Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties

Journal of Medicinal Chemistry

Volumn 50, Issue 2, 2007, Pages 254-263

  Guile, Simon D ^a   Bantick, John R ^a   Cooper, Martin E ^a,b   Donald, David K ^a   Eyssade, Christine ^a   Ingall, Anthony H ^a   Lewis, Richard J ^a   Martin, Barrie P ^a   Mohammed, Rukhsana T ^a   Potter, Timothy J ^a   Reynolds, Rachel H ^a   St Gallay, Stephen A ^a   Wright, Andrew D ^a  

^a ASTRAZENECA   (United Kingdom)

^b 7TM Pharma A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

6 [(3,5 DIMETHYL 1H PYRAZOL 4 YL)METHYL] 5 [(4 HYDROXYISOXAZOLIDIN 2 YL)CARBONYL] 1 ISOBUTYL 3 METHYLTHIENO[2,3 D]PYRIMIDINE 2,4(1H,3H) DIONE; AMIDE; IMMUNOSUPPRESSIVE AGENT; IONOMYCIN; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 1 BLOCKER; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; DRUG POTENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOMODULATION; ISOMER; NUCLEAR MAGNETIC RESONANCE; PERIPHERAL BLOOD MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION;

ISOMERISM; ISOXAZOLES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MONOCARBOXYLIC ACID TRANSPORTERS; NAPHTHALENES; PYRROLIDINES; QUINOLINES; SYMPORTERS; THIAZOLIDINES;

EID: 33846404916     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060995h     Document Type: Article

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