Kinetics and clonality of immunological memory in humans

Seminars in Immunology

Volumn 16, Issue 5, 2004, Pages 315-321

  Beverley, Peter C L ^a  

^a EDWARD JENNER INST FOR VACC RES   (United Kingdom)

Author keywords

Human; Kinetics; Memory; Telomerase; Telomere

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; TELOMERASE;

AGING; CELL DIVISION; CELL FUNCTION; CELL HETEROGENEITY; CELL KINETICS; CELL MIGRATION; CELL POPULATION; ENZYME REGULATION; HUMAN; IMMUNIZATION; IMMUNOLOGICAL MEMORY; MEMORY CELL; NONHUMAN; PHENOTYPE; REVIEW; T LYMPHOCYTE; TELOMERE;

EID: 7444256078     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2004.08.012     Document Type: Article

References (95)

1. W.E. Demkowicz, R.A. Littaua, J. Wang, and F.A. Ennis Human cytotoxic T-cell memory: long-lived response to vaccinia virus J Virol 70 1996 2627 2631
2. S.M. Hsieh, S.C. Pan, S.Y. Chen, P.F. Huang, and S.C. Chang Age distribution for T cell reactivity to vaccinia virus in a healthy population Clin Infect Dis 38 2004 86 89
3. S. Crotty, and R. Ahmed Immunological memory in humans Semin Immunol 16 2004 197 203
4. U. Klein, K. Rajewsky, and R. Kuppers Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mytated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells J Exp Med 188 1998 1679 1689
5. I. Forster, and K. Rajewsky The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow Proc Natl Acad Sci USA 87 1990 4781 4784
6. D. Kipling, and H.J. Cooke Hypervariable ultra-long telomeres in mice Nature 347 1990 400 402
7. G. Pawelec, Y. Barnett, R. Forsey, D. Frasca, A. Globerson, and J. McLeod T cells and aging, January 2002 update Front Biosci 7 2002 d1056 d1083
8. Russell JC. Populations in Europe 500-1500. In Cipola 1978;1:25-71.
9. D.C. Douek, R.D. McFarland, P.H. Keiser, EA. Gage, J.M. Massey, and D.F. Haynes Changes in thymic function with age and during the treatment of HIV infection Nature 396 1998 690 695
10. C.L. Mackall, and R.E. Gress Thymic aging and T-cell regeneration Immunol Rev 160 1997 91 102
11. T.T. Yoshikawa Perspective: aging and infectious diseases: past, present, and future J Infect Dis 176 1997 1053 1057
12. S. Crotty, P. Felgner, H. Davies, J. Glidewell, L. Villarreal, and R. Ahmed Cutting edge: long-term B cell memory in humans after smallpox vaccination J Immunol 171 2003 4969 4973
13. P. Van Damme, J. Banatvala, O. Fay, S. Iwarson, B. McMahon, and K. Van Herck Hepatitis A booster vaccination: is there a need? Lancet 362 2003 1065 1071
14. E. Hammarlund, M.W. Lewis, S.G. Hansen, L.I. Strelow, J.A. Nelson, and G.J. Sexton Duration of antiviral immunity after smallpox vaccination Nat Med 9 2003 1131 1137
15. A.Z. La Croix, S. Lipson, T.P. Miles, and L. Whilte Prospective study of pneumonia hospitalisation and mortality of U.S. older people: the role of chronic conditions, health behavious and nutritional status Publ Health Rep 104 1989 350 360
16. B. Chattopadhyay, and M. Al Zahawi Septicaemia and its unacceptably high mortality in the elderly J Infect 7 1983 134 138
17. M.J. Sprenger, P.G. Mulder, W.E. Beyer, R. Van Strik, and N. Masurel Impact of influenza on mortality in relation to age and underlying disease, 1967-1989 Int J Epidemiol 22 1993 334 340
18. R. Berger, G. Florent, and M. Just Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged Infect Immun 32 1981 24 27
19. Y. Zhang, M. Cosyns, M.J. Levin, and A.R. Hayward Cytokine production in varicella zoster virus-limiting dilution lymphocyte cultures Clin Exp Immunol 98 1994 128 133
20. R.R. Amara, P. Nigam, S. Sharma, J. Liu, and V. Bostik Long-lived poxvirus immunity, robust CD4 help, and better persistence of CD4 than CD8 T cells J Virol 78 2004 3811 3816
21. N. Khan, N. Shariff, M. Cobbold, R. Bruton, J.A. Ainsworth, and A.J. Sinclair Cytomegalovirus seropositivity drives the CD8 Tcell repertoire toword greater clonality in healthy elderly individuals J Immunol 169 2002 1984 1992
22. Q. Ouyang, W.M. Wagner, W. Zheng, A. Wikby, E.J. Remarque, and G. Pawelec Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly Exp Gerontol 39 2004 607 613
23. K. Murali-Krishna, L.L. Lau, S. Sambhara, F. Lemmier, J. Altmann, and R. Ahmed Persistence of memory CD8 T cells in MHC class I-deficient mice Science 286 1999 1267 1268
24. S.M. Kaech, E.J. Wherry, and R. Ahmed Effector and memory T-cell differentiation: implications for vaccine development Nat Rev Immunol 2 2002 251 262
25. D.F. Tough, P. Borrow, and J. Sprent Induction of bystander T cell proliferation by viruses and Type 1 interferon in vivo Science 272 1996 1947 1950
26. G. Eberl, P. Brawand, and H.R. MacDonald Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation J Immunol 165 2000 4305 4311
27. J. Geginat, F. Sallusto, and A. Lanzavecchia Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells Pathol Biol (Paris) 51 2003 64 66
28. M. Berard, K. Brandt, S. Bulfone-Paus, and D.F. Tough IL-15 promotes the survival of naive and memory phenotype CD8+ T cells J Immunol 170 2003 5018 5026
29. P. Marrack, and J. Kappler Control of T cell viability Annu Rev Immunol 22 2004 765 787
30. N.L. Bernasconi, E. Traggiai, and A. Lanzavecchia Maintenance of serological memory by polyclonal activation of human memory B cells Science 298 2002 2199 2202
31. L. Hayflick Living forever and dying in the attempt Exp Gerontol 38 2003 1231 1242
32. K.E. Buckton, W.M. Court Brown, and P.G. Smith Lymphocyte survival in men treated with X-rays for ankylosing spondylitis Nature 214 1967 470 473
33. K.T. Bogen Reassessment of human peripheral T-lymphocyte lifespan deduced from cytogenetic and cytotoxic effects of radiation Int J Radiat Biol 64 1993 195 204
34. C.A. Michie, A. McLean, C. Alcock, and P.C.L. Beverley Lifespan of human lymphocyte subsets defined by CD45 isoforms Nature 360 1992 264 265
35. A. McLean, and C.A. Michie In vivo estimates of division and death rates of human T lymphocytes Proc Natl Acad Sci 92 1995 3797 3811
36. D.F. Tough, and J. Sprent Turnover of naive- and memory-phenotype T cells J Exp Med 179 1994 1127 1135
37. D.C. Macallan, C.A. Fullerton, R. Neese, K. Haddock, S. Park, and M.K. Hellerstein Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: studies in vitro, in animals and in humans Proc Natl Acad Sci 95 1998 708 713
38. D.C. Macallan, B. Asquith, A. Irvine, D.L. Wallace, A. Worth, and H. Ghattas Measurement and modeling of human T cell kinetics Eur J Immunol 33 2003 2316 2326
39. D.C. Macallan, B. Asquith, A. Irvine, D.L. Wallace, A. Worth, and H. Ghattas Correction: measurement and modeling of human T cell kinetics Eur J Immunol 33 2003 2947
40. V. Lundblad, and W.E. Wright Telomeres and telomerase: a simple picture becomes complex Cell 87 1996 369 375
41. B.T. Hu, S.C. Lee, E. Marin, D.H. Ryan, and R.A. Insel Telomerase is up-regulated in human germinal centre B cells in vivo and can be re-expressed in memory B cells activaed in vitro J Immunol 159 1997 1068 1071
42. N.P. Weng, L. Granger, and R.J. Hodes Telomere lengthening and telomerase activation during human B cell differentiation Proc Natl Acad Sci 94 1997 10827 10832
43. M.K. Maini, Soares MVD, C.F. Zilch, A.N. Akbar, and P.C.L. Beverley Virus-induced CD8+T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence J Immunol 162 1999 4521 4526
44. N.-P. Weng, B.L. Levine, C.H. June, and R.J. Hodes Human naive and memory T lymphocytes differ in telomeric length and replicative potential Proc Natl Acad Sci 92 1995 11091 11094
45. H.F. Valenzuela, and R.B. Effros Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus Clin Immunol 105 2002 117 125
46. N. Rufer, M. Migliaccio, J. Antonchuk, R.K. Humphries, E. Roosnek, and P.M. Lansdorp Transfer of the human tleomerase reverse transcriptase (TERT) gene into T lymphocytes, results in extension of replicative potential Blood 98 2001 597 603
47. R.M. Luiten, J. Pene, H. Yssel, and H. Spits Ectopic hTERT expression extends the life span of human CD+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis Blood 101 2003 4512 4519
48. D. Xu, S. Erickson, M. Szeps, A. Gruber, O. Sangfelt, and S. Einhorn Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells Blood 96 2000 431 438
49. J.R. Reed, M. Vukmanovic-Stejic, J.M. Fletcher, M.V. Soares, J.E. Cook, and C.H. Orteu Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo J Exp Med 17 2004 1433 1443
50. T.R. Mosmann, and R.L. Coffman TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties Annu Rev Immunol 7 1989 145 173
51. S. Romagnani Lymphokine production by human T cells in disease states Annu Rev Immunol 12 1994 227 258
52. F. Sallusto, D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 1999 708 712
53. M.K. Hellerstein, R.A. Hoh, M.B. Hanley, D. Ceasr, D. Lee, and R.A. Neese Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection J Clin Invest 112 2003 956 966
54. A.N. Akbar, N.J. Borthwick, M. Salmon, W. Gombert, M. bofel, and N. Shamsadeen The significance of low bcl-2 expression by CD45R0 T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory J Exp Med 178 1993 427 438
55. M.F.C. Callan, C. Fazou, H.B. Yang, T. Rostron, K. Poon, and C. Hatton CD8+ T-cell selection, function, and death in the primary response in vivo J Clin Invest 106 2000 1251 1261
56. D.C. Macallan, D.L. Wallace, A.J. Irvine, B. Asquith, A. Worth, and H. Ghattas Rapid turnover of T cells in acute infectious mononucleosis Eur J Immunol 33 2003 2655 2665
57. L.E. Harrington, R.R. Most, J.L. Whitton, and R. Ahmed Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope J Virol 76 2002 3329 3337
58. D. Hamann, P.A. Baars, M.H.G. Rep, B. Hooibrink, S.R. Kerkhof-Garde, and M.R. Klein Phenotypic and functional separation of memory and effector human CD8+ T cells J Exp Med 186 1997 1407 1418
59. D. Hamann, S. Kostense, K.C. Wolthers, S.A. Otto, P.A. Baars, and F. Miedema Evidence that human CD8+CD45RA+CD27-cells are induced by antigen and evolve through extensive rounds of division Int Immunol 11 1999 1027 1033
60. M.K. Maini, N. Gudgeon, L.R. Wedderburn, A.B. Rickinson, and P.C.L. Beverley Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype J Immunol 165 2000 5729 5737
61. J.M. Faint, N.E. Annels, S.J. Curnow, P. Shields, D. Pilling, and A.D. Hislop Memory Cells constitute and subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics J Immunol 167 2001 212 220
62. P.J. Dunne, J.M. Faint, N.H. Gudgeon, J.M. Fletcher, F.J. Plunkett, and M.V. Soares Epstein Barr virus-specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential Blood 100 2002 933 940
63. M.R. Wills, G. Okecha, M.P. Weekes, P.J. Sissons, and A.J. Carmichael Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response J Immunol 168 2002 5455 5464
64. D.L. Wallace, Y. Zhang, H. Ghattas, A. Worth, A. Irvine, and A.R. Bennett Changes in T cell turnover in healthy elderly men and women J. Immunol. 173 2004 1787 1794
65. Y. Fujii, M. Okumura, K. Inada, and K. Nakahara Reversal of CD45R isoform switching in CD8+ T cells Cell Immunol 139 1992 176 184
66. M. Plebanski, M. Saunders, S.S. Burtles, S. Crowe, and D.C. Hooper Primary and secondary human in vitro T-cell responses to soluble antigens are mediated by subsets bearing different CD45 isoforms Immunology 75 1992 86 91
67. J.L. Young, J.S.H. Gaston, and P.C.L. Beverley In vitro responses of human CD45RObrightRA- and CD45RO-CD45RA bright T cell subsets and their relationship to memory and naive T cells Eur J Immunol 27 1997 2383 2389
68. C. Morimoto, and S.F.P. Schlossman Rambotti Lecture. Human naive and memory T cells revisited: new markers (CD31 and CD27) that help define CD4+ T cell subsets. Clin Exp Rheumatol 11 1993 241 247
69. C.H. Kim, L. Rott, E.J. Kunkel, M.C. Genovese, D.P. Andrew, and L. Wu Rules of chemokine receptor association with T cell polarization in vivo J Clin Invest 108 2001 1331 1339
70. I. Gomez, U. Hainz, B. Jenewein, S. Schwaiger, A.M. Wolf, and B. Grubeck-Loebenstein Changes in the expression of CD31 and CXCR3 in CD4+ naive T cells in elderly persons Mech Ageing Dev 124 2003 395 402
71. S. Kimmig, G.K. Przybylski, C.A. Schmidt, K. Laurisch, B. Mowes, and A. Radbruch Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood J Exp Med 195 2002 789 794
72. M.K. Maini, G. Casorati, P. Dellabona, A. Wack, and P.C.L. Beverley T-cell clonality in immune responses Immunol Today 20 1999 262 266
73. D. Homann, L. Teyton, and M.B. Oldstone Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory Nat Med 7 2001 913 919
74. I.G. Ovsyannikova, N. Dhiman, R.M. Jacobson, R.A. Vierkant, and G.A. Poland Frequency of measles virus-specific CD4+ and CD8+ T cells in subjects seronegative or highly seropositive for measles vaccine Clin Diagn Lab Immunol 10 2003 411 416
75. M.K. Maini, L.R. Wedderburn, F.C. Hall, A. Wack, G. Casorati, and P.C.L. Beverley A comparison of two techniques for the molecular tracking of specific T-cell responses: CD4+ T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population Immunology 94 1998 529 535
76. J.E. Callahan, J.W. Kappler, and P. Marrack Unexpected expansions of CD8-bearing cells in old mice J Immunol 151 1993 6657 6669
77. M.F.C. Callan, N. Steven, P. Krausa, J.D. Wilson, P.A. Moss, and G.M. Gillespie Large clonal expansions of CD8+ T cells in acute infectious mononucleosis Nat Med 2 1996 906 911
78. L.C. Tan, N. Gudgeon, N.E. Annels, P. Hansasuta, C.A. O'Callaghan, and S. Rowland-Jones A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers J Immunol 16 1999 1827 1835
79. V. Baron, C. Bouneaud, A. Cumano, A. Lim, T.P. Arstila, and P. Kourisky The repertoires of circulating human central and effector memory T cell subsets are largely distinct Immunity 18 2003 193 204
80. N.E. Annels, M.F. Callan, L. Tan, and A.B. Rickinson Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response J Immunol 165 2000 4831 4841
81. L.R. Wedderburn, R.E. O'Hehir, C.R.A. Hewitt, J.R. Lamb, and M.J. Owen In-vivo clonal dominance and limited T-cell receptor usage in human CD4(+) T-cell recognition of house dust mite allergens Proc Natl Acad Sci 90 1993 8214 8218
82. A.D. Hislop, N.E. Annels, N.H. Gudgeon, A.M. Leese, and A.B. Rickinson Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection J Exp Med 195 2002 893 905
83. M.P. Davenport, C. Fazou, A.J. McMichael, and M.F. Callan Clonal selection, clonal senescence, and clonal succession: the evolution of the T cell response to infection with a persistent virus J Immunol 168 2002 3309 3317
84. R.M. Welsh, K. Bahl, and X.Z. Wang Apoptosis and loss of virus-specific CD8+ T-cell memory Curr Opin Immunol 16 2004 271 276
85. P. Champagne, G.S. Ogg, A.S. King, C. Knabenhans, K. Ellefsen, and M. Nobile Skewed maturation of memory HIV-specific CD8 T lymphocytes Nature 410 2001 106 111
86. V. Appay, P.R. Dunbar, and M. Callan Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections Nat Med 8 2002 379 385
87. A.D. Hislop, N.H. Gudgeon, and M.F. Callan EBV-specific CD8+ T cell memory: relationships betwween epitope specificity, cell phenotype and immediate effector function J Immunol 167 2001 2019 2029
88. E. Amyes, C. Hatton, and D. Montamat-Sicotte Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection J Exp Med 198 2003 903 911
89. T.W. Kuijpers, M.T. Vossen, and M.R. Gent Frequencies of circulating cytolytic, CD45RA+CD27-CD8+ T lymphocytes depend on infection with CMV J Immunol 170 2003 4342 4348
90. F. Kern, E. Khatamzas, and I. Surel Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms Eur J Immunol 29 1997 2908 2915
91. A. Cossarizza, C. Ortolani, and R. Paganelli CD45 isoforms expression on CD4(+) and CD8(+) T-cells throughout life, from newborns to centenarians - implications for T-cell memory Mech Ageing Dev 3 1996 173 175
92. A. Peres, M. Bauer, I.B. da Cruz, N.B. Nardi, and J.A. Chies Immunophenotyping and T-cell proliferative capacity in a healthy aged population Biogerontology 4 2003 289 296
93. D.N. Posnett, R. Sinha, S. Kabak, and C. Russo Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammopathy?" J Exp Med 179 1994 609 618
94. C.C. Ku, B. Kotwin, J. Kappler, and P. Marrack CD8+ T-cell clones in old mice Immunol Rev 160 1997 139 144
95. A. Wack, A. Cossarizza, and S. Heltai Age-related modifications of the human ab T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets Int Immunol 10 1998 1281 1288