Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: Implications for trinucleotide repeat expansion diseases

Cell Cycle

Volumn 3, Issue 11, 2004, Pages 1370-1374

  Freudenreich, Catherine H ^a   Lahiri, Mayurika ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Checkpoint proteins; Claspin; DNA damage; DNA repair; Fragility; Inherited genetic disease; Mrc1; Stability; Trinucleotide repeat

Indexed keywords

OKAZAKI FRAGMENT; TRINUCLEOTIDE;

CELL CYCLE S PHASE; CELL VIABILITY; CHROMOSOME BREAKAGE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENE DELETION; GENETIC DISORDER; GENOMIC INSTABILITY; HUMAN; HUNTINGTON CHOREA; MUTATION RATE; MYOTONIC DYSTROPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE DEGENERATION; TRINUCLEOTIDE REPEAT;

EID: 13444253858     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.11.1246     Document Type: Review

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