Bupivacaine induces apoptosis via ROS in the Schwann cell line

Journal of Dental Research

Volumn 84, Issue 9, 2005, Pages 852-857

  Park, C J ^a   Park, S A ^a   Yoon, T G ^b   Lee, S J ^a   Yum, K W ^a   Kim, H J ^a  

^a School of Dentistry   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Apoptosis; Bupivacaine; Neurotoxicity; Reactive oxygen species; Schwann cell

Indexed keywords

BUPIVACAINE; CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; FLUORESCENT DYE; LOCAL ANESTHETIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ANALYSIS OF VARIANCE; APOPTOSIS; ARTICLE; CELL LINE; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; NONPARAMETRIC TEST; POLYACRYLAMIDE GEL ELECTROPHORESIS; SCHWANN CELL; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; APOPTOSIS; BLOTTING, WESTERN; BUPIVACAINE; CASPASE 3; CASPASES; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; FLUORESCENT DYES; HUMANS; NITRIC OXIDE; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SCHWANN CELLS; STATISTICS, NONPARAMETRIC;

EID: 27244432312     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910508400914     Document Type: Article

References (28)

1. Annunziato L, Amoroso S, Pannaccione A, Cataldi M, Pignataro G, D'Alessio A, et al. (2003). Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. Toxicol Lett 139:125-133.
2. Bergman BD, Hebl JR, Kent J, Horlocker TT (2003). Neurologic complications of 405 consecutive continuous axillary catheters. Anesth Analg 96:247-252.
3. Conti G, Scarpini E, Rostami A, Livraghi S, Clerici R, Piccio L, et al. (1999). Schwann cell apoptosis during cell-mediated demyelination. Ann NY Acad Sci 883:518-519.
4. Decker P, Muller S (2002). Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr Pharm Biotechnol 3:275-283.
5. Fiskum G (2004). Mechanisms of neuronal death and neuroprotection. J Neurosurg Anesthesiol 16:108-110.
6. Friederich P, Schmitz TP (2002). Lidocaine-induced cell death in a human model of neuronal apoptosis. Eur J Anaesthesiol 19:564-570.
7. Groban L (2003). Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model. Reg Anesth Pain Med 28:3-11.
8. Haas DA (1998). Localized complications from local anesthesia. J CA Dent Assoc 26:677-682.
9. Hai M, Muja N, DeVries GH, Quarles RH, Patel PI (2002). Comparative analysis of Schwann cell lines as model systems for myelin gene transcription studies. J Neurosci Res 69:497-508.
10. Imada M, Sueoka N (1978). Clonal sublines of rat neurotumor RT4 and cell differentiation. I. Isolation and characterization of cell lines and cell type conversion. Dev Biol 66:97-108.
11. Johnson ME, Uhl CB, Spittler KH, Wang H, Gores GJ (2004). Mitochondrial injury and caspase activation by the local anesthetic lidocaine. Anesthesiology 101:1184-1194.
12. Kalichman MW (1993). Physiologic mechanisms by which local anesthetics may cause injury to nerve and spinal cord. Reg Anesth 18:448-452.
13. Kalichman MW, Powell HC, Myers RR (1989). Quantitative histologic analysis of local anesthetic-induced injury to rat sciatic nerve. J Pharmacol Exp Ther 250:406-413.
14. Kanai Y, Katsuki H, Takasaki M (1998). Graded, irreversible changes in crayfish giant axon as manifestations of lidocaine neurotoxicity in vitro. Anesth Analg 86:569-573.
15. Kasaba T, Onizuka S, Takasaki M (2003). Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics. Anesth Analg 97:85-90.
16. Kohase H, Miyamoto T, Umino M (2002). A new method of continuous maxillary nerve block with an indwelling catheter. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:162-166.
17. Kytta J, Heinonen E, Rosenberg PH, Wahlstrom T, Gripenberg J, Huopaniemi T (1986). Effects of repeated bupivacaine administration on sciatic nerve and surrounding muscle tissue in rats. Acta Anaesthesiol Scand 30:625-629.
18. Nau C, Vogel W, Hempelmann G, Brau ME (1999). Stereoselectivity of bupivacaine in local anesthetic-sensitive ion channels of peripheral nerve. Anesthesiology 91:786-795.
19. Pardo L, Blanck TJ, Recio-Pinto E (2002). The neuronal lipid membrane permeability was markedly increased by bupivacaine and mildly affected by lidocaine and ropivacaine. Eur J Pharmacol 455:81-90.
20. Powell HC, Kalichman MW, Garrett RS, Myers RR (1988). Selective vulnerability of unmyelinated fiber Schwann cells in nerves exposed to local anesthetics. Lab Invest 59:271-280.
21. Radwan IA, Saito S, Goto F (2002). The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine. Anesth Analg 94:319-324.
22. Sadeh M, Czyewski K, Stern LZ (1985). Chronic myopathy induced by repeated bupivacaine injections. J Neurol Sci 67:229-238.
23. Stevens MJ, Obrosova I, Cao X, Van Huysen C, Greene DA (2000). Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes 49:1006-1015.
24. Tan Z, Dohi S, Chen J, Banno Y, Nozawa Y (2002). Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death. Anesthesiology 96:1191-1201.
25. Thorburn A (2004). Death receptor-induced cell killing. Cell Signal 16:139-144.
26. Vincent AM, Brownlee M, Russell JW (2002). Oxidative stress and programmed cell death in diabetic neuropathy. Ann NY Acad Sci 959:368-383.
27. Vladimirov M, Nau C, Mok WM, Strichartz G (2000). Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies. Anesthesiology 93:744-755.
28. Zhu Y, Ghosh P, Charnay P, Burns DK, Parada LF (2002). Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296:920-922.