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Volumn 10, Issue 1, 2010, Pages 43-57

Effect of second-generation antipsychotics on cognition: Current issues and future challenges

Author keywords

Antipsychotic medication; Biomarker; Cognition; Neuropsychology; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; ILOPERIDONE; NEUROLEPTIC AGENT; OLANZAPINE; PALIPERIDONE; QUETIAPINE; RISPERIDONE; ZIPRASIDONE;

EID: 74949104026     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.09.143     Document Type: Review
Times cited : (190)

References (116)
  • 1
    • 0028157763 scopus 로고
    • The neuropsychological signature of schizophrenia: Generalized or differential deficit?
    • Blanchard JJ, Neale JM. The neuropsychological signature of schizophrenia: generalized or differential deficit? Am. J. Psychiatry 151(1), 40-48 (1994).
    • (1994) Am. J. Psychiatry , vol.151 , Issue.1 , pp. 40-48
    • Blanchard, J.J.1    Neale, J.M.2
  • 2
    • 0028144551 scopus 로고
    • Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
    • Saykin AJ, Shtasel DL, Gur RE et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch. Gen. Psychiatry 51(2), 124-131 (1994).
    • (1994) Arch. Gen. Psychiatry , vol.51 , Issue.2 , pp. 124-131
    • Saykin, A.J.1    Shtasel, D.L.2    Gur, R.E.3
  • 3
    • 0031903740 scopus 로고    scopus 로고
    • Neurocognitive deficit in schizophrenia: A quantitative review of the evidence
    • Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12, 426-445 (1998).
    • (1998) Neuropsychology , vol.12 , pp. 426-445
    • Heinrichs, R.W.1    Zakzanis, K.K.2
  • 4
    • 52949095724 scopus 로고    scopus 로고
    • Neuropsychological course in the prodrome and first episode of psychosis: Findings from the PRIME North America Double Blind Treatment study
    • Hawkins KA, Keefe RS, Christensen BK et al. Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment study. Schizophr. Res. 105(1-3), 1-9 (2008).
    • (2008) Schizophr. Res , vol.105 , Issue.1-3 , pp. 1-9
    • Hawkins, K.A.1    Keefe, R.S.2    Christensen, B.K.3
  • 5
    • 1642417691 scopus 로고    scopus 로고
    • Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia
    • Hill SK, Schuepbach D, Herbener ES, Keshavan MS, Sweeney JA. Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia. Schizophr. Res. 68(1), 49-63 (2004).
    • (2004) Schizophr. Res , vol.68 , Issue.1 , pp. 49-63
    • Hill, S.K.1    Schuepbach, D.2    Herbener, E.S.3    Keshavan, M.S.4    Sweeney, J.A.5
  • 6
    • 0032858515 scopus 로고    scopus 로고
    • Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia
    • Hoff AL, Sakuma M, Wieneke M, Horon R, Kushner M, DeLisi LE. Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. Am. J. Psychiatry 156(9), 1336-1341 (1999).
    • (1999) Am. J. Psychiatry , vol.156 , Issue.9 , pp. 1336-1341
    • Hoff, A.L.1    Sakuma, M.2    Wieneke, M.3    Horon, R.4    Kushner, M.5    DeLisi, L.E.6
  • 7
    • 0029918481 scopus 로고    scopus 로고
    • What are the functional consequences of neurocognitive deficits in schizophrenia?
    • Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am. J. Psychiatry 153(3), 321-330 (1996).
    • (1996) Am. J. Psychiatry , vol.153 , Issue.3 , pp. 321-330
    • Green, M.F.1
  • 8
    • 0029101224 scopus 로고
    • The cost of cognitive impairment in schizophrenia
    • Sevy S, Davidson M. The cost of cognitive impairment in schizophrenia. Schizophr. Res. 17(1), 1-3 (1995).
    • (1995) Schizophr. Res , vol.17 , Issue.1 , pp. 1-3
    • Sevy, S.1    Davidson, M.2
  • 9
    • 33846407977 scopus 로고    scopus 로고
    • The cost of schizophrenia: Lessons from an international comparison
    • Blomqvist AG, Leger PT, Hoch JS. The cost of schizophrenia: lessons from an international comparison. J. Ment. Health Policy Econ. 9(4), 177-183 (2006).
    • (2006) J. Ment. Health Policy Econ , vol.9 , Issue.4 , pp. 177-183
    • Blomqvist, A.G.1    Leger, P.T.2    Hoch, J.S.3
  • 11
    • 0017644231 scopus 로고
    • Antipsychotic drugs: Clinical pharmacology and therapeutic use
    • Davis JM, Casper R. Antipsychotic drugs: clinical pharmacology and therapeutic use. Drugs 14(4), 260-282 (1977).
    • (1977) Drugs , vol.14 , Issue.4 , pp. 260-282
    • Davis, J.M.1    Casper, R.2
  • 12
    • 0029014326 scopus 로고
    • Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: The effects of quinpirole on memory and motor performance in monkeys
    • Arnsten AF, Cai JX, Steere JC, Goldman-Rakic PS. Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys. J. Neurosci. 15, 3429-3439 (1995).
    • (1995) J. Neurosci , vol.15 , pp. 3429-3439
    • Arnsten, A.F.1    Cai, J.X.2    Steere, J.C.3    Goldman-Rakic, P.S.4
  • 13
    • 0034678029 scopus 로고    scopus 로고
    • Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation
    • Castner SA, Williams GV, Goldman-Rakic PS. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation. Science 287, 2020-2022 (2000).
    • (2000) Science , vol.287 , pp. 2020-2022
    • Castner, S.A.1    Williams, G.V.2    Goldman-Rakic, P.S.3
  • 14
    • 0028085278 scopus 로고
    • The role of D1-dopamine receptor in working memory: Local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task
    • Sawaguchi T, Goldman-Rakic PS. The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task. J. Neurophysiol. 71, 515-528 (1994).
    • (1994) J. Neurophysiol , vol.71 , pp. 515-528
    • Sawaguchi, T.1    Goldman-Rakic, P.S.2
  • 15
    • 0032927133 scopus 로고    scopus 로고
    • Psychomotor, cognitive, extrapyramidal, and affective functions of healthy volunteers during treatment with an atypical (amisulpride) and a classic (haloperidol) antipsychotic
    • Ramaekers JG, Louwerens JW, Muntjewerff ND et al. Psychomotor, cognitive, extrapyramidal, and affective functions of healthy volunteers during treatment with an atypical (amisulpride) and a classic (haloperidol) antipsychotic. J Clin. Psychopharmacol. 19, 209-221 (1999).
    • (1999) J Clin. Psychopharmacol , vol.19 , pp. 209-221
    • Ramaekers, J.G.1    Louwerens, J.W.2    Muntjewerff, N.D.3
  • 16
    • 0034025771 scopus 로고    scopus 로고
    • Relationship between dopamine D(2) occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia
    • Kapur S, Zipursky R, Jones C, Remington G, Houle S. Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am. J. Psychiatry 157(4), 514-520 (2000).
    • (2000) Am. J. Psychiatry , vol.157 , Issue.4 , pp. 514-520
    • Kapur, S.1    Zipursky, R.2    Jones, C.3    Remington, G.4    Houle, S.5
  • 17
    • 0141958820 scopus 로고    scopus 로고
    • Procedural learning in schizophrenia after 6 months of double-blind treatment with olanzapine, risperidone, and haloperidol
    • Purdon SE, Woodward N, Lindborg SR, Stip E. Procedural learning in schizophrenia after 6 months of double-blind treatment with olanzapine, risperidone, and haloperidol. Psychopharmacology 169(3-4), 390-397 (2003).
    • (2003) Psychopharmacology , vol.169 , Issue.3-4 , pp. 390-397
    • Purdon, S.E.1    Woodward, N.2    Lindborg, S.R.3    Stip, E.4
  • 18
    • 0034213705 scopus 로고    scopus 로고
    • Procedural learning in schizophrenia: Further consideration on the deleterious effect of neuroleptics
    • Bedard MA, Scherer H, Stip E, Cohen H, Rodriguez JP, Richer F. Procedural learning in schizophrenia: further consideration on the deleterious effect of neuroleptics. Brain Cogn. 43, 31-39 (2000).
    • (2000) Brain Cogn , vol.43 , pp. 31-39
    • Bedard, M.A.1    Scherer, H.2    Stip, E.3    Cohen, H.4    Rodriguez, J.P.5    Richer, F.6
  • 19
    • 33750719948 scopus 로고    scopus 로고
    • Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    • Reilly JL, Harris MS, Keshavan MS, Sweeney JA. Adverse effects of risperidone on spatial working memory in first-episode schizophrenia. Arch. Gen. Psychiatry 63(11), 1189-1197 (2006).
    • (2006) Arch. Gen. Psychiatry , vol.63 , Issue.11 , pp. 1189-1197
    • Reilly, J.L.1    Harris, M.S.2    Keshavan, M.S.3    Sweeney, J.A.4
  • 20
    • 0002765562 scopus 로고    scopus 로고
    • Cognitive effects of typical antipsychotic treatment: Another look
    • Sharma T, Harvey PD Eds, Oxford University Press, NY, USA
    • Blyler CR, Gold JM. Cognitive effects of typical antipsychotic treatment: another look. In: Cognition in Schizophrenia. Sharma T, Harvey PD (Eds). Oxford University Press, NY, USA 241-265 (2000).
    • (2000) Cognition in Schizophrenia , pp. 241-265
    • Blyler, C.R.1    Gold, J.M.2
  • 21
    • 0024844894 scopus 로고
    • Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia
    • Spohn HE, Strauss ME. Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia. J. Abnorm. Psychol. 98, 367-380 (1989).
    • (1989) J. Abnorm. Psychol , vol.98 , pp. 367-380
    • Spohn, H.E.1    Strauss, M.E.2
  • 22
    • 0025635720 scopus 로고
    • Neuroleptics: Effects on neuropsychological function in chronic schizophrenic patients
    • Cassens G, Inglis AK, Appelbaum PS, Gutheil TG. Neuroleptics: effects on neuropsychological function in chronic schizophrenic patients. Schizophr. Bull. 16(3), 477-499 (1990).
    • (1990) Schizophr. Bull , vol.16 , Issue.3 , pp. 477-499
    • Cassens, G.1    Inglis, A.K.2    Appelbaum, P.S.3    Gutheil, T.G.4
  • 24
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
    • Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch. Gen. Psychiatry 45(9), 789-796 (1988).
    • (1988) Arch. Gen. Psychiatry , vol.45 , Issue.9 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3    Meltzer, H.4
  • 25
    • 0034284828 scopus 로고    scopus 로고
    • To model a psychiatric disorder in animals: Schizophrenia as a reality test
    • Lipska BK, Weinberger DR. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology 23(3), 223-239 (2000).
    • (2000) Neuropsychopharmacology , vol.23 , Issue.3 , pp. 223-239
    • Lipska, B.K.1    Weinberger, D.R.2
  • 26
    • 0032527894 scopus 로고    scopus 로고
    • Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine
    • Adams B, Moghaddam B. Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J. Neurosci. 18(14), 5545-5554 (1998).
    • (1998) J. Neurosci , vol.18 , Issue.14 , pp. 5545-5554
    • Adams, B.1    Moghaddam, B.2
  • 27
    • 0037308979 scopus 로고    scopus 로고
    • Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: Differential modulation by antipsychotic drugs
    • Cochran SM, Kennedy M, McKerchar CE, Steward LJ, Pratt JA, Morris BJ. Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs. Neuropsychopharmacology 28(2), 265-275 (2003).
    • (2003) Neuropsychopharmacology , vol.28 , Issue.2 , pp. 265-275
    • Cochran, S.M.1    Kennedy, M.2    McKerchar, C.E.3    Steward, L.J.4    Pratt, J.A.5    Morris, B.J.6
  • 28
    • 35548983971 scopus 로고    scopus 로고
    • Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine
    • Kargieman L, Santana N, Mengod G, Celada P, Artigas F. Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine. Proc. Natl Acad. Sci. USA 104(37), 14843-14848 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.37 , pp. 14843-14848
    • Kargieman, L.1    Santana, N.2    Mengod, G.3    Celada, P.4    Artigas, F.5
  • 29
    • 0344442803 scopus 로고    scopus 로고
    • Pre-clinical models of cognitive dysfunction in schizophrenia: New avenues to addressing unmet needs
    • Jentsch J. Pre-clinical models of cognitive dysfunction in schizophrenia: new avenues to addressing unmet needs. Clin. Neurosci. Res. 3, 303-315 (2003).
    • (2003) Clin. Neurosci. Res , vol.3 , pp. 303-315
    • Jentsch, J.1
  • 30
    • 42749094416 scopus 로고    scopus 로고
    • Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex
    • Abekawa T, Ito K, Nakagawa S, Nakato Y, Koyama T. Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex. Schizophr. Res. 101(1-3), 84-94 (2008).
    • (2008) Schizophr. Res , vol.101 , Issue.1-3 , pp. 84-94
    • Abekawa, T.1    Ito, K.2    Nakagawa, S.3    Nakato, Y.4    Koyama, T.5
  • 31
    • 71849098622 scopus 로고    scopus 로고
    • The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-d-aspartate and D(1) receptor binding in rats
    • DOI:10.1016/j.neuroscience.2009. 10.039 , Epub ahead of print
    • Toua C, Brand L, Mo Ller M, Emsley RA, Harvey BH. The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-d-aspartate and D(1) receptor binding in rats. Neuroscience DOI:10.1016/j.neuroscience.2009. 10.039 (2009) (Epub ahead of print).
    • (2009) Neuroscience
    • Toua, C.1    Brand, L.2    Mo Ller, M.3    Emsley, R.A.4    Harvey, B.H.5
  • 32
    • 67349136493 scopus 로고    scopus 로고
    • Behavioral abnormality and pharmacologic response in social isolation-reared mice
    • Koike H, Ibi D, Mizoguchi H et al. Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behav. Brain Res. 202(1), 114-121 (2009).
    • (2009) Behav. Brain Res , vol.202 , Issue.1 , pp. 114-121
    • Koike, H.1    Ibi, D.2    Mizoguchi, H.3
  • 33
    • 33947123173 scopus 로고    scopus 로고
    • Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats
    • Li N, Wu X, Li L. Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats. Behav. Pharmacol. 18(2), 135-145 (2007).
    • (2007) Behav. Pharmacol , vol.18 , Issue.2 , pp. 135-145
    • Li, N.1    Wu, X.2    Li, L.3
  • 34
    • 33747053349 scopus 로고    scopus 로고
    • Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
    • Barr AM, Powell SB, Markou A, Geyer MA. Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology 51(3), 457-465 (2006).
    • (2006) Neuropharmacology , vol.51 , Issue.3 , pp. 457-465
    • Barr, A.M.1    Powell, S.B.2    Markou, A.3    Geyer, M.A.4
  • 35
    • 26844530147 scopus 로고    scopus 로고
    • Reversal of isolation-rearing-induced PPI deficits by an a7 nicotinic receptor agonist
    • Cilia J, Cluderay JE, Robbins MJ et al. Reversal of isolation-rearing-induced PPI deficits by an a7 nicotinic receptor agonist. Psychopharmacology (Berl.) 182(2), 214-219 (2005).
    • (2005) Psychopharmacology (Berl.) , vol.182 , Issue.2 , pp. 214-219
    • Cilia, J.1    Cluderay, J.E.2    Robbins, M.J.3
  • 36
    • 25644439235 scopus 로고    scopus 로고
    • Neurotensin-deficient mice have deficits in prepulse inhibition: Restoration by clozapine but not haloperidol, olanzapine, or quetiapine
    • Kinkead B, Dobner PR, Egnatashvili V, Murray T, Deitemeyer N, Nemeroff CB. Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapine. J. Pharmacol. Exp. Ther. 315(1), 256-264 (2005).
    • (2005) J. Pharmacol. Exp. Ther , vol.315 , Issue.1 , pp. 256-264
    • Kinkead, B.1    Dobner, P.R.2    Egnatashvili, V.3    Murray, T.4    Deitemeyer, N.5    Nemeroff, C.B.6
  • 37
    • 12244296144 scopus 로고    scopus 로고
    • The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat
    • Abdul-Monim Z, Reynolds GP, Neill JC. The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat. J. Psychopharmacol. 17(1), 57-66 (2003).
    • (2003) J. Psychopharmacol , vol.17 , Issue.1 , pp. 57-66
    • Abdul-Monim, Z.1    Reynolds, G.P.2    Neill, J.C.3
  • 38
    • 34447628356 scopus 로고    scopus 로고
    • Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats
    • Amitai N, Semenova S, Markou A. Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats. Psychopharmacology 193(4), 521-537 (2007).
    • (2007) Psychopharmacology , vol.193 , Issue.4 , pp. 521-537
    • Amitai, N.1    Semenova, S.2    Markou, A.3
  • 39
    • 32044451085 scopus 로고    scopus 로고
    • The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-X-sub(L)/ Bax ratio in the posterior cingulate cortex in rats
    • He J, Xu H, Yang Y, Rajakumar D, Li X, Li XM. The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-X-sub(L)/ Bax ratio in the posterior cingulate cortex in rats. Behav. Brain Res. 168(2), 236-242 (2006).
    • (2006) Behav. Brain Res , vol.168 , Issue.2 , pp. 236-242
    • He, J.1    Xu, H.2    Yang, Y.3    Rajakumar, D.4    Li, X.5    Li, X.M.6
  • 40
    • 33745868380 scopus 로고    scopus 로고
    • The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats
    • He J, Yang Y, Yu Y, Li X, Li XM. The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats. Behav. Brain Res. 172(1), 39-45 (2006).
    • (2006) Behav. Brain Res , vol.172 , Issue.1 , pp. 39-45
    • He, J.1    Yang, Y.2    Yu, Y.3    Li, X.4    Li, X.M.5
  • 41
    • 42749092601 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: Role of serotonin 5-HT-sub(1A) receptors
    • Hagiwara H, Fujita Y, Ishima T et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT-sub(1A) receptors. Eur. Neuropsychopharmacol. 18(6), 448-454 (2008).
    • (2008) Eur. Neuropsychopharmacol , vol.18 , Issue.6 , pp. 448-454
    • Hagiwara, H.1    Fujita, Y.2    Ishima, T.3
  • 42
    • 33846839304 scopus 로고    scopus 로고
    • Clozapine, SCH 23390 and α-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance
    • Dunn MJ, Killcross S. Clozapine, SCH 23390 and α-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance. Psychopharmacology 190(4), 403-414 (2007).
    • (2007) Psychopharmacology , vol.190 , Issue.4 , pp. 403-414
    • Dunn, M.J.1    Killcross, S.2
  • 43
    • 27744496919 scopus 로고    scopus 로고
    • Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress
    • Luo C, Xu H, Li XM. Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress. Brain Res. 1063(1), 32-89 (2005).
    • (2005) Brain Res , vol.1063 , Issue.1 , pp. 32-89
    • Luo, C.1    Xu, H.2    Li, X.M.3
  • 44
    • 23844547937 scopus 로고    scopus 로고
    • Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats
    • He J, Yang Y, Xu H, Zhang X, Li XM. Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology 30(8), 1511-1520 (2005).
    • (2005) Neuropsychopharmacology , vol.30 , Issue.8 , pp. 1511-1520
    • He, J.1    Yang, Y.2    Xu, H.3    Zhang, X.4    Li, X.M.5
  • 46
    • 33750377539 scopus 로고    scopus 로고
    • Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice
    • Hou Y, Wu CF, Yang JY, Guo T. Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 30(8), 1486-1495 (2006).
    • (2006) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.30 , Issue.8 , pp. 1486-1495
    • Hou, Y.1    Wu, C.F.2    Yang, J.Y.3    Guo, T.4
  • 47
    • 39149113460 scopus 로고    scopus 로고
    • Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats
    • Matsumoto M, Shikanai H, Togashi H et al. Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Brain Res. 1195, 50-55 (2008).
    • (2008) Brain Res , vol.1195 , pp. 50-55
    • Matsumoto, M.1    Shikanai, H.2    Togashi, H.3
  • 48
    • 38149075870 scopus 로고    scopus 로고
    • Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    • Elsworth JD, Jentseh JD, Morrow BA, Roth RH, Redmond DE Jr. Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Neuropsychopharmacology 33(3), 491-496 (2008).
    • (2008) Neuropsychopharmacology , vol.33 , Issue.3 , pp. 491-496
    • Elsworth, J.D.1    Jentseh, J.D.2    Morrow, B.A.3    Roth, R.H.4    Redmond Jr., D.E.5
  • 49
    • 10744223983 scopus 로고    scopus 로고
    • N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d- aspartate receptor activity
    • Sur C, Mallorga PJ, Wittmann M et al. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d- aspartate receptor activity. Proc. Natl Acad. Sci. USA 100(23), 13674-13679 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.23 , pp. 13674-13679
    • Sur, C.1    Mallorga, P.J.2    Wittmann, M.3
  • 50
    • 0028149927 scopus 로고
    • The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance
    • Buchanan RW, Holstein C, Breier A. The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance. Biol. Psychiatry 36(11), 717-725 (1994).
    • (1994) Biol. Psychiatry , vol.36 , Issue.11 , pp. 717-725
    • Buchanan, R.W.1    Holstein, C.2    Breier, A.3
  • 51
    • 0028019245 scopus 로고
    • Effects of clozapine on cognitive function in schizophrenia
    • Lee MA, Thompson PA, Meltzer HY. Effects of clozapine on cognitive function in schizophrenia. J. Clin. Psychiatry 55(Suppl. B), 82-87 (1994).
    • (1994) J. Clin. Psychiatry , vol.55 , Issue.SUPPL. B , pp. 82-87
    • Lee, M.A.1    Thompson, P.A.2    Meltzer, H.Y.3
  • 52
    • 0030967398 scopus 로고    scopus 로고
    • Does risperidone improve verbal working memory in treatment-resistant schizophrenia?
    • Green MF, Marshall BD Jr, Wirshing WC et al. Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am. J. Psychiatry 154(6), 799-804 (1997).
    • (1997) Am. J. Psychiatry , vol.154 , Issue.6 , pp. 799-804
    • Green, M.F.1    Marshall Jr, B.D.2    Wirshing, W.C.3
  • 53
    • 0032977410 scopus 로고    scopus 로고
    • The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia
    • Meltzer HY, McGurk SR. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophrenia Bull. 25(2), 233-255 (1999).
    • (1999) Schizophrenia Bull , vol.25 , Issue.2 , pp. 233-255
    • Meltzer, H.Y.1    McGurk, S.R.2
  • 54
    • 0036143756 scopus 로고    scopus 로고
    • Recent studies on the neurocognitive effects of second-generation antipsychotic medications
    • Green MF. Recent studies on the neurocognitive effects of second-generation antipsychotic medications. Curr. Opin. Psychiatry 15(1), 25-29 (2002).
    • (2002) Curr. Opin. Psychiatry , vol.15 , Issue.1 , pp. 25-29
    • Green, M.F.1
  • 55
    • 74949096420 scopus 로고    scopus 로고
    • Effect of atypical antipsychotic drugs on cognitive function in schizophrenia
    • Brenner HD, Boker W, Genner R Eds, Hogrefe & Huber Publishers, Ashland, OH, USA
    • Meltzer HY, McGurk SR. Effect of atypical antipsychotic drugs on cognitive function in schizophrenia. In: The treatment of schizophrenia: status and emerging trends. Brenner HD, Boker W, Genner R (Eds). Hogrefe & Huber Publishers, Ashland, OH, USA, 49-59 (2001).
    • (2001) The treatment of schizophrenia: Status and emerging trends , pp. 49-59
    • Meltzer, H.Y.1    McGurk, S.R.2
  • 56
    • 0033021909 scopus 로고    scopus 로고
    • The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: A review and meta-analysis
    • Keefe RSE, Silva SG, Perkins DO, Lieberman JA. The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophr. Bull. 25(2), 201-222 (1999).
    • (1999) Schizophr. Bull , vol.25 , Issue.2 , pp. 201-222
    • Keefe, R.S.E.1    Silva, S.G.2    Perkins, D.O.3    Lieberman, J.A.4
  • 57
    • 21244448316 scopus 로고    scopus 로고
    • Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. Int. J. Neuropsychopharmacol. 8(3), 457-472 (2005).
    • Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. Int. J. Neuropsychopharmacol. 8(3), 457-472 (2005).
  • 58
    • 0037097412 scopus 로고    scopus 로고
    • Another view of therapy for cognition in schizophrenia
    • Presents the indirect action hypothesis that the beneficial cognitive effects of second-generation antipsychotics (SGAs) observed in early studies were merely a release from the adverse effects of first-generation antipsychotics, •
    • Carpenter WT, Gold JM. Another view of therapy for cognition in schizophrenia. Biol. Psychiatry 51(12), 969-971 (2002). • Presents the indirect action hypothesis that the beneficial cognitive effects of second-generation antipsychotics (SGAs) observed in early studies were merely a release from the adverse effects of first-generation antipsychotics.
    • (2002) Biol. Psychiatry , vol.51 , Issue.12 , pp. 969-971
    • Carpenter, W.T.1    Gold, J.M.2
  • 59
    • 0022648764 scopus 로고
    • Memory deficits and anticholinergic levels in chronic schizophrenia
    • Perlick D, Stastny P, Katz I, Mayer M, Mattis S. Memory deficits and anticholinergic levels in chronic schizophrenia. Am. J. Psychiatry 143(2), 230-232 (1986).
    • (1986) Am. J. Psychiatry , vol.143 , Issue.2 , pp. 230-232
    • Perlick, D.1    Stastny, P.2    Katz, I.3    Mayer, M.4    Mattis, S.5
  • 60
    • 0019960101 scopus 로고
    • Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients
    • Tune LE, Strauss ME, Lew MF, Breitlinger E, Coyle JT. Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients. Am. J. Psychiatry 139(11), 1460-1462 (1982).
    • (1982) Am. J. Psychiatry , vol.139 , Issue.11 , pp. 1460-1462
    • Tune, L.E.1    Strauss, M.E.2    Lew, M.F.3    Breitlinger, E.4    Coyle, J.T.5
  • 61
    • 0034095251 scopus 로고    scopus 로고
    • Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol
    • Purdon SE, Jones BDW, Stip E et al. Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. Arch. Gen. Psychiatry 57(3), 249-258 (2000).
    • (2000) Arch. Gen. Psychiatry , vol.57 , Issue.3 , pp. 249-258
    • Purdon, S.E.1    Jones, B.D.W.2    Stip, E.3
  • 62
    • 2942565924 scopus 로고    scopus 로고
    • Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: A randomized, double-blind trial of olanzapine versus low doses of haloperidol
    • Keefe RSE, Seidman LJ, Christensen BK et al. Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol. Am. J. Psychiatry 161(6), 985-995 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , Issue.6 , pp. 985-995
    • Keefe, R.S.E.1    Seidman, L.J.2    Christensen, B.K.3
  • 63
    • 30944460855 scopus 로고    scopus 로고
    • Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis
    • Keefe RS, Seidman LJ, Christensen BK et al. Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis. Biol. Psychiatry 59(2), 97-105 (2006).
    • (2006) Biol. Psychiatry , vol.59 , Issue.2 , pp. 97-105
    • Keefe, R.S.1    Seidman, L.J.2    Christensen, B.K.3
  • 64
    • 17444362717 scopus 로고    scopus 로고
    • Treatment of cognitive impairment in early psychosis: A comparison of risperidone and haloperidol in a large long-term trial
    • Harvey PD, Rabinowitz J, Eerdekens M, Davidson M. Treatment of cognitive impairment in early psychosis: a comparison of risperidone and haloperidol in a large long-term trial. Am. J. Psychiatry 162(10), 1888-1895 (2005).
    • (2005) Am. J. Psychiatry , vol.162 , Issue.10 , pp. 1888-1895
    • Harvey, P.D.1    Rabinowitz, J.2    Eerdekens, M.3    Davidson, M.4
  • 65
    • 33645743002 scopus 로고    scopus 로고
    • The impact of atypical antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: A quantitative review
    • Thornton AE, Van Snellenberg JX, Sepehry AA, Honer WG. The impact of atypical antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: a quantitative review. Psychopharmacology 20(3), 335-346 (2006).
    • (2006) Psychopharmacology , vol.20 , Issue.3 , pp. 335-346
    • Thornton, A.E.1    Van Snellenberg, J.X.2    Sepehry, A.A.3    Honer, W.G.4
  • 66
    • 34948816016 scopus 로고    scopus 로고
    • Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: Is it a practice effect?
    • Provides empirical support for the notion that treatment-related cognitive improvements may not be greater than expected practice effects, ••
    • Goldberg TE, Goldman RS, Burdick KE et al. Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect? Arch. Gen. Psychiatry 64(10), 1115-1122 (2007). •• Provides empirical support for the notion that treatment-related cognitive improvements may not be greater than expected practice effects.
    • (2007) Arch. Gen. Psychiatry , vol.64 , Issue.10 , pp. 1115-1122
    • Goldberg, T.E.1    Goldman, R.S.2    Burdick, K.E.3
  • 67
    • 33750078103 scopus 로고    scopus 로고
    • Neurocognitive functioning in patients with first-episode schizophrenia: Results of a prospective 5-year follow-up study
    • Albus M, Hubmann W, Mohr F et al. Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 5-year follow-up study. Eur. Arch. Psychiatry Clin. Neurosci. 256(7), 442-451 (2006).
    • (2006) Eur. Arch. Psychiatry Clin. Neurosci , vol.256 , Issue.7 , pp. 442-451
    • Albus, M.1    Hubmann, W.2    Mohr, F.3
  • 68
    • 68049137330 scopus 로고    scopus 로고
    • A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia
    • Hill SK, Reilly JL, Harris MS et al. A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia. Schizophr. Res. 113(2-3), 167-175 (2009).
    • (2009) Schizophr. Res , vol.113 , Issue.2-3 , pp. 167-175
    • Hill, S.K.1    Reilly, J.L.2    Harris, M.S.3
  • 69
    • 67049161211 scopus 로고    scopus 로고
    • Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: A randomized, controlled 1-year follow-up comparison
    • Crespo-Facorro B, Rodriguez-Sanchez JM, Perez-Iglesias R et al. Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison. J. Clin. Psychiatry 70(5), 717-729 (2009).
    • (2009) J. Clin. Psychiatry , vol.70 , Issue.5 , pp. 717-729
    • Crespo-Facorro, B.1    Rodriguez-Sanchez, J.M.2    Perez-Iglesias, R.3
  • 70
    • 33845285511 scopus 로고    scopus 로고
    • Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects. Schizophr. Res. 89(1-3), 211-224 (2007). •• This is a meta-analysis that separately evaluates open-label and randomized double-blind controlled trials. Perhaps more interesting is an upcoming meta-analysis from this group, which includes Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) findings and is expected to report a small mean effect size (∼0.10) for the beneficial cognitive effects of SGAs.
    • Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects. Schizophr. Res. 89(1-3), 211-224 (2007). •• This is a meta-analysis that separately evaluates open-label and randomized double-blind controlled trials. Perhaps more interesting is an upcoming meta-analysis from this group, which includes Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) findings and is expected to report a small mean effect size (∼0.10) for the beneficial cognitive effects of SGAs.
  • 71
    • 0018079906 scopus 로고
    • The measurement of differential deficit
    • Chapman LJ, Chapman JP. The measurement of differential deficit. J. Psychiatry Res. 14, 303-311 (1978).
    • (1978) J. Psychiatry Res , vol.14 , pp. 303-311
    • Chapman, L.J.1    Chapman, J.P.2
  • 72
    • 0035095004 scopus 로고    scopus 로고
    • Demonstrating specific cognitive deficits: A psychometric perspective
    • Strauss ME. Demonstrating specific cognitive deficits: a psychometric perspective. J. Abnorm. Psychol. 110(1), 6-14 (2001).
    • (2001) J. Abnorm. Psychol , vol.110 , Issue.1 , pp. 6-14
    • Strauss, M.E.1
  • 73
    • 53249084473 scopus 로고    scopus 로고
    • General and specific cognitive deficits in schizophrenia: Goliath defeats David?
    • Presents the hypothesis that rather than tapping into domain-specific processes, clinical neuropsychological tests converge on a generalized cognitive factor, ••
    • Dickinson D, Ragland JD, Gold JM, Gur RC. General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biol. Psychiatry 64(9), 823-827 (2008). •• Presents the hypothesis that rather than tapping into domain-specific processes, clinical neuropsychological tests converge on a generalized cognitive factor.
    • (2008) Biol. Psychiatry , vol.64 , Issue.9 , pp. 823-827
    • Dickinson, D.1    Ragland, J.D.2    Gold, J.M.3    Gur, R.C.4
  • 74
    • 39549107542 scopus 로고    scopus 로고
    • Hill SK, Sweeney JA, Hamer RM et al. Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia. J. Int. Neuropsychol. Soc. 14(2), 209-221 (2008). • Uses clinical trial data to show that neuropsychological measures primarily assess a generalized cognitive factor, both prior to and after treatment.
    • Hill SK, Sweeney JA, Hamer RM et al. Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia. J. Int. Neuropsychol. Soc. 14(2), 209-221 (2008). • Uses clinical trial data to show that neuropsychological measures primarily assess a generalized cognitive factor, both prior to and after treatment.
  • 75
    • 33644924944 scopus 로고    scopus 로고
    • Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia
    • Harris MS, Reilly JL, Keshavan MS, Sweeney JA. Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia. Psychol. Med. 36(4), 485-494 (2006).
    • (2006) Psychol. Med , vol.36 , Issue.4 , pp. 485-494
    • Harris, M.S.1    Reilly, J.L.2    Keshavan, M.S.3    Sweeney, J.A.4
  • 76
    • 34247643916 scopus 로고    scopus 로고
    • Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial
    • Keefe RS, Bilder RM, Davis SM et al. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial. Arch. Gen. Psychiatry 64(6), 633-647 (2007).
    • (2007) Arch. Gen. Psychiatry , vol.64 , Issue.6 , pp. 633-647
    • Keefe, R.S.1    Bilder, R.M.2    Davis, S.M.3
  • 77
    • 66949133915 scopus 로고    scopus 로고
    • Cognitive effects of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: A randomized, open-label clinical trial (EUFEST)
    • Davidson M, Galderisi S, Weiser M et al. Cognitive effects of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: a randomized, open-label clinical trial (EUFEST). Am. J. Psychiatry 166(6), 675-682 (2009).
    • (2009) Am. J. Psychiatry , vol.166 , Issue.6 , pp. 675-682
    • Davidson, M.1    Galderisi, S.2    Weiser, M.3
  • 78
    • 34547218379 scopus 로고    scopus 로고
    • Keefe RS, Sweeney JA, Gu H et al. Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison. Am. J. Psychiatry 164(7), 1061-1071 (2007). •• Reports Comparison of Atypicals for First-Episode Psychosis (CAFE) findings regarding cognitive outcomes.
    • Keefe RS, Sweeney JA, Gu H et al. Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison. Am. J. Psychiatry 164(7), 1061-1071 (2007). •• Reports Comparison of Atypicals for First-Episode Psychosis (CAFE) findings regarding cognitive outcomes.
  • 79
    • 46449113979 scopus 로고    scopus 로고
    • Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS)
    • Keefe RS, Harvey PD, Goldberg TE et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophr. Res. 102(1-3), 108-115 (2008).
    • (2008) Schizophr. Res , vol.102 , Issue.1-3 , pp. 108-115
    • Keefe, R.S.1    Harvey, P.D.2    Goldberg, T.E.3
  • 80
    • 33746812609 scopus 로고    scopus 로고
    • A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis
    • Dickinson D, Ragland JD, Calkins ME, Gold JM, Gur RC. A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophr. Res. 85(1-3), 20-29 (2006).
    • (2006) Schizophr. Res , vol.85 , Issue.1-3 , pp. 20-29
    • Dickinson, D.1    Ragland, J.D.2    Calkins, M.E.3    Gold, J.M.4    Gur, R.C.5
  • 81
    • 48949099564 scopus 로고    scopus 로고
    • Initial Phase 2 trial of a nicotinic agonist in schizophrenia
    • Freedman R, Olincy A, Buchanan RW et al. Initial Phase 2 trial of a nicotinic agonist in schizophrenia. Am. J. Psychiatry 165(8), 1040-1047 (2008).
    • (2008) Am. J. Psychiatry , vol.165 , Issue.8 , pp. 1040-1047
    • Freedman, R.1    Olincy, A.2    Buchanan, R.W.3
  • 82
    • 0036853362 scopus 로고    scopus 로고
    • Impact of risperidone versus haloperidol on activities of daily living in the treatment of refractory schizophrenia
    • Liberman RP, Gutkind D, Mintz J et al. Impact of risperidone versus haloperidol on activities of daily living in the treatment of refractory schizophrenia. Comprehensive Psychiatry 43(6), 469-473 (2002).
    • (2002) Comprehensive Psychiatry , vol.43 , Issue.6 , pp. 469-473
    • Liberman, R.P.1    Gutkind, D.2    Mintz, J.3
  • 83
    • 0032704025 scopus 로고    scopus 로고
    • Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia
    • Manschreck TC, Redmond DA, Candela SF, Maher BA. Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia. J. Neuropsych. Clin. Neurosci. 11(4), 481-489 (1999).
    • (1999) J. Neuropsych. Clin. Neurosci , vol.11 , Issue.4 , pp. 481-489
    • Manschreck, T.C.1    Redmond, D.A.2    Candela, S.F.3    Maher, B.A.4
  • 84
    • 24944542801 scopus 로고    scopus 로고
    • Patient outcomes in schizophrenia II: The impact of cognition
    • Hofer A, Baumgartner S, Bodner T et al. Patient outcomes in schizophrenia II: the impact of cognition. Eur. Psychiatry 20(5-6), 395-402 (2005).
    • (2005) Eur. Psychiatry , vol.20 , Issue.5-6 , pp. 395-402
    • Hofer, A.1    Baumgartner, S.2    Bodner, T.3
  • 86
    • 4444254472 scopus 로고    scopus 로고
    • Quality of life in schizophrenia: The impact of psychopathology, attitude toward medication, and side effects
    • Hofer A, Kemmler G, Eder U, Edlinger M, Hummer M, Fleischhacker WW. Quality of life in schizophrenia: the impact of psychopathology, attitude toward medication, and side effects. J. Clin. Psychiatry 65(7), 932-939 (2004).
    • (2004) J. Clin. Psychiatry , vol.65 , Issue.7 , pp. 932-939
    • Hofer, A.1    Kemmler, G.2    Eder, U.3    Edlinger, M.4    Hummer, M.5    Fleischhacker, W.W.6
  • 87
    • 39049127765 scopus 로고    scopus 로고
    • Association of symptomatology and cognitive deficits to functional capacity in schizophrenia
    • Perlick DA, Rosenheck RA, Kaczynski R, Collins J, Bingham S. Association of symptomatology and cognitive deficits to functional capacity in schizophrenia. Schizophr. Res. 99(1-3), 192-199 (2008).
    • (2008) Schizophr. Res , vol.99 , Issue.1-3 , pp. 192-199
    • Perlick, D.A.1    Rosenheck, R.A.2    Kaczynski, R.3    Collins, J.4    Bingham, S.5
  • 88
    • 0032975810 scopus 로고    scopus 로고
    • Symptoms and cognition as predictors of community functioning: A prospective analysis
    • Norman RM, Malla AK, Cortese L et al. Symptoms and cognition as predictors of community functioning: a prospective analysis. Am. J. Psychiatry 156(3), 400-405 (1999).
    • (1999) Am. J. Psychiatry , vol.156 , Issue.3 , pp. 400-405
    • Norman, R.M.1    Malla, A.K.2    Cortese, L.3
  • 89
    • 0033522368 scopus 로고    scopus 로고
    • Social functioning and neurocognitive deficits in outpatients with schizophrenia: A 2-year follow-up
    • Dickerson F, Boronow JJ, Ringel N, Parente F. Social functioning and neurocognitive deficits in outpatients with schizophrenia: a 2-year follow-up. Schizophr. Res. 37(1), 13-20 (1999).
    • (1999) Schizophr. Res , vol.37 , Issue.1 , pp. 13-20
    • Dickerson, F.1    Boronow, J.J.2    Ringel, N.3    Parente, F.4
  • 90
    • 34047146487 scopus 로고    scopus 로고
    • Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: Findings from the NIMH CATIE study
    • Swartz MS, Perkins DO, Stroup TS et al. Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study. Am. J. Psychiatry 164(3), 428-436 (2007).
    • (2007) Am. J. Psychiatry , vol.164 , Issue.3 , pp. 428-436
    • Swartz, M.S.1    Perkins, D.O.2    Stroup, T.S.3
  • 91
    • 10044247109 scopus 로고    scopus 로고
    • Impact of atypical antipsychotics on quality of life in patients with schizophrenia
    • Awad AG, Voruganti LN. Impact of atypical antipsychotics on quality of life in patients with schizophrenia. CNS Drugs 18(13), 877-893 (2004).
    • (2004) CNS Drugs , vol.18 , Issue.13 , pp. 877-893
    • Awad, A.G.1    Voruganti, L.N.2
  • 92
    • 68449086874 scopus 로고    scopus 로고
    • Relationships among neurocognition, symptoms and functioning in patients with schizophrenia: A path-analytic approach for associations at baseline and following 24 weeks of antipsychotic drug therapy
    • Lipkovich IA, Deberdt W, Csernansky JG, Sabbe B, Keefe RS, Kollack-Walker S. Relationships among neurocognition, symptoms and functioning in patients with schizophrenia: a path-analytic approach for associations at baseline and following 24 weeks of antipsychotic drug therapy. BMC Psychiatry 9, 44 (2009).
    • (2009) BMC Psychiatry , vol.9 , pp. 44
    • Lipkovich, I.A.1    Deberdt, W.2    Csernansky, J.G.3    Sabbe, B.4    Keefe, R.S.5    Kollack-Walker, S.6
  • 93
    • 33745609207 scopus 로고    scopus 로고
    • Cognitive rehabilitation for schizophrenia and the putative role of motivation and expectancies
    • Velligan DI, Kern RS, Gold JM. Cognitive rehabilitation for schizophrenia and the putative role of motivation and expectancies. Schizophr. Bull. 32(3), 474-485 (2006).
    • (2006) Schizophr. Bull , vol.32 , Issue.3 , pp. 474-485
    • Velligan, D.I.1    Kern, R.S.2    Gold, J.M.3
  • 94
    • 67649910511 scopus 로고    scopus 로고
    • Abbreviated neuropsychological assessment in schizophrenia: Prediction of different aspects of outcome
    • Harvey PD, Keefe RS, Patterson TL, Heaton RK, Bowie CR. Abbreviated neuropsychological assessment in schizophrenia: prediction of different aspects of outcome. J. Clin. Exp. Neuropsychol. 31(4), 462-471 (2009).
    • (2009) J. Clin. Exp. Neuropsychol , vol.31 , Issue.4 , pp. 462-471
    • Harvey, P.D.1    Keefe, R.S.2    Patterson, T.L.3    Heaton, R.K.4    Bowie, C.R.5
  • 95
    • 33749645423 scopus 로고    scopus 로고
    • Cognitive dysfunction in schizophrenia: Convergence of gamma-aminobutyric acid and glutamate alterations
    • Lewis DA, Moghaddam B. Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch. Neurol. 63(10), 1372-1376 (2006).
    • (2006) Arch. Neurol , vol.63 , Issue.10 , pp. 1372-1376
    • Lewis, D.A.1    Moghaddam, B.2
  • 96
    • 54149109208 scopus 로고    scopus 로고
    • GABA neurons and the mechanisms of network oscillations: Implications for understanding cortical dysfunction in schizophrenia
    • One of the few bottom-up, translational neuroscience approaches capable of leading to effective procognitive pharmacological treatments, ••
    • Gonzalez-Burgos G, Lewis DA. GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia. Schizophr. Bull. 34(5), 944-961 (2008). •• One of the few bottom-up, translational neuroscience approaches capable of leading to effective procognitive pharmacological treatments.
    • (2008) Schizophr. Bull , vol.34 , Issue.5 , pp. 944-961
    • Gonzalez-Burgos, G.1    Lewis, D.A.2
  • 97
    • 0033705948 scopus 로고    scopus 로고
    • Inhibition-based rhythms: Experimental and mathematical observations on network dynamics
    • Whittington MA, Traub RD, Kopell N, Ermentrout B, Buhl EH. Inhibition-based rhythms: experimental and mathematical observations on network dynamics. Int. J. Psychophysiol. 38(3), 315-336 (2000).
    • (2000) Int. J. Psychophysiol , vol.38 , Issue.3 , pp. 315-336
    • Whittington, M.A.1    Traub, R.D.2    Kopell, N.3    Ermentrout, B.4    Buhl, E.H.5
  • 98
    • 16344372645 scopus 로고    scopus 로고
    • Cortical inhibitory neurons and schizophrenia
    • Lewis DA, Hashimoto T, Volk DW. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 6(4), 312-324 (2005).
    • (2005) Nat. Rev. Neurosci , vol.6 , Issue.4 , pp. 312-324
    • Lewis, D.A.1    Hashimoto, T.2    Volk, D.W.3
  • 99
    • 33845945707 scopus 로고    scopus 로고
    • Impairments in frontal cortical g synchrony and cognitive control in schizophrenia
    • Cho RY, Konecky RO, Carter CS. Impairments in frontal cortical g synchrony and cognitive control in schizophrenia. Proc. Natl Acad. Sci. USA 103(52), 19878-19883 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.52 , pp. 19878-19883
    • Cho, R.Y.1    Konecky, R.O.2    Carter, C.S.3
  • 100
    • 57349167353 scopus 로고    scopus 로고
    • Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia
    • Lewis DA, Cho RY, Carter CS et al. Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia. Am. J. Psychiatry 165(12), 1585-1593 (2008).
    • (2008) Am. J. Psychiatry , vol.165 , Issue.12 , pp. 1585-1593
    • Lewis, D.A.1    Cho, R.Y.2    Carter, C.S.3
  • 101
    • 46849095050 scopus 로고    scopus 로고
    • Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia
    • This is a unique report directly comparing the sensitivity of oculomotor and neuropsychological measures to antipsychotic treatments, ••
    • Hill SK, Reilly JL, Harris MS, Khine T, Sweeney JA. Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia. Schizophr. Bull. 34(3), 494-506 (2007). •• This is a unique report directly comparing the sensitivity of oculomotor and neuropsychological measures to antipsychotic treatments.
    • (2007) Schizophr. Bull , vol.34 , Issue.3 , pp. 494-506
    • Hill, S.K.1    Reilly, J.L.2    Harris, M.S.3    Khine, T.4    Sweeney, J.A.5
  • 102
    • 0034062159 scopus 로고    scopus 로고
    • Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications
    • Light GA, Geyer MA, Clementz BA, Cadenhead KA, Braff DL. Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications. Am. J. Psychiatry 157(5), 767-771 (2000).
    • (2000) Am. J. Psychiatry , vol.157 , Issue.5 , pp. 767-771
    • Light, G.A.1    Geyer, M.A.2    Clementz, B.A.3    Cadenhead, K.A.4    Braff, D.L.5
  • 103
    • 56349168983 scopus 로고    scopus 로고
    • Pharmacological treatment effects on eye movement control
    • A comprehensive review of the beneficial and adverse effects of antipsychotics on oculomotor paradigms, ••
    • Reilly JL, Lencer R, Bishop JR, Keedy S, Sweeney JA. Pharmacological treatment effects on eye movement control. Brain Cogn. 68(3), 415-435 (2008). •• A comprehensive review of the beneficial and adverse effects of antipsychotics on oculomotor paradigms.
    • (2008) Brain Cogn , vol.68 , Issue.3 , pp. 415-435
    • Reilly, J.L.1    Lencer, R.2    Bishop, J.R.3    Keedy, S.4    Sweeney, J.A.5
  • 104
    • 13244249919 scopus 로고    scopus 로고
    • Mismatch negativity deficits are associated with poor functioning in schizophrenia patients
    • Light GA, Braff DL. Mismatch negativity deficits are associated with poor functioning in schizophrenia patients. Arch. Gen. Psychiatry 62(2), 127-136 (2005).
    • (2005) Arch. Gen. Psychiatry , vol.62 , Issue.2 , pp. 127-136
    • Light, G.A.1    Braff, D.L.2
  • 105
    • 62149122593 scopus 로고    scopus 로고
    • An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia
    • Keedy SK, Rosen C, Khine T, Rajarethinam R, Janicak PG, Sweeney JA. An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia. Psychiatry Res. 172(1), 16-23 (2009).
    • (2009) Psychiatry Res , vol.172 , Issue.1 , pp. 16-23
    • Keedy, S.K.1    Rosen, C.2    Khine, T.3    Rajarethinam, R.4    Janicak, P.G.5    Sweeney, J.A.6
  • 106
    • 33745512492 scopus 로고    scopus 로고
    • Targeting information-processing deficit in schizophrenia: A novel approach to psychotherapeutic drug discovery
    • Hajos M. Targeting information-processing deficit in schizophrenia: a novel approach to psychotherapeutic drug discovery. Trends Pharmacol. Sci. 27(7), 391-398 (2006).
    • (2006) Trends Pharmacol. Sci , vol.27 , Issue.7 , pp. 391-398
    • Hajos, M.1
  • 108
    • 0346367105 scopus 로고    scopus 로고
    • Bringing order to the glutamate chaos in schizophrenia
    • Moghaddam B. Bringing order to the glutamate chaos in schizophrenia. Neuron 40(5), 881-884 (2003).
    • (2003) Neuron , vol.40 , Issue.5 , pp. 881-884
    • Moghaddam, B.1
  • 109
    • 33748529631 scopus 로고    scopus 로고
    • The neurobiology of cognition in schizophrenia
    • Tamminga CA. The neurobiology of cognition in schizophrenia. J. Clin. Psychiatry 67(Suppl. 9), 9-13 (2006).
    • (2006) J. Clin. Psychiatry , vol.67 , Issue.SUPPL. 9 , pp. 9-13
    • Tamminga, C.A.1
  • 110
    • 0035660267 scopus 로고    scopus 로고
    • Prefrontal neurons and the genetics of schizophrenia
    • Weinberger DR, Egan MF, Bertolino A et al. Prefrontal neurons and the genetics of schizophrenia. Biol. Psychiatry 50(11), 825-844 (2001).
    • (2001) Biol. Psychiatry , vol.50 , Issue.11 , pp. 825-844
    • Weinberger, D.R.1    Egan, M.F.2    Bertolino, A.3
  • 111
    • 4744376592 scopus 로고    scopus 로고
    • Interaction of COMT Val108/158 Met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    • Bertolino A, Caforio G, Blasi G et al. Interaction of COMT Val108/158 Met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. Am. J. Psychiatry 161(10), 1798-1805 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , Issue.10 , pp. 1798-1805
    • Bertolino, A.1    Caforio, G.2    Blasi, G.3
  • 112
    • 33846624143 scopus 로고    scopus 로고
    • COMT Val108/158Met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia
    • Woodward ND, Jayathilake K, Meltzer HY. COMT Val108/158Met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophr. Res. 90(1-3), 86-96 (2007).
    • (2007) Schizophr. Res , vol.90 , Issue.1-3 , pp. 86-96
    • Woodward, N.D.1    Jayathilake, K.2    Meltzer, H.Y.3
  • 113
    • 2942625728 scopus 로고    scopus 로고
    • Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression
    • Hill SK, Keshavan MS, Thase ME, Sweeney JA. Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression. Am. J. Psychiatry 161(6), 996-1003 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , Issue.6 , pp. 996-1003
    • Hill, S.K.1    Keshavan, M.S.2    Thase, M.E.3    Sweeney, J.A.4
  • 114
    • 11844252134 scopus 로고    scopus 로고
    • Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia
    • Reilly JL, Harris MSH, Keshavan MS, Sweeney JA. Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia. Biol. Psychiatry 57(2), 145-154 (2005).
    • (2005) Biol. Psychiatry , vol.57 , Issue.2 , pp. 145-154
    • Reilly, J.L.1    Harris, M.S.H.2    Keshavan, M.S.3    Sweeney, J.A.4
  • 115
    • 40849097803 scopus 로고    scopus 로고
    • Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia
    • Reilly JL, Harris MS, Khine TT, Keshavan MS, Sweeney JA. Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia. Biol. Psychiatry 63(8), 776-783 (2008).
    • (2008) Biol. Psychiatry , vol.63 , Issue.8 , pp. 776-783
    • Reilly, J.L.1    Harris, M.S.2    Khine, T.T.3    Keshavan, M.S.4    Sweeney, J.A.5
  • 116
    • 57849103895 scopus 로고    scopus 로고
    • Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia
    • Harris MS, Wiseman CL, Reilly JL, Keshavan MS, Sweeney JA. Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia. Neuropsychopharmacology 34(2), 468-476 (2009).
    • (2009) Neuropsychopharmacology , vol.34 , Issue.2 , pp. 468-476
    • Harris, M.S.1    Wiseman, C.L.2    Reilly, J.L.3    Keshavan, M.S.4    Sweeney, J.A.5


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