Evidence that human CD8+ CD45RA+ CD27- cells are induced by antigen and evolve through extensive rounds of division

International Immunology

Volumn 11, Issue 7, 1999, Pages 1027-1033

  Hamann, Dörte ^a   Kostense, Stefan ^a   Wolthers, Katja C ^a   Otto, Sigrid A ^a   Baars, Paul A ^a   Miedema, Frank ^a,b   Van Lier, R A W ^a,c  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c CENTRAL LABORATORY   (Netherlands)

Author keywords

CD27; CD45rA; CD8; Single strand confirmation polymorphism; Telomeric restriction fragment

Indexed keywords

CD27 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; CELL DIVISION; EFFECTOR CELL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; RESTRICTION FRAGMENT; SINGLE STRAND CONFORMATION POLYMORPHISM; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD27; ANTIGENS, CD45; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; TELOMERE;

EID: 0032813589     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.7.1027     Document Type: Article

References (27)

1. Ahmed, R. and Gray, D. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
2. Gray, D. 1993. Immunological memory. Annu. Rev. Immunol. 11:49.
3. pos T cells. J. Exp. Med. 186:1407.
4. + lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo. Eur. J. Immunol. 22:993.
5. Hintzen, R. Q., De Jong, R., Lens, S. M. A., Brouwer, M., Baars, P. and van Lier, R. A. W. 1993. Regulation of CD27 expression on subsets of mature T-lymphocytes. J. Immunol. 151:2426.
6. + T cells. Cell. Immunol. 139:176.
7. Merkenschlager, M. and Beverley, P. C. L. 1989. Evidence for differential expression of CD45 isoforms by precursor for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1). Int. Immunol. 1:450.
8. - T cell subset contains specialized primed T cells. J. Immunol. 154:17.
9. + T-cell repopulation kinetics during highly active antiretroviral therapy. Aids 12:235.
10. Maslanka, K., Piatek, T., Gorski, J. and Yassai, M. 1995. Molecular analysis of T cell repertoires. Spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity or fluorescence. Hum. Immunol. 44:28.
11. Schelonka, R. L., Raaphorst, F. M., Infante, D., Kraig, E., Teale, J. M. and Infante, A. J. 1998. T cell receptor repertoire diversity and clonal expansion in human neonates. Pediatr. Res. 43:396.
12. + subsets of T lymphocytes in monozygotic twins. J. Immunol. 150:2033.
13. Davey, M. P., Meyer, M. M. and Bakke, A. C. 1994. T-cell receptor Vbeta gene expression in monozygotic twins. Discordance in CD8 subset and in disease states. J. Immunol. 152:315.
14. n present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85:6622.
15. Harley, C. B., Futcher, A. B. and Greider, C. W. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458.
16. Vaziri, H., Schachter, F., Uchida, I., Wei, L., Zhu, X., Effros, R., Cohen, D. and Harley, C. B. 1993. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet 52:661.
17. Weng, N.-P., Levine, B. L., June, C. H. and Hodes, R. J. 1995. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA 92:11091.
18. Rufer, N., Dragowska, W., Thornbury, G., Roosnek, E. and Lansdorp, P. M. 1998. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16:743.
19. Akbar, A. N., Terry, L., Timms, A., Beverley, P. C. L. and Janossy, G. 1988. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J. Immunol. 140:2171.
20. Unutmaz, D., Pileri, P. and Abrignani, S. 1997. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180:1159.
21. Unutmaz, D., Baldoni, F. and Abrignani, S. 1995. Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells. Int. Immunol. 7:1417.
22. + T-cell subsets characterized by coexpression of CD45RA and CD45RO isoforms. Blood 88:3513.
23. Liu, Y., Wenger, R. H., Zhao, M. and Nielsen, P. J. 1997. Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J. Exp. Med. 185:252.
24. + counterparts, J. Immunol. 156:3587.
25. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10:F17.
26. Effros, R. B. and Pawelec, G. 1997. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? Immunol. Today 18:450.
27. Bunce, C. and Bell, E. B. 1997. CD45RC isoforms define two types of CD4 memory T cell, one of which depends on persisting antigen. J. Exp. Med. 185:767.