CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

EMBO Journal

Volumn 19, Issue 15, 2000, Pages 3896-3904

  Kirk, P ^a   Wilson, M C ^b   Heddle, C ^b   Brown, M H ^a   Barclay, A N ^a   Halestrap, A P ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

CD147; Chaperone; Lactate transport; Monocarboxylate transporter; OX 47

Indexed keywords

CARRIER PROTEIN; CD147; CELL MEMBRANE PROTEIN; CELL SURFACE PROTEIN; CHAPERONE; GLYCOPROTEIN; LACTIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CROSS LINKING; GENETIC TRANSFECTION; HEART MUSCLE CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALIA; MAMMALIA;

EID: 0034254638     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.15.3896     Document Type: Article

References (54)

1. Abumrad, N., Coburn, C. and Ibrahimi, A. (1999) Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. Biochim. Biophys. Acta, 1441, 4-13.
2. Barclay, A.N., Brown, M.H., Law, S.K., McKnight, A.J., Tomlinson, M. and van der Merwe, P.A. (1997) The Leucocyte Antigen Factsbook, 2nd edn. Academic Press, London, UK.
3. Bergersen, L., Johannsson, E., Veruki, M.L., Nagelhus, E.A., Halestrap, A., Sejersted, O.M. and Ottersen, O.P. (1999) Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat. Neuroscience, 90, 319-331.
4. Biswas, C., Zhang, Y., DeCastro, R., Guo, H., Nakamura, T., Kataoka, H. and Nabeshima, K. (1995) The human tumour cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res., 55, 434-439.
5. Bröer, S., Schneider, H.P, Bröer, A., Rahman, B., Hamprecht, B. and Deitmer, J.W. (1998) Characterization of the monocarboxylate transporter I expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem. J., 333, 167-174.
6. Bröer, S., Bröer, A., Schneider, H.P., Stegen, C., Halestrap, A.P. and Deitmer, J.W. (1999) Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem. J., 341, 529-535.
7. Bruce, L.J., Groves, J.D., Okubo, Y., Thilaganathan, B. and Tanner, M.J. (1994) Altered band 3 structure and function in glycophorin A- and B-deficient (MkMk) red blood cells. Blood. 84, 916-922.
8. Caudroy, S., Polette, M., Tournier, J.M., Burlet, H., Toole, B., Zucker, S. and Birembaut, P. (1999) Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions. J. Histochem. Cytochem., 47, 1575-1580.
9. Chu, G., Hayakawa, H. and Berg, P. (1987) Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res., 15, 1311-1326.
10. Fan, Q.W., Kadomatsu, K., Uchimura, K. and Muramatsu, T. (1998) Embigin/basigin subgroup of the immunoglobulin superfamily: different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers. Dev. Growth Differ., 40, 277-286.
11. Finnemann, S.C., Marmorstein, A.D., Neill, J.M. and Rodriguez-Boulan, E. (1997) Identification of the retinal pigment epithelium protein RET-PE2 as CE-9/OX-47, a member of the immunoglobulin superfamily. Invest. Ophthalmol. Vis. Sci., 38, 2366-2374.
12. Fossum, S., Mallett, S. and Barclay, A.N. (1991) The MRC OX-47 antigen is a member of the immunoglohulin superfamily with an unusual transmembrane sequence. Eur. J. Immunol., 21, 671-679.
13. Garcia, C.K., Goldstein, J.L., Pathak, R.K., Anderson, R.G.W. and Brown, M.S. (1994) Molecular characterization of a membrane transporter for lactate. pyruvate and other monocarboxylates - implications for the Cori cycle. Cell, 76, 865-873.
14. Garnett, D. (1993) Characterization of leucocyte glycoproteins with reference to their mode of membrane attachment. DPhil thesis, University of Oxford, Oxford, UK.
15. Gerhart, D.Z., Leino, R.L. and Drewes, L.R. (1999) Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina. Neuroscience, 92, 367-375.
16. Gould, K.G., Scotney, H., Townsend, A.R., Bastin, J. and Brownlee, G.G. (1987) Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin. J. Exp. Med., 166, 693-701.
17. Green, N.M. (1991) Biological membranes. The semiotics of charge. Nature, 351, 349-350.
18. Hahn, E.L., Halestrap, A.P. and Gamielli, R.L. (2000) Expression of the lactate transporter MCT1 in macrophages. Shock, 13, 253-260
19. Haji-Michael, P.G., Ladriere, L., Sener, A., Vincent, J.L. and Malaisse, W.J. (1999) Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism, 48, 779-785.
20. Halestrap, A.P. and Price, N.T. (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J., 343, 281-299.
21. Halestrap, A.P., Wang, X.M., Poole, R.C., Jackson, V.N. and Price, N.T. (1997) Lactate transport in heart in relation to myocardial ischemia. Am. J. Cardiol., 80, 17A-25A.
22. He, Q., Beyers, A.D., Barclay, A.N. and Williams.A.F. (1988) A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen. Cell, 54, 979-984.
23. Hill, I.E., Selkirk, C.P., Hawkes, R.B. and Beesley, P.W. (1988) Characterization of novel glycoprotein components of synaptic membranes and postsynaptic densities, gp65 and gp55, with a monoclonal antibody. Brain Res., 461, 27-43.
24. Huang, R.P., Ozawa, M., Kadomatsu, K. and Muramatsu, T. (1990) Developmentally regulated expression of embigin, a member of the immunoglobulin superfamily found in embryonal carcinoma cells. Differentiation, 45, 76-83.
25. Jackson, V.N., Price, N.T., Carpenter, L. and Halestrap, A.P. (1997) Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Biochem. J., 324, 447-453.
26. Juel, C and Halestrap, A.P. (1999) Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J. Physiol. (Lond.), 517, 633-642.
27. Kafitz, K.W., Rose, C.R., Thoenen, H. and Konnerth, A. (1999) Neurotrophin-evoked rapid excitation through TrkB receptors, Nature, 401, 918-921.
28. Kanai, Y., Segawa, H., Miyamoto, K., Uchino, H., Takeda, E. and Endou, H. (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem., 273, 23629-23632.
29. Kanekura, T., Miyauchi, T., Tashiro, M. and Muramatsu, T. (1991) Basigin, a new member of the immunoglobulin superfamily: genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences. Cell Struct. Funct., 16, 23-30.
30. Kasinrerk, W., Fiebiger, E., Stefanova, I., Baumruker, T., Knapp, W. and7 Stockinger, H. (1992) Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin and chicken HT7 molecule. J. Immunol., 149, 847-854.
31. Kunita, R., Nakabayashi, O., Kikuchi, T. and Mizuno, S. (1997) Predominant expression of a Z-chromosome-linked immunoglobulin superfamily gene, ZOV3, in steroidogenic cells of ovarian follicles and in embryonic gonads of chickens. Differentiation, 62, 63-70.
32. Langnaese, K., Beesley, P.W. and Gundelfinger, E.D. (1997) Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily. J. Biol. Chem., 272, 821-827.
33. Lanier, L.L., Yu, G. and Phillips, J.H. (1989) Co-association of CD3 ζ with a receptor (CD16) for IgG Fc on human natural killer cells. Nature, 342, 803-805.
34. Lanier, L.L., Corliss, B., Wu, J. and Phillips, J.H. (1998) Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity, 8, 693-701.
35. Malhotra, J.D., Kazen-Gillespie, K., Hortsch, M. and Isom, L.L. (2000) Sodium channel β subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. J. Biol. Chem., 275, 11383-11388.
36. Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P.J., Loffing, J., Shoemaker, C.B. and Verrey, F. (1998) Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature, 395, 288-291.
37. McLatchie, L.M., Fraser, N.J., Main, M.J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M.G. and Foord, S.M. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393, 333-339.
38. Miyauchi, T., Masuzawa, Y. and Muramatsu, T. (1991) The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J. Biochem. (Tokyo), 110, 770-774.
39. Muraoka, K., Nabeshima, K., Murayama, T., Biswas, C. and Koono, M. (1993) Enhanced expression of a tumour-cell-derived collagenase-stimulatory factor in urothelial carcinoma: its usefulness as a tumour marker for bladder cancers. Int. J. Cancer, 55, 19-26.
40. Nehme, C.L., Fayos, B.E. and Bartles, J.R. (1995) Distribution of the integral plasma membrane glycoprotein CE9 (MRC OX-47) among rat tissues and its induction by diverse stimuli of metabolic activation. Biochem. J., 310, 693-698.
41. Paterson, D,J., Jefferies, W.A., Green, J.R., Brandon, M.R., Corthesy, P., Puklavec, M. and Williams, A.F. (1987) Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol., 24, 1281-1290.
42. Pfeiffer, R., Rossier, G., Spindler, B., Meier, C., Kuhn, L. and Verrey, F. (1999) Amino acid transport of y+L-type by heterodimers of 4F2hc/ CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J., 18, 49-57.
43. Poole, R.C. and Halestrap, A.P. (1993) Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol., 264, C761-C782.
44. Poole, R.C. and Halestrap, A.P. (1997) Interaction of the erythrocyte lactate transporter (monocarboxylate transporter 1) with an integral 70-kDa membrane glycoprotein of the immunoglobulin superfamily. J. Biol. Chem., 272, 14624-14628.
45. Poole, R.C., Sansom, C.E. and Halestrap, A.P. (1996) Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1). Biochem. J., 320, 817-824.
46. Saier, M.H., Jr (1994) Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis and evolution. Microbiol. Rev., 58, 71-93.
47. Schlosshauer, B., Bauch, H. and Frank, R. (1995) Neurothelin: amino acid sequence, cell surface dynamics and actin colocalization. Eur. J. Cell Biol., 68, 159-166.
48. Seulberger, H., Unger, C.M. and Risau, W. (1992) HT7, neurothelin. basigin, gp42 and OX-47-many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons. Neurosci. Lett., 140, 93-97.
49. Shirozu, M. et al. (1996) Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics, 37, 273-280.
50. Smalla, K.H. et al. (2000) The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses. Proc. Natl Acad. Sci. USA, 97, 4327-4332.
51. Torrents, D. et al. (1999) Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene. Nature Genet., 21, 293-296.
52. Vernon-Wilson, E.F., Kee, W.-J., Willis, A.C., Barclay, A.N., Simmons, D.L. and Brown, M.H. (2000) CD47 (integrin associated protein) is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPaI. Eur. J. Immunol., in press.
53. Wang, X.M., Levi, A.J. and Halestrap, A.P. (1994) Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pH(i). Am. J. Physiol, 267, H1759-H1769.
54. Wilson, M.C. et al. (1998) Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem., 273, 15920-15926.