In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity

Anesthesia and Analgesia

Volumn 106, Issue 5, 2008, Pages 1456-1464

  Lirk, Philipp ^a,c   Haller, Ingrid ^a   Peter, Hans ^a   Lang, Leopold ^a   Tomaselli, Bettina ^a   Klimaschewski, Lars ^a   Gerner, Peter ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BUPIVACAINE; LIDOCAINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; ROPIVACAINE; STRESS ACTIVATED PROTEIN KINASE; 1,3 BUTADIENE DERIVATIVE; AMIDE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; IMIDAZOLE DERIVATIVE; LOCAL ANESTHETIC AGENT; NITRILE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SODIUM CURRENT; SPINAL GANGLION; ANIMAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CELL PROTECTION; CELL SIZE; CELL SURVIVAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; ANTHRACENES; BUPIVACAINE; BUTADIENES; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GANGLIA, SPINAL; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIDOCAINE; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS, AFFERENT; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

EID: 42449139616     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e318168514b     Document Type: Article

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