Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: Mechanisms via reactive oxygen species generation and Akt activation

Chinese Medical Journal

Volumn 120, Issue 24, 2007, Pages 2271-2277

  Liu, Li ^a   Zhang, Xiao Jin ^a   Jiang, Su Rong ^a   Ding, Zheng Nian ^a   Ding, Guo Xian ^a   Huang, Jun ^a   Cheng, Yun Lin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Heat shock protein 27; Mitochondrial potential; Superoxide

Indexed keywords

HEAT SHOCK PROTEIN 27; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; GENETIC TRANSFECTION; HEART MUSCLE CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 38349155476     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200712020-00023     Document Type: Article

References (35)

1. Kang PM, Izumo S. Apoptosis and heart failure: a critical review of the literature. Circ Res 2000; 86: 1107-1113.
2. Lien YC, Lin SM, Nithipongvanitch R, Oberley TD, Noel T, Zhac Q, et al. Tumor necrosis factor receptor deficiency exacerbated Adriamycin-induced cardiomyocytes apoptosis: an insight into the Fas connection. Moll Cancer Ther 2006; 5: 261-269.
3. Tarzami ST, Miao W, Mani K, Lopez L, Factor SM, Berman JW, et al. Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfitsion injury: recruitment of potentially damaging neutrophils and direct myocardial protection. Circulation 2003; 108: 2387-2392.
4. Nakamura Y, Yasuda T, Weisel RD, Li RK. Enhanced cell transplantation: preventing apoptosis increases cell survival and ventricular function. Am J Physiol Heart Circ Physiol 2006; 291: H939-H947.
5. Foo RS, Siow RC, Brown MJ, Bennett MR. Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy. J Cell Physiol 2006; 209: 1-7.
6. Wang R, Miura T, Harada N, Kametani I, Shibuya M, Fukagawa Y, et al. Pleiotropic effects of the beta-adrenoceptor blocker carvedilol on calcium regulation during oxidative stress-induced apoptosis in cardiomyocytes. J Pharmacol Exp Ther 2006; 318: 45-52.
7. Hare JM. Oxidative stress and apoptosis in heart failure progression. Circ Res 2001; 89: 198-200.
8. Sarkar S, Chawla-Sarkar M, Young D, Nishiyama K, Rayborn ME, Hollyfield JG, et al. Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. J Biol Chem 2004; 279: 52630-52642.
9. Mehlen P, Preville X, Chareyron P, Briolay J, Klemenz R, Arrigo AR Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts. J Immunol 1995; 154: 363-374.
10. Ito H, Okamoto Y, Kato K. Enhancement of expression of stress proteins by agents that lower the levels of glutathione in cells. Biochim Biophys Acta 1998; 1397: 223-230.
11. Concannon Cg, Orrenius S, Samali A. Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. Gene Expr 2001; 9: 195-201.
12. Akbar MT, Lundberg AM, Liu K, Vidyadaran S, Wells KE, Dolatshad H, et al. The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. J Biol Chem 2003; 278: 19956-19965.
13. Efthymiou CA, Mocanu MM, de Belleroche J, Wells DJ, Latchmann DS, Yellon DM. Heat shock protein 27 protects the heart against myocardial infarction. Basic Res Cardiol 2004; 99: 392-394
14. Hollander JM, Martin JL, Belke DD, Scott BT, Swanson E, Krishnamoorthy V, et al. Overexpression of wild-type heat shock protein 27 and a nonphoshorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation 2004; 110: 3544-3552.
15. Chen H, Wu XJ, Lu XY, Zhu L, Wang LP, Yang HT, et al. Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats. Acta Pharmacol Sin 2005; 26: 806-812.
16. Yan LJ, Christians ES, Liu L, Xiao X, Sohal RS, Benjamin IJ. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J 2002; 21: 5164-5172.
17. Sueur S, Pesant M, Rochette L, Connat JL. Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex. Mol Cell Cardiol 2005; 39: 955-963.
18. Mehlen P, Kretz-Remy C, Preville X, Arrigo AP. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J 1996; 15: 2695-2706.
19. Preville X, Salvemini F, Giraud S, Chaufour S, Paul C, Stepien G, et al. Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery. Exp Cell Res 1999; 247: 61-78.
20. Arrigo AP, Virot S, Chaufour S, Firdaus W, Kretz-Remy C, Diaz-Latoud C. Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels. Antioxid Redox Signal 2005; 7: 414-422.
21. Son GH, Geum D, Chung S, Park E, Lee KH, Choi S, et al. A protective role of 27-kDa heat shock protein in glucocorticoid-evoked apoptotic cell death of hippocampal progenitor cells. Biochem Biophys Res Commun 2005; 338: 1751-1758.
22. Tsuchiya A, Tashiro E, Yoshida M, Imoto M. Involvement of nuclear accumulation of heat shock protein 27 in leptomycin B-induced apoptosis in HeLa cells. J Antibiot (Tokyo) 2005; 58: 910-816.
23. Casado P, Zuazua-Villar P, Valle ED, Martinez-Campa C, Lazo PS, Ramos S. Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells. Cancer Lett 2007; 247: 273-282.
24. Isoherranen K, Peltola V, Laurikainen L, Punnonen J, Laihia J, Ahotupa M, et al. Regulation of copper/zinc and manganese superoxide dismutase by UVB irradiation, oxidative stress and cytokines. J Photochem Photobiol B 1997; 40: 288-293.
25. Pupe A, Degreef H, Garmyn M. Induction of tumor necrosis factor-alpha by UVB: a role for reactive oxygen intermediates and eicosanoids. Photochem Photobiol 2003; 78: 68-74.
26. 2-dependent mechanism. Med Mycol 2006; 44: 363-368.
27. Pollack M, Phaneuf S, Dirks A, Leeuwenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann N Y Acad Sci 2002; 959: 93-107.
28. Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssiere JL, Petit PX, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 1995; 181: 1661-1672.
29. Hagen TM, Moreau R, Suh JH, Visioli F. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Ann N Y Acad Sci 2002; 959: 491-507.
30. Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 1998; 8: 267-271.
31. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
32. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
33. Konishi H, Matsuzaki H., Tanaka M, Takemura Y, Kuroda S, Ono Y, et al. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett 1997; 410: 493-498.
34. Nakajima K, Hirade K Ishisaki A, Matsuno H, Suga H, Kanno Y, et al. Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase. Life Sci 2005; 77: 96-107.
35. Rane MJ, Pan Y, Singh S, Powell DW, Wu R, Cummins T, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem 2003; 278: 27828-27835.