Interaction of COMT Val108/158 met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia

American Journal of Psychiatry

Volumn 161, Issue 10, 2004, Pages 1798-1805

  Bertolino, Alessandro ^a   Caforio, Grazia ^b   Blasi, Giuseppe ^b   De Candia, Mariapia ^b   Latorre, Valeria ^b   Petruzzella, Vittoria ^b   Altamura, Mario ^b   Nappi, Gaetano ^b   Papa, Sergio ^b   Callicott, Joseph H ^b   Mattay, Venkata S ^b   Bellomo, Antonello ^b   Scarabino, Tommaso ^b   Weinberger, Daniel R ^b   Nardini, Marcello ^b  

^a UNIVERSITY OF BARI   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CATECHOL METHYLTRANSFERASE; OLANZAPINE;

ADULT; ALLELE; ARTICLE; BRAIN FUNCTION; CATABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; NEGATIVE SYNDROME; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITIVE SYNDROME; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHIZOPHRENIA; SCORING SYSTEM; WORKING MEMORY;

EID: 4744376592     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.161.10.1798     Document Type: Article

References (53)

1. Baddeley A: Human Memory: Theory and Practice. New York, Taylor & Francis, 1990
2. Goldman-Rakic PS: The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. Biol Psychiatry 1999; 46:650-661
3. Cohen JD, Perlstein WM, Braver TS, Nystrom LE, Noll DC, Jonides J, Smith EE: Temporal dynamics of brain activation during a working memory task. Nature 1997; 386:604-608
4. Callicott JH, Mattay VS, Bertolino A, Finn K, Coppola R, Frank JA, Goldberg TE, Weinberger DR: Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex 1999; 9:20-26
5. Lidow MS, Williams GV, Goldman-Rakic PS: The cerebral cortex: a case for a common site of action of antipsychotics. Trends Pharmacol Sci 1998; 19:136-140
6. Seamans JK, Gorelova N, Durstewitz D, Yang CR: Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. J Neurosci 2001; 21:3628-3638
7. Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA, Coppola R, Berman KF, Goldberg TE, Weinberger DR: Effects of dextroamphetamine on cognitive performance and cortical activation. Neuroimage 2000; 12:268-275
8. Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, Kolachana B, Callicott JH, Weinberger DR: Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 2003; 100:6186-6191
9. Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW: Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci 2000; 20:RC65
10. Weickert TW, Goldberg TE, Gold JM, Bigelow LB, Egan MF, Weinberger DR: Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry 2000; 57:907-913
11. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT: Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J Abnorm Psychol 1999; 108:176-181
12. Egan MF, Goldberg TE, Gscheidle T, Weirich M, Bigelow LB, Weinberger DR: Relative risk of attention deficits in siblings of patients with schizophrenia. Am J Psychiatry 2000; 157:1309-1316
13. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kaprio J, Koskenvuo M: The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000; 67:369-382
14. Weinberger DR, Berman KF, Zec RF: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, I: regional cerebral blood flow evidence. Arch Gen Psychiatry 1986; 43:114-124
15. Bertolino A, Esposito G, Callicott JH, Mattay VS, Van Horn JD, Frank JA, Berman KF, Weinberger DR: Specific relationship between prefrontal neuronal N-acetylaspartate and activation of the working memory cortical network in schizophrenia. Am J Psychiatry 2000; 157:26-33
16. Bertolino A, Sciota D, Brudaglio F, Altamura M, Blasi G, Bellomo A, Antonucci N, Callicott JH, Goldberg TE, Scarabino T, Weinberger DR, Nardini M: Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder. Am J Psychiatry 2003; 160:483-489
17. Callicott JH, Ramsey NF, Tallent K, Bertolino A, Knable MB, Coppola R, Goldberg TE, van Gelderen P, Mattay VS, Frank JA, Moonen CT, Weinberger DR: Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology 1998; 18:186-196
18. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, Goldberg TE, Weinberger DR: Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 2000; 10:1078-1092
19. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, Saper CB, Warach S: Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry 1999; 45:1128-1137
20. Manoach DS: Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr Res 2003; 60:285-298
21. Barch DM, Sheline YI, Csernansky JG, Snyder AZ: Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression. Biol Psychiatry 2003; 53:376-384
22. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD: Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry 1998; 155:1285-1287
23. Quintana J, Wong T, Ortiz-Portillo E, Kovalik E, Davidson T, Marder SR, Mazziotta JC: Prefrontal-posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations. Biol Psychiatry 2003; 53:12-24
24. Perlstein WM, Dixit NK, Carter CS, Noll DC, Cohen JD: Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biol Psychiatry 2003; 53:25-38
25. Menon V, Anagnoson RT, Mathalon DH, Glover GH, Pfefferbaum A: Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms. Neuroimage 2001; 13:433-446
26. Weinberger DR: Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44:660-669
27. Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE: Catechol O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 2003; 23:2008-2013
28. Grace AA: Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 1991; 41:1-24
29. Carlsson A: The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1988; 1:179-186
30. Bertolino A, Knable MB, Saunders RC, Callicott JH, Kolachana B, Mattay VS, BachevalierJ, Frank JA, Egan M, Weinberger DR: The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia. Biol Psychiatry 1999; 45:660-667
31. Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, Huang Y, Hwang DR, Keilp J, Kochan L, Van Heertum R, Gorman JM, Laruelle M: Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 2002; 22:3708-3719
32. Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR: Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience 2003; 116:127-137
33. Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey Al: Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 1998; 18:2697-2708
34. Moron JA, Brockington A, Wise RA, Rocha BA, Hope BT: Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci 2002; 22:389-395
35. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M: Catechol O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 1998; 95:9991-9996
36. Liljequist R, Haapalinna A, Ahlander M, Li YH, Mannisto PT: Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav Brain Res 1997; 82:195-202
37. Gasparini M, Fabrizio E, Bonifati V, Meco G: Cognitive improvement during Tolcapone treatment in Parkinson's disease. J Neural Transm 1997; 104:887-894
38. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98:6917-6922
39. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J: Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34:4202-4210
40. Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL, Ni X, Goldman RS, Hoptman MJ, Sheitman B, Lindenmayer JP, Citrome L, McEvoy JP, Kunz M, Chakos M, Cooper TB, Lieberman JA: Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 2002; 52:701-707
41. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D: A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 2002; 159:652-654
42. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risen N, Zak NB, Darvasi A: A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 2002; 71:1296-1302
43. Gessa GL, Devoto P, Diana M, Flore G, Melis M, Pistis M: Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex. Neuropsychopharmacology 2000; 22:642-649
44. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders Research Version (SCID-I). New York, New York State Psychiatric Institute, Biometrics Research, 1996
45. Fristen KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RSJ: Statistical parametric mapping in functional imaging: a general approach. Hum Brain Mapp 1995; 2:189-210
46. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain: Three-Dimensional Proportional System. New York, Thieme Medical, 1988
47. Deutch AY: The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J Neural Transm Suppl 1992; 36:61-89
48. 1 dopamine receptor binding in neuroleptic-naive patients with schizophrenia. Am J Psychiatry 2002; 159:761-767
49. Tuppurainen H, Kuikka J, Viinamaki H, Husso-Saastamoinen M, Bergstrom K, Tiihonen J: Extrastriatal dopamine D(2/3) receptor density and distribution in drug-naive schizophrenic patients. Mol Psychiatry 2003; 8:453-455
50. Purdon SE, Jones BD, Slip E, Labelle A, Addington D, David SR, Breier A, Tollefson GD (Canadian Collaborative Group for Research in Schizophrenia): Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. Arch Gen Psychiatry 2000; 57:249-258
51. Manoach DS, Halpern EF, Kramer TS, Chang Y, Goff DC, Rauch SL, Kennedy DN, Gollub RL: Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am J Psychiatry 2001; 158:955-958
52. Press DZ, Mechanic DJ, Tarsy D, Manoach DS: Cognitive slowing in Parkinson's disease resolves after practice. J Neurol Neurosurg Psychiatry 2002; 73:524-528
53. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE: Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 2001; 50:825-844