Chk1 Instability Is Coupled to Mitotic Cell Death of p53-deficient Cells in Response to Virus-induced DNA Damage Signaling

Journal of Molecular Biology

Volumn 372, Issue 2, 2007, Pages 397-406

  Jurvansuu, Jaana ^a   Fragkos, Michalis ^a   Ingemarsdotter, Carin ^a   Beard, Peter ^a  

^a National Center of Competence in Research in Molecular Oncology   (Switzerland)

Author keywords

adeno associated virus; Chk1; DNA damage signaling; p53

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; CYCLIN B1; POLO LIKE KINASE 1; PROTEIN CDC25C; PROTEIN P53; UNCLASSIFIED DRUG; VIRUS DNA;

ADENO ASSOCIATED VIRUS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HCT116; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN STABILITY; VIRUS REPLICATION;

ADENO-ASSOCIATED VIRUS;

EID: 34547946751     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.06.077     Document Type: Article

References (41)

1. Shieh S.Y., Ahn J., Tamai K., Taya Y., and Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14 (2000) 289-300
2. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282 (1998) 1497-1501
3. Nigg E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nature Rev. Mol. Cell Biol. 2 (2001) 21-32
4. O'Farrell P.H. Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 11 (2001) 512-519
5. Kho P.S., Wang Z., Zhuang L., Li Y., Chew J.L., Ng H.H., et al. p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J. Biol. Chem. 279 (2004) 21183-21192
6. Krause K., Wasner M., Reinhard W., Haugwitz U., Dohna C.L., Mossner J., and Engeland K. The tumour suppressor protein p53 can repress transcription of cyclin B. Nucl. Acids Res 28 (2000) 4410-4418
7. Sadhu K., Reed S.I., Richardson H., and Russell P. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl Acad. Sci. USA 87 (1990) 5139-5143
8. Bulavin D.V., Higashimoto Y., Demidenko Z.N., Meek S., Graves P., Phillips C., et al. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nature Cell Biol. 5 (2003) 545-551
9. Barr F.A., Sillje H.H., and Nigg E.A. Polo-like kinases and the orchestration of cell division. Nature Rev. Mol. Cell Biol. 5 (2004) 429-440
10. Elia A.E., Cantley L.C., and Yaffe M.B. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299 (2003) 1228-1231
11. Elia A.E., Rellos P., Haire L.F., Chao J.W., Ivins F.J., Hoepker K., et al. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell 115 (2003) 83-95
12. Toyoshima-Morimoto F., Taniguchi E., and Nishida E. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep. 3 (2002) 341-348
13. Toyoshima-Morimoto F., Taniguchi E., Shinya N., Iwamatsu A., and Nishida E. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature 410 (2001) 215-220
14. Jackman M., Lindon C., Nigg E.A., and Pines J. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nature Cell Biol. 5 (2003) 143-148
15. Gottifredi V., Karni-Schmidt O., Shieh S.S., and Prives C. p53 down-regulates CHK1 through p21 and the retinoblastoma protein. Mol. Cell. Biol. 21 (2001) 1066-1076
16. Cummings M., Siitonen T., Higginbottom K., Newland A.C., and Allen P.D. p53-mediated downregulation of Chk1 abrogates the DNA damage-induced G2/M checkpoint in K562 cells, resulting in increased apoptosis. Br. J. Haematol. 116 (2002) 421-428
17. Agarwal R., Tang Z., Yu H., and Cohen-Fix O. Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J. Biol. Chem. 278 (2003) 45027-45033
18. Yoo H.Y., Kumagai A., Shevchenko A., Shevchenko A., and Dunphy W.G. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117 (2004) 575-588
19. Smits V.A., Klompmaker R., Arnaud L., Rijksen G., Nigg E.A., and Medema R.H. Polo-like kinase-1 is a target of the DNA damage checkpoint. Nature Cell Biol. 2 (2000) 672-676
20. van Vugt M.A., Smits V.A., Klompmaker R., and Medema R.H. Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. J. Biol. Chem. 276 (2001) 41656-41660
21. Peng C.Y., Graves P.R., Thoma R.S., Wu Z., Shaw A.S., and Piwnica-Worms H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277 (1997) 1501-1505
22. Sanchez Y., Wong C., Thoma R.S., Richman R., Wu Z., Piwnica-Worms H., and Elledge S.J. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277 (1997) 1497-1501
23. Furnari B., Blasina A., Boddy M.N., McGowan C.H., and Russell P. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. Mol. Biol. Cell 10 (1999) 833-845
24. Kaneko Y.S., Watanabe N., Morisaki H., Akita H., Fujimoto A., Tominaga K., et al. Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene 18 (1999) 3673-3681
25. Ng C.P., Lee H.C., Ho C.W., Arooz T., Siu W.Y., Lau A., and Poon R.Y. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J. Biol. Chem. 279 (2004) 8808-8819
26. Raj K., Ogston P., and Beard P. Virus-mediated killing of cells that lack p53 activity. Nature 412 (2001) 914-917
27. Jurvansuu J., Raj K., Stasiak A., and Beard P. Viral transport of DNA damage that mimics a stalled replication fork. J. Virol. 79 (2005) 569-580
28. Unal E., Arbel-Eden A., Sattler U., Shroff R., Lichten M., Haber J.E., and Koshland D. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol. Cell 16 (2004) 991-1002
29. Strom L., Lindroos H.B., Shirahige K., and Sjogren C. Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol. Cell 16 (2004) 1003-1015
30. Chow J.P., Siu W.Y., Ho H.T., Ma K.H., Ho C.C., and Poon R.Y. Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints. J. Biol. Chem. 278 (2003) 40815-40828
31. Zhang Y.W., Otterness D.M., Chiang G.G., Xie W., Liu Y.C., Mercurio F., and Abraham R.T. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol. Cell 19 (2005) 607-618
32. Syljuasen R.G., Jensen S., Bartek J., and Lukas J. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res. 66 (2006) 10253-10257
33. Sorensen C.S., Hansen L.T., Dziegielewski J., Syljuasen R.G., Lundin C., Bartek J., and Helleday T. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature Cell Biol. 7 (2005) 195-201
34. Nitta M., Kobayashi O., Honda S., Hirota T., Kuninaka S., Marumoto T., et al. Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Oncogene 23 (2004) 6548-6558
35. Bartek J., and Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr. Opin. Cell Biol. 13 (2001) 738-747
36. Salvetti A., Oreve S., Chadeuf G., Favre D., Cherel Y., Champion-Arnaud P., et al. Factors influencing recombinant adeno-associated virus production. Hum. Gene Ther. 9 (1998) 695-706
37. Mailand N., Podtelejnikov A.V., Groth A., Mann M., Bartek J., and Lukas J. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J. 21 (2002) 5911-5920
38. Macmillan J.C., Hudson J.W., Bull S., Dennis J.W., and Swallow C.J. Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer. Ann. Surg. Oncol. 8 (2001) 729-740
39. Haruki N., Saito H., Tatematsu Y., Konishi H., Harano T., Masuda A., et al. Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer. Cancer Res. 60 (2000) 4689-4692
40. Mailand N., Falck J., Lukas C., Syljuasen R.G., Welcker M., Bartek J., and Lukas J. Rapid destruction of human Cdc25A in response to DNA damage. Science 288 (2000) 1425-1429
41. Shtivelman E. Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR. Mol. Cancer Res. 1 (2003) 959-969