • (2001) J Biol Chem , vol.276 , pp. 17693-17698
    • Hu, B.1    Zhou, X.Y.2    Wang, X.3    Zeng, Z.C.4    Iliakis, G.5    Wang, Y.6
  • 39
    • 0037837096 scopus 로고    scopus 로고
    • Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells
    • Perego P, Gatti L, Righetti SC, Beretta GL, Carenini N, Corna E, et al. Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells. Int J Cancer 2003; 105:617-24.
    • (2003) Int J Cancer , vol.105 , pp. 617-624
    • Perego, P.1    Gatti, L.2    Righetti, S.C.3    Beretta, G.L.4    Carenini, N.5    Corna, E.6
  • 40
    • 1542365321 scopus 로고    scopus 로고
    • Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
    • Ng CP, Lee HC, Ho CW, Arooz T, Siu WY, Lau A, et al. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J Biol Chem 2004; 279:8808-19.
    • (2004) J Biol Chem , vol.279 , pp. 8808-8819
    • Ng, C.P.1    Lee, H.C.2    Ho, C.W.3    Arooz, T.4    Siu, W.Y.5    Lau, A.6
  • 41
    • 16444379514 scopus 로고    scopus 로고
    • Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis
    • Jin ZH, Kurosu T, Yamaguchi M, Arai A, Miura O. Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. Oncogene 2005; 24:1973-81.
    • (2005) Oncogene , vol.24 , pp. 1973-1981
    • Jin, Z.H.1    Kurosu, T.2    Yamaguchi, M.3    Arai, A.4    Miura, O.5
  • 42
    • 13444268947 scopus 로고    scopus 로고
    • Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response
    • Maude SL, Enders GH. Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. Cancer Res 2005; 65:780-6.
    • (2005) Cancer Res , vol.65 , pp. 780-786
    • Maude, S.L.1    Enders, G.H.2
  • 43
    • 35848966121 scopus 로고    scopus 로고
    • Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells
    • Matthew EM, Yen TJ, Dicker DT, Dorsey JF, Yang W, Navaraj A, et al. Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells. Cell Cycle 2007; 6:2571-8.
    • (2007) Cell Cycle , vol.6 , pp. 2571-2578
    • Matthew, E.M.1    Yen, T.J.2    Dicker, D.T.3    Dorsey, J.F.4    Yang, W.5    Navaraj, A.6
  • 44
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004; 6:45-59.
    • (2004) Cancer Cell , vol.6 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2    Elledge, S.J.3    Rosen, J.M.4
  • 45
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756-60.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6
  • 46
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-9.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 47
    • 22844436238 scopus 로고    scopus 로고
    • Chk1 is essential for tumor cell viability following activation of the replication checkpoint
    • Cho SH, Toouli CD, Fujii GH, Crain C, Parry D. Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle 2005; 4:131-9.
    • (2005) Cell Cycle , vol.4 , pp. 131-139
    • Cho, S.H.1    Toouli, C.D.2    Fujii, G.H.3    Crain, C.4    Parry, D.5
  • 49
    • 34547109117 scopus 로고    scopus 로고
    • The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor/progesterone receptor/HER-2 breast carcinomas
    • Verlinden L, Vanden Bempt I, Eelen G, Drijkoningen M, Verlinden I, Marchal K, et al. The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor/progesterone receptor/HER-2 breast carcinomas. Cancer Res 2007; 67:6574-81.
    • (2007) Cancer Res , vol.67 , pp. 6574-6581
    • Verlinden, L.1    Vanden Bempt, I.2    Eelen, G.3    Drijkoningen, M.4    Verlinden, I.5    Marchal, K.6
  • 50
    • 59449085778 scopus 로고    scopus 로고
    • Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
    • Lundgren K, Holm K, Nordenskjold B, Borg A, Landberg G. Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer. Breast Cancer Res 2008; 10:81.
    • (2008) Breast Cancer Res , vol.10 , pp. 81
    • Lundgren, K.1    Holm, K.2    Nordenskjold, B.3    Borg, A.4    Landberg, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.