-
1
-
-
23844474726
-
Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells
-
Okhrimenko H, Lu W, Xiang C, Hamburger N, Kazimirsky G, Brodie C: Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. Cancer Res 65:7301-7309, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 7301-7309
-
-
Okhrimenko, H.1
Lu, W.2
Xiang, C.3
Hamburger, N.4
Kazimirsky, G.5
Brodie, C.6
-
2
-
-
34250319339
-
PKC delta is required for survival of cells expressing activated p21Ras
-
Xia S, Forman LW, Faller DV: PKC delta is required for survival of cells expressing activated p21Ras. J Biol Chem 282:13199-13210, 2007
-
(2007)
J Biol Chem
, vol.282
, pp. 13199-13210
-
-
Xia, S.1
Forman, L.W.2
Faller, D.V.3
-
3
-
-
9144256765
-
Protein kinase C delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: A mechanism involving BAD and the mitochondria
-
Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D: Protein kinase C delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem 279:47985-47991, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 47985-47991
-
-
Murriel, C.L.1
Churchill, E.2
Inagaki, K.3
Szweda, L.I.4
Mochly-Rosen, D.5
-
4
-
-
6944241423
-
Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert
-
Suzuki E, Handa K, Toledo MS, Hakomori S, Suzuki E, Handa K, Toledo MS, Hakomori S: Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proc Natl Acad Sci U SA 101:14788-14793, 2004
-
(2004)
Proc Natl Acad Sci U SA
, vol.101
, pp. 14788-14793
-
-
Suzuki, E.1
Handa, K.2
Toledo, M.S.3
Hakomori, S.4
Suzuki, E.5
Handa, K.6
Toledo, M.S.7
Hakomori, S.8
-
5
-
-
33645644483
-
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes
-
Li L, Sampat K, Hu N, Zakari J, Yuspa SH: Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J Biol Chem 281:3237-3243, 2006
-
(2006)
J Biol Chem
, vol.281
, pp. 3237-3243
-
-
Li, L.1
Sampat, K.2
Hu, N.3
Zakari, J.4
Yuspa, S.H.5
-
6
-
-
0035907311
-
The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
-
Lee YI, Kang-Park S, Do SI, Lee YI: The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem 276:16969-16977, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 16969-16977
-
-
Lee, Y.I.1
Kang-Park, S.2
Do, S.I.3
Lee, Y.I.4
-
7
-
-
0037409458
-
IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells
-
Fung MM, Rohwer F, McGuire KL: IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells. Cell Signal 15:625-636, 2003
-
(2003)
Cell Signal
, vol.15
, pp. 625-636
-
-
Fung, M.M.1
Rohwer, F.2
McGuire, K.L.3
-
8
-
-
0038387243
-
Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation
-
Ha KS, Kim KM, Kwon YG, Bai SK, Nam WD, Yoo YM, Kim PK, Chung HT, Billiar TR, Kim YM: Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation. FASEB J 17:1036-1047, 2003
-
(2003)
FASEB J
, vol.17
, pp. 1036-1047
-
-
Ha, K.S.1
Kim, K.M.2
Kwon, Y.G.3
Bai, S.K.4
Nam, W.D.5
Yoo, Y.M.6
Kim, P.K.7
Chung, H.T.8
Billiar, T.R.9
Kim, Y.M.10
-
9
-
-
0036015168
-
TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma
-
Sandra F, Matsuki NA, Takeuchi H, Ikebe T, Kanematsu T, Ohishi M, Hirata M: TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cell Signal 14:771-778, 2002
-
(2002)
Cell Signal
, vol.14
, pp. 771-778
-
-
Sandra, F.1
Matsuki, N.A.2
Takeuchi, H.3
Ikebe, T.4
Kanematsu, T.5
Ohishi, M.6
Hirata, M.7
-
10
-
-
25144492129
-
Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast
-
Rodriguez-Escudero I, Roelants FM, Thorner J, Nombela C, Molina M, Cid VJ: Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J 390:613-623, 2005
-
(2005)
Biochem J
, vol.390
, pp. 613-623
-
-
Rodriguez-Escudero, I.1
Roelants, F.M.2
Thorner, J.3
Nombela, C.4
Molina, M.5
Cid, V.J.6
-
11
-
-
37649024728
-
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner
-
11
-
11.Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B: Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad SciUSA104:19011-19016, 2007
-
(2007)
Proc Natl Acad SciUSA
, vol.104
, pp. 19011-19016
-
-
Andrabi, S.1
Gjoerup, O.V.2
Kean, J.A.3
Roberts, T.M.4
Schaffhausen, B.5
-
12
-
-
4544314719
-
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes
-
Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM: Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol 24:8778-8789, 2004
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8778-8789
-
-
Ugi, S.1
Imamura, T.2
Maegawa, H.3
Egawa, K.4
Yoshizaki, T.5
Shi, K.6
Obata, T.7
Ebina, Y.8
Kashiwagi, A.9
Olefsky, J.M.10
-
13
-
-
0034718540
-
Modulation ofAkt kinase activity by binding to Hsp90
-
Sato S, Fujita N, Tsuruo T: Modulation ofAkt kinase activity by binding to Hsp90. Proc Natl Acad SciUSA97:10832-10837, 2000
-
(2000)
Proc Natl Acad SciUSA
, vol.97
, pp. 10832-10837
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
14
-
-
27744512550
-
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
-
Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S: Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 280:36029-36036, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 36029-36036
-
-
Van Kanegan, M.J.1
Adams, D.G.2
Wadzinski, B.E.3
Strack, S.4
-
15
-
-
0037432156
-
Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation
-
Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S: Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett 536:180-186, 2003
-
(2003)
FEBS Lett
, vol.536
, pp. 180-186
-
-
Haendeler, J.1
Hoffmann, J.2
Rahman, S.3
Zeiher, A.M.4
Dimmeler, S.5
-
16
-
-
33746628448
-
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation
-
Koga F, Xu W, Karpova TS, McNally JG, Baron R, Neckers L: Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation. Proc Natl Acad SciUSA103:11318-11322, 2006
-
(2006)
Proc Natl Acad SciUSA
, vol.103
, pp. 11318-11322
-
-
Koga, F.1
Xu, W.2
Karpova, T.S.3
McNally, J.G.4
Baron, R.5
Neckers, L.6
-
17
-
-
24044485916
-
HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction
-
Lee YJ, Lee DH, Cho CK, Bae S, Jhon GJ, Lee SJ, Soh JW, Lee YS: HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction. J Biol Chem 280:18108-18119, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 18108-18119
-
-
Lee, Y.J.1
Lee, D.H.2
Cho, C.K.3
Bae, S.4
Jhon, G.J.5
Lee, S.J.6
Soh, J.W.7
Lee, Y.S.8
-
18
-
-
64549112952
-
-
Liu Z, Liu X, Nakayama KI, Nakayama K, Ye K: Protein kinase C-delta
-
Liu Z, Liu X, Nakayama KI, Nakayama K, Ye K: Protein kinase C-delta
-
-
-
-
19
-
-
33846995658
-
-
phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival. J Neurochem 100:1278-1288, 2007
-
phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival. J Neurochem 100:1278-1288, 2007
-
-
-
-
20
-
-
0036202678
-
Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodelling in a type II diabetic rat model
-
Jesmin S, Sakuma I, Hattori Y, Fujii S, Kitabatake A: Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodelling in a type II diabetic rat model. Diabetologia 45:402-415, 2002
-
(2002)
Diabetologia
, vol.45
, pp. 402-415
-
-
Jesmin, S.1
Sakuma, I.2
Hattori, Y.3
Fujii, S.4
Kitabatake, A.5
-
21
-
-
0041877454
-
Alteration in haemodynamics and pathological changes in the cardiovascular system during the development of type 2 diabetes mellitus in OLETF rats
-
Saito F, Kawaguchi M, Izumida J, Asakura T, Maehara K, Maruyama Y: Alteration in haemodynamics and pathological changes in the cardiovascular system during the development of type 2 diabetes mellitus in OLETF rats. Diabetologia 46:1161-1169, 2003
-
(2003)
Diabetologia
, vol.46
, pp. 1161-1169
-
-
Saito, F.1
Kawaguchi, M.2
Izumida, J.3
Asakura, T.4
Maehara, K.5
Maruyama, Y.6
-
22
-
-
33845865582
-
Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-acti-vated protein kinase
-
Huang Q, Bu S, Yu Y, Guo Z, Ghatnekar G, Bu M, Yang L, Lu B, Feng Z, Liu S, Wang F: Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-acti-vated protein kinase. Endocrinology 148:81-91, 2007
-
(2007)
Endocrinology
, vol.148
, pp. 81-91
-
-
Huang, Q.1
Bu, S.2
Yu, Y.3
Guo, Z.4
Ghatnekar, G.5
Bu, M.6
Yang, L.7
Lu, B.8
Feng, Z.9
Liu, S.10
Wang, F.11
-
23
-
-
36248992993
-
Protein kinase C 8 regulates anti-apoptotic αB-crystallin in the retina of type 2 diabetes
-
Kim YH, Choi MY, Kim YS, Lee JH, Park CH, Kang SS, Choi WS, Cho GJ: Protein kinase C 8 regulates anti-apoptotic αB-crystallin in the retina of type 2 diabetes. Neurobiol Dis 28:293-303, 2007
-
(2007)
Neurobiol Dis
, vol.28
, pp. 293-303
-
-
Kim, Y.H.1
Choi, M.Y.2
Kim, Y.S.3
Lee, J.H.4
Park, C.H.5
Kang, S.S.6
Choi, W.S.7
Cho, G.J.8
-
24
-
-
23944474255
-
Expression of 14-3-3 zeta and interaction with protein kinase C in the rat retina in early diabetes
-
Kim YH, Kim YS, Kang SS, Noh HS, Kim HJ, Cho GJ, Choi WS: Expression of 14-3-3 zeta and interaction with protein kinase C in the rat retina in early diabetes. Diabetologia 48:1411-1415, 2005
-
(2005)
Diabetologia
, vol.48
, pp. 1411-1415
-
-
Kim, Y.H.1
Kim, Y.S.2
Kang, S.S.3
Noh, H.S.4
Kim, H.J.5
Cho, G.J.6
Choi, W.S.7
-
25
-
-
20444376192
-
Changes in rhodopsin kinase and transducin in the rat retina in early-stage diabetes
-
Kim YH, Kim YS, Noh HS, Kang SS, Cheon EW, Park SK, Lee BJ, Choi WS, Cho GJ: Changes in rhodopsin kinase and transducin in the rat retina in early-stage diabetes. Exp Eye Res 80:753-760, 2005
-
(2005)
Exp Eye Res
, vol.80
, pp. 753-760
-
-
Kim, Y.H.1
Kim, Y.S.2
Noh, H.S.3
Kang, S.S.4
Cheon, E.W.5
Park, S.K.6
Lee, B.J.7
Choi, W.S.8
Cho, G.J.9
-
26
-
-
0038743109
-
Retinal expression of clusterin in the streptozotocin-induced diabetic rat
-
Kim YS, Kim YH, Cheon EW, Park JM, Yoo JM, Kang SS, Cho GJ, Choi WS: Retinal expression of clusterin in the streptozotocin-induced diabetic rat. Brain Res 976:53-59, 2003
-
(2003)
Brain Res
, vol.976
, pp. 53-59
-
-
Kim, Y.S.1
Kim, Y.H.2
Cheon, E.W.3
Park, J.M.4
Yoo, J.M.5
Kang, S.S.6
Cho, G.J.7
Choi, W.S.8
-
27
-
-
34248595599
-
Triamcinolone suppresses retinal vascular pathology via a potent interruption of proinflammatory signal-regulated activation of VEGF during a relative hypoxia
-
Kim YH, Chung IY, Choi MY, Kim YS, Lee JH, Park CH, Kang SS, Roh GS, Choi WS, Yoo JM, Cho GJ: Triamcinolone suppresses retinal vascular pathology via a potent interruption of proinflammatory signal-regulated activation of VEGF during a relative hypoxia. Neurobiol Dis 26:569-576, 2007
-
(2007)
Neurobiol Dis
, vol.26
, pp. 569-576
-
-
Kim, Y.H.1
Chung, I.Y.2
Choi, M.Y.3
Kim, Y.S.4
Lee, J.H.5
Park, C.H.6
Kang, S.S.7
Roh, G.S.8
Choi, W.S.9
Yoo, J.M.10
Cho, G.J.11
-
28
-
-
34249006580
-
Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons
-
Zhang D, Kanthasamy A, Yang Y, Anantharam V, Kanthasamy A: Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J Neurosci 27:5349-5362, 2007
-
(2007)
J Neurosci
, vol.27
, pp. 5349-5362
-
-
Zhang, D.1
Kanthasamy, A.2
Yang, Y.3
Anantharam, V.4
Kanthasamy, A.5
-
29
-
-
33947607017
-
Protein kinase C delta enhances proliferation and survival of murine mammary cells
-
Grossoni VC, Falbo KB, Kazanietz MG, de Kier Joffe ED, Urtreger AJ: Protein kinase C delta enhances proliferation and survival of murine mammary cells. Mol Carcinog 46:381-390, 2007
-
(2007)
Mol Carcinog
, vol.46
, pp. 381-390
-
-
Grossoni, V.C.1
Falbo, K.B.2
Kazanietz, M.G.3
de Kier Joffe, E.D.4
Urtreger, A.J.5
-
30
-
-
0037034186
-
Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by overexpression
-
Zhong M, Lu Z, Foster DA: Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by overexpression. Oncogene 21:1071-1078, 2002
-
(2002)
Oncogene
, vol.21
, pp. 1071-1078
-
-
Zhong, M.1
Lu, Z.2
Foster, D.A.3
-
31
-
-
19444365828
-
The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade
-
Liao YF, Hung YC, Chang WH, Tsay GJ, Hour TC, Hung HC, Liu GY: The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. Life Sci 77:707-719, 2005
-
(2005)
Life Sci
, vol.77
, pp. 707-719
-
-
Liao, Y.F.1
Hung, Y.C.2
Chang, W.H.3
Tsay, G.J.4
Hour, T.C.5
Hung, H.C.6
Liu, G.Y.7
-
32
-
-
0035851112
-
Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase C δ tyrosine phosphoryla-tion
-
Stephen, PD: Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase C δ tyrosine phosphoryla-tion. J Biol Chem 276:37986-37992, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 37986-37992
-
-
Stephen, P.D.1
-
33
-
-
0043016254
-
Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apopto-sis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C
-
Tillman DM, Izeradjene K, Szucs KS, Douglas L, Houghton JA: Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apopto-sis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer Res 63:5118-5125, 2003
-
(2003)
Cancer Res
, vol.63
, pp. 5118-5125
-
-
Tillman, D.M.1
Izeradjene, K.2
Szucs, K.S.3
Douglas, L.4
Houghton, J.A.5
-
34
-
-
36248947920
-
Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta
-
Xu SZ: Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. Basic Clin Pharmacol Toxicol 101:459-464, 2007
-
(2007)
Basic Clin Pharmacol Toxicol
, vol.101
, pp. 459-464
-
-
Xu, S.Z.1
-
35
-
-
0037131334
-
Regulation of kinase activity of 3-phosphoino-sitide-dependent protein kinase-1 by binding to 14-3-3
-
Sato S, Fujita N, Tsuruo T: Regulation of kinase activity of 3-phosphoino-sitide-dependent protein kinase-1 by binding to 14-3-3. J Biol Chem 277:39360-39367, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 39360-39367
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
36
-
-
0028339457
-
Rottlerin, a novel protein kinase inhibitor
-
Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rinche G, Marks F: Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199:93-98, 1994
-
(1994)
Biochem Biophys Res Commun
, vol.199
, pp. 93-98
-
-
Gschwendt, M.1
Muller, H.J.2
Kielbassa, K.3
Zang, R.4
Kittstein, W.5
Rinche, G.6
Marks, F.7
-
37
-
-
34248358605
-
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-express-ing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta
-
Kurosu T, Tsuji K, Kida A, Koyama T, Yamamoto M, Miura O: Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-express-ing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. Oncogene 26:2975-2687, 2006
-
(2006)
Oncogene
, vol.26
, pp. 2975-2687
-
-
Kurosu, T.1
Tsuji, K.2
Kida, A.3
Koyama, T.4
Yamamoto, M.5
Miura, O.6
|