Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis

Biological Psychiatry

Volumn 59, Issue 2, 2006, Pages 97-105

  Keefe, Richard S E ^a,k   Seidman, Larry J ^d   Christensen, Bruce K ^g   Hamer, Robert M ^b,c   Sharma, Tonmoy ^h   Sitskoorn, Margriet M ⁱ   Rock, Stephanie L ^j   Woolson, Sandra ^b   Tohen, Mauricio ^d,j   Tollefson, Gary D ^e,j   Sanger, Todd M ^j   Lieberman, Jeffrey A ^f  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c IL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e INDIANA UNIVERSITY   (United States)

^f Clinical Neuroscience Research Centre ^*  (United States)

^g UNIVERSITY OF TORONTO   (Canada)

^h NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

ⁱ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^j ELI LILLY AND COMPANY   (United States)

^k DUKE UNIVERSITY MEDICAL CENTER   (United States)

more..

Author keywords

Double blind; First episode; Haloperidol; Neurocognition; Olanzapine; Schizophrenia

Indexed keywords

HALOPERIDOL; OLANZAPINE;

ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; TASK PERFORMANCE;

ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; COGNITION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HALOPERIDOL; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PRINCIPAL COMPONENT ANALYSIS; PSYCHOTIC DISORDERS; STATISTICS, NONPARAMETRIC;

EID: 30944460855     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.06.022     Document Type: Article

References (60)

1. A.L. Benton, A.B. Sivan, KdeS. Hamsher, N.R. Varney, O. Spreen Contributions to Neuropsychological Assessment A Clinical Manual, Second Edition 1994 Oxford University Press New York
2. R.M. Bilder, R.S. Goldman, D. Robinson, G. Reiter, L. Bell, J.A. Bates Neuropsychology of first-episode schizophrenia Initial characterization and clinical correlates Am J Psychiatry 157 2000 549 559
3. R.M. Bilder, R.S. Goldman, J. Volavka, P. Czobor, M. Hoptman, B. Sheitman Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder Am J Psychiatry 159 2002 1018 1028
4. R.M. Bilder, E. Turkel, J.A. Bates, R.S. Goldman, J.A. Lieberman, N. Schooler Concurrent validation of computerized neurocognitive assessment tools Is the mouse mightier than the pen? Biol Psychiatry 49 suppl 1 2001 56S
5. R.M. Bilder, E. Turkel, L. Lipschutz-Broch, J.A. Lieberman Antipsychotic medication effects on neuropsychological functions Psychopharmaco Bull 28 1992 353 366
6. J.S. Brekke, A. Raine, M. Ansel, T. Lencz, L. Bird Neuropsychological and psychophysiological correlates of psychosocial functioning in schizophrenia Schizophr Bull 23 1997 19 28
7. R.W. Buchanan, C. Holstein, A. Breier The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance Biol Psychiatry 36 1994 717 725
8. W.T. Carpenter, J.M. Gold Another view of therapy for cognition in schizophrenia Biol Psychiatry 51 2002 969 971
9. C. Carter, L. Robertson, T. Nordahl, M. Chaderjian, L. Kraft, L. O'Shora-Celaya Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients Biol Psychiatry 40 1996 930 932
10. B.A. Cornblatt, J.G. Keilp Impaired attention, genetics, and the pathophysiology of schizophrenia Schizophr Bull 20 1994 31 46 Erratum in: Schizophr Bull 1994 20:248
11. B. Cornblatt, M. Obuchowski, S. Roberts, S. Pollack, L. Erlenmeyer-Kimling Cognitive and behavioral precursors of schizophrenia Dev Psychopathol 11 1999 487 508
12. D.C. Delis, J.H. Kramer, E. Kaplan, B.A. Ober The California Verbal Learning Test 1987 Psychological Corporation San Antonio, TX (Manual)
13. J.D. Evans, R.K. Heaton, J.S. Paulsen, B.W. Palmer, T. Patterson, D.V. Jeste The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenic patients Biol Psychiatry 53 2003 422 430
14. J.M. Gold, R.W. Goldberg, S.W. McNary, L.B. Dixon, A.F. Lehman Cognitive correlates of job tenure among patients with severe mental illness Am J Psychiatry 159 2002 1395 1402
15. C.J. Golden Stroop Color and Word Test Manual 1978 Stoelting Company Wood Dale, IL
16. M.F. Green What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153 1996 321 330
17. M.F. Green, R.S. Kern, D.L. Braff, J. Mintz Neurocognitive deficits and functional outcome in schizophrenia Are we measuring the "right stuff"? Schizophr Bull 26 2000 119 136
18. M.F. Green, S.R. Marder, S.M. Glynn, S.R. McGurk, W.C. Wirshing, D.A. Wirshing The neurocognitive effects of low-dose haloperidol A two-year comparison with risperidone Biol Psychiatry 51 2002 972 978
19. M.F. Green, B.D. Marshall Jr, W.C. Wirshing, D. Ames, S.R. Marder, S. McGurk Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am J Psychiatry 154 1997 799 804
20. C. Hagger, P. Buckley, J.T. Kenny, L. Friedman, D. Ubogy, H.Y. Meltzer Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine Biol Psychiatry 34 1993 702 712
21. P.D. Harvey, M.F. Green, S.R. McGurk, H.Y. Meltzer Changes in cognitive functioning with risperidone and olanzapine treatment A large-scale, double-blind, randomized study Psychopharmacology 169 2003 404 411 (Berl)
22. P.D. Harvey, E. Howanitz, M. Parrella, L. White, M. Davidson, R.C. Mohs Symptoms, cognitive functioning, and adaptive skills in geriatric patients with lifelong schizophrenia A comparison across treatment sites Am J Psychiatry 155 1998 1080 1086
23. P.D. Harvey, R.S.E. Keefe Cognitive impairment in schizophrenia and implications of atypical neuroleptic treatment CNS Spectr 2 1997 1 11
24. P.D. Harvey, R.S.E. Keefe Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment Am J Psychiatry 158 2001 176 184
25. K.A. Hawkins, B.E. Wexler California Verbal Learning Test practice effects in a schizophrenia sample Schizophr Res 39 1999 73 78
26. R.K. Heaton Wisconsin Card Sorting Test Manual 1993 Psychological Assessment Resources Odessa, FL
27. R.W. Heinrichs, K.K. Zakzanis Neurocognitive deficit in schizophrenia A quantitative review of the evidence Neuropsychology 12 1998 426 445
28. A.L. Hoff, D. Harris, W.O. Faustman, M. Beal, D. DeVilliers, R.D. Mone A neuropsychological study of early onset schizophrenia Schizophr Res 20 1996 21 28
29. A.L. Hoff, H. Riordan, D.W. O'Donnell, L. Morris, L.E. DeLisi Neuropsychological functioning of first-episode schizophreniform patients Am J Psychiatry 149 1992 898 903
30. Keefe RSE, Gold JM (in press): Pharmacologic Effects on Cognitive Deficits in Schizophrenia. London: Science Press.
31. R.S.E. Keefe, L.J. Seidman, B.K. Christensen, R.M. Hamer, T. Sharma, M.M. Sitskoorn Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis A randomized, double-blind trial of olanzapine versus low doses of haloperidol Am J Psychiatry 161 2004 985 995
32. R.S.E. Keefe, S.G. Silva, D.O. Perkins, J.A. Lieberman The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia A review and meta-analysis Schizophr Bull 25 1999 201 222
33. R.S.E. Keefe, J.M. Silverman, R.C. Mohs, L.J. Siever, P.D. Harvey, L. Friedman Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia Arch Gen Psychiatry 54 1997 169 176
34. M.A. Lee, P.A. Thompson, H.Y. Meltzer Effects of clozapine on cognitive function in schizophrenia J Clin Psychiatry 55 1994 82 87
35. H.Y. Meltzer, S.R. McGurk The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia Schizophr Bull 25 1999 233 255
36. A.L. Mishara, T.E. Goldberg A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia Opening a closed book Biol Psychiatry 55 2004 1013 1022
37. S. Mohamed, J.S. Paulsen, D. O'Leary, S. Arndt, N. Andreasen Generalized cognitive deficits in schizophrenia A study of first-episode patients Arch Gen Psychiatry 56 1999 749 754
38. H.E. Nelson National Adult Reading Test (NART) 2nd ed. 1991 NFER-NELSON, (NART-Revised) Windsor, England
39. K.H. Neuchterlein, M.E. Dawson, J. Ventura, D. Miclowitz, G. Konishi Information-processing anomalies in the early course of schizophrenia and bipolar disorder Schizophr Res 5 1991 195 196
40. R.C. Oldfield The assessment and analysis of handedness The Edinburgh inventory Neuropsychologia 9 1971 97 113
41. S.E. Purdon Cognitive improvement in schizophrenia with novel antipsychotic medications Schizophr Res 35 suppl 1999 S51 S60
42. S.E. Purdon, B.D. Jones, E. Stip, A. Labelle, D. Addington, S.R. David The Canadian Collaborative Group for research in schizophrenia Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol Arch Gen Psychiatry 57 2000 249 258
43. S.E. Purdon, A. Malla, A. Labelle, W. Lit Neuropsychological change in patients with schizophrenia after treatment with quetiapine or haloperidol J Psychiatry Neurosci 26 2001 137 149
44. R.M. Ruff Ruff Figural Fluency Test Manual 1996 Psychological Assessment Resources Odessa, FL
45. A.J. Saykin, D.L. Shtasel, R.E. Gur, D.B. Kester, L.H. Mozley, P. Stafiniak, R.C. Gur Neuropsychological deficits in neuroleptic naïve patients with first-episode schizophrenia Arch Gen Psychiatry 51 1994 124 131
46. K.W. Sax, S.M. Strakowski, P.E. Keck, S.L. McElroy, S.A. West, S.P. Stanton Symptom following affective correlates of attentional improvement hospitalization for a first episode of psychosis Biol Psychiatry 44 1998 784 786
47. L.J. Seidman Schizophrenia and brain dysfunction An integration of recent neurodiagnostic findings Psychol Bull 94 1983 195 238
48. L.J. Seidman, G. Cassens, W.S. Kremen, J.R. Pepple The neuropsychology of schizophrenia R.F. White Clinical Syndromes in Adult Neuropsychology 1992 Elsevier Science Amsterdam 381 450
49. L.J. Seidman, M. Oscar-Berman, A.G. Kalinowski, O. Ajilore Experimental and clinical neuropsychological measures of prefrontal dysfunction in schizophrenia Neuropsychology 9 1995 481 490
50. L.J. Seidman, J.R. Pepple, S.V. Faraone, W.S. Kremen, A.I. Green, W.A. Brown, M.T. Tsuang Neuropsychological performance in chronic schizophrenia in response to neuroleptic dose reduction Biol Psychiatry 33 1993 575 584
51. T. Sharma, C. Hughes, W. Soni, V. Kumari Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia Psychopharmacology 16 2003 398 403
52. O. Spreen, E. Strauss A Compendium of Neuropsychological Tests Administration, Norms, and Commentary 2nd ed. 1998 Oxford University Press New York
53. E. Stip, I. Lussier The effect of risperidone on cognition in patients with schizophrenia Can J Psychiatry 41 suppl 2 1996 S35 S40
54. D.I. Velligan, C.C. Bow-Thomas Executive function in schizophrenia Semin Clin Neuropsychiatry 4 1999 24 33
55. D.I. Velligan, C.C. Bow-Thomas, R.K. Mahurin, A.L. Miller, L.C. Halgunseth Do specific neurocognitive deficits predict specific domains of community function in schizophrenia? J Nerv and Mental Dis 188 2000 518 524
56. D.I. Velligan, R.K. Mahurin, P.L. Diamond, B.C. Hazleton, S.L. Eckert, A.L. Miller The functional significance of symptomatology and cognitive function in schizophrenia Schizophr Res 25 1997 21 31
57. D.I. Velligan, J. Newcomer, J. Pultz, J. Csernansky, A.L. Hoff, R.K. Mahurin, A.L. Miller Does cognitive function improve with quetiapine in comparison to haloperidol? Schizophr Res 53 2002 239 248
58. D. Wechsler Wechsler Adult Intelligence Scale-Revised 1974 Psychological Corporation San Antonio, TX
59. D. Wechsler Wechsler Memory Scale-Revised 1987 The Psychological Corporation San Antonio, TX
60. T.W. Weickert, T.E. Goldberg, J.M. Gold, L.B. Bigelow, M.F. Egan, D.R. Weinberger Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect Arch Gen Psychiatry 57 2000 907 913 Erratum in: Arch Gen Psychiatry 2000;57:1122