Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle

Journal of Biological Chemistry

Volumn 284, Issue 30, 2009, Pages 20011-20021

  Wilson, Marieangela C ^a   Meredith, David ^a,b   Bunnun, Chotirote ^a   Sessions, Richard B ^a   Halestrap, Andrew P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b OXFORD BROOKES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; CHANNEL SELECTIVITY; COVALENT MODIFICATIONS; EXPERIMENTAL DATA; HOMOLOGY MODELS; HYDROPHOBIC ENVIRONMENT; ION PAIRS; ISOTHIOCYANATE; OPEN CONFORMATION; PLASMA MEMBRANES; POSITIVELY CHARGED; SITE DIRECTED MUTAGENESIS; SUBSTRATE-BINDING; XENOPUS LAEVIS OOCYTES;

AMINO ACIDS; BINDING ENERGY; CELL MEMBRANES; ENZYME ACTIVITY; MUTAGENESIS; PROTONS;

BINDING SITES;

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; LYSINE; MONOCARBOXYLATE TRANSPORTER 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CERCOPITHECUS AETHIOPS; COS CELLS; ERYTHROCYTE MEMBRANE; GLYCOPROTEINS; LYSINE; MODELS, MOLECULAR; MONOCARBOXYLIC ACID TRANSPORTERS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS; RATS; SYMPORTERS; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 67749133881     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014217     Document Type: Article

References (34)

1. Halestrap, A. P., and Meredith, D. (2004) Pflugers Arch. 447, 619-628
2. Poole, R. C., Sansom, C. E., and Halestrap, A. P. (1996) Biochem. J. 320, 817-824
3. Halestrap, A. P., and Price, N. T. (1999) Biochem. J. 343, 281-299
4. Bröer, S., Schneider, H. P., Bröer, A., Rahman, B., Hamprecht, B., and Deitmer, J. W. (1998) Biochem. J. 333, 167-174
5. Bröer, S., Bröer, A., Schneider, H. P., Stegen, C., Halestrap, A. P., and Deitmer, J. W. (1999) Biochem. J. 341, 529-535
6. Grollman, E. F., Philp, N. J., McPhie, P., Ward, R. D., and Sauer, B. (2000) Biochemistry 39, 9351-9357
7. Dimmer, K. S., Friedrich, B., Lang, F., Deitmer, J. W., and Bröer, S. (2000) Biochem. J. 350, 219-227
8. Manning Fox, J. E., Meredith, D., and Halestrap, A. P. (2000) J. Physiol. 529, 285-293
9. Poole, R. C., and Halestrap, A. P. (1993) Am. J. Physiol. 264, C761-782
10. Friesema, E. C., Ganguly, S., Abdalla, A., Manning Fox, J. E., Halestrap, A. P., and Visser, T. J. (2003) J. Biol. Chem. 278, 40128-40135
11. Kim, D. K., Kanai, Y., Chairoungdua, A., Matsuo, H., Cha, S. H., and Endou, H. (2001) J. Biol. Chem. 276, 17221-17228
12. Deuticke, B. (1982) J. Membr. Biol. 70, 89-103
13. Poole, R. C., and Halestrap, A. P. (1990) Biochem. Soc. Trans. 18, 1245-1246
14. Poole, R. C., and Halestrap, A. P. (1991) Biochem. J. 275, 307-312
15. Poole, R. C., and Halestrap, A. P. (1992) Biochem. J. 283, 855-862
16. Poole, R. C., and Halestrap, A. P. (1997) J. Biol. Chem. 272, 14624-14628
17. Guenette, R. S., Sridhar, S., Herley, M., Mooibroek, M., Wong, P., and Tenniswood, M. (1997) Dev. Genet. 21, 268-278
18. Muramatsu, T., and Miyauchi, T. (2003) Histol. Histopathol. 18, 981-987
19. Kirk, P., Wilson, M. C., Heddle, C., Brown, M. H., Barclay, A. N., and Halestrap, A. P. (2000) EMBO J. 19, 3896-3904
20. Wilson, M. C., Meredith, D., and Halestrap, A. P. (2002) J. Biol. Chem. 277, 3666-3672
21. Wilson, M. C., Meredith, D., Fox, J. E., Manoharan, C., Davies, A. J., and Halestrap, A. P. (2005) J. Biol. Chem. 280, 27213-27221
22. Rahman, B., Schneider, H. P., Bröer, A., Deitmer, J. W., and Bröer, S. (1999) Biochemistry 38, 11577-11584
23. Galić, S., Schneider, H. P., Bröer, A., Deitmer, J. W., and Bröer, S. (2003) Biochem. J. 376, 413-422
24. Manoharan, C., Wilson, M. C., Sessions, R. B., and Halestrap, A. P. (2006) Mol. Membr. Biol. 23, 486-498
25. Poole, R. C., and Halestrap, A. P. (1988) Biochem. J. 254, 385-390
26. Deleted in proof
27. Carpenter, L., and Halestrap, A. P. (1994) Biochem. J. 304, 751-760
28. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Science 301, 610-615
29. Zhou, Y., Guan, L., Freites, J. A., and Kaback, H. R. (2008) Proc. Nat. Acad. Sci. U.S.A. 105, 3774-3778
30. Smirnova, I., Kasho, V., Choe, J. Y., Altenbach, C., Hubbell, W. L., and Kaback, H. R. (2007) Proc. Nat. Acad. Sci. 104, 16504-16509
31. Guan, L., Mirza, O., Verner, G., Iwata, S., and Kaback, H. R. (2007) Proc. Nat. Acad. Sci. 104, 15294-15298
32. Law, C. J., Maloney, P. C., and Wang, D. N. (2008) Annu. Rev. Microbiol. 62, 289-305
33. Garcia, C. K., Goldstein, J. L., Pathak, R. K., Anderson, R. G., and Brown, M. S. (1994) Cell 76, 865-873
34. Poole, R. C., Cranmer, S. L., Holdup, D. W., and Halestrap, A. P. (1991) Biochim. Biophys. Acta 1070, 69-76