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Volumn 184, Issue 1, 2010, Pages 65-77

Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME FRAGILE SITE; DOUBLE STRANDED DNA BREAK; GENE DELETION; GENE STRUCTURE; HOMOLOGOUS RECOMBINATION; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

EID: 74249111370     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.109.111039     Document Type: Article
Times cited : (56)

References (73)
  • 1
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: A mechanistic view of its causes and consequences
    • AGUILERA, A., and B. GOMEZ-GONZALEZ, 2008 Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 9: 204-217.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 204-217
    • AGUILERA, A.1    GOMEZ-GONZALEZ, B.2
  • 2
    • 0023392267 scopus 로고
    • A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
    • ALANI, E., L. CAO and N. KLECKNER, 1987 A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116: 541-545.
    • (1987) Genetics , vol.116 , pp. 541-545
    • ALANI, E.1    CAO, L.2    KLECKNER, N.3
  • 4
    • 13444283383 scopus 로고    scopus 로고
    • Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance
    • BJERGBAEK, L., J. A. COBB, M. TSAI- PFLUGFELDER and S. M. GASSER, 2005 Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. EMBO J. 24: 405-417.
    • (2005) EMBO J , vol.24 , pp. 405-417
    • BJERGBAEK, L.1    COBB, J.A.2    TSAI- PFLUGFELDER, M.3    GASSER, S.M.4
  • 5
    • 0142027842 scopus 로고    scopus 로고
    • Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility
    • CALLAHAN, J. L., K. J. ANDREWS, V. A. ZAKIAN and C. H. FREUDENREICH, 2003 Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol. Cell. Biol. 23: 7849-7860.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 7849-7860
    • CALLAHAN, J.L.1    ANDREWS, K.J.2    ZAKIAN, V.A.3    FREUDENREICH, C.H.4
  • 6
    • 0033557344 scopus 로고    scopus 로고
    • DNA cleavage and degradation by the SbcCD protein complex from Escherichia coli
    • CONNELLY, J. C., E. S. DE LEAU and D. R. LEACH, 1999 DNA cleavage and degradation by the SbcCD protein complex from Escherichia coli. Nucleic Acids Res. 27: 1039-1046.
    • (1999) Nucleic Acids Res , vol.27 , pp. 1039-1046
    • CONNELLY, J.C.1    DE LEAU, E.S.2    LEACH, D.R.3
  • 7
    • 0034892653 scopus 로고    scopus 로고
    • Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
    • COSTANZO, V., K. ROBERTSON, M. BIBIKOVA, E. KIM, D. GRIECO et al., 2001 Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol. Cell 8: 137-147.
    • (2001) Mol. Cell , vol.8 , pp. 137-147
    • COSTANZO, V.1    ROBERTSON, K.2    BIBIKOVA, M.3    KIM, E.4    GRIECO, D.5
  • 8
    • 0035012766 scopus 로고    scopus 로고
    • Therefore, what are recombination proteins there for?
    • COURCELLE, J., A. K. GANESAN and P. C. HANAWALT, 2001 Therefore, what are recombination proteins there for? Bioessays 23: 463-470.
    • (2001) Bioessays , vol.23 , pp. 463-470
    • COURCELLE, J.1    GANESAN, A.K.2    HANAWALT, P.C.3
  • 9
    • 33845785225 scopus 로고    scopus 로고
    • Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae
    • DAEE, D. L., T. MERTZ and R. S. LAHUE, 2007 Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae. Mol. Cell. Biol. 27: 102-110.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 102-110
    • DAEE, D.L.1    MERTZ, T.2    LAHUE, R.S.3
  • 10
    • 0019484879 scopus 로고
    • Internuclear transfer of genetic information in kar1-1/KAR1 heterokaryons in Saccharomyces cerevisiae
    • DUTCHER, S. K., 1981 Internuclear transfer of genetic information in kar1-1/KAR1 heterokaryons in Saccharomyces cerevisiae. Mol. Cell. Biol. 1: 245-253.
    • (1981) Mol. Cell. Biol , vol.1 , pp. 245-253
    • DUTCHER, S.K.1
  • 11
    • 33845651294 scopus 로고    scopus 로고
    • Replication fork regression in repetitive DNAs
    • FOUCHE, N., S. OZGUR, D. ROY and J. D. GRIFFITH, 2006 Replication fork regression in repetitive DNAs. Nucleic Acids Res. 34: 6044-6050.
    • (2006) Nucleic Acids Res , vol.34 , pp. 6044-6050
    • FOUCHE, N.1    OZGUR, S.2    ROY, D.3    GRIFFITH, J.D.4
  • 12
    • 13444253858 scopus 로고    scopus 로고
    • Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: Implications for trinucleotide repeat expansion diseases
    • FREUDENREICH, C. H., and M. LAHIRI, 2004 Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases. Cell Cycle 3: 1370-1374.
    • (2004) Cell Cycle , vol.3 , pp. 1370-1374
    • FREUDENREICH, C.H.1    LAHIRI, M.2
  • 13
    • 0030895078 scopus 로고    scopus 로고
    • Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome
    • FREUDENREICH, C. H., J. B. STAVENHAGEN and V. A. ZAKIAN, 1997 Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome. Mol. Cell. Biol. 17: 2090-2098.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 2090-2098
    • FREUDENREICH, C.H.1    STAVENHAGEN, J.B.2    ZAKIAN, V.A.3
  • 14
    • 0032488872 scopus 로고    scopus 로고
    • Expansion and length-dependent fragility of CTG repeats in yeast
    • FREUDENREICH, C. H., S. M. KANTROW and V. A. ZAKIAN, 1998 Expansion and length-dependent fragility of CTG repeats in yeast. Science 279: 853-856.
    • (1998) Science , vol.279 , pp. 853-856
    • FREUDENREICH, C.H.1    KANTROW, S.M.2    ZAKIAN, V.A.3
  • 15
    • 35649025318 scopus 로고    scopus 로고
    • Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae
    • GANGAVARAPU, V., S. PRAKASH and L. PRAKASH, 2007 Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae. Mol. Cell. Biol. 27: 7758-7764.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 7758-7764
    • GANGAVARAPU, V.1    PRAKASH, S.2    PRAKASH, L.3
  • 16
    • 0034595842 scopus 로고    scopus 로고
    • Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion
    • HENRICKSEN, L.A., S. TOM, Y. LIU and R. A. BAMBARA, 2000 Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion. J. Biol. Chem. 275: 16420-16427.
    • (2000) J. Biol. Chem , vol.275 , pp. 16420-16427
    • HENRICKSEN, L.A.1    TOM, S.2    LIU, Y.3    BAMBARA, R.A.4
  • 17
    • 0033551777 scopus 로고    scopus 로고
    • Genetic instabilities in (CTG.CAG) repeats occur by recombination
    • JAKUPCIAK, J. P., and R. D. WELLS, 1999 Genetic instabilities in (CTG.CAG) repeats occur by recombination. J. Biol. Chem. 274: 23468-23479.
    • (1999) J. Biol. Chem , vol.274 , pp. 23468-23479
    • JAKUPCIAK, J.P.1    WELLS, R.D.2
  • 18
    • 0034704123 scopus 로고    scopus 로고
    • Gene conversion (recombination) mediates expansions of CTG[middle dot]CAG repeats
    • JAKUPCIAK, J. P., and R. D. WELLS, 2000 Gene conversion (recombination) mediates expansions of CTG[middle dot]CAG repeats. J. Biol. Chem. 275: 40003-40013.
    • (2000) J. Biol. Chem , vol.275 , pp. 40003-40013
    • JAKUPCIAK, J.P.1    WELLS, R.D.2
  • 19
    • 0034102420 scopus 로고    scopus 로고
    • Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast
    • JANKOWSKI, C., F. NASAR and D. K. NAG, 2000 Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast. Proc. Natl. Acad. Sci. USA 97: 2134-2139.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2134-2139
    • JANKOWSKI, C.1    NASAR, F.2    NAG, D.K.3
  • 20
    • 34147136044 scopus 로고    scopus 로고
    • CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease
    • JUNG, J., and N. BONINI, 2007 CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. Science 315: 1857-1859.
    • (2007) Science , vol.315 , pp. 1857-1859
    • JUNG, J.1    BONINI, N.2
  • 21
    • 59649119505 scopus 로고    scopus 로고
    • SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
    • KERREST, A., R. P. ANAND, R. SUNDARARAJAN, R. BERMEJO, G. LIBERI et al., 2009 SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination. Nat. Struct. Mol. Biol. 16: 159-167.
    • (2009) Nat. Struct. Mol. Biol , vol.16 , pp. 159-167
    • KERREST, A.1    ANAND, R.P.2    SUNDARARAJAN, R.3    BERMEJO, R.4    LIBERI, G.5
  • 22
    • 34249337762 scopus 로고    scopus 로고
    • OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
    • KOVTUN, I. V., Y. LIU, M. BJORAS, A. KLUNGLAND, S. H. WILSON et al., 2007 OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 447: 447-452.
    • (2007) Nature , vol.447 , pp. 447-452
    • KOVTUN, I.V.1    LIU, Y.2    BJORAS, M.3    KLUNGLAND, A.4    WILSON, S.H.5
  • 23
    • 38049100631 scopus 로고    scopus 로고
    • Features of trinucleotide repeat instability in vivo
    • KOVTUN, I. V., and C. T. MCMURRAY, 2008 Features of trinucleotide repeat instability in vivo. Cell Res. 18: 198-213.
    • (2008) Cell Res , vol.18 , pp. 198-213
    • KOVTUN, I.V.1    MCMURRAY, C.T.2
  • 24
    • 34247566575 scopus 로고    scopus 로고
    • Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication
    • KRISHNA, S., B. M. WAGENER, H. P. LIU, Y. C. LO, R. STERK et al., 2007 Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA Repair (Amst) 6: 797-808.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 797-808
    • KRISHNA, S.1    WAGENER, B.M.2    LIU, H.P.3    LO, Y.C.4    STERK, R.5
  • 25
    • 33645119826 scopus 로고    scopus 로고
    • Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity
    • KROGH, B. O., B. LLORENTE, A. LAM and L. S. SYMINGTON, 2005 Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics 171: 1561-1570.
    • (2005) Genetics , vol.171 , pp. 1561-1570
    • KROGH, B.O.1    LLORENTE, B.2    LAM, A.3    SYMINGTON, L.S.4
  • 26
    • 10344263324 scopus 로고    scopus 로고
    • Recombination proteins in yeast
    • KROGH, B. O., and L. S. SYMINGTON, 2004 Recombination proteins in yeast. Annu. Rev. Genet. 38: 233-271.
    • (2004) Annu. Rev. Genet , vol.38 , pp. 233-271
    • KROGH, B.O.1    SYMINGTON, L.S.2
  • 27
    • 3242658268 scopus 로고    scopus 로고
    • Expanded CAG repeats activate the DNA damage checkpoint pathway
    • LAHIRI, M., T. L. GUSTAFSON, E. R. MAJORS and C. H. FREUDENREICH, 2004 Expanded CAG repeats activate the DNA damage checkpoint pathway. Mol. Cell 15: 287-293.
    • (2004) Mol. Cell , vol.15 , pp. 287-293
    • LAHIRI, M.1    GUSTAFSON, T.L.2    MAJORS, E.R.3    FREUDENREICH, C.H.4
  • 28
    • 0942268167 scopus 로고    scopus 로고
    • Repair of DNA double strand breaks by non-homologous end joining
    • LEES-MILLER, S. P., and K. MEEK, 2003 Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85: 1161-1173.
    • (2003) Biochimie , vol.85 , pp. 1161-1173
    • LEES-MILLER, S.P.1    MEEK, K.2
  • 29
    • 36248942617 scopus 로고    scopus 로고
    • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
    • LENGSFELD, B. M., A. J. RATTRAY, V. BHASKARA, R. GHIRLANDO and T. T. PAULL, 2007 Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol. Cell 28: 638-651.
    • (2007) Mol. Cell , vol.28 , pp. 638-651
    • LENGSFELD, B.M.1    RATTRAY, A.J.2    BHASKARA, V.3    GHIRLANDO, R.4    PAULL, T.T.5
  • 30
    • 0242718930 scopus 로고    scopus 로고
    • Trinucleotide repeat instability: A hairpin curve at the crossroads of replication, recombination, and repair
    • LENZMEIER, B. A., and C. H. FREUDENREICH, 2003 Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repair. Cytogenet. Genome Res. 100: 7-24.
    • (2003) Cytogenet. Genome Res , vol.100 , pp. 7-24
    • LENZMEIER, B.A.1    FREUDENREICH, C.H.2
  • 31
    • 38049173021 scopus 로고    scopus 로고
    • Homologous recombination in DNA repair and DNA damage tolerance
    • LI, X., and W. D. HEYER, 2008 Homologous recombination in DNA repair and DNA damage tolerance. Cell Res. 18: 99-113.
    • (2008) Cell Res , vol.18 , pp. 99-113
    • LI, X.1    HEYER, W.D.2
  • 32
    • 19944432787 scopus 로고    scopus 로고
    • Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase
    • LIBERI, G., G. MAFFIOLETTI, C. LUCCA, I. CHIOLO, A. BARYSHNIKOVA et al., 2005 Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev. 19: 339-350.
    • (2005) Genes Dev , vol.19 , pp. 339-350
    • LIBERI, G.1    MAFFIOLETTI, G.2    LUCCA, C.3    CHIOLO, I.4    BARYSHNIKOVA, A.5
  • 33
    • 32244438870 scopus 로고    scopus 로고
    • Transcription promotes contraction of CAG repeat tracts in human cells
    • LIN, Y., V. DION and J. H.WILSON, 2006 Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13: 179-180.
    • (2006) Nat. Struct. Mol. Biol , vol.13 , pp. 179-180
    • LIN, Y.1    DION, V.2    WILSON, J.H.3
  • 34
    • 34548204316 scopus 로고    scopus 로고
    • Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair.Mol
    • LIN, Y., and J. H. WILSON, 2007 Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair.Mol. Cell. Biol. 27: 6209-6217.
    • (2007) Cell. Biol , vol.27 , pp. 6209-6217
    • LIN, Y.1    WILSON, J.H.2
  • 35
    • 1942422156 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability
    • LIU, Y., H. ZHANG, J. VEERARAGHAVAN, R. A. BAMBARA and C. H. FREUDENREICH, 2004 Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Mol. Cell. Biol. 24: 4049-4064.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 4049-4064
    • LIU, Y.1    ZHANG, H.2    VEERARAGHAVAN, J.3    BAMBARA, R.A.4    FREUDENREICH, C.H.5
  • 36
    • 6344254299 scopus 로고    scopus 로고
    • The Mre11 nuclease is not required for 5′ to 3′ resection at multiple HO-induced double-strand breaks
    • LLORENTE, B., and L. S. SYMINGTON, 2004 The Mre11 nuclease is not required for 5′ to 3′ resection at multiple HO-induced double-strand breaks. Mol. Cell. Biol. 24: 9682-9694.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 9682-9694
    • LLORENTE, B.1    SYMINGTON, L.S.2
  • 37
    • 0037169325 scopus 로고    scopus 로고
    • The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
    • LOBACHEV, K. S., D. A. GORDENIN and M. A. RESNICK, 2002 The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108: 183-193.
    • (2002) Cell , vol.108 , pp. 183-193
    • LOBACHEV, K.S.1    GORDENIN, D.A.2    RESNICK, M.A.3
  • 38
    • 0031820288 scopus 로고    scopus 로고
    • LONGTINE, M. S., A. MCKENZIE, 3RD, D. J. DEMARINI, N. G. SHAH, A. WACH et al., 1998 Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961.
    • LONGTINE, M. S., A. MCKENZIE, 3RD, D. J. DEMARINI, N. G. SHAH, A. WACH et al., 1998 Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961.
  • 39
    • 0033514926 scopus 로고    scopus 로고
    • DNA secondary structure: A common and causative factor for expansion in human disease
    • MCMURRAY, C. T., 1999 DNA secondary structure: a common and causative factor for expansion in human disease. Proc. Natl. Acad. Sci. USA 96: 1823-1825.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1823-1825
    • MCMURRAY, C.T.1
  • 40
    • 54849404458 scopus 로고    scopus 로고
    • MMEJ repair of double-strand breaks (director's cut): Deleted sequences and alternative endings
    • MCVEY, M., and S. E. LEE, 2008 MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet. 24: 529-538.
    • (2008) Trends Genet , vol.24 , pp. 529-538
    • MCVEY, M.1    LEE, S.E.2
  • 41
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • MIMITOU, E. P., and L. S. SYMINGTON, 2008 Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • MIMITOU, E.P.1    SYMINGTON, L.S.2
  • 42
    • 0032514711 scopus 로고    scopus 로고
    • Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae
    • MIRET, J. J., L. PESSOA-BRANDAO and R. S. LAHUE, 1998 Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95: 12438-12443.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12438-12443
    • MIRET, J.J.1    PESSOA-BRANDAO, L.2    LAHUE, R.S.3
  • 43
    • 34250878426 scopus 로고    scopus 로고
    • Expandable DNA repeats and human disease
    • MIRKIN, S. M., 2007 Expandable DNA repeats and human disease. Nature 447: 932-940.
    • (2007) Nature , vol.447 , pp. 932-940
    • MIRKIN, S.M.1
  • 44
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • MOREAU, S., J. R. FERGUSON and L. S. SYMINGTON, 1999 The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19: 556-566.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 556-566
    • MOREAU, S.1    FERGUSON, J.R.2    SYMINGTON, L.S.3
  • 45
    • 6944230944 scopus 로고    scopus 로고
    • Both CAG repeats and inverted DNA repeats stimulate spontaneous unequal sister-chromatid exchange in Saccharomyces cerevisiae
    • NAG, D. K., M. SURI and E. K. STENSON, 2004 Both CAG repeats and inverted DNA repeats stimulate spontaneous unequal sister-chromatid exchange in Saccharomyces cerevisiae. Nucleic Acids Res. 32: 5677-5684.
    • (2004) Nucleic Acids Res , vol.32 , pp. 5677-5684
    • NAG, D.K.1    SURI, M.2    STENSON, E.K.3
  • 46
    • 34547692622 scopus 로고    scopus 로고
    • Trinucleotide repeat disorders
    • ORR, H. T., and H. Y. ZOGHBI, 2007 Trinucleotide repeat disorders. Annu. Rev. Neurosci. 30: 575-621.
    • (2007) Annu. Rev. Neurosci , vol.30 , pp. 575-621
    • ORR, H.T.1    ZOGHBI, H.Y.2
  • 47
    • 25844468819 scopus 로고    scopus 로고
    • OWEN, B. A., Z. YANG, M. LAI, M. GAJEK, J. D. BADGER, 2ND et al., 2005 (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat. Struct. Mol. Biol. 12: 663-670.
    • OWEN, B. A., Z. YANG, M. LAI, M. GAJEK, J. D. BADGER, 2ND et al., 2005 (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat. Struct. Mol. Biol. 12: 663-670.
  • 48
    • 25844524498 scopus 로고    scopus 로고
    • Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair
    • PANIGRAHI, G. B., R. LAU, S. E. MONTGOMERY, M. R. LEONARD and C. E. PEARSON, 2005 Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nat. Struct. Mol. Biol. 12: 654-662.
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 654-662
    • PANIGRAHI, G.B.1    LAU, R.2    MONTGOMERY, S.E.3    LEONARD, M.R.4    PEARSON, C.E.5
  • 49
    • 0033556218 scopus 로고    scopus 로고
    • Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli
    • PARNIEWSKI, P., A. BACOLLA, A. JAWORSKI and R. D. WELLS, 1999 Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli. Nucleic Acids Res. 27: 616-623.
    • (1999) Nucleic Acids Res , vol.27 , pp. 616-623
    • PARNIEWSKI, P.1    BACOLLA, A.2    JAWORSKI, A.3    WELLS, R.D.4
  • 50
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • PAULL, T. T., and M. GELLERT, 1998 The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1: 969-979.
    • (1998) Mol. Cell , vol.1 , pp. 969-979
    • PAULL, T.T.1    GELLERT, M.2
  • 51
  • 53
    • 32644440337 scopus 로고    scopus 로고
    • Interactions among DNA ligase I, the flap endonuclease and proliferating cell nuclear antigen in the expansion and contraction of CAG repeat tracts in yeast
    • REFSLAND, E. W., and D. M. LIVINGSTON, 2005 Interactions among DNA ligase I, the flap endonuclease and proliferating cell nuclear antigen in the expansion and contraction of CAG repeat tracts in yeast. Genetics 171: 923-934.
    • (2005) Genetics , vol.171 , pp. 923-934
    • REFSLAND, E.W.1    LIVINGSTON, D.M.2
  • 54
    • 0034252264 scopus 로고    scopus 로고
    • Mini- and microsatellite expansions: The recombination connection
    • RICHARD, G. F., and F. PAQUES, 2000 Mini- and microsatellite expansions: the recombination connection. EMBO Rep. 1: 122-126.
    • (2000) EMBO Rep , vol.1 , pp. 122-126
    • RICHARD, G.F.1    PAQUES, F.2
  • 55
    • 0342965192 scopus 로고    scopus 로고
    • Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats
    • RICHARD, G. F., B. DUJON and J. E. HABER, 1999 Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats. Mol. Gen. Genet. 261: 871-882.
    • (1999) Mol. Gen. Genet , vol.261 , pp. 871-882
    • RICHARD, G.F.1    DUJON, B.2    HABER, J.E.3
  • 56
    • 0034658187 scopus 로고    scopus 로고
    • Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex
    • RICHARD, G. F., G. M. GOELLNER, C. T. MCMURRAY and J. E. HABER, 2000 Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex. EMBO J. 19: 2381-2390.
    • (2000) EMBO J , vol.19 , pp. 2381-2390
    • RICHARD, G.F.1    GOELLNER, G.M.2    MCMURRAY, C.T.3    HABER, J.E.4
  • 57
    • 0037459055 scopus 로고    scopus 로고
    • Contractions and expansions of CAG/CTG trinucleotide repeats occur during ectopic gene conversion in yeast, by a MUS81-independent mechanism
    • RICHARD, G. F., C. CYNCYNATUS and B. DUJON, 2003 Contractions and expansions of CAG/CTG trinucleotide repeats occur during ectopic gene conversion in yeast, by a MUS81-independent mechanism. J. Mol. Biol. 326: 769-782.
    • (2003) J. Mol. Biol , vol.326 , pp. 769-782
    • RICHARD, G.F.1    CYNCYNATUS, C.2    DUJON, B.3
  • 58
    • 0030725454 scopus 로고    scopus 로고
    • Trinucleotide repeats affect DNA replication in vivo
    • SAMADASHWILY, G. M., G. RACA and S. M. MIRKIN, 1997 Trinucleotide repeats affect DNA replication in vivo. Nat. Genet. 17: 298-304.
    • (1997) Nat. Genet , vol.17 , pp. 298-304
    • SAMADASHWILY, G.M.1    RACA, G.2    MIRKIN, S.M.3
  • 59
    • 0037543991 scopus 로고    scopus 로고
    • CTG repeat instability and size variation timing in DNA repair-deficient mice
    • SAVOURET, C., E. BRISSON, J. ESSERS, R. KANAAR, A. PASTINK et al., 2003 CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J. 22: 2264-2273.
    • (2003) EMBO J , vol.22 , pp. 2264-2273
    • SAVOURET, C.1    BRISSON, E.2    ESSERS, J.3    KANAAR, R.4    PASTINK, A.5
  • 60
    • 0028178792 scopus 로고
    • The Saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation
    • SCHULZ, V. P., and V. A. ZAKIAN, 1994 The Saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell 76: 145-155.
    • (1994) Cell , vol.76 , pp. 145-155
    • SCHULZ, V.P.1    ZAKIAN, V.A.2
  • 61
    • 0032779262 scopus 로고    scopus 로고
    • The effect of DNA replication mutations on CAG tract stability in yeast
    • SCHWEITZER, J. K., and D. M. LIVINGSTON, 1999 The effect of DNA replication mutations on CAG tract stability in yeast. Genetics 152: 953-963.
    • (1999) Genetics , vol.152 , pp. 953-963
    • SCHWEITZER, J.K.1    LIVINGSTON, D.M.2
  • 62
    • 0033369989 scopus 로고    scopus 로고
    • Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats
    • SPIRO, C., R. PELLETIER, M. L. ROLFSMEIER, M. J. DIXON, R. S. LAHUE et al., 1999 Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats. Mol. Cell 4: 1079-1085.
    • (1999) Mol. Cell , vol.4 , pp. 1079-1085
    • SPIRO, C.1    PELLETIER, R.2    ROLFSMEIER, M.L.3    DIXON, M.J.4    LAHUE, R.S.5
  • 63
    • 0026530911 scopus 로고
    • Characterization of doublestrand break-induced recombination: Homology requirements and single-stranded DNA formation
    • SUGAWARA, N., and J. E. HABER, 1992 Characterization of doublestrand break-induced recombination: homology requirements and single-stranded DNA formation. Mol. Cell. Biol. 12: 563-575.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 563-575
    • SUGAWARA, N.1    HABER, J.E.2
  • 64
    • 67349167663 scopus 로고    scopus 로고
    • The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress
    • TITTEL-ELMER, M., C. ALABERT, P. PASERO and J. A. COBB, 2009 The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBOJ. 28: 1142-1156.
    • (2009) EMBOJ , vol.28 , pp. 1142-1156
    • TITTEL-ELMER, M.1    ALABERT, C.2    PASERO, P.3    COBB, J.A.4
  • 65
    • 33646122683 scopus 로고    scopus 로고
    • ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks
    • TRENZ, K., E. SMITH, S. SMITH and V. COSTANZO, 2006 ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J. 25: 1764-1774.
    • (2006) EMBO J , vol.25 , pp. 1764-1774
    • TRENZ, K.1    SMITH, E.2    SMITH, S.3    COSTANZO, V.4
  • 66
    • 0035929667 scopus 로고    scopus 로고
    • DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex
    • TRUJILLO, K. M., and P. SUNG, 2001 DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J. Biol. Chem. 276: 35458-35464.
    • (2001) J. Biol. Chem , vol.276 , pp. 35458-35464
    • TRUJILLO, K.M.1    SUNG, P.2
  • 67
    • 19344366752 scopus 로고    scopus 로고
    • Role of Saccharomyces singlestranded DNA-binding protein RPA in the strand invasion step of double-strand break repair
    • WANG, X., and J. E. HABER, 2004 Role of Saccharomyces singlestranded DNA-binding protein RPA in the strand invasion step of double-strand break repair. PLoS Biol. 2: E21.
    • (2004) PLoS Biol , vol.2
    • WANG, X.1    HABER, J.E.2
  • 68
    • 0038700698 scopus 로고    scopus 로고
    • Molecular views of recombination proteins and their control
    • WEST, S. C., 2003 Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell. Biol. 4: 435-445.
    • (2003) Nat. Rev. Mol. Cell. Biol , vol.4 , pp. 435-445
    • WEST, S.C.1
  • 69
    • 34948899943 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template
    • WILLIAMS, R. S., J. S.WILLIAMS and J. A. TAINER, 2007 Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell Biol. 85: 509-520.
    • (2007) Biochem. Cell Biol , vol.85 , pp. 509-520
    • WILLIAMS, R.S.1    WILLIAMS, J.S.2    TAINER, J.A.3
  • 70
    • 0042307369 scopus 로고    scopus 로고
    • Huntington disease expansion mutations in humans can occur before meiosis is completed
    • YOON, S. R., L. DUBEAU, M. DE YOUNG, N. S. WEXLER and N. ARNHEIM, 2003 Huntington disease expansion mutations in humans can occur before meiosis is completed. Proc. Natl. Acad. Sci. USA 100: 8834-8838.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8834-8838
    • YOON, S.R.1    DUBEAU, L.2    DE YOUNG, M.3    WEXLER, N.S.4    ARNHEIM, N.5
  • 71
    • 34447129653 scopus 로고    scopus 로고
    • Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination
    • ZHANG, Y., M. L. HEFFERIN, L. CHEN, E. Y. SHIM, H. M. TSENG et al., 2007 Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat. Struct. Mol. Biol. 14: 639-646.
    • (2007) Nat. Struct. Mol. Biol , vol.14 , pp. 639-646
    • ZHANG, Y.1    HEFFERIN, M.L.2    CHEN, L.3    SHIM, E.Y.4    TSENG, H.M.5
  • 72
    • 0036226637 scopus 로고    scopus 로고
    • Statistical and algorithmic methods for fluctuation analysis with SALVADOR as an implementation
    • ZHENG, Q., 2002 Statistical and algorithmic methods for fluctuation analysis with SALVADOR as an implementation. Math. Biosci. 176: 237-252.
    • (2002) Math. Biosci , vol.176 , pp. 237-252
    • ZHENG, Q.1
  • 73
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA doublestrand break ends
    • ZHU, Z., W. H. CHUNG, E. Y. SHIM, S. E. LEE and G. IRA, 2008 Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA doublestrand break ends. Cell 134: 981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • ZHU, Z.1    CHUNG, W.H.2    SHIM, E.Y.3    LEE, S.E.4    IRA, G.5


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