Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling

Anesthesiology

Volumn 107, Issue 1, 2007, Pages 136-143

  Werdehausen, Robert ^a   Braun, Sebastian ^a   Essmann, Frank ^a   Schulze Osthoff, Klaus ^a   Walczak, Henning ^b   Lipfert, Peter ^a   Stevens, Markus F ^a,c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL LYMPHOMA 2 PROTEIN; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GENE PRODUCT; LIDOCAINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER CELL CULTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANESTHETICS, LOCAL; APOPTOSIS; BLOTTING, WESTERN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CELL SURVIVAL; CYCLIN D1; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; JURKAT CELLS; LIDOCAINE; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION;

EID: 34250853465     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000268389.39436.66     Document Type: Article

References (46)

1. Johnson ME: Potential neurotoxicity of spinal anesthesia with lidocaine. Mayo Clin Proc 2000; 75:921-32
2. Zaric D, Christiansen C, Pace NL, Punjasawadwong Y: Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics. Cochrane Database Syst Rev 2005:CD003006
3. Myers RR, Kalichman MW, Reisner LS, Powell HC: Neurotoxicity of local anesthetics: Altered perineurial permeability, edema, and nerve fiber injury. ANESTHESIOLOGY 1986; 64:29-35
4. Kalichman MW, Powell HC, Myers RR: Pathology of local anesthetic-induced nerve injury. Acta Neuropathol (Berl) 1988; 75:583-9
5. Seitz RJ, Lipfert P, Willrich A, Himmelmann F: Toxic effects of triethyldodecylammoniumbromide (TEA-C12) on myelinated nerve fibers and blood-nerve barrier in the mouse. Exp Brain Res 1989; 74:293-302
6. Sakura S, Bollen AW, Ciriales R, Drasner K: Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg 1995; 81:338-48
7. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD: Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 1998; 285:413-21
8. Zink W, Bohl JR, Hacke N, Sinner B, Martin E, Graf BM: The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks. Anesth Analg 2005; 101:548-54
9. 2+ regulation in murine skeletal muscle fibers. A NESTHESIOLOGY 2005; 102:793-8
10. Friederich P, Schmitz TP: Lidocaine-induced cell death in a human model of neuronal apoptosis. Eur J Anaesthesiol 2002; 19:564-70
11. Boselli E, Duflo F, Debon R, Allaouchiche B, Chassard D, Thomas L, Portoukalian J: The induction of apoptosis by local anesthetics: A comparison between lidocaine and ropivacaine. Anesth Analg 2003; 96:755-6
12. Johnson ME, Uhl CB, Spittler KH, Wang H, Gores GJ: Mitochondrial injury and caspase activation by the local anesthetic lidocaine. A NESTHESIOLOGY 2004; 101:1184-94
13. Lirk P, Haller I, Myers RR, Klimaschewski L, Kau YC, Hung YC, Gerner P: Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo. ANESTHESIOLOGY 2006; 104:1266-73
14. Cohen GM: Caspases: The executioners of apoptosis. Biochem J 1997; 326:1-16
15. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X: Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 1999; 15:269-90
16. Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H: Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. Embo J 2002; 21:4520-30
17. Bossy-Wetzel E, Green DR: Apoptosis: Checkpoint at the mitochondrial frontier. Mutat Res 1999; 434:243-51
18. Los M, Wesselborg S, Schulze-Osthoff K: The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice. Immunity 1999; 10:629-39
19. Muravchick S, Levy RJ: Clinical implications of mitochondrial dysfunction. ANESTHESIOLOGY 2006; 105:819-37
20. Cory S, Huang DC, Adams JM: The Bcl-2 family: Roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607
21. Daniel PT, Schulze-Osthoff K, Belka C, Guner D: Guardians of cell death: The Bcl-2 family proteins. Essays Biochem 2003; 39:73-88
22. Antignani A, Youle RJ: How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 2006; 18:685-9
23. Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K: Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene 2000; 19:1181-90
24. Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Janicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S: Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 2000; 19:4563-73
25. Samraj AK, Keil E, Ueffing N, Schulze-Osthoff K, Schmitz I: Loss of caspase-9 provides genetic evidence for the type I/ II concept of CD95-mediated apoptosis. J Biol Chem 2006; 281:29652-9
26. Juo P, Kuo CJ, Yuan J, Blenis J: Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol 1998; 8:1001-8
27. Reddy UR, Venkatakrishnan G, Roy AK, Chen J, Hardy M, Mavilio F, Rovera G, Pleasure D, Ross AH: Characterization of two neuroblastoma cell lines expressing recombinant nerve growth factor receptors. J Neurochem 1991; 56:67-74
28. Fulda S, Susin SA, Kroemer G, Debatin KM: Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res 1998; 58:4453-60
29. Reers M, Smith TW, Chen LB: J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 1991; 30:4480-6
30. Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C: A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′- tetrachloro-1,1′,3,3′-tetraethylbenzimidazol-carbocyanine iodide (JC-1). Biochem Biophys Res Commun 1993; 197:40-5
31. Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dorken B, Schmalz HG, Daniel PT, Henze G: Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 2001; 15:1735-42
32. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C: A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Methods 1995; 184:39-51
33. Denson DD, Bridenbaugh PO, Turner PA, Phero JC: Comparison of neural blockade and pharmacokinetics after subarachnoid lidocaine in the rhesus monkey: II. Effects of volume, osmolality, and baricity. Anesth Analg 1983; 62:995-1001
34. Kontargiris E, Kolettas E, Vadalouca A, Trougakos IP, Gonos ES, Kalfakakou V: Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine. Cell Res 2004; 14:415-22
35. Kim M, Lee YS, Mathews HL, Wurster RD: Induction of apoptotic cell death in a neuroblastoma cell line by dibucaine. Exp Cell Res 1997; 231:235-41
36. Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW, Kim HJ: Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res 2005; 84:852-7
37. Kamiya Y, Ohta K, Kaneko Y: Lidocaine-induced apoptosis and necrosis in U937 cells depending on its dosage. Biomed Res 2005; 26:231-9
38. Nishimura Y, Kanada A, Yamaguchi JY, Horimoto K, Kobayashi M, Tatsuishi T, Kanemaru K, Ueno SY, Oyama Y: Cytometric analysis of lidocaine-induced cytotoxicity: A model experiment using rat thymocytes. Toxicology 2006; 218:48-57
39. Lirk P, Haller I, Hausott B, Ingorokva S, Deibl M, Gerner P, Klimaschewski L: The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity. Anesth Analg 2006; 102:1728-33
40. Tan Z, Dohi S, Chen J, Banno Y, Nozawa Y: Involvement of the mitogenactivated protein kinase family in tetracaine-induced PC12 cell death. ANESTHESIOLOGY 2002; 96:1191-201
41. Green D, Kroemer G: The central executioners of apoptosis: Caspases or mitochondria? Trends Cell Biol 1998; 8:267-71
42. Drasner K: Local anesthetic neurotoxicity: Clinical injury and strategies that may minimize risk. Reg Anesth Pain Med 2002; 27:576-80
43. Kroemer G, Reed JC: Mitochondrial control of cell death. Nat Med 2000; 6:513-9
44. Sztark F, Malgat M, Dabadie P, Mazat JP: Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. ANESTHESIOLOGY 1998; 88:1340-9
45. Kitagawa N, Oda M, Totoki T: Possible mechanism of irreversible nerve injury caused by local anesthetics: Detergent properties of local anesthetics and membrane disruption. ANESTHESIOLOGY 2004; 100:962-7
46. Yon JH, Daniel-Johnson J, Carter LB, Jevtovic-Todorovic V: Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience 2005; 135:815-27