Potent blockers of the monocarboxylate transporter MCT1: Novel immunomodulatory compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2260-2265

  Guile, S D ^a   Bantick, J R ^a   Cheshire, D R ^a   Cooper, M E ^a,b   Davis, A M ^a   Donald, D K ^a   Evans, R ^a   Eyssade, C ^a   Ferguson, D D ^a   Hill, S ^a   Hutchinson, R ^a   Ingall, A H ^a   Kingston, L P ^a   Martin, I ^a,c   Martin, B P ^a   Mohammed, R T ^a   Murray, C ^a   Perry, M W D ^a   Reynolds, R H ^a   Thorne, P V ^a   Wilkinson, D J ^a   Withnall, J ^a   more..

^a ASTRAZENECA   (United Kingdom)

^b 7TM Pharma A S   (Denmark)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Immunomodulatory; Monocarboxylate; Transporter

Indexed keywords

AMIDE; HETEROCYCLIC COMPOUND; IMMUNOMODULATING AGENT; MONOCARBOXYLATE TRANSPORTER;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; IMMUNOMODULATION; LIPOPHILICITY; REDUCTION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; GRAFT VS HOST DISEASE; HERPESVIRIDAE; HUMANS; IMMUNOLOGIC FACTORS; MONOCARBOXYLIC ACID TRANSPORTERS; SYMPORTERS; T-LYMPHOCYTES;

EID: 33644815278     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.024     Document Type: Article

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